GNCA / Genocea Biosciences Inc - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Genocea Biosciences Inc
US ˙ NASDAQ
HINDI NA ACTIVE ANG SIMBONG ITO

Mga Batayang Estadistika
LEI 549300BRZWG25RBYA369
CIK 1457612
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Genocea Biosciences Inc
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
June 13, 2022 15-12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. 001-36289 Commission File Number GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified i

June 9, 2022 POS AM

As filed with the Securities and Exchange Commission on June 9, 2022

As filed with the Securities and Exchange Commission on June 9, 2022 Registration No.

June 9, 2022 POS AM

As filed with the Securities and Exchange Commission on June 9, 2022

As filed with the Securities and Exchange Commission on June 9, 2022 Registration No.

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2014initials-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-194021 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-194021 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its cha

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2020incrementals-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-238878 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-238878 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2021evergreens-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-253364 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-253364 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its c

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2017evergreens-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-216183 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-216183 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its c

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2022evergreens-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-263699 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-263699 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its c

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2015evergreens-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-202333 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-202333 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its c

June 6, 2022 S-8 POS

As filed with the Securities and Exchange Commission on June 3, 2022

S-8 POS 1 a2014espps-8pos.htm S-8 POS As filed with the Securities and Exchange Commission on June 3, 2022 Registration No. 333-197127 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: FORM S-8 REGISTRATION STATEMENT NO. 333-197127 UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charte

June 3, 2022 POS AM

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 3, 2022 POS AM

As filed with the Securities and Exchange Commission on June 3, 2022

As filed with the Securities and Exchange Commission on June 3, 2022 Registration No.

June 2, 2022 25

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-36289 GENOCEA BIOSCIENCES,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 001-36289 GENOCEA BIOSCIENCES, INC. THE NASDAQ CAPITAL MARKET (Exact name of Issuer as specified in its charter, and name of Exchange where security is listed and/or registered) 10

June 1, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 25, 2022 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 27, 2022 SC 13D/A

GNCA / Genocea Biosciences Inc / New Enterprise Associates 16, L.P. - NEW ENTERPRISE ASSOCIATES 16, L.P. / GENOCEA BIOSCIENCES -- SCHEDULE 13D/A5E Activist Investment

Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 5)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842

May 24, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 20, 2022 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 GENOCEA BIOSCIENCES, INC.

April 29, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36289 GENOCE

April 29, 2022 EX-10.30

Amendment to the Amended and Restated Employment Letter Agreement between Jessica Flechtner and Genocea Biosciences, Inc., dated September 12, 2016

Exhibit 10.30 September 12, 2016 Dear Jess: This letter (the "Amendment") amends the letter agreement between you and Genocea Biosciences, Inc. (the "Company"), dated January 16, 2014 (the "Employment Agreement"), effective as of the date hereof. All capitalized terms used in this Amendment shall have the meanings ascribed to them in the Employment Agreement unless otherwise expressly provided her

April 28, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Costs Associated with Exit or Disposal Activities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 28, 2022 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

April 28, 2022 EX-99.1

Genocea Initiates Restructuring and Announces Plan to Explore Strategic Alternatives

Investor Contact: Media Contact: Dan Ferry Sarah O?Connell daniel@lifesciadvisors.

March 18, 2022 EX-4.11

Description of the Registrant's Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934

Exhibit 4.11 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of December 31, 2021, Genocea Biosciences Inc. (?Genocea,? ?we,? ?our,? or ?us?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended: our common stock, $0.001 par value per share. DESCRIPTION OF CAPITAL STOCK The

March 18, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36289 GENOCEA BIOSCIENCES, INC.

March 18, 2022 EX-FILING FEES

Filing Fee Table (filed herewith)

Exhibit 107 Calculation of Filing Fee Tables FORM S-8 (Form Type) GENOCEA BIOSCIENCES, INC.

March 18, 2022 S-8

As filed with the Securities and Exchange Commission on March 18, 2022

As filed with the Securities and Exchange Commission on March 18, 2022 Registration No.

March 18, 2022 EX-10.28

Collaboration and Option Agreement between the Company and Janssen Biotech, Inc., dated December 28, 2021

Exhibit 10.28 Portions of this exhibit have been redacted because they are both (i) not material and (ii) would likely cause competitive harm if publicly disclosed. Information that was omitted has been noted in this document with a placeholder identified by the mark [* * *]. COLLABORATION & OPTION AGREEMENT This Collaboration & Option Agreement (?Agreement?) is dated December 28, 2021, (the ?Effe

March 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2022 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

March 10, 2022 EX-99.1

Genocea Provides Fourth Quarter 2021 Corporate Update Initial GEN-011 clinical trial data to be presented at AACR Conference call today at 8:30 a.m. ET

Investor Contact: Media Contact: Dan Ferry Sarah O?Connell daniel@lifesciadvisors.

March 7, 2022 EX-99.1

John Lunger, of Adaptimmune, Joins Genocea Biosciences' Board of Directors

John Lunger, of Adaptimmune, Joins Genocea Biosciences' Board of Directors CAMBRIDGE, Mass.

March 7, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2022 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

February 14, 2022 SC 13G/A

GNCA / Genocea Biosciences Inc / COMMODORE CAPITAL LP - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2022 SC 13G/A

GNCA / Genocea Biosciences Inc / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 4 TO THE SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 4)1 Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427401 (CUSIP Number) December

February 14, 2022 SC 13G/A

GNCA / Genocea Biosciences Inc / CITADEL ADVISORS LLC - GENOCEA BIOSCIENCES, INC. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO ? 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO ? 240.13d-2 (Amendment No. 2)* Genocea Biosciences Inc (Name of Issuer) Common Stock, $0.001 par value per share (the ?Shares?) (Title of Class of Securities) 372427401 (

February 10, 2022 SC 13G/A

GNCA / Genocea Biosciences Inc / GLAXOSMITHKLINE PLC - AMENDMENT TO SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427104 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

January 4, 2022 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 28, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

January 4, 2022 EX-99.1

Genocea Biosciences Provides Corporate Update Enters into Inhibigen™ R&D collaboration and option agreement with Janssen Reports progress on the GEN-011 TiTAN™ trial

Investor Contact: Dan Ferry 617-430-7576 [email protected] Media Contact: Sarah O’Connell [email protected] Genocea Biosciences Provides Corporate Update Enters into Inhibigen™ R&D collaboration and option agreement with Janssen Reports progress on the GEN-011 TiTAN™ trial CAMBRIDGE, Mass., January 4, 2022 - Genocea Biosciences, Inc. (Nasdaq: GNCA), a biopharmaceutical company

October 28, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 28, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

October 28, 2021 EX-99.1

Genocea Provides Third Quarter 2021 Corporate Update GEN-011 neoantigen-targeted peripheral T cell therapy clinical trial continues Strong presence at the SITC 36th Annual Meeting Conference call today at 8:30 a.m. E.T.

Investor Contact: Media Contact: Dan Ferry Sarah O?Connell daniel@lifesciadvisors.

October 28, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 GENOCEA BIOSCIENCES, INC.

September 13, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2021 GENOCEA BIOSCIE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 8, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

September 13, 2021 EX-99.1

Jennifer Herron, of ADC Therapeutics, Joins Genocea Biosciences' Board of Directors

Investor Contact: Media Contact: Dan Ferry Sarah O?Connell daniel@lifesciadvisors.

July 29, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 GENOCEA BIOSCIENCES, INC.

July 29, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 29, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 29, 2021 EX-99.1

Genocea Provides Second Quarter 2021 Corporate Update GEN-011 neoantigen-targeted peripheral T cell therapy clinical trial continues GEN-009 neoantigen vaccine candidate shows promising long-term clinical results Conference call today at 8:30 a.m. E.

Investor Contact: Media Contact: Dan Ferry Sarah O?Connell daniel@lifesciadvisors.

July 13, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 13, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 13, 2021 EX-99.1

Genocea Doses First Patient in Phase 1/2a TiTAN Clinical Trial for GEN-011 Neoantigen-Targeted T cell Therapy

Investor Contact: Dan Ferry 617-430-7576 [email protected] Media Contact: Sarah O?Connell [email protected] Genocea Doses First Patient in Phase 1/2a TiTAN Clinical Trial for GEN-011 Neoantigen-Targeted T cell Therapy CAMBRIDGE, Mass., July 13, 2021 - Genocea Biosciences, Inc. (Nasdaq: GNCA), a biopharmaceutical company developing next-generation neoantigen immunotherapies, to

June 24, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 24, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

June 24, 2021 EX-3.1

Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K, File No. 001-36289, filed on June 24, 2021)

Exhibit 3.1 GENOCEA BIOSCIENCES, INC. Restated Certificate of Incorporation Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware, Genocea Biosciences, Inc. has adopted this Restated Certificate of Incorporation restating, integrating and further amending its Amended and Restated Certificate of Incorporation (originally filed on August 16, 2006, under the name ?G

June 4, 2021 EX-99.1

Genocea Presents Promising Long-term Results from GEN-009 Neoantigen Vaccine Phase 1 Trial at ASCO 2021 Four of nine checkpoint inhibitor-sensitive patients experienced RECIST responses post vaccination; median duration without disease progression af

Investor Contact: Dan Ferry 617-430-7576 [email protected] Media Contact: Sarah O?Connell [email protected] Genocea Presents Promising Long-term Results from GEN-009 Neoantigen Vaccine Phase 1 Trial at ASCO 2021 Four of nine checkpoint inhibitor-sensitive patients experienced RECIST responses post vaccination; median duration without disease progression after initial GEN-009 v

June 4, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 10, 2021 424B5

$35,808,111 GENOCEA BIOSCIENCES, INC. Common Stock

424B5 1 prospectussupplementatm.htm 424B5 Filed pursuant to Rule 424(b)(5) Registration No. 333-255610 PROSPECTUS SUPPLEMENT (To Prospectus dated May 10, 2021) $35,808,111 GENOCEA BIOSCIENCES, INC. Common Stock We have entered into a sales agreement (the "Sales Agreement") with Cowen and Company, LLC ("Cowen"), relating to shares of our common stock offered by this prospectus supplement. In accord

May 10, 2021 424B5

$23,972,805 GENOCEA BIOSCIENCES, INC. Common Stock

Filed pursuant to Rule 424(b)(5) Registration No. 333-255610 PROSPECTUS SUPPLEMENT (To Prospectus dated May 10, 2021) $23,972,805 GENOCEA BIOSCIENCES, INC. Common Stock We have entered into a purchase agreement (the "Purchase Agreement") with Lincoln Park Capital Fund, LLC ("Lincoln Park") on October 23, 2019, relating to shares of our common stock offered by this prospectus supplement. In accorda

May 6, 2021 CORRESP

GENOCEA BIOSCIENCES, INC. 100 Acorn Park Drive Cambridge, Massachusetts 02149 (617) 876-8191

GENOCEA BIOSCIENCES, INC. 100 Acorn Park Drive Cambridge, Massachusetts 02149 (617) 876-8191 May 6, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F. Street, N.E. Washington, D.C. 20549 RE: Genocea Biosciences, Inc. Registration Statement on Form S-3 (File No. 333-255610) Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 promulgated und

April 29, 2021 EX-5.3

Opinion of Ropes & Gray LLP relating to the purchase agreement (filed herewith)

Exhibit 5.3 April 29, 2021 Genocea Biosciences, Inc. Cambridge Discovery Park 100 Acorn Park Drive, 5th Floor Cambridge, MA 02140 Re: Registration Statement on Form S-3 Ladies and Gentlemen: This opinion is furnished to you in connection with the registration statement on Form S-3 (the ?Registration Statement?) filed on the date hereof with the Securities and Exchange Commission, the base prospect

April 29, 2021 EX-99.1

Genocea Provides First Quarter 2021 Corporate Update GEN-011 and GEN-009 immuno-oncology programs continue to advance Research on Inhibigens™ and SARS-CoV-2 continues to progress Conference call today at 8:30 a.m. E.T.

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides First Quarter 2021 Corporate Update GEN-011 and GEN-009 immuno-oncology programs continue to advance Research on Inhibigens? and SARS-CoV-2 continues to progress Conference call today at 8:30 a.m. E.T. CAMBRIDGE, Mass., APRIL 29, 2021 - Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical company developi

April 29, 2021 S-3

- S-3

As filed with the Securities and Exchange Commission on April 29, 2021 Registration No.

April 29, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 GENOCEA BIOSCIENCES, INC.

April 29, 2021 DEF 14A

- DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 29, 2021 EX-10.1

Form of Performance-Based Restricted Stock Unit Award Agreement under the Genocea Biosciences, Inc. 2014 Equity Inventive Plan (incorporated by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q, File No. 001-36289, filed on April 29, 2021)

Name of Grantee: [] Target Number of PSUs: [] Date of Grant: [] Genocea Biosciences, Inc.

April 29, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

April 29, 2021 DEFA14A

- DEFA14A

DEFA14A 1 a2021proxynotice.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rul

April 14, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 12, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

April 14, 2021 PRE 14A

- PRE 14A

PRE 14A 1 a2021gncaproxyprelim.htm PRE 14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: ý Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by

April 14, 2021 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities)

Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842

March 31, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)* Genocea Biosciences, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

March 31, 2021 EX-1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned, and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements.

February 22, 2021 EX-10.7

of the Company's Annual Report on Form 10-K, File No. 001-36289, filed on February 22, 2021)

Exhibit 10.7 SUBLEASE This instrument is a Sublease (the ?Sublease?) dated as of November 30, 2020 (the ?Execution Date?) between GENOCEA BIOSCIENCES, INC., a Delaware corporation (?Sublessor?), and ZYMERGEN INC., a Delaware corporation (?Sublessee?). The parties to this instrument hereby agree with each other as follows: Article 1 SUMMARY OF BASIC SUBLEASE PROVISIONS 1.1 BASIC DATA ALL CAPITALIZE

February 22, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on February 22, 2021 Registration No.

February 22, 2021 EX-10.26

Loan and Security Agreement between the Company and Silicon Valley Bank, dated February 18, 2021

Exhibit 10.26 Portions of this exhibit have been redacted because they are both (i) not material and (ii) would likely cause competitive harm if publicly disclosed. Information that was omitted has been noted in this document with a placeholder identified by the mark [* * *]. LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this ?Agreement?) dated as of February 18, 2021 (the ?Effecti

February 22, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36289 GENOCEA BIOSCIENCES, INC.

February 22, 2021 EX-4.10

Warrant Agreement between the Company and Silicon Valley Bank, dated February 18, 2021 (incorporated by reference to Exhibit 4.10 of the Company's Annual Report on Form 10-K, File No. 001-36289, filed on February 22, 2021)

Exhibit 4.10 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTA

February 16, 2021 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the common stock of Genocea Biosciences, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each of the

February 16, 2021 SC 13G/A

December 31, 2020

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G*/ (Rule 13d-102) Under the Securities Exchange Act of 1934 (Amendment No. 1)* Genocea Biosciences, Inc. (Name of Issuer) Common stock, $0.001 par value per share (Title of Class of Securities) 372427401 (CUSIP Number) December 31, 2020 Date of Event Which Requires Filing of the Statement Check the appropriate box

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427401 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

February 12, 2021 SC 13G

Genocea Biosciences, Inc.

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 372427401 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursuan

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of S

SC 13G/A 1 gnca-sc13ga021221.htm AMENDMENT TO FORM SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427104 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing o

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 3)1 Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427401 (CUSIP Number) December

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securitie

SC 13G/A 1 ea135462-13ga2vivoopgenocea.htm AMENDMENT NO. 2 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) December 31, 2020 (Date of Event which Requires

February 11, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 11, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

February 11, 2021 EX-99.1

Genocea Provides Fourth Quarter 2020 Corporate Update GEN-011 and GEN-009 clinical trials continue to advance ATLASTM stimulatory antigen and inhibitory antigen (InhibigenTM) identification profiled in Cancer Discovery Announcing SARS-CoV-2 T cell an

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides Fourth Quarter 2020 Corporate Update GEN-011 and GEN-009 clinical trials continue to advance ATLASTM stimulatory antigen and inhibitory antigen (InhibigenTM) identification profiled in Cancer Discovery Announcing SARS-CoV-2 T cell antigen discovery program Conference call today at 8:30 a.m. E.T. CAMBRIDGE, Mass.,

January 4, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 4, 2021 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissi

January 4, 2021 EX-99.1

Better personalized cancer immunotherapies through better neoantigen targeting January 2021 2 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and

genoceacorporatepresenta Better personalized cancer immunotherapies through better neoantigen targeting January 2021 2 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

November 18, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 18, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

November 18, 2020 EX-99.1

Better personalized cancer immunotherapies through better neoantigen targeting November 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and

genoceacorporatepresenta Better personalized cancer immunotherapies through better neoantigen targeting November 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

November 9, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

November 9, 2020 EX-99.1

GEN-009 Part B SITC data presentation November 9, 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information current

sitcinvestorpresentation GEN-009 Part B SITC data presentation November 9, 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

November 9, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

November 9, 2020 EX-99.1

Genocea Presents Positive GEN-009 Clinical Results, Update on GEN-011 Program and New InhibigenTM Mechanism of Action Data at Virtual SITC 2020 Novel clinical and durable immune response patterns suggest addition of GEN-009 may offer additive clinica

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Presents Positive GEN-009 Clinical Results, Update on GEN-011 Program and New InhibigenTM Mechanism of Action Data at Virtual SITC 2020 Novel clinical and durable immune response patterns suggest addition of GEN-009 may offer additive clinical benefit in combination with PD-1-based therapies GEN-011, a neoantigen-targeted

October 29, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 29, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

October 29, 2020 EX-99.1

Genocea Provides Third Quarter 2020 Corporate Update Initiated GEN-011 Phase1/2a clinical trial Presented positive follow-up GEN-009 Part B data at ESMO Virtual Congress 2020 demonstrating potential added benefit to PD-1 inhibitor therapy Closed fina

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides Third Quarter 2020 Corporate Update Initiated GEN-011 Phase1/2a clinical trial Presented positive follow-up GEN-009 Part B data at ESMO Virtual Congress 2020 demonstrating potential added benefit to PD-1 inhibitor therapy Closed financing with net proceeds of $74.5 million Upcoming presentations at SITC 2020 Virtu

October 29, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

September 22, 2020 EX-99.1

Genocea Announces FDA Acceptance of GEN-011 IND Application Novel adoptive T cell therapy targets checkpoint-refractory solid tumors with neoantigen-specific T cells from peripheral blood

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Announces FDA Acceptance of GEN-011 IND Application Novel adoptive T cell therapy targets checkpoint-refractory solid tumors with neoantigen-specific T cells from peripheral blood CAMBRIDGE, Mass., September 22, 2020 – Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical company developing next-generation neoantig

September 22, 2020 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2020 GENOCEA BIOSCI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 22, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commi

August 28, 2020 424B3

GENOCEA BIOSCIENCES, INC. 21,390,902 Shares of Common Stock Warrants to Purchase 45,835,978 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-248103 PROSPECTUS GENOCEA BIOSCIENCES, INC. 21,390,902 Shares of Common Stock Warrants to Purchase 45,835,978 Shares of Common Stock This prospectus relates to the resale or other disposition from time to time of up to (i) 21,390,902 shares of our common stock, par value $0.001 per share (the “Common Stock”), and (ii) up to 45,835,978 shares of

August 26, 2020 CORRESP

-

CORRESP 1 filename1.htm GENOCEA BIOSCIENCES, INC. 100 Acorn Park Drive Cambridge, Massachusetts 02149 (617) 876-8191 August 26, 2020 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F. Street, N.E. Washington, D.C. 20549 RE: Genocea Biosciences, Inc. Registration Statement on Form S-3 (File No. 333-248103) Request for Acceleration Ladies and Gentlemen: Pursuant

August 18, 2020 S-3

- S-3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification No.) 100 Acorn Park Drive Cambridge, Massachusetts 02140 (617) 876-

August 5, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

August 3, 2020 SC 13D/A

GNCA / Genocea Biosciences, Inc. / New Enterprise Associates 16, L.p. - NEW ENTERPRISE ASSOCIATES 16, L.P. / GENOCEA BIOSCIENCES -- SCHEDULE 13D/A3 Activist Investment

Schedule 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842

July 31, 2020 SC 13G

GNCA / Genocea Biosciences, Inc. / CITADEL ADVISORS LLC - SCHDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G*/ (Rule 13d-102) Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427401 (CUSIP Number) July 22, 2020 Date of Event Which Requires Filing of the Statement Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ¨

July 31, 2020 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the common stock of Genocea Biosciences, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each of the

July 30, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 30, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 30, 2020 EX-99.1

GEN-009 Ph1/2a Part B Discussion of Initial Clinical Data July 30, 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on in

gen-009partbdatajuly2020 GEN-009 Ph1/2a Part B Discussion of Initial Clinical Data July 30, 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

July 30, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 30, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 30, 2020 EX-99.1

Webcast/conference call scheduled today, July 30th at 8:00 a.m. EDT Three of five patients achieved separate RECIST responses after GEN-009 administration GEN-009 elicited antigen-specific CD4+ and CD8+ T cell responses in 100% of treated patients

Investor Contact: Dan Ferry 617-430-7576 [email protected] Webcast/conference call scheduled today, July 30th at 8:00 a.m. EDT Three of five patients achieved separate RECIST responses after GEN-009 administration GEN-009 elicited antigen-specific CD4+ and CD8+ T cell responses in 100% of treated patients CAMBRIDGE, Mass., July 30, 2020 – Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopha

July 23, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

July 23, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 23, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 23, 2020 EX-3.5

Certificate of Correction to the Certificate of Amendment to the Restated Certificate of Incorporation of Genocea Biosciences, Inc. (incorporated by reference to Exhibit 3.5 to the Company’s Quarterly Report on Form 10-Q, File No. 001-36289, filed on July 23, 2020)

STATE OF DELAWARE CERTIFICATE OF CORRECTION OF GENOCEA BIOSCIENCES, INC. Genocea Biosciences, Inc., a corporation duly organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify as follows: FIRST: The name of the corporation is Genocea Biosciences, Inc. SECOND: A Certificate of Amendment to the Restated Certificate of

July 23, 2020 EX-99.1

Genocea Provides Second Quarter 2020 Corporate Update Upcoming GEN-009 data update planned for July 30th at 8 a.m. EDT Filed IND application for GEN-011 and is working with the FDA to provide additional information Private Placement with Leading Life

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides Second Quarter 2020 Corporate Update Upcoming GEN-009 data update planned for July 30th at 8 a.m. EDT Filed IND application for GEN-011 and is working with the FDA to provide additional information Private Placement with Leading Life Science Investment Funds Conference call today at 8:30 a.m. EDT CAMBRIDGE, Mass.,

July 22, 2020 EX-4.1

Form of Pre-Funded Warrant

gncaformofprefundedwarra NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS.

July 22, 2020 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 22, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 22, 2020 EX-4.2

(incorporated by reference to Exhibit 4.2 to the Company’s Current Report on Form 8-K, File No. 001-36289, filed on July 22, 2020)

gncaformofwarrant NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS.

July 22, 2020 EX-10.1

Form of Purchase Agreement

gncapurchaseagreement SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 22, 2020 (the “Effective Date”), among Genocea Biosciences, Inc.

July 20, 2020 EX-99.1

GENOCEA BIOSCIENCES PROVIDES CLINICAL UPDATE

Investor Contact: Dan Ferry 617-430-7576 [email protected] GENOCEA BIOSCIENCES PROVIDES CLINICAL UPDATE CAMBRIDGE, Mass., July 20, 2020 - Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical company developing next-generation neoantigen immunotherapies, today announced updates to its clinical programs, the neoantigen vaccine GEN-009 and the neoantigen cell therapy, GEN-011. GEN-0

July 20, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 20, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 6, 2020 EX-99.1

Better cancer immunotherapies through better antigen selection July 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on i

corpdeckjuly2020 Better cancer immunotherapies through better antigen selection July 2020 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

July 6, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 6, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

June 19, 2020 8-K/A

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

June 19, 2020 EX-24

EX-24

POWER OF ATTORNEY Know all by those present, that the undersigned hereby constitutes and appoints each of William Clark and Diantha Duvall, signing singly, as the undersignedTMs true and lawful attorney-in-fact to: (1) execute for and on behalf of the undersigned, in the undersignedTMs capacity as an officer and/or director of Genocea Biosciences, Inc.

June 2, 2020 S-8

- S-8

Registration No. 333- As filed with the Securities and Exchange Commission on June 2, 2020 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (IRS Emplo

June 2, 2020 EX-10.1

Genocea Biosciences, Inc. Amended and Restated 2014 Equity Incentive Plan (incorporated by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K, File No. 001-36289, filed on June 2, 2020)

GENOCEA BIOSCIENCES, INC. AMENDED AND RESTATED 2014 EQUITY INCENTIVE PLAN 1. DEFINED TERMS Exhibit A, which is incorporated by reference, defines the terms used in the Plan and sets forth certain operational rules related to those terms. 2. PURPOSE The Plan has been established to advance the interests of the Company by providing for the grant to Participants of Stock-based Awards. 3. ADMINISTRATI

June 2, 2020 EX-3.1

Certificate of Amendment to Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K, File No. 001-36289, filed on June 2, 2020)

CERTIFICATE OF AMENDMENT TO THE RESTATED CERTIFICATE OF INCORPORATION OF GENOCEA BIOSCIENCES, INC.

June 2, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 22, 2020 DEFR14A

- DEFR14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ý Defi

May 22, 2020 EX-99.1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ý Filed by a Party other than the Registra

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ý Defi

May 22, 2020 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 22, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 12, 2020 EX-99.1

GEN-011: Transforming T cell therapy for solid tumors KOL Symposium 12 May 2020 GEN-011: Designed to improve upon TIL therapy T cells targeting the right tumor neoantigens Peripheral blood T cells enabling greater activity and durability Robust and r

gen011kolsymposium12may2 GEN-011: Transforming T cell therapy for solid tumors KOL Symposium 12 May 2020 GEN-011: Designed to improve upon TIL therapy T cells targeting the right tumor neoantigens Peripheral blood T cells enabling greater activity and durability Robust and rapidly scalable manufacturing process 2 TIL therapy: Current gold standard for solid tumor cell therapy Tumor-infiltrating lymphocyte (TIL) 2,3,4 CAR-T therapy Unproven in solid tumors TCR-transduced (TCR-T) Limited clinical validation HLA-limited Durable efficacy Potential safety concerns1 in checkpoint-refractory patients 1.

May 12, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

April 30, 2020 EX-10.2

Employment Letter Agreement between Thomas Davis and Genocea Biosciences, Inc., dated October 1, 2018 (incorporated by reference to Exhibit 10.2 to the Company’s Quarterly Report on Form 10-Q, File No. 001-36289, filed on April 30, 2020)

Exhibit 10.2 September 17, 2018 Dear Tom: This letter agreement (“Agreement”) sets forth the terms and conditions of your offer of employment with Genocea Biosciences, Inc. (the “Company”). If accepted, the terms hereof shall be effective and your employment shall commence on October 1, 2018 (the “Effective Date”). 1.Position and Duties. You shall serve, on a full-time basis, as the Company’s Chie

April 30, 2020 EX-10.3

Form of Restricted Stock Unit Award Agreement under the Genocea Biosciences, Inc. 2014 Equity Incentive Plan (incorporated by reference to Exhibit 10.3 to the Company’s Quarterly Report on Form 10-Q, File No. 001-36289, filed on April 30, 2020)

Exhibit 10.3 Name: [] Number of Restricted Stock Units subject to Award: [] Date of Grant: [] GENOCEA BIOSCIENCES, INC. 2014 EQUITY INCENTIVE PLAN RESTRICTED STOCK UNIT AWARD AGREEMENT This agreement (this “Agreement”) evidences an award (the “Award”) of restricted stock units granted by Genocea Biosciences, Inc. (the “Company”) to the individual named above (the “Grantee”), pursuant to and subjec

April 30, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

April 30, 2020 EX-99.1

Genocea Provides First Quarter 2020 Corporate Update Clinical stage programs GEN-009 and GEN-011 continue to advance Anticipate GEN-011 IND filing in Q2 Expect GEN-009 Phase 1/2a Part B readout in Q3 GEN-011 Virtual Symposium planned for May 12th Con

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides First Quarter 2020 Corporate Update Clinical stage programs GEN-009 and GEN-011 continue to advance Anticipate GEN-011 IND filing in Q2 Expect GEN-009 Phase 1/2a Part B readout in Q3 GEN-011 Virtual Symposium planned for May 12th Conference call today at 8:30 a.m. EDT CAMBRIDGE, Mass., April 30, 2020 - Genocea Bio

April 30, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

April 30, 2020 EX-10.1

Employment Letter Agreement between Girish Aakalu and Genocea Biosciences, Inc., dated December 6, 2018 (incorporated by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q, File No. 001-36289, filed on April 30, 2020)

Exhibit 10.1 November 6, 2018 Dear Girish: This letter agreement ("Agreement") sets forth the terms and conditions of your offer of employment with Genocea Biosciences, Inc. (the "Company"). If accepted, the terms hereof shall be effective, and your employment shall commence on December 6, 2018 (the "Effective Date"). 1.Position and Duties. You shall serve, on a full-time basis, as the Company's C

April 20, 2020 DEF 14A

GNCA / Genocea Biosciences, Inc. DEF 14A - - DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ý Definitive Proxy State

April 20, 2020 DEFA14A

GNCA / Genocea Biosciences, Inc. DEFA14A - - DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Definitive Proxy State

April 6, 2020 PRE 14A

GNCA / Genocea Biosciences, Inc. PRE 14A - - PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: ý Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Definitive Proxy State

February 28, 2020 SC 13G/A

GNCA / Genocea Biosciences, Inc. / GLAXOSMITHKLINE PLC - AMENDMENT NO. 2 TO FORM SC 13G Passive Investment

SC 13G/A 1 gnca-sc13ga021320.htm AMENDMENT NO. 2 TO FORM SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427104 (CUSIP Number) February 13, 2020 (Date of Event Which Requires Fi

February 14, 2020 SC 13G/A

GNCA / Genocea Biosciences, Inc. / GLAXOSMITHKLINE PLC - AMENDMENT TO FORM SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427104 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

February 14, 2020 SC 13G/A

GNCA / Genocea Biosciences, Inc. / Vivo Opportunity, Llc - AMENDMENT NO. 1 TO SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) December 31, 2019 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule

February 14, 2020 SC 13G/A

GNCA / Genocea Biosciences, Inc. / Biotechnology Value Fund L P - AMENDMENT NO. 2 TO THE SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 2)1 Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427401 (CUSIP Number) December

February 14, 2020 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement The undersigned hereby agree that the Statement on Schedule 13G dated February 14, 2020 with respect to the common stock, par value $0.001 per share, of Genocea Biosciences, Inc., and any further amendments thereto executed by each and any of the undersigned shall be filed on behalf of each of the undersigned pursuant to and in accordance with the provisions of

February 13, 2020 EX-10.2

Amended and Restated License Agreement between Genocea Biosciences, Inc. and President and Fellows of Harvard College, dated November 19, 2012 (incorporated by reference to Exhibit 10.2 to the Company's Annual Report on Form 10-K, File No. 001-36289, filed on February 13, 2020)

EXHIBIT 10.2 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO GENOCEA BIOSCIENCES, INC. IF PUBLICLY DISCLOSED. AMENDED AND RESTATED LICENSE AGREEMENT This Amended and Restated License Agreement (“Agreement”) is entered into as of this 19th day of November, 2012 (the “Amended and Rest

February 13, 2020 EX-10.23

Second Amendment to the Lease, dated May 1, 2019, between 100 Discovery Park DE, LLC, a Delaware limited liability company (as successor in interest to TBCI, LLC, as Trustee of 100 Discovery Park Realty Trust) and Genocea Biosciences, Inc. (incorporated by reference to Exhibit 10.23 to the Company's Annual Report on Form 10-K, File No. 001-36289, filed on February 13, 2020)

SECOND AMENDMENT OF LEASE THIS SECOND AMENDMENT OF LEASE (this “Amendment”) is made as of the 1st day of May, 2019, by 100 Discovery Park DE, LLC, a Delaware limited liability company (as successor in interest to TBCI, LLC, as Trustee of 100 Discovery Park Realty Trust) (“Landlord”), and Genocea Biosciences, Inc.

February 13, 2020 10-K

GNCA / Genocea Biosciences, Inc. 10-K - Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 001-36289 GENOCEA BIOSCIENCES, INC.

February 13, 2020 EX-4.8

Description of the Registrant's Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 19

DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 As of December 31, 2019, Genocea Biosciences Inc.

February 13, 2020 S-8

Powers of Attorney (included on the signature page in Part II).

Registration No. 333- As filed with the Securities and Exchange Commission on February 13, 2020 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (IRS

February 13, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

February 13, 2020 EX-99.1

Genocea Provides Fourth Quarter 2019 Corporate Update ATLASTM identifies Inhibigenstm that can undermine immunotherapy Dosed first patient in Part B of GEN-009 neoantigen vaccine Phase 1/2a trial Progressed GEN-011 neoantigen cell therapy - IND filin

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides Fourth Quarter 2019 Corporate Update ATLASTM identifies Inhibigenstm that can undermine immunotherapy Dosed first patient in Part B of GEN-009 neoantigen vaccine Phase 1/2a trial Progressed GEN-011 neoantigen cell therapy - IND filing expected in Q2 2020 Appointed Dr. Gisela Schwab to Genocea’s Board of Directors

February 13, 2020 SC 13G

GNCA / Genocea Biosciences, Inc. / UBS OCONNOR LLC - SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427401 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate th

January 13, 2020 EX-99.1

Next generation cancer immunotherapies 1 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available t

genoceacorporatepresenta Next generation cancer immunotherapies 1 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

January 13, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2020 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

November 19, 2019 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

November 19, 2019 EX-99.1

Next generation neoantigen immunotherapies | CONFIDENTIAL 1 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information cu

genoceacorporatepresenta Next generation neoantigen immunotherapies | CONFIDENTIAL 1 This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

November 19, 2019 EX-10.1

First Amendment to Amended and Restated Loan and Security Agreement between the Company, the several banks and other financial institutions or entities from time to time parties thereto and Hercules Capital, Inc., dated November 14, 2019 (incorporated by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K, File No. 001-36289, filed on November 19, 2019)

FIRST AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This FIRST AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Amendment”) is dated as of November 14, 2019 and is entered into by and between (a) GENOCEA BIOSCIENCES, INC.

November 8, 2019 424B5

$50,000,000 Common Stock

424B5 1 prospectussupplement1182019.htm 424B5 Filed pursuant to Rule 424(b)(5) Registration No. 333-225086 PROSPECTUS SUPPLEMENT (To Prospectus dated June 5, 2018) $50,000,000 Common Stock We have entered into a sales agreement with Cowen and Company, LLC ("Cowen"), relating to shares of our common stock offered by this prospectus supplement and the accompanying prospectus. In accordance with the

November 5, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

November 5, 2019 EX-99.1

Genocea Presents Preclinical Research that Shows Inhibitory Neoantigens Stifle Protective Anti-Tumor Immune Responses at Society for Immunotherapy of Cancer (SITC) Proportions of inhibitory neoantigens found in cancer patients with the ATLAS™ biology

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Presents Preclinical Research that Shows Inhibitory Neoantigens Stifle Protective Anti-Tumor Immune Responses at Society for Immunotherapy of Cancer (SITC) Proportions of inhibitory neoantigens found in cancer patients with the ATLAS™ biology-driven platform may also predict patient responses to immunotherapy Confirm posit

October 24, 2019 424B5

Up to $30,000,000 of Shares of Common Stock and 289,966 Shares of Common Stock GENOCEA BIOSCIENCES, INC.

Filed pursuant to Rule 424(b)(5) Registration No. 333-225086 PROSPECTUS SUPPLEMENT (To Prospectus dated June 5, 2018) Up to $30,000,000 of Shares of Common Stock and 289,966 Shares of Common Stock GENOCEA BIOSCIENCES, INC. This prospectus supplement relates to the issuance and sale of up to $30,000,000 in shares of our common stock, and an additional 289,966 shares of common stock as Commitment Sh

October 24, 2019 10-Q

GNCA / Genocea Biosciences, Inc. 10-Q - Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

October 24, 2019 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 23, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commiss

October 24, 2019 EX-99.1

PURCHASE AGREEMENT

Execution Version PURCHASE AGREEMENT THIS PURCHASE AGREEMENT (the “Agreement”), dated as of October 23, 2019 (the “Execution Date”), is entered into by and between GENOCEA BIOSCIENCES, INC.

October 24, 2019 EX-99.2

Genocea Provides Corporate Update and Reports Third Quarter 2019 Financial Results Generated unprecedented 98% GEN-009 immune response frequency with ATLAS™ Continued advancement of GEN-011, expect to file an IND in first half of 2020 Entered into a

Investor Contact: Dan Ferry 617-430-7576 [email protected] Genocea Provides Corporate Update and Reports Third Quarter 2019 Financial Results Generated unprecedented 98% GEN-009 immune response frequency with ATLAS™ Continued advancement of GEN-011, expect to file an IND in first half of 2020 Entered into a common stock purchase agreement for up to $30M with Lincoln Park Capital Conferenc

October 24, 2019 EX-4.1

Registration Rights Agreement, dated as of October 23, 2019, by and between Genocea Biosciences, Inc. and Lincoln Park Capital Fund, LLC.

Execution Version REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of October 23, 2019, is entered into by and between GENOCEA BIOSCIENCES, INC.

July 25, 2019 EX-99.1

Genocea Provides Corporate Update, Including Second-Quarter 2019 Financial Results Initiated Part B of Phase 1/2a clinical trial of neoantigen vaccine candidate GEN-009; Plans to present additional GEN-009 immunogenicity data at ESMO 2019 Conference

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Provides Corporate Update, Including Second-Quarter 2019 Financial Results Initiated Part B of Phase 1/2a clinical trial of neoantigen vaccine candidate GEN-009; Plans to present additional GEN-009 immunogenicity data at ESMO 2019 Conference call today at 8:30 am ET CAMBRIDGE, Mass., July 25, 2019 - Genocea Biosciences, Inc. (

July 25, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

July 25, 2019 EX-10.1

Separation Agreement dated July 22, 2019 between Genocea Biosciences, Inc. and Pamela Carroll

July 22, 2019 Pam Carroll Dear Pam: As we have discussed, this letter separation and transition agreement (this “Agreement”) confirms the terms of the remainder of your employment with Genocea Biosciences, Inc.

July 25, 2019 10-Q

GNCA / Genocea Biosciences, Inc. 10-Q - Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

June 28, 2019 SC 13D/A

GNCA / Genocea Biosciences, Inc. / New Enterprise Associates 16, L.p. - NEW ENTERPRISE ASSOCIATES 16, L.P. - GENOCEA BIOSCIENCES 13D/A (#2) Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842-4000 (Name,

June 21, 2019 424B4

10,500,000 Shares Common Stock

Filed pursuant to Rule 424(b)(4) Registration No. 333-232023 PROSPECTUS 10,500,000 Shares Common Stock We are offering 10,500,000 shares of our common stock in this offering. Our common stock is listed on The Nasdaq Capital Market under the symbol “GNCA”. On June 19, 2019, the last sale price on our common stock was $3.85 per share. We are an “emerging growth company” as that term is used in the J

June 20, 2019 S-1MEF

GNCA / Genocea Biosciences, Inc. S-1MEF - - S-1MEF

As filed with the Securities and Exchange Commission on June 19, 2019 Registration No.

June 18, 2019 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 Genocea Biosciences, Inc. [·] Shares of Common Stock ($0.001 par value per share) Underwriting Agreement New York, New York June [·], 2019 SVB Leerink LLC Stifel, Nicolaus & Company, Incorporated As Representatives of the several Underwriters c/o SVB Leerink LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 c/o Stifel, Nicolaus & Company, Incorporated 787 Seventh Avenue, 1

June 18, 2019 S-1/A

GNCA / Genocea Biosciences, Inc. S-1/A - - S-1/A

S-1/A 1 s-1documentxamended.htm S-1/A As filed with the Securities and Exchange Commission on June 18, 2019 Registration No. 333-232023 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware (State or other ju

June 18, 2019 CORRESP

GNCA / Genocea Biosciences, Inc. CORRESP - -

CORRESP 1 filename1.htm SVB Leerink LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 Stifel, Nicolaus & Company, Incorporated 787 Seventh Avenue, 11th Floor New York, New York 10019 June 18, 2019 Via EDGAR Submission Securities and Exchange Commission Division of Corporation Finance 100 F Street N.E. Washington, DC 20549-7010 Attn: Ada D. Sarmento Re: Genocea Biosciences, Inc. Regist

June 17, 2019 CORRESP

GNCA / Genocea Biosciences, Inc. CORRESP - -

CORRESP 1 filename1.htm June 17, 2019 VIA EDGAR Securities and Exchange Commission Division of Corporate Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ada D. Sarmento Re: Genocea Biosciences, Inc. Registration Statement on Form S-1 (File No. 333-232023) Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933, as amended, Genocea Biosciences, Inc., a Delaware corp

June 7, 2019 S-1

GNCA / Genocea Biosciences, Inc. S-1 - Registration Statement - S-1

As filed with the Securities and Exchange Commission on June 7, 2019 Registration No.

June 3, 2019 8-K

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 3, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

June 3, 2019 EX-99.1

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea’s GEN-009 Vaccine Demonstrates Best-in-Class Immune Responses to ATLAS™-selected Neoantigens in Cancer Patients Post-vaccination T cell responses detected to 91% of vaccine neoan

a20190603gncapr Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea’s GEN-009 Vaccine Demonstrates Best-in-Class Immune Responses to ATLAS™-selected Neoantigens in Cancer Patients Post-vaccination T cell responses detected to 91% of vaccine neoantigens, including CD8+ T cell responses to 53% of vaccine neoantigens Conference call and webcast to discuss results TODAY at 8:30 am

May 21, 2019 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 21, 2019 EX-3.1

Certificate of Amendment to the Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K, File No. 001-36289, filed on May 21, 2019)

degenoceaamendment Delaware Page 1 The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE CERTIFICATE OF AMENDMENT OF “GENOCEA BIOSCIENCES, INC.”, FILED IN THIS OFFICE ON THE TWENTIETH DAY OF MAY, A.D. 2019, AT 4:54 O`CLOCK P.M. AND I DO HEREBY FURTHER CERTIFY THAT THE EFFECTIVE DATE OF THE AFORESAID CERT

May 16, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

May 16, 2019 EX-99.1

Genocea Announces Positive Interim Immunogenicity Data from GEN-009 Neoantigen Vaccine Phase 1/2a Clinical Trial Post-vaccination immune responses detected to 93% of vaccine neoantigens in first three patients analyzed Additional data to be presented

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Announces Positive Interim Immunogenicity Data from GEN-009 Neoantigen Vaccine Phase 1/2a Clinical Trial Post-vaccination immune responses detected to 93% of vaccine neoantigens in first three patients analyzed Additional data to be presented June 1st at ASCO 2019 and discussed on a conference call and webcast on June 3rd CAMB

May 14, 2019 424B3

GENOCEA BIOSCIENCES, INC. 25,599,979 Shares of Common Stock 11,712,494 Shares of Common Stock Issuable upon Exercise of Warrants

Filed pursuant to Rule 424(b)(3) Registration Statement 333-230577 PROSPECTUS GENOCEA BIOSCIENCES, INC.

May 10, 2019 CORRESP

GNCA / Genocea Biosciences, Inc. CORRESP - -

GENOCEA BIOSCIENCES, INC. 100 Acorn Park Drive Cambridge, Massachusetts 02140 (617) 876-8191 May 10, 2019 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F. Street, N.E. Washington, D.C. 20549 RE: Genocea Biosciences, Inc. Registration Statement on Form S-3 (File No. 333-230577) Request for Acceleration Ladies and Gentlemen: Pursuant to Rule 461 promulgated un

April 30, 2019 S-3/A

GNCA / Genocea Biosciences, Inc. S-3/A S-3/A

S-3/A 1 s-3document1.htm S-3/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification No.) 100 Acorn Pa

April 30, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

April 30, 2019 EX-99.1

Genocea Provides Corporate Update, Including First-Quarter 2019 Financial Results Company anticipates presenting first GEN-009 immunogenicity data at ASCO 2019 Conference call today at 9:00 am ET

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Provides Corporate Update, Including First-Quarter 2019 Financial Results Company anticipates presenting first GEN-009 immunogenicity data at ASCO 2019 Conference call today at 9:00 am ET CAMBRIDGE, Mass., April 30, 2019 - Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical company developing personalized cancer immu

April 30, 2019 EX-10.1

Subscription Agreement, dated February 11, 2019, among Genocea Biosciences, Inc. and the purchasers party thereto (incorporated by reference to Exhibit 10.1 to the Company’s Quarterly Report on Form 10-Q, File No. 001-36289, filed on April 30, 2019)

a1subscriptionagreemente SUBSCRIPTION AGREEMENT This Subscription Agreement (this “Agreement”) is dated as of February 11, 2019 (the “Effective Date”), among Genocea Biosciences, Inc.

April 30, 2019 CORRESP

GNCA / Genocea Biosciences, Inc. CORRESP - -

ROPES & GRAY LLP PRUDENTIAL TOWER 800 BOYLSTON STREET BOSTON, MA 02199-3600 WWW.ROPESGRAY.COM April 30, 2019 Marc Rubenstein 617-951-7826 617-413-2944 fax [email protected] BY FEDEX AND EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Joseph McCann, Staff Attorney Re: Genocea Biosciences, Inc. Registration Sta

April 30, 2019 10-Q

GNCA / Genocea Biosciences, Inc. 10-Q Quarterly Report 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

March 29, 2019 DEFA14A

GNCA / Genocea Biosciences, Inc. DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Definitive Proxy State

March 29, 2019 DEF 14A

GNCA / Genocea Biosciences, Inc. DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ý Definitive Proxy State

March 28, 2019 S-3

Power of Attorney (previously filed)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification No.) 100 Acorn Park Drive Cambridge, Massachusetts 02140 (617) 876-

March 7, 2019 PRE 14A

GNCA / Genocea Biosciences, Inc. PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: ý Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Definitive Proxy State

March 4, 2019 S-8

Powers of Attorney (included on the signature page in Part II).

Registration No. 333- As filed with the Securities and Exchange Commission on March 4, 2019 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (IRS Empl

February 28, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

February 28, 2019 EX-99.1

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Reports Fourth Quarter 2018 Results and Announces Hiring of New Chief Financial Officer Company advancing lead clinical-stage neoantigen cancer vaccine candidate and expanding pi

exhibit991gncaq4resultsp Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Reports Fourth Quarter 2018 Results and Announces Hiring of New Chief Financial Officer Company advancing lead clinical-stage neoantigen cancer vaccine candidate and expanding pipeline into adoptive cell therapy Diantha Duvall to join as CFO, bringing broad life science financial leadership experience

February 28, 2019 EX-4.8

Form of Class B Warrant to Purchase Shares of Common Stock of Genocea Biosciences, Inc. (incorporated by reference to Exhibit 4.8 to the Company's Annual Report on Form 10-K, File No. 001-36289, filed on February 28, 2019)

NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS.

February 28, 2019 10-K

GNCA / Genocea Biosciences, Inc. 10-K (Annual Report)

10-K 1 gnca-20181231x10k.htm 10-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number 00

February 28, 2019 EX-10.28

Amendment No. 2 to the Loan and Security Agreement between the Company and Hercules Technology Growth Capital, Inc., dated January 19, 2018

Exhibit 10.30 SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is dated as of January 22, 2018 (the “Second Amendment Date”) is entered into by and among GENOCEA BIOSCIENCES, INC., a Delaware corporation (“Borrower”), HERCULES CAPITAL, INC., a Maryland corporation (“HC”), in its capacity as administrative agent for itself and L

February 25, 2019 SC 13G

GNCA / Genocea Biosciences, Inc. / GLAXOSMITHKLINE PLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 372427104 (CUSIP Number) February 14, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

February 22, 2019 SC 13D/A

GNCA / Genocea Biosciences, Inc. / New Enterprise Associates 16, L.p. - NEW ENTERPRISE ASSOCIATES 16, L.P. - GENOCEA BIOSCIENCES 13D/A (#1) Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) Louis S. Citron, Esq. New Enterprise Associates 1954 Greenspring Drive, Suite 600, Timonium, MD 21093 (410) 842-4000 (Name,

February 14, 2019 EX-99.A

AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13D

EX-99.A CUSIP No. 372427104 Page 1 2 of 13 Exhibit A AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE 13D The undersigned, being duly authorized thereunto, hereby execute this agreement as an exhibit to this Schedule 13D to evidence the agreement of the below-named parties, in accordance with the rules promulgated pursuant to the Securities Exchange Act of 1934, to file this Schedule jointly on be

February 14, 2019 SC 13D/A

GNCA / Genocea Biosciences, Inc. / Polaris Venture Partners V, L.P. - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3)* GENOCEA BIOSCIENCES, INC. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 372427104 (CUSIP Number) Polaris Partners One Marina Park Drive, 10th Floor Boston, MA 02210 Attn: Max Eisenberg (855) 787-3500 Gunderson De

February 14, 2019 SC 13G/A

GNCA / Genocea Biosciences, Inc. / Biotechnology Value Fund L P - AMENDMENT NO. 1 TO THE SCHEDULE 13G Passive Investment

SC 13G/A 1 sc13ga107422gen02142019.htm AMENDMENT NO. 1 TO THE SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Genocea Biosciences, Inc. (Name of Issuer) Common Stock, $0.001

February 12, 2019 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 11, 2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commis

February 12, 2019 EX-99.1

Genocea Announces Private Placement Financing of Up to $39 Million

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Announces Private Placement Financing of Up to $39 Million CAMBRIDGE, Mass., February 12, 2019 - Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical company developing personalized cancer immunotherapies, today announced that it has entered into a private placement with certain existing and new investors providing fo

February 12, 2019 EX-4.2

Form of Warrant

NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS.

February 12, 2019 EX-4.1

Form of Pre-Funded Warrant to Purchase Shares of Common Stock of Genocea Biosciences, Inc. (incorporated by reference to Exhibit 4.1 to the Company's Form 8-K, File No. 001-36289, filed on February 12, 2019)

NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS.

January 7, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 01/07/2019 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission Fi

January 7, 2019 EX-99.1

Beyond Machines for Antigen Selection: Using ATLAS™ to Enable Novel Cancer Immunotherapies January 2019 Disclaimer This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our man

genoceajanuary2019 Beyond Machines for Antigen Selection: Using ATLAS™ to Enable Novel Cancer Immunotherapies January 2019 Disclaimer This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

December 13, 2018 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 12/13/2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission Fi

November 1, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 11/1/2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission Fil

November 1, 2018 EX-99.1

Genocea Reports Third Quarter 2018 Financial and Operating Results Neoantigen vaccine program GEN-009 Phase 1/2a clinical trial enrolling patients Presenting novel findings at upcoming SITC conference Conference call today at 9:00 am ET

Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Reports Third Quarter 2018 Financial and Operating Results Neoantigen vaccine program GEN-009 Phase 1/2a clinical trial enrolling patients Presenting novel findings at upcoming SITC conference Conference call today at 9:00 am ET CAMBRIDGE, Mass., November 1, 2018 – Genocea Biosciences, Inc. (NASDAQ: GNCA), a biopharmaceutical

November 1, 2018 10-Q

GNCA / Genocea Biosciences, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2018 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

October 2, 2018 EX-99.1

P R E S S R E L E A S E S G E N O C E A S T R E N G T H E N S L E A D E R S H I P T E A M : T H O M A S D A V I S , M . D . A P P O I N T E D C H I E F M E D I C A L O F F I C E R ; D E R E K M E I S N E R , J . D . J O I N S A S G E N E R A L C O U

exhibit99110118 P R E S S R E L E A S E S G E N O C E A S T R E N G T H E N S L E A D E R S H I P T E A M : T H O M A S D A V I S , M . D . A P P O I N T E D C H I E F M E D I C A L O F F I C E R ; D E R E K M E I S N E R , J . D . J O I N S A S G E N E R A L C O U N S E L October 1, 2018 at 7:30 AM EDT CAMBRIDGE, Mass., Oct. 01, 2018 (GLOBE NEWSWIRE) - Genocea Biosc

October 2, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 10/1/2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission Fil

September 24, 2018 8-K

Amendment to Registrant's Code of Ethics, or Waiver of a Provision of the Code of Ethics, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 9/20/2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission Fil

September 24, 2018 EX-14.1

Genocea Biosciences, Inc. Code of Business Conduct and Ethics, September 2018

finalcodeofbusinessethic Genocea Biosciences, Inc. Code of Business Conduct and Ethics I. INTRODUCTION This Code of Business Conduct and Ethics (“Code”) provides a general statement of the expectations of Genocea Biosciences, Inc. (“Genocea”, or the “Company”) regarding the ethical standards that each director, officer and employee should adhere to while acting on behalf of Genocea. You are expect

August 7, 2018 EX-4.6

Narinderjeet Singh Inducement Stock Option Agreement (filed herewith).

narindersinghinducementa

August 7, 2018 S-8

2014 Employee Stock Purchase Plan, as amended

Registration No. 333- As filed with the Securities and Exchange Commission on August 7, 2018 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 51-0596811 (State or other jurisdiction of incorporation or organization) (IRS Emp

August 3, 2018 10-Q

GNCA / Genocea Biosciences, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2018 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36289 Genocea Biosciences, Inc.

August 3, 2018 EX-10.4

Amended and Restated Loan and Security Agreement between the Company, the several banks and other financial institutions or entities from time to time parties thereto and Hercules Capital, Inc., dated April 24, 2018 (incorporated by reference to Exhibit 10.4 to the Company's Quarterly Report on Form 10-Q, File No. 001-36289, filed on August 3, 2018)

Exhibit 10.4 THIS EXHIBIT HAS BEEN REDACTED AND IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST. REDACTED MATERIAL IS MARKED WITH [* * *] AND HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT is made and dated as of April 24, 2018 and is entered into by and between GENOCEA

August 2, 2018 EX-99.1

Genocea Reports Second Quarter 2018 Financial and Operating Results Neoantigen vaccine program GEN-009 Phase 1/2a clinical trial underway ATLAS™ platform continues to stand apart from in silico methods of neoantigen identification Conference call tod

Exhibit 99.1 Contact: Jennifer LaVin 617-715-6687 [email protected] Genocea Reports Second Quarter 2018 Financial and Operating Results Neoantigen vaccine program GEN-009 Phase 1/2a clinical trial underway ATLAS™ platform continues to stand apart from in silico methods of neoantigen identification Conference call today at 9:00 am ET CAMBRIDGE, Mass., August 2, 2018 – Genocea Biosciences,

August 2, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 8/2/18 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission File N

June 25, 2018 EX-10.2

Genocea Biosciences, Inc. 2014 Employee Stock Purchase Plan, as amended (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, File No. 001-36289, filed on June 25, 2018)

GENOCEA BIOSCIENCES, INC. 2014 EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED Section 1. Defined Terms Exhibit A, which is incorporated by reference, defines the terms used in the Plan and sets forth certain operational rules related to those terms. Section 2. Purpose of Plan The Plan is intended to enable Eligible Employees of the Company and its Designated Subsidiaries to use payroll deductions to pur

June 25, 2018 EX-3.1

Certificate of Amendment to the Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K, File No. 001-36289, filed on June 25, 2018)

CERTIFICATE OF AMENDMENT TO THE RESTATED CERTIFICATE OF INCORPORATION OF GENOCEA BIOSCIENCES, INC.

June 25, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2018 GENOCEA BIOSCIENCES, INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 001-36289 (Commission File Numbe

June 25, 2018 EX-10.1

Genocea Biosciences, Inc. Amended and Restated 2014 Equity Incentive Plan (previously filed as Exhibit 10.1 to the Company's Current Report of Form 8-K (File No. 001-36289) filed on June 25, 2018 and incorporated herein by reference).

GENOCEA BIOSCIENCES, INC. AMENDED AND RESTATED 2014 EQUITY INCENTIVE PLAN 1.DEFINED TERMS Exhibit A, which is incorporated by reference, defines the terms used in the Plan and sets forth certain operational rules related to those terms. 2. PURPOSE The Plan has been established to advance the interests of the Company by providing for the grant to Participants of Stock-based Awards. 3. ADMINISTRATIO

June 21, 2018 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

8-K 1 gnca8kx6x21x18.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2018 GENOCEA BIOSCIENCES, INC. (Exact name of Registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 001

June 8, 2018 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commission

June 8, 2018 EX-99.1

Pioneering Neoantigen Vaccines JUNE 2018 Disclaimer This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently

gncacorppresentation6818 Pioneering Neoantigen Vaccines JUNE 2018 Disclaimer This presentation contains “forward-looking” statements that are within the meaning of federal securities laws and are based on our management’s beliefs and assumptions and on information currently available to management.

June 4, 2018 CORRESP

GNCA / Genocea Biosciences, Inc. CORRESP

CORRESP 1 filename1.htm Genocea Biosciences, Inc. 100 Acorn Park Drive Cambridge, MA 02140 June 4, 2018 Via EDGAR Transmission U.S. Securities and Exchange Commission Division of Corporation Finance 100 F. Street, N.E. Washington, D.C. 20549 Re: Genocea Biosciences, Inc. Registration Statement on Form S-3 (File No. 333-225086) Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securi

May 21, 2018 EX-12.1

Statement Regarding Computation of Ratio of Combined Fixed Charges and Preferred Stock Dividends to Earnings (filed herewith)

Exhibit 12.1 STATEMENT REGARDING COMPUTATION OF RATIO OF COMBINED FIXED CHARGES AND PREFERRED STOCK DIVIDENDS TO EARNINGS The following table reflects the computation of the ratio of combined fixed charges and preferred stock dividends to earnings for the periods presented (in thousands): Three Months Ended March 31, 2018 Year Ended December 31, 2017 2016 2015 2014 2013 Net loss $ (10,591 ) $ (56,

May 21, 2018 S-3

GNCA / Genocea Biosciences, Inc. S-3

S-3 1 gncas-3.htm S-3 As filed with the Securities and Exchange Commission on May 21, 2018 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 51-0596811 (I.R.S E

May 11, 2018 NT 10-Q

GNCA / Genocea Biosciences, Inc. NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-36289 NOTIFICATION OF LATE FILING CUSIP NUMBER 372427104 (Check one) ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: March 31, 2018 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transit

May 10, 2018 10-Q

GNCA / Genocea Biosciences, Inc. 10-Q (Quarterly Report)

10-Q 1 gnca-20180331x10q.htm 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2018 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission

May 10, 2018 EX-99.1

Genocea Reports First Quarter 2018 Financial and Operating Results - Company files IND for lead neoantigen vaccine program, GEN-009 - - ATLAS™ platform continues to stand apart from in silico methods of neoantigen identification - - Conference call t

Exhibit 99.1 For media: Jennifer LaVin 617-715-6687 [email protected] Genocea Reports First Quarter 2018 Financial and Operating Results - Company files IND for lead neoantigen vaccine program, GEN-009 - - ATLAS™ platform continues to stand apart from in silico methods of neoantigen identification - - Conference call today at 9 am ET - CAMBRIDGE, Mass., May 10, 2018 - Genocea Biosciences,

May 10, 2018 8-K/A

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K/A 1 gnca331188ka.htm 8-K/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdicti

May 10, 2018 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 gnca331188k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): 5/9/2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incor

May 10, 2018 EX-99

Genocea Reports First Quarter 2018 Financial and Operating Results - Company files IND for lead neoantigen vaccine program, GEN-009 - - ATLAS™ platform continues to stand apart from in silico methods of neoantigen identification - - Conference call t

Exhibit 99.1 For media: Jennifer LaVin 617-715-6687 [email protected] Genocea Reports First Quarter 2018 Financial and Operating Results - Company files IND for lead neoantigen vaccine program, GEN-009 - - ATLAS™ platform continues to stand apart from in silico methods of neoantigen identification - - Conference call today at 9 am ET - CAMBRIDGE, Mass., May 10, 2018 - Genocea Biosciences,

April 30, 2018 EX-10.1

Amendment to Equity Rights Letter Agreement between the Company, Hercules Capital, Inc. (f/k/a Hercules Technology Growth Capital, Inc.), dated April 24, 2018 (incorporated by reference to Exhibit 10.1 to the Company's Current Report on Form 8-K, File No. 001-36289, filed on April 30, 2018)

AMENDMENT TO EQUITY RIGHTS LETTER AGREEMENT THIS AMENDMENT TO EQUITY RIGHTS LETTER AGREEMENT (this “Amendment”) is made effective as of April 24, 2018 by and between Hercules Capital, Inc.

April 30, 2018 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2018 GENOCEA BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) Delaware 001-36289 51-0596811 (State or other jurisdiction of incorporation) (Commissio

April 30, 2018 EX-4.1

Warrant Agreement between the Company and Hercules Capital, Inc., dated April 24, 2018 (incorporated by reference to Exhibit 4.1 to the Company's Current Report on Form 8-K, File No. 001-36289, filed on April 30, 2018)

THIS WARRANT AND THE SHARES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY STATE SECURITIES LAWS, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR, SUBJECT TO SECTION 11 HEREOF, AN OPINION OF COUNSEL (WHICH MAY BE COMPANY COUNSEL) REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT, OR ANY APPLICABLE STATE SECURITIES LAWS.

April 24, 2018 DEFA14A

GNCA / Genocea Biosciences, Inc. DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) o Definitive Proxy State

April 24, 2018 DEF 14A

GNCA / Genocea Biosciences, Inc. DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ý Filed by a Party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ý Definitive Proxy State

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