Market Value840,835,000
Total Holdings156
File Date2018-05-15
Original Filing (Click here)

All hedge funds or institutions that manage over $100M are required by the SEC to file quarterly reports on their holdings. These reports are called 13F reports. However, the filings are required the following quarter from the reporting period, which means that by the time the filing is made (and we see them), the information could be five months old.

For funds with long term positions that make few trades, the holdings might closely resemble their current holdings, even after several months. However, for funds that have high turnover, the holdings data we see might differ significantly from their current holdings. Institutions are required to report CALL and PUT options, and those positions are identified in the table. However, they are not required to report short positions.

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Security Imputed
Share Price		 Prev
Shares		 Current
Shares		 Change
(Percent)		 Prev Value
(USD x1000)		 Current Value
(USD x1000)		 Change
(Percent)
INCY / Incyte Corporation
INCY / Incyte Corporation Call
INCY / Incyte Corporation Put
NURO / NeuroMetrix, Inc.
CFRX / ContraFect Corp
BIIB / Biogen Inc. Call
BIIB / Biogen Inc. Put
BIIB / Biogen Inc.
ADVM / Adverum Biotechnologies, Inc. Call
NSPR / InspireMD, Inc.
TSRO / TESARO, Inc. Call
KZIA / Kazia Therapeutics Limited - Depositary Receipt (Common Stock)
INSM / Insmed Incorporated
INSM / Insmed Incorporated Put
SESN / Sesen Bio Inc.
ICPT / Intercept Pharmaceuticals Inc Call
YMTX / Yumanity Therapeutics Inc
BBI / Brickell Biotech Inc
ONSIZ / Oncobiologics, Inc. Series B Warrant Expiring 5/18
TSRO / TESARO, Inc.
74979C113 / RXI Pharmaceuticals Corporation, Warrants
US00163U1060 / AMAG Pharmaceuticals, Inc.
SPDR S&P BIOTECH / S&P BIOTECH Call (78464A970)
BMY / Bristol-Myers Squibb Company
LPTX / Leap Therapeutics, Inc.
MRK / Merck & Co., Inc.
MRK / Merck & Co., Inc. Call
MRK / Merck & Co., Inc. Put
GALT / Galectin Therapeutics Inc.
OASM / Oasmia Pharmaceutical AB
US0153511094 / Alexion Pharmaceuticals, Inc. Call
US0153511094 / Alexion Pharmaceuticals, Inc. Put
OCLS / Oculus Innovative Sciences, Inc.
ADVM / Adverum Biotechnologies, Inc.
NKTR / Nektar Therapeutics
NKTR / Nektar Therapeutics Call
NKTR / Nektar Therapeutics Put
XLRN / Acceleron Pharma Inc
XLRN / Acceleron Pharma Inc Call
IDRA / Idera Pharmaceuticals, Inc.
SIOX / Sio Gene Therapies Inc. Put
SIOX / Sio Gene Therapies Inc.
SIOX / Sio Gene Therapies Inc. Call
ROSG / Rosetta Genomics, Ltd.
HALO / Halozyme Therapeutics, Inc.
HALO / Halozyme Therapeutics, Inc. Call
HMNY / Helios and Matheson Analytics Inc.
ESPR / Esperion Therapeutics, Inc.
ESPR / Esperion Therapeutics, Inc. Call
ESPR / Esperion Therapeutics, Inc. Put
ADXS / Ayala Pharmaceuticals, Inc. Call
HMNY / Helios and Matheson Analytics Inc. Put
AXSM / Axsome Therapeutics, Inc.
QNRX / Quoin Pharmaceuticals, Ltd. - Depositary Receipt (Common Stock)
GBT / Global Blood Therapeutics Inc. Call
/ InspireMD Inc. Series B Warrants, exercisable for one share of common stock (Expiring March 14, 2022
FOLD / Amicus Therapeutics, Inc. Put
ONCE / Spark Therapeutics, Inc.
ALNY / Alnylam Pharmaceuticals, Inc.
ALNY / Alnylam Pharmaceuticals, Inc. Put
ASXC / Asensus Surgical, Inc. Put
ASXC / Asensus Surgical, Inc.
ONCS / OncoSec Medical Inc
DBVT / DBV Technologies S.A. - Depositary Receipt (Common Stock) Call
YTEN / Yield10 Bioscience, Inc.
ODT / Odonate Therapeutics Inc
MRNS / Marinus Pharmaceuticals, Inc. Call
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Call
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) Put
APDNW / Applied DNA Sciences, Inc., Warrants
H03579101 / Auris Medical Holding Ltd
SGMO / Sangamo Therapeutics, Inc.
RGNX / REGENXBIO Inc. Call
CGRN / Capstone Green Energy Corp.
/ Immunomedics, Inc. Put
IMUC.WS / ImmunoCellular Therapeutics, Ltd., Warrants
XENE / Xenon Pharmaceuticals Inc.
JAGUAR HEALTH INC / (47010C201)
ABEO / Abeona Therapeutics Inc.
BMYMP / Bristol-Myers Squibb Company - Preferred Security Call
ZGNX / Zogenix Inc Call
ZGNX / Zogenix Inc Put
ONSIW / Oncobiologics, Inc. Series A Warrant Expiring 2/18/2018
45779A119 / InspireMD, Inc. Warrants
EIGR / Eiger BioPharmaceuticals, Inc.
ONCE / Spark Therapeutics, Inc. Put
AQB / AquaBounty Technologies, Inc.
IMGN / ImmunoGen, Inc. Put
OPGN / OpGen, Inc.
0HBB / Aimmune Therapeutics Inc Put
ONCE / Spark Therapeutics, Inc. Call
68232V116 / Onconova Therapeutics, Inc. Warrants
XLRN / Acceleron Pharma Inc Put
IMMP / Immutep Limited - Depositary Receipt (Common Stock)
SCON / Superconductor Technologies Inc.
SPDR S&P BIOTECH / S&P BIOTECH Put (78464A950)
VNRX / VolitionRx Limited
US00163U1060 / AMAG Pharmaceuticals, Inc. Put
BNTCW / Benitec Biopharma Ltd
FOLD / Amicus Therapeutics, Inc.
JUNO / Juno Therapeutics, Inc. Call
US00163U1060 / AMAG Pharmaceuticals, Inc. Call
FOLD / Amicus Therapeutics, Inc. Call
BNTCW / Benitec Biopharma Ltd Call
CYTXW / Cytori Therapeutics, Inc. Warrants Call
SLNO / Soleno Therapeutics, Inc.
ANTH / Anthera Pharmaceuticals, Inc. Put
BMYMP / Bristol-Myers Squibb Company - Preferred Security Put
US00448Q2012 / Achillion Pharmaceuticals, Inc.
ZCOR / Zyla Life Sciences
IPCI / Intellipharmaceutics International Inc.
RDUS / Radius Recycling, Inc. Call
ALNY / Alnylam Pharmaceuticals, Inc. Call
SGLB / Sigma Labs Inc
AEZS / COSCIENS Biopharma Inc. Call
AEZS / COSCIENS Biopharma Inc. Put
FCEL / FuelCell Energy, Inc. Put
SGYPQ / SYNERGY PHARMACEUTICALS INC DEL Call
/ GW Pharmaceuticals Plc. Put
FGEN / FibroGen, Inc. Call
PRTA / Prothena Corporation plc
PRTA / Prothena Corporation plc Call
PRTA / Prothena Corporation plc Put
VRTX / Vertex Pharmaceuticals Incorporated Put
SNES / SenesTech, Inc.
GALT / Galectin Therapeutics Inc. Put
0HBB / Aimmune Therapeutics Inc
OEF / iShares Trust - iShares S&P 100 ETF Put
SRPT / Sarepta Therapeutics, Inc. Call
SRPT / Sarepta Therapeutics, Inc. Put
DERM / Journey Medical Corporation Put
DERM / Journey Medical Corporation
CI / The Cigna Group Call
ABIO / ARCA biopharma, Inc.
CYTXW / Cytori Therapeutics, Inc. Warrants
ZSAN / Zosano Pharma Corp
TMBR / Timber Pharmaceuticals Inc
FCSC / Fibrocell Science Inc.
AGEN / Agenus Inc. Call
AGEN / Agenus Inc. Put
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock)
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Call
AMRN / Amarin Corporation plc - Depositary Receipt (Common Stock) Put
IONS / Ionis Pharmaceuticals, Inc. Call
ADOM / Envirotech Vehicles Inc
SPHS / Sophiris Bio Inc
OTLK / Outlook Therapeutics, Inc.
OCGN / Ocugen, Inc.
ARAV / Aravive, Inc. Call
AKBA / Akebia Therapeutics, Inc.
NAOV / NanoVibronix, Inc.
VRTX / Vertex Pharmaceuticals Incorporated Call
PRPO / Precipio, Inc.
ARMP / Armata Pharmaceuticals, Inc.
SPHS / Sophiris Bio Inc Call
SPHS / Sophiris Bio Inc Put
/ Achaogen Inc Call
/ Achaogen Inc Put
NOVN / Novan Inc
QLGN / Qualigen Therapeutics, Inc.
TSRO / TESARO, Inc. Put
IONS / Ionis Pharmaceuticals, Inc. Put
IMUC.WS / ImmunoCellular Therapeutics, Ltd., Warrants Call
RKDA / Arcadia Biosciences, Inc.
CLVS / Clovis Oncology Inc Call
BIOA / BioAge Labs, Inc.
NBRV / Nabriva Therapeutics Plc
FCEL / FuelCell Energy, Inc.
ABBV / AbbVie Inc.
ABBV / AbbVie Inc. Call
ABBV / AbbVie Inc. Put
ARAV / Aravive, Inc.
GLYC / GlycoMimetics, Inc.
GILD / Gilead Sciences, Inc. Call
CLSN / Imunon Inc
EYEN / Eyenovia, Inc.
PSTI / Pluristem Therapeutics Inc
PSTI / Pluristem Therapeutics Inc Put
SLDB / Solid Biosciences Inc.
NHWK / NightHawk Biosciences, Inc.
VTVT / vTv Therapeutics Inc.
INPX / Inpixon
BIOC / Biocept Inc
IDXG / Interpace Biosciences, Inc.
PRQR / ProQR Therapeutics N.V.
PAVM / PAVmed Inc.
PULM / Pulmatrix, Inc.
VTGN / Vistagen Therapeutics, Inc.
US00448Q2012 / Achillion Pharmaceuticals, Inc. Call
US00448Q2012 / Achillion Pharmaceuticals, Inc. Put
BLUE / bluebird bio, Inc. Call
BLUE / bluebird bio, Inc. Put
CHEK / Check-Cap Ltd.
MBOT / Microbot Medical Inc.
BPTH / Bio-Path Holdings, Inc.
TNDM / Tandem Diabetes Care, Inc.
CTXR / Citius Pharmaceuticals, Inc.
SGMO / Sangamo Therapeutics, Inc. Call
SGMO / Sangamo Therapeutics, Inc. Put
TPST / Tempest Therapeutics, Inc.
MNKD / MannKind Corporation
MNKD / MannKind Corporation Call
MNKD / MannKind Corporation Put
SAGE / Sage Therapeutics, Inc. Call
SAGE / Sage Therapeutics, Inc. Put
PTCT / PTC Therapeutics, Inc. Call
COGT / Cogent Biosciences, Inc.
ALKS / Alkermes plc Call
ALKS / Alkermes plc Put
NUWE / Nuwellis, Inc.
VIRX / Viracta Therapeutics, Inc.
CANF / Can-Fite BioPharma Ltd. - Depositary Receipt (Common Stock)
VIRX / Viracta Therapeutics, Inc. Call
SLS / SELLAS Life Sciences Group, Inc.
SLS / SELLAS Life Sciences Group, Inc. Call
SSKN / STRATA Skin Sciences, Inc.
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock)
EDAP / EDAP TMS S.A. - Depositary Receipt (Common Stock) Put
MDGS / Medigus Ltd. - Depositary Receipt (Common Stock)
AFMD / Affimed N.V.
AMRS / Amyris Inc Put
APDN / Applied DNA Sciences, Inc.
RDHL / RedHill Biopharma Ltd. - Depositary Receipt (Common Stock)
PHIO / Phio Pharmaceuticals Corp.
ATNM / Actinium Pharmaceuticals, Inc.
SEEL / Seelos Therapeutics, Inc.
BCLI / Brainstorm Cell Therapeutics Inc.
SPY / SPDR S&P 500 ETF Put
AVEO / AVEO Pharmaceuticals Inc Call
ONTX / Onconova Therapeutics, Inc.
OEF / iShares Trust - iShares S&P 100 ETF Call
SPY / SPDR S&P 500 ETF Call
SPY / SPDR S&P 500 ETF