NWBO / Northwest Biotherapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Northwest Biotherapeutics, Inc.
US ˙ OTCPK ˙ US66737P6007

Mga Batayang Estadistika
LEI 5493002DRWWEOWTT8005
CIK 1072379
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Northwest Biotherapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST

July 1, 2025 424B5

17,727,273 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 25, 2022) Registration No.

May 15, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST

March 31, 2025 EX-10.8

Loan Agreement, dated April 26, 2024, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.

Exhibit 10.8 C O M M E R C I A L L O A N A G R E E M E N T THIS COMMERCIAL LOAN AGREEMENT (this “Loan Agreement”), dated as of April 26, 2024, is entered into by and between NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation (“Borrower”), and STREETERVILLE CAPITAL, LLC, a Utah limited liability company, its successors and/or assigns (“Lender”). A.Lender desires to loan and Borrower desires to

March 31, 2025 EX-10.9

Stock Purchase Agreement, dated June 4, 2024, by and between Northwest Biotherapeutics, Inc. and SIO Capital Management LLC.

Exhibit 10.9 NORTHWEST BIOTHERAPEUTICS, INC. SECURITIES PURCHASE AGREEMENT THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of June 4, 2024 (the “Effective Date”), by and between Northwest Biotherapeutics, Inc., a Delaware Corporation (the “Company”) and Sio Capital Management, LLC (the “Purchaser”). RECITALS WHEREAS, subject to the terms and conditions set forth i

March 31, 2025 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 Subsidiaries of the Registrant Name: Jurisdiction Northwest Biotherapeutics Limited United Kingdom Northwest Biotherapeutics Capital Limited United Kingdom NW Bio GmbH Germany Northwest Biotherapeutics B.V. Netherlands Flaskworks LLC United States

March 31, 2025 EX-10.10

Loan Agreement, dated October 18, 2024, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.

Exhibit 10.10 COMMERCIAL LOAN AGREEMENT THIS COMMERCIAL LOAN AGREEMENT (this “Loan Agreement”), dated as of October 18, 2024, is entered into by and between NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation (“Borrower”), and STREETERVILLE CAPITAL, LLC, a Utah limited liability company, its successors and/or assigns (“Lender”). A.Lender desires to loan and Borrower desires to borrow, upon the

March 31, 2025 EX-4.1

Description of Securities

Exhibit 4.1 DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 The following description of the common stock of Northwest Biotherapeutics, Inc. (the “Corporation,” “us,” “our” or ”we”) does not purport to be complete and is subject to, and qualified in its entirety by, our certificate of incorporation, as amended (“certificate”), and

March 31, 2025 EX-10.5

Equity Compensation Plan, dated May 29, 2020 and as amended on February 25, 2022.

Exhibit 10.5 NORTHWEST BIOTHERAPEUTICS, INC. 2020 COMPENSATION PLAN 1.GENERAL. (a)Eligible Award Recipients. The persons eligible to receive Awards are Employees, Directors and Consultants inside and outside of the United States. (b)Awards. (i)Equity Awards. The Plan provides for the grant of any type of equity security, equity-linked security or equity security equivalent (including without limit

March 31, 2025 EX-19.1

Insider Trading Policy

Exhibit 19.1 Insider Trading Policy All employees must comply with applicable laws and rules relating to insider trading, pursuant to which employees are prohibited from trading in Northwest stock or the stock of any other company on the basis of material, non-public information (i.e., “Inside Information”). Inside Information is any non-public information that an investor would reasonably conside

March 31, 2025 EX-10.11

Standby Equity Purchase Agreement, dated December 19, 2024, by and between Northwest Biotherapeutics, Inc. and YA II PN, LTD.

Exhibit 10.11 STANDBY EQUITY PURCHASE AGREEMENT THIS STANDBY EQUITY PURCHASE AGREEMENT (this “Agreement”) dated as of December 19, 2024, is made by and between YA II PN, LTD., a Cayman Islands exempt limited company (the “Investor”), and NORTHWEST BIOTHERAPEUTICS, INC., a company incorporated under the laws of the State of Delaware (the “Company”). The Investor and the Company may be referred to h

December 26, 2024 EX-99.1

Northwest Biotherapeutics Announces $5 Million Convertible Note Financing and Standby Facility for Up to $50 Million Additional Financing

Exhibit 99.1 4800 Montgomery Lane Suite 800 Bethesda, MD 20814 t (240) 497-9024 f (240) 627-4121 www.nwbio.com OTCQB: NWBO For release at 9:30 a.m. EST on December 26, 2024 Northwest Biotherapeutics Announces $5 Million Convertible Note Financing and Standby Facility for Up to $50 Million Additional Financing BETHESDA, Md., December 26, 2024 - Northwest Biotherapeutics (OTCQB:NWBO) (the “Company”

December 26, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 19, 2024 Northwest Bioth

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 19, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Empl

December 26, 2024 424B5

21,587,302 Shares of Common Stock

424B5 1 tm2432020d1424b5.htm 424B5 PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 25, 2022) Registration No. 333-267933 21,587,302 Shares of Common Stock On December 19, 2024, Northwest Biotherapeutics, Inc. (the “Company”) entered into transactions totaling $5,500,000 pursuant to this prospectus supplement from offerings at a blended average of $0.255 per

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORT

November 1, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 31, 2024 Northwest Biothe

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 31, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emplo

August 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents d UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

August 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 2, 2024 Northwest Biothera

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 2, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

July 3, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 29, 2024 Northwest Biotherap

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 29, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

June 25, 2024 DEFA14A

As filed with the Securities and Exchange Commission on June 25, 2024 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

As filed with the Securities and Exchange Commission on June 25, 2024 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

June 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 31, 2024 Northwest Biotherape

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 31, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

June 3, 2024 DEF 14A

As filed with the Securities and Exchange Commission on June 3, 2024 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June 3, 2024 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

May 22, 2024 PRE 14A

As filed with the Securities and Exchange Commission on June [3], 2024 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June [3], 2024 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

May 10, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

May 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 26, 2024 Northwest Biothera

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 26, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

April 29, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

March 22, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 18, 2024 Northwest Biothera

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 18, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

March 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 8, 2024 Northwest Biotherap

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 8, 2024 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

March 5, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST

March 5, 2024 EX-10.89

Loan Agreement, dated March 2, 2023, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.

Exhibit 10.89 C O M M E R C IA L LO A N AG R E E M E N T THIS COMMERCIAL LOAN AGREEMENT (this “Loan Agreement”), dated as of March 2, 2023, is entered into by and between NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation (“Borrower”), and STREETERVILLE CAPITAL, LLC, a Utah limited liability company, its successors and/or assigns (“Lender”). A.Lender desires to loan and Borrower desires to bo

March 5, 2024 EX-10.90

Loan Agreement, dated November 10, 2023, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.

Exhibit 10.90 COMMERCIAL LOAN AGREEMENT THIS C0M!V1ERCIAL LOAN AGREEMENT (this “Loan Agreement”), dated as of November 10, 2023, is entered into by and between NORTHWEST BI0THERAPEUTICS, INC., a Delaware corporation (“Borrower”), and STREETERVILLE CAPITAL, LLC, a Utah limited liability company, its successors and/or assigns (“Lender”). A.Lender desires to loan and Borrower desires to borrow, upon

March 1, 2024 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): x Form 10-K ¨ Form 20-F ¨ Form 11-K ¨ Form 10-Q ¨ Form 10-D ¨ Form N-CEN ¨ Form N-CSR For Period Ended: December 31, 2023 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transition Report on Form 10-Q For the Transition Pe

November 16, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 10, 2023 Northwest Bioth

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 10, 2023 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Empl

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORT

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST

August 9, 2023 EX-21.1

Subsidiaries of the Registrant

EXHIBIT 21.1 Subsidiaries of the Registrant Name: Jurisdiction Northwest Biotherapeutics Limited United Kingdom Aracaris Capital, Ltd. United Kingdom NW Bio Gmbh Germany Northwest Biotherapeutics B.V. Netherlands Flaskworks LLC United States

August 9, 2023 EX-21.2

Certificate of Incorporation on Change of Name

EXHIBIT 21.2 CERTIFICATE OF INCORPORATION ON CHANGE OF NAME Company Number 9103355 The Registrar of Companies for England and Wales hereby certifies that under the Companies Act 2006: ARACARIS LIMITED a company incorporated as private limited by shares, having its registered office situated in England and Wales, has changed its name to: NORTHWEST BIOTHERAPEUTICS LIMITED Given at Companies House on

May 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

March 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 2, 2023 Northwest Biotherap

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 2, 2023 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

February 28, 2023 EX-10.88

Loan Agreement, dated September 26, 2022, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C (incorporated by reference to Exhibit 10.88 filed with the Registrant’s Annual Report on Form 10 - K on February 28, 2023).

Exhibit 10.88 COMMERCIAL PROMISSORY NOTE U.S. $5,505,000.00 September 26, 2022 FOR VALUE RECEIVED, Northwest Biotherapeutics, Inc., a Delaware corporation (“Borrower”), promises to pay in lawful money of the United States of America to the order of Streeterville Capital, LLC, a Utah limited liability company, or its successors or assigns (“Lender”), the principal sum of $5,505,000.00, together wit

February 28, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST

January 13, 2023 EX-3.1

Amendment to Seventh Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on January 13, 2023).

Exhibit 3.1

January 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 9, 2023 Northwest Biother

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 9, 2023 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employ

January 6, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 30, 2022 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Empl

December 23, 2022 DEFA14A

As filed with the Securities and Exchange Commission on December [XX], 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

As filed with the Securities and Exchange Commission on December [XX], 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

December 16, 2022 DEFA14A

As filed with the Securities and Exchange Commission on December 16, 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

As filed with the Securities and Exchange Commission on December 16, 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

December 5, 2022 DEF 14A

As filed with the Securities and Exchange Commission on December 5, 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

DEF 14A 1 tm2231325-2def14a.htm DEF 14A TABLE OF CONTENTS As filed with the Securities and Exchange Commission on December 5, 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, f

November 25, 2022 PRE 14A

As filed with the Securities and Exchange Commission on November 25, 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on November 25, 2022 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

November 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORT

November 9, 2022 EX-32._1

Certification of President, Chief Executive Officer and Principal Financial and Accounting Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.

Exhibit 32.1 CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the quarterly report of Northwest Biotherapeutics, Inc. (the “Company”) on Form 10-Q for the quarter ended September 30, 2022, as filed with the Securities and Exchange Commission (the “Report”), I, Linda F. Powers, certify, pursuant to 18 U.S.C. Se

November 9, 2022 EX-31._1

Certification of President (Principal Executive Officer and Principal Financial and Accounting Officer), Pursuant to Exchange Act Rules 13a-14(a) and 15d-14(a), as Adopted Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.

Exhibit 31.1 CERTIFICATION PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Linda F. Powers, certify that: (1) I have reviewed this quarterly report on Form 10-Q of Northwest Biotherapeutics, Inc.; (2) Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circum

October 24, 2022 CORRESP

Northwest Biotherapeutics, Inc. 4800 Montgomery Lane, Suite 800 Bethesda, MD 20814

Northwest Biotherapeutics, Inc. 4800 Montgomery Lane, Suite 800 Bethesda, MD 20814 October 24, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Daniel Crawford Re: Request for Acceleration of Effectiveness of Registration Statement on Form S-3 (File No. 333-267933) Dear Mr. Crawford: Northwest Biother

October 21, 2022 CORRESP

Northwest Biotherapeutics, Inc. 4800 Montgomery Lane, Suite 800 Bethesda, MD 20814

Northwest Biotherapeutics, Inc. 4800 Montgomery Lane, Suite 800 Bethesda, MD 20814 October 21, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Daniel Crawford Re: Request for Acceleration of Effectiveness of Registration Statement on Form S-3 (File No. 333-267933) Dear Mr. Crawford: Northwest Biother

October 18, 2022 EX-4.6

Form of Senior Indenture.

EXHIBIT 4.6 NORTHWEST BIOTHERAPEUTICS, INC. AND , TRUSTEE INDENTURE DATED AS OF , 2022 SENIOR DEBT SECURITIES NORTHWEST BIOTHERAPEUTICS, INC. RECONCILIATION AND TIE BETWEEN TRUST INDENTURE ACT OF 1939 AND INDENTURE, DATED AS OF , 2022 Section of Trust Indenture Act of 1939 Section(s) of Indenture § 310(a)(1) 609 (a)(2) 609 (a)(3) Not Applicable (a)(4) Not Applicable (a)(5) 609 (b) 608, 610 § 311(a

October 18, 2022 EX-4.7

Form of Subordinated Indenture.

Exhibit 4.7 NORTHWEST BIOTHERAPEUTICS, INC. AND , TRUSTEE INDENTURE DATED AS OF , 2022 SUBORDINATED DEBT SECURITIES NORTHWEST BIOTHERAPEUTICS, INC. RECONCILIATION AND TIE BETWEEN TRUST INDENTURE ACT OF 1939 AND INDENTURE, DATED AS OF , 2022 Section of Trust Indenture Act of 1939 Section(s) of Indenture § 310(a)(1) 609 (a)(2) 609 (a)(3) Not Applicable (a)(4) Not Applicable (a)(5) 609 (b) 608, 610 §

October 18, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) NORTHWEST BIOTHERAPEUTICS, INC.

October 18, 2022 S-3

As filed with the U.S. Securities and Exchange Commission on October 18, 2022

As filed with the U.S. Securities and Exchange Commission on October 18, 2022 Registration No. 333 - UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NORTHWEST BIOTHERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 94-

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

July 26, 2022 EX-3.2

Certificate of Designations of Series C Convertible Preferred Stock (incorporated by reference to Exhibit 3.2 filed with the Registrant’s Current Report on Form 8-K on July 26, 2022).

Exhibit 3.2 CERTIFICATE OF DESIGNATIONS OF SERIES C CONVERTIBLE PREFERRED STOCK OF NORTHWEST BIOTHERAPEUTICS, INC. Northwest Biotherapeutics, Inc. (the ?Company?), a corporation formed and existing under the Delaware General Corporation Law (the ?DGCL?), does hereby determine and certify that, pursuant to Section 151 of the DGCL and authority conferred upon its Board of Directors (the ?Board of Di

July 26, 2022 EX-3.1

Certificate of Elimination of the Series A Convertible Preferred Stock and Series B Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on July 26, 2022).

Exhibit 3.1 CERTIFICATE OF ELIMINATION OF THE SERIES A CONVERTIBLE PREFERRED STOCK AND SERIES B CONVERTIBLE PREFERRED STOCK OF NORTHWEST BIOTHERAPEUTICS, INC. (Pursuant to Section 151(g) of the General Corporation Law of the State of Delaware) Northwest Biotherapeutics, Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware (the ?Corporation?), does h

July 26, 2022 8-K

Material Modification to Rights of Security Holders, Financial Statements and Exhibits, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 20, 2022 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

June 30, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 2)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 2) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

May 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

May 2, 2022 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWES

March 1, 2022 EX-10.87

Sub-lease Agreement, dated December 31, 2021, by and between Aracaris Ltd. and Northwest Biotherapeutics, Inc. (collectively the “Sub-Lessor”) and Advent BioServices, Ltd. (the “Sub-Lessee”).

Exhibit 10.87 ? SUB-LEASE AGREEMENT ? This Sub-lease Agreement (?Agreement?) is made and entered into effective as of December 31, 2021 (the ?Effective Date?), by and between Aracaris Ltd. (?Aracaris?), a United Kingdom (U.K.) company and Northwest Biotherapeutics, Inc. (?NWBio?), a U.S. Delaware company (Aracaris and NWBio, collectively, the ?Sub-Lessor?), and Advent BioServices, Ltd. (the ?Sub-L

March 1, 2022 EX-10.86

Loan Agreement, dated November 22, 2021, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.

Exhibit 10.86 CO M M E R C I A L LO A N AG R E E M E N T ? THIS COMMERCIAL LOAN AGREEMENT (this ?Loan Agreement?), dated as of November 22, 2021, is entered into by and between NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation (?Borrower?), and STREETERVILLE CAPITAL, LLC, a Utah limited liability company, its successors and/or assigns (?Lender?). ? A.Lender desires to loan and Borrower desir

March 1, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

November 29, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 22, 2021 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Empl

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORT

August 16, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

May 24, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 18, 2021 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

April 16, 2021 DEF 14A

- DEF 14A

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on April 16, 2021 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

March 31, 2021 EX-10.83

Agreement to acquire Flaskworks, L.L.C, August 28, 2020.

? Exhibit 10.83 ? Execution Version ? UNIT PURCHASE AGREEMENT ? UNIT PURCHASE AGREEMENT, dated as of August 28, 2020 (this ?Agreement?), among Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Buyer?), Flaskworks, LLC, a Massachusetts limited liability company (?Flaskworks?), and each of the other Persons (as hereinafter defined) set forth on the signature pages hereto (each, a ?Seller

March 31, 2021 EX-10.85

Loan Agreement, dated March 1, 2021, by and between Northwest Biotherapeutics, Inc. and Streeterville Capital, L.L.C.

Exhibit 10.85 ? COMMERCIAL LOAN AGREEMENT ? THIS COMMERCIAL LOAN AGREEMENT (this ?Loan Agreement?), dated as of March 1, 2021, is entered into by and between NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation (?Borrower?), and STREETERVILLE CAPITAL, LLC, a Utah limited liability company, its successors and/or assigns (?Lender?). ? A. Lender desires to loan and Borrower desires to borrow, upon

March 31, 2021 EX-10.81

Equity Compensation Plan, dated May 29, 2020.

? Exhibit 10.81 ? NORTHWEST BIOTHERAPEUTICS, INC. ? 2020 EQUITY COMPENSATION PLAN ? 1. GENERAL. ? (a) Eligible Award Recipients. The persons eligible to receive Awards are Employees, Directors and Consultants inside and outside of the United States. ? (b) Available Securites. The Plan provides for the grant of any type of equity security, equity-linked security or equity security equivalent, inclu

March 31, 2021 EX-21.1

Subsidiaries of the Registrant.

? EXHIBIT 21.1 ? Subsidiaries of the Registrant ? Name: Jurisdiction Aracaris, Ltd. United Kingdom Aracaris Capital, Ltd. United Kingdom NW Bio Gmbh Germany Northwest Biotherapeutics B.V. Netherlands ? ? ? Flaskworks LLC United States ?

March 31, 2021 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

March 31, 2021 EX-4.1

Description of Securities

? Exhibit 4.1 ? DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 ? The following description of the common stock of Northwest Biotherapeutics, Inc. (the ?Corporation,? ?us,? ?our? or ?we?) does not purport to be complete and is subject to, and qualified in its entirety by, our certificate of incorporation, as amended (?certificate?

March 31, 2021 EX-10.82

Note and Loan Agreement, dated August 14, 2021, by and between Northwest Biotherapeutics, Inc. and Iliad Research and Trading L.P.

Exhibit 10.82 ? NOTE PURCHASE AGREEMENT ? THIS NOTE PURCHASE AGREEMENT (this "Agreement"), dated as of August 14, 2020, is entered into by and between NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation ("Company"), and ILIAD RESEARCH AND TRADING, L.P., a Utah limited partnership, its successors and/or assigns ("Investor"). ? A. Investor desires to purchase and Company desires to issue and sel

March 5, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 1, 2021 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

January 26, 2021 EX-16.1

Change in Registrant’s Accountants (incorporated by reference as Exhibit 16.1 filed with the Company’s Current Report on Form 8-K January 26, 2021).

Exhibit 16.1 January 25, 2021 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read the statements made by Northwest Biotherapeutics, Inc. under Item 4.01 of its Form 8-K dated January 21, 2021. We agree with the statements concerning our Firm in such Form 8-K; we are not in a position to agree or disagree with other statements of Northwest Biothera

January 26, 2021 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 20, 2021 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emplo

January 15, 2021 10-Q

Quarterly Report - FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORT

November 10, 2020 NT 10-Q

- NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 (Check one): ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-CEN ¨ Form N-CSR For Period Ended: September 30, 2020 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Tr

November 2, 2020 8-K

Other Events - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 2, 2020 (October 31, 2020) Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Co

October 13, 2020 424B5

12,224,963 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

September 15, 2020 8-K/A

Submission of Matters to a Vote of Security Holders - FORM 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 18, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Com

September 1, 2020 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 1, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Empl

September 1, 2020 EX-99.1

Northwest Biotherapeutics Acquires Flaskworks Breakthrough Automation Technology For Cell Therapy Products To Enable Scale-Up of Production Volumes and Reduction of Production Costs

Exhibit 99.1 4800 Montgomery Lane Suite 800 Bethesda, MD 20814 t (240) 497-9024 f (240) 627-4121 www.nwbio.com OTCQB: NWBO For immediate release on Tuesday, September 1, 2020 Northwest Biotherapeutics Acquires Flaskworks Breakthrough Automation Technology For Cell Therapy Products To Enable Scale-Up of Production Volumes and Reduction of Production Costs BETHESDA, Md., September 1, 2020 - Northwes

August 20, 2020 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 14, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employ

August 10, 2020 10-Q

Quarterly Report - FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST

August 7, 2020 424B5

21,750,669 Shares of Common Stock

424B5 1 tm2026961d1424b5.htm 424B5 PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No. 333-234248 21,750,669 Shares of Common Stock On August 5, 2020, the Company entered into financings totaling $7,960,214 pursuant to this prospectus supplement (the “Offering”). The financings were comprised of: · $6,960,214 from an offering at $0.32

June 26, 2020 424B5

5,834,350 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

June 24, 2020 10-Q

Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2020 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS,

June 24, 2020 10-K/A

Annual Report - FORM 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS,

June 12, 2020 424B5

9,361,421 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

June 8, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 2, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

June 4, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 29, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

May 29, 2020 424B5

15,695,182 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

May 27, 2020 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 20, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

May 20, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 20, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

May 12, 2020 NT 10-Q

- NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 (Check one): ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-CEN ¨ Form N-CSR For Period Ended: March 31, 2020 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transi

April 23, 2020 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 18, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

April 9, 2020 424B5

19,947,032 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

April 1, 2020 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 26, 2020 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

March 27, 2020 DEF 14A

NWBO / Northwest Biotherapeutics, Inc. DEF 14A - - FORM DEF 14A

DEF 14A 1 tm2013863-1def14a.htm FORM DEF 14A TABLE OF CONTENTS As filed with the Securities and Exchange Commission on March 27, 2020 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate

March 16, 2020 10-K

March 16, 2020

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS, I

March 16, 2020 EX-4.1

Description of Securities

Exhibit 4.1 DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 The following description of the common stock of Northwest Biotherapeutics, Inc. (the “Corporation,” “us,” “our” or ”we”) does not purport to be complete and is subject to, and qualified in its entirety by, our certificate of incorporation, as amended (“certificate”), and

March 16, 2020 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 Subsidiaries of the Registrant Name: Jurisdiction Aracaris, Ltd. United Kingdom Aracaris Capital, Ltd. United Kingdom NW Bio Gmbh Germany Northwest Biotherapeutics B.V. Netherlands

February 24, 2020 424B5

25,799,918 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

January 15, 2020 424B5

3,446,914 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

January 3, 2020 424B5

12,475,253 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated October 18, 2019) Registration No.

December 13, 2019 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2019 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction of incorporation or o

November 12, 2019 10-Q

November 12, 2019

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUT

October 29, 2019 CORRESP

NWBO / Northwest Biotherapeutics, Inc. CORRESP - -

October 29, 2019 Via Edgar Only United States Securities and Exchange Commission Mail Stop 6010 Washington, D.

October 28, 2019 424B5

3,505,152 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

October 18, 2019 424B5

10,442,726 Shares of Common Stock

424B5 1 tm1920518d1424b5.htm 424B5 PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No. 333-213777 10,442,726 Shares of Common Stock Pursuant to this prospectus supplement and the accompanying prospectus, Northwest Biotherapeutics, Inc. (the “Company,” “we” or “us”) is offering for sale, directly to selected investors, 10,442,726 shar

October 18, 2019 EX-4.6

Form of Indenture relating to the issuance from time to time in one or more series of debentures, notes, bonds or other evidences of indebtedness.

Exhibit 4.6 NORTHWEST BIOTHERAPEUTICS, INC. AND , TRUSTEE INDENTURE DATED AS OF , 2019 DEBT SECURITIES NORTHWEST BIOTHERAPEUTICS, INC. RECONCILIATION AND TIE BETWEEN TRUST INDENTURE ACT OF 1939 AND INDENTURE, DATED AS OF , 2019 Section of Trust Indenture Act of 1939 Section(s) of Indenture § 310(a)(1) 609 (a)(2) 609 (a)(3) Not Applicable (a)(4) Not Applicable (a)(5) 609 (b) 608, 610 § 311(a) 613 (

October 18, 2019 S-3

NWBO / Northwest Biotherapeutics, Inc. S-3 - - FORM S-3

As filed with the U.S. Securities and Exchange Commission on October 18, 2019 Registration No. 333 - UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NORTHWEST BIOTHERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 94-

August 9, 2019 10-Q

November 12, 2019

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2019 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS,

July 22, 2019 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 16, 2019 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

July 18, 2019 424B5

11,782,609 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

July 17, 2019 424B5

11,782,609 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

May 28, 2019 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 21, 2019 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

May 10, 2019 10-Q

May 10, 2019

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2019 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS,

April 2, 2019 EX-10.74

Settlement and Amendment Agreement (2017 Obligations Agreement), dated as of December 31, 2017, by and between Northwest Biotherapeutics, Inc. and Cognate BioServices, Inc.

Exhibit 10.74 SETTLEMENT AND AMENDMENT AGREEMENT THIS SETTLEMENT AND AMENDMENT AGREEMENT (this “Agreement”) is made and entered into as of December 31, 2017 (the “Effective Date”), by and between Cognate BioServices, Inc., a Delaware corporation (“Cognate”) and Northwest Biotherapeutics, Inc., a Delaware corporation (“NWBio” and together with Cognate, the “Parties”). RECITALS WHEREAS, pursuant to

April 2, 2019 EX-21.1

Subsidiaries of the Registrant.

EXHIBIT 21.1 Subsidiaries of the Registrant Name: Jurisdiction Aracaris, Ltd. United Kingdom Aracaris Capital, Ltd. United Kingdom NW Bio Gmbh Germany

April 2, 2019 EX-10.77

Promissory Note in the principal amount of $1,388,888.89, dated as of May 1, 2018, by and between Northwest Biotherapeutics, Inc. and Adar Bays, LLC.

Exhibit 10.77 THE SECURITIES OFFERED HEREBY HAVE NOT BEEN AND WILL NOT BE REGISTERED WITH THE UNITED STATES SECURITIES AND EXCHANGE COMMISSION, OR THE SECURITIES COMMISSION OF ANY STATE PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY SECTION 3(b) OF THE SECURITIES ACT OF 1933, AS AMENDED, AND THE RULES AND REGULATIONS PROMULGATED THEREUNDER (THE “1933 ACT) US $1,388,888.89 NORTHWEST BIOTHER

April 2, 2019 EX-10.78

Form of Loan Agreement, dated as of November 7, 2018, by and between Northwest Biotherapeutics, Inc. and a Group of Private Lenders.

Exhibit 10.78 FORM OF UNSECURED PROMISSORY NOTE AGREEMENT PLUS WARRANT NOVEMBER 7, 2018 US $ NORTHWEST BIOTHERAPEUTICS, INC 10% NON-RECOURSE REDEEMABLE NOTE DUE NOVEMBER 7, 2019 FOR VALUE RECEIVED, Northwest Biotherapeutics, Inc. (the “Company”) promises to pay to the order of and his authorized successors and permitted assigns (“Holder”), the aggregate principal face amount of Dollars (U.S. $ ) o

April 2, 2019 EX-10.75

Note and Loan Agreement, dated as of March 14, 2018, by and between Northwest Biotherapeutics, Inc. and Linda F. Powers.

Exhibit 10.75 LOAN AGREEMENT and PROMISSORY NOTE US $4,000,000 March 14, 2018 SECTION 1. GENERAL. Linda F. Powers (the “Holder”) has granted to Northwest Biotherapeutics, Inc., a Delaware company (the “Maker”) a loan in the principal amount of Four Million Dollars (US $4,000,000) (the “Loan”) on the terms and conditions set forth in this Loan Agreement and Promissory Note (the “Note”). The Loan wi

April 2, 2019 EX-10.73

Settlement and Amendment Agreement (2016 Obligations Agreement), dated as of December 31, 2017, by and between Northwest Biotherapeutics, Inc. and Cognate BioServices, Inc.

Exhibit 10.73 SETTLEMENT AND AMENDMENT AGREEMENT THIS SETTLEMENT AND AMENDMENT AGREEMENT (this “Agreement”) is made and entered into as of December 31, 2017 (the “Effective Date”), by and between Cognate BioServices, Inc., a Delaware corporation (“Cognate”) and Northwest Biotherapeutics, Inc., a Delaware corporation (“NWBio” and together with Cognate, the “Parties”). RECITALS WHEREAS, pursuant to

April 2, 2019 EX-10.80

Lease Relating to Vision Centre, Sawston, Cambridge, by and between Aracaris Capital Limited and Aracaris Limited, dated as of December 14, 2018.

Exhibit 10.80 LEASE RELATING TO VISION CENTRE, SAWSTON, CAMBRIDGE Dated: 14 December 2018 Between ARACARIS CAPITAL LIMITED and ARACARIS LIMITED CMS Cameron McKenna Nabarro Olswang LLP Cannon Place 78 Cannon Street London EC4N 6AF T +44 20 7367 3000 F +44 20 7367 2000 cms.law TABLE OF CONTENTS 1. Definitions 1 2. Interpretation 6 3. Grant and Term 7 4. Rights Granted 8 5. Exceptions and Reservation

April 2, 2019 10-K

April 2, 2019

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018 ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS, I

April 2, 2019 EX-10.79

Contract Relating to Sale of Spicers, Sawston, Cambridge, dated as of December 5, 2018, by and between Aracaris Capital Limited and Huawei Technologies Research & Development (UK) Limited.

Exhibit 10.79 Contract treated as exchanged 1:15 pm Law Society Formula. Ref: on behalf of the Buyer DATE: 5th December 2018 CONTRACT RELATING TO SALE OF SPICERS, SAWSTON, CAMBRIDGE Between ARACARIS CAPITAL LIMITED and HUAWEI TECHNOLOGIES RESEARCH & DEVELOPMENT (UK) LIMITED Annexure 1: Electronic Data Rooms document list. Annexure 2: Agreed form of transfer. Annexure 3: Agreed form of Lease. CMS C

April 2, 2019 EX-10.76

Note and Loan Agreement, dated as of March 19, 2018, by and between Northwest Biotherapeutics, Inc. and Linda F. Powers.

Exhibit 10.76 LOAN AGREEMENT and PROMISSORY NOTE US $400,000 March 19, 2018 SECTION 1. GENERAL. Linda F. Powers (the “Holder”) has granted to Northwest Biotherapeutics, Inc., a Delaware company (the “Maker”) a loan in the principal amount of Four Hundred Thousand Dollars (US $400,000) (the “Loan”) on the terms and conditions set forth in this Loan Agreement and Promissory Note (the “Note”). The Lo

March 19, 2019 NT 10-K

NWBO / Northwest Biotherapeutics, Inc. NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 (Check one): x Form 10-K ¨ Form 20-F ¨ Form 11-K ¨ Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: December 31, 2018 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Tra

February 14, 2019 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / Woodford Investment Management LLP - AMENDMENT NO. 3 TO SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Final Amendment (Amendment No.

February 14, 2019 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / CF Woodford Equity Income Fund - AMENDMENT NO. 5 TO SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Final Amendment (Amendment No.

February 7, 2019 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 2, 2019 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emplo

January 7, 2019 DEF 14A

NWBO / Northwest Biotherapeutics, Inc. DEFINITIVE PROXY STATEMENT

DEF 14A 1 tv510447-def14a.htm DEFINITIVE PROXY STATEMENT TABLE OF CONTENTS As filed with the Securities and Exchange Commission on January 8, 2019 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check th

December 20, 2018 8-K

Completion of Acquisition or Disposition of Assets

8-K 1 tv5096368-k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 14, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other j

December 11, 2018 EX-99.1

NW Bio Announces Non-Dilutive Funding of Approximately $47.3 Million

Exhibit 99.1 NW Bio Announces Non-Dilutive Funding of Approximately $47.3 Million Through UK Property Transaction BETHESDA, Md., December 11, 2018 - Northwest Biotherapeutics (OTCQB: NWBO) - (“NW Bio”), a biotechnology company developing DCVax® personalized immune therapies for solid tumor cancers, announced today that it has entered into agreements with a large multi-national corporation for a pa

December 11, 2018 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 5, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emp

November 28, 2018 8-K

Regulation FD Disclosure

8-K 1 tv5080698k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 28, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorpo

November 23, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

8-K 1 tv5078058-k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 18, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorp

November 16, 2018 10-Q

NWBO / Northwest Biotherapeutics, Inc. FORM 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2018 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUT

November 15, 2018 NT 10-Q

NWBO / Northwest Biotherapeutics, Inc. NT 10-Q

NT 10-Q 1 tv507345nt10q.htm NT 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: September 30, 2018 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition R

November 13, 2018 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 7, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission Fil

September 13, 2018 8-K

Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 7, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission Fi

August 14, 2018 10-Q

NWBO / Northwest Biotherapeutics, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2018 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS,

June 28, 2018 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 22, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File N

June 28, 2018 EX-10.2

Form of Class D-3 Common Stock Purchase Warrant.

Exhibit 10.2 FORM OF COMMON STOCK PURCHASE WARRANT CLASS D-3 NORTHWEST BIOTHERAPEUTICS, INC. Warrant Shares: Initial Exercise Date: , 2018 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the dat

June 28, 2018 EX-10.1

Form of Securities Purchase Agreement, dated June 22, 2017, by and between Northwest Biotherapeutics, Inc. and certain purchasers.

Exhibit 10.1 NORTHWEST BIOTHERAPEUTICS, INC. FORM OF SECURITIES PURCHASE AGREEMENT

June 28, 2018 424B5

4,000,000 Shares of Common Stock Class D-3 Warrants to Purchase 2,000,000 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

June 18, 2018 8-K

Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 12, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File N

June 1, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 28, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File Nu

May 31, 2018 8-K

Unregistered Sales of Equity Securities

8-K 1 tv4955418k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 24, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporatio

May 21, 2018 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 15, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction of incorporation) (Commiss

May 16, 2018 10-Q

NWBO / Northwest Biotherapeutics, Inc. FORM 10-Q (Quarterly Report)

10-Q 1 tv49400810q.htm FORM 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2018 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001

May 16, 2018 NT 10-Q

NWBO / Northwest Biotherapeutics, Inc. NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 ¨ Form 10-K ¨ Form 20-F ¨ Form 11-K x Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: March 31, 2018 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transition Report o

May 7, 2018 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 1, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File Num

May 2, 2018 EX-3.1

Certificate of Amendment of the Seventh Amended and Restated Certificate of Incorporation of Northwest Biotherapeutics, Inc., filed on May 2, 2018.

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF THE SEVENTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF NORTHWEST BIOTHERAPEUTICS,

May 2, 2018 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 26, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File

April 17, 2018 EX-21.1

Subsidiaries of the Registrant

EXHIBIT 21.1 Subsidiaries of the Registrant Name: Jurisdiction Aracaris, Ltd. United Kingdom Aracaris Capital, Ltd. United Kingdom NW Bio Gmbh Germany NW Bio Europe S.A.R.L. Switzerland (closed June 2015)

April 17, 2018 EX-10.69

Sawston Lease, dated October 10, 2017.

Exhibit 10.69 CMS Law.Tax DATE: 10 October 2017 LEASE RELATING TO CDC WAREHOUSE, SAWSTON, CAMBRIDGE Between ARACARIS CAPITAL LIMITED and ROUTEBUY LIMITED and COMMODITY CENTRE (GROUP) LIMITED CMS Cameron McKenna Nabarro Olswang LLP Cannon Place 78 Cannon Street London EC4N 6AF T +44 20 7367 3000 F +44 20 7367 2000 cms.law TABLE OF CONTENTS 1. Definitions 1 2. Interpretation 6 3. Grant and Term 7 4.

April 17, 2018 10-K

NWBO / Northwest Biotherapeutics, Inc. 10-K (Annual Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K x ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2017 ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS, INC. (Exact n

April 12, 2018 DEFR14A

NWBO / Northwest Biotherapeutics, Inc. DEFR14A

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on April 12, 2018 SCHEDULE 14A Amendment No.

April 9, 2018 DEF 14A

NWBO / Northwest Biotherapeutics, Inc. DEFINITIVE PROXY STATEMENT

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on April 9, 2018 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☑ Definitive Proxy Statement ☐ Definitive Additional Materials ☐ Soliciting Material Pursuant to §240.

April 4, 2018 PRER14A

NWBO / Northwest Biotherapeutics, Inc. PRELIMINARY PROXY STATEMENT

PRER14A 1 tv490287-prer14a.htm PRELIMINARY PROXY STATEMENT TABLE OF CONTENTS As filed with the Securities and Exchange Commission on April 4, 2018 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☑ Filed by a Party other than the Reg

April 4, 2018 CORRESP

NWBO / Northwest Biotherapeutics, Inc. CORRESP

April 4, 2018 VIA EDGAR Dorrie Yale and Mary Beth Breslin Office of Healthcare & Insurance Division of Corporation Finance U.

April 3, 2018 NT 10-K

NWBO / Northwest Biotherapeutics, Inc. NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 x Form 10-K ¨ Form 20-F ¨ Form 11-K ¨ Form 10-Q ¨ Form 10-D ¨ Form N-SAR ¨ Form N-CSR For Period Ended: December 31, 2017 ¨ Transition Report on Form 10-K ¨ Transition Report on Form 20-F ¨ Transition Report on Form 11-K ¨ Transition Repor

March 26, 2018 424B5

Series A Convertible Preferred Stock Class D-1 Warrants to Purchase Shares of Common Stock

Supplement No. 1 dated March 26, 2018 to the Prospectus Supplement dated December 4, 2017 Filed Pursuant to Rule 424(b)(5) Registration No. 333-213777 (To the Prospectus dated September 23, 2016) Series A Convertible Preferred Stock Class D-1 Warrants to Purchase Shares of Common Stock This prospectus supplement (the “Supplement”) supplements information contained in that certain prospectus supple

March 26, 2018 PRE 14A

NWBO / Northwest Biotherapeutics, Inc. PRELIMINARY PROXY STATEMENT

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on March 26, 2018 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☑ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Statement ☐ Definitive Additional Materials ☐ Soliciting Material Pursuant to §240.

March 22, 2018 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 22, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction of incorporation) (Commi

March 22, 2018 EX-99.1

(Twenty Five Million, One Hundred and Seventy Thousand Pounds)

Exhibit 99.1 19th December 2017 T +44 (0)20 7198 2000 F +44 (0)20 7198 2001 Private & Confidential www.lsh.co.uk Lambert Smith Hampton Dennis Mehiel Esq United Kingdom House Four M Purchasers LLC 180 Oxford Street 7 Renaissance Square, 5th Floor London White Plains W1D 1NN NY 10601 Our Ref: LWVAL/SJ/MAF Dear Sir Client: Dennis Mehiel of Four M Purcharers LLC. Request: A valuation report in respect

March 20, 2018 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 14, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File

March 15, 2018 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): March 9, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission File N

March 7, 2018 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 28, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction of incorporation) (Co

March 2, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities

8-K 1 tv4876388k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 26, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorpo

February 21, 2018 8-K

Unregistered Sales of Equity Securities

8-K 1 tv4847618k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): February 15, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other juri

February 13, 2018 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / INTRACOASTAL CAPITAL, LLC - AMENDMENT NO. 1 TO FORM SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Northwest Biotherapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 6673P600 (CUSIP Number) December 31, 2017 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to design

February 13, 2018 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / Woodford Investment Management LLP - AMENDMENT NO. 2 TO SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 13, 2018 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / CF Woodford Equity Income Fund - AMENDMENT NO. 5 TO SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 9, 2018 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / CVI Investments, Inc. - SC 13G/A Passive Investment

CUSIP No: 66737P600 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 2)* Northwest Biotherapeutics, Inc. (Name of Issuer) Common Stock, $.001 par value per share (Title of Class of Securities) 66737P600 (CUS

January 25, 2018 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 21, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emp

January 16, 2018 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): January 16, 2018 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emp

January 9, 2018 DEF 14A

NWBO / Northwest Biotherapeutics, Inc. DEF 14A

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on January 9, 2018 SCHEDULE 14A (Rule 14a-101) INFORMATION REQUIRED IN PROXY STATEMENT SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☑ Definitive Proxy Statement ☐ Definitive Additional Materials ☐ Soliciting Material Pursuant to §240.

January 5, 2018 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities

8-K 1 tv4828168k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 31, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other ju

January 4, 2018 EX-3.1

Amended and Restated Certificate of Designations of Series B Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on January 4, 2018).

Exhibit 3.1 CERTIFICATE OF DESIGNATIONS OF SERIES B CONVERTIBLE PREFERRED STOCK OF NORTHWEST BIOTHERAPEUTICS, INC. Northwest Biotherapeutics, Inc. (the ?Company?), a corporation formed and existing under the Delaware General Corporation Law (the ?DGCL?), does hereby determine and certify that, pursuant to Section 151 of the DGCL and authority conferred upon its Board of Directors (the ?Board of Di

January 4, 2018 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 tv4826658k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 29, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdict

January 4, 2018 EX-10.3

Form of Subscription Agreement.

Exhibit 10.3 NORTHWEST BIOTHERAPEUTICS, INC. SUBSCRIPTION AGREEMENT THIS SUBSCRIPTION AGREEMENT (this ?Agreement?), is made as of , 2017, by and among Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Company?), and , the purchaser identified on the signature pages hereto (the ?Purchaser?). WHEREAS, the Company has determined to engage in an offering pursuant to Regulation D as promulg

January 4, 2018 EX-10.2

Form of Voting Agreement.

Exhibit 10.2 VOTING AGREEMENT This Voting Agreement (the ?Agreement?) is effective as of a , 2017, and is by and between Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Company?) and , a (the ?Investor?). RECITALS WHEREAS, the Company has established a class of Series B Preferred Stock (the ?Series B Preferred?) and the terms and conditions of such Series B Preferred are set forth in

January 4, 2018 EX-10.1

Form of Class D-2 Common Stock Purchase Warrant.

Exhibit 10.1 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?). THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO SUCH SECURITIES UNDER THE ACT OR UNLESS SUCH TRANSACTION IS IN COMPLIANCE WITH APPLICABLE FEDERAL AND STATE SECURITIES LAWS. NORTHWEST BI

December 21, 2017 EX-99.1

NW Bio Announces Regulation D Offering for Accredited Investors Financing Responds to Shareholder Requests Following Recent Series A Preferred Stock Financing

Exhibit 99.1 4800 Montgomery Lane Suite 800 Bethesda, MD 20814 t (240) 497-9024 f (240) 627-4121 www.nwbio.com NASDAQ: NWBO NW Bio Announces Regulation D Offering for Accredited Investors Financing Responds to Shareholder Requests Following Recent Series A Preferred Stock Financing BETHESDA, Md., December 19, 2017 - Northwest Biotherapeutics (OTCQB: NWBO) - (NW Bio), a biotechnology company develo

December 21, 2017 EX-3.1

Amended and Restated Certificate of Designations of Series A Convertible Preferred Stock (incorporated by reference to Exhibit 3.1 filed with the Registrant’s Current Report on Form 8-K on December 21, 2017).

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF DESIGNATIONS OF SERIES A CONVERTIBLE PREFERRED STOCK OF NORTHWEST BIOTHERAPEUTICS, INC. Northwest Biotherapeutics, Inc. (the ?Company?), a corporation formed and existing under the Delaware General Corporation Law (the ?DGCL?), in accordance with the provisions of Section 103(f) of the DGCL does hereby amend and restate the Certificate of Designation

December 21, 2017 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 15, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission Fi

December 7, 2017 EX-10.1

Form of Class D-1 Common Stock Purchase Warrant (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on December 7, 2017).

Exhibit 10.1 NORTHWEST BIOTHERAPEUTICS, INC. CLASS D-1 WARRANTS No. WD1- , 2017 This Certifies That, for value received, or its assigns (the ?Holder?), is entitled to subscribe for and purchase from Northwest Biotherapeutics, Inc., a Delaware corporation, with its principal office in Bethesda, Maryland (the ?Company?), such number of Exercise Shares as provided herein at the Exercise Price as prov

December 7, 2017 EX-99.1

NW Bio Announces Completion of $12 Million Financing Majority of Financing from New Investors

Exhibit 99.1 4800 Montgomery Lane Suite 800 Bethesda, MD 20814 t (240) 497-9024 f (240) 627-4121 www.nwbio.com OTCQB: NWBO For immediate release on Monday, December 4, 2017 NW Bio Announces Completion of $12 Million Financing Majority of Financing from New Investors BETHESDA, Md., December 4, 2017 - Northwest Biotherapeutics (OTCQB: NWBO) (NWBio), a biotechnology company developing DCVax? personal

December 7, 2017 EX-10.2

Form of Voting Agreement (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on December 7, 2017).

EX-10.2 4 tv480895ex10-2.htm EXHIBIT 10.2 Exhibit 10.2 VOTING AGREEMENT This Voting Agreement (the “Agreement”) is effective as of a , 2017, and is by and between Northwest Biotherapeutics, Inc., a Delaware corporation (the “Company”) and , a (the “Investor”). RECITALS WHEREAS, the Company has established a class of Series A Preferred Stock (the “Series A Preferred”) and the terms and conditions o

December 7, 2017 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): December 1, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emp

December 7, 2017 EX-10.3

Form of Subscription Agreement (incorporated by reference as Exhibit 10.3 filed with the Company’s Current Report on Form 8-K on December 7, 2017).

Exhibit 10.3 NORTHWEST BIOTHERAPEUTICS, INC. SUBSCRIPTION AGREEMENT THIS SUBSCRIPTION AGREEMENT (this ?Agreement?), is made as of , 2017, by and among Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Company?), and , the purchaser identified on the signature pages hereto (the ?Purchaser?). WHEREAS, subject to the terms and conditions set forth in this Agreement and pursuant to an effe

December 7, 2017 EX-3.1

Certificate of Designations of Series A Preferred Stock.

Exhibit 3.1 CERTIFICATE OF DESIGNATIONS OF SERIES A CONVERTIBLE PREFERRED STOCK OF NORTHWEST BIOTHERAPEUTICS, INC. Northwest Biotherapeutics, Inc. (the ?Company?), a corporation formed and existing under the Delaware General Corporation Law (the ?DGCL?), does hereby determine and certify that, pursuant to Section 151 of the DGCL and authority conferred upon its Board of Directors (the ?Board of Di

December 5, 2017 424B5

Series A Convertible Preferred Stock Class D-1 Warrants to Purchase Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

November 21, 2017 EX-99.1

NW Bio Issues Notice Of Proposed Agreement Settling Derivative Lawsuit Notice Being Issued to Fulfill Settlement Agreement Condition

Exhibit 99.1 4800 Montgomery Lane Suite 800 Bethesda, MD 20814 t (240) 497-9024 f (240) 627-4121 www.nwbio.com NASDAQ: NWBO For immediate release on Monday, November 20, 2017 NW Bio Issues Notice Of Proposed Agreement Settling Derivative Lawsuit Notice Being Issued to Fulfill Settlement Agreement Condition BETHESDA, Md., November 20, 2017 – Northwest Biotherapeutics, Inc. (OTCQB: NWBO) (“NW Bio”),

November 21, 2017 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): November 20, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission Fi

November 20, 2017 10-Q

NWBO / Northwest Biotherapeutics, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2017 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUT

November 14, 2017 NT 10-Q

NWBO / Northwest Biotherapeutics, Inc. NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 ? Form 10-K ? Form 20-F ? Form 11-K ? Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: September 30, 2017 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Repo

October 24, 2017 424B5

2,941,176 Shares of Common Stock Class D Warrants to Purchase 1,470,588 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

October 16, 2017 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): October 10, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission Fil

September 22, 2017 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 22, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 0-35737 (Commission F

September 22, 2017 EX-99.1

NW BIO Announces Registered Direct Offering Of $1.75 Million

Exhibit 99.1 4800 Montgomery Lane Suite 800 Bethesda, MD 20814 t (240) 497-9024 f (240) 627-4121 www.nwbio.com NASDAQ: NWBO For immediate release at 8:00 a.m. on Wednesday, September 20, 2017 NW BIO Announces Registered Direct Offering Of $1.75 Million BETHESDA, Md., September 20, 2017 - Northwest Biotherapeutics (OTCQB: NWBO) (NW Bio), a biotechnology company developing DCVax? personalized immune

September 22, 2017 EX-10.3

Engagement Agreement with Rodman & Renshaw, a unit of H.C. Wainwright & Co., LLC (incorporated by reference as Exhibit 10.3 filed with the Company’s Current Report on Form 8-K on September 22, 2017).

Exhibit 10.3 September 19, 2017 STRICTLY CONFIDENTIAL Northwest Biotherapeutics, Inc. 4800 Montgomery Lane, Suite 800 Bethesda, MD 20814 Attn: Linda Powers, Chief Executive Officer Dear Ms. Powers: This letter agreement (this ?Agreement?) constitutes the agreement between Northwest Biotherapeutics, Inc. (the ?Company?) and Rodman & Renshaw, a unit of H.C. Wainwright & Co., LLC (?Rodman?) that duri

September 22, 2017 EX-10.1

Form of Securities Purchase Agreement, dated September 20, 2017, by and between Northwest Biotherapeutics, Inc. and certain institutional investors (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on September 22, 2017).

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this ?Agreement?) is dated as of September 20, 2017, between Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Company?), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a ?Purchaser? and collectively the ?Purchasers?). WHEREAS, subject to the terms an

September 22, 2017 EX-10.2

Form of Class A Common Stock Purchase Warrant (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on September 22, 2017).

Exhibit 10.2 COMMON STOCK PURCHASE WARRANT northwest biotherapeutics, inc. Warrant Shares: Initial Exercise Date: September , 2017 THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof

September 22, 2017 8-K

Northwest Biotherapeutics 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): September 20, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Emp

September 22, 2017 424B5

8,750,000 Shares of Common Stock Class A Warrants to Purchase 4,375,000 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

September 11, 2017 SC 13G/A

Northwest Biotherapeutics AMENDMENT NO. 3 TO SCHEDULE 13G (Passive Acquisition of More Than 5% of Shares)

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

September 11, 2017 SC 13G/A

Northwest Biotherapeutics AMENDMENT NO. 1 TO SCHEDULE 13G (Passive Acquisition of More Than 5% of Shares)

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

August 21, 2017 10-Q

NWBO / Northwest Biotherapeutics, Inc. FORM 10-Q (Quarterly Report)

10-Q 1 v47364010q.htm FORM 10-Q UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2017 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-3

August 21, 2017 EX-10.1

NORTHWEST BIOTHERAPEUTICS, INC. LOAN AGREEMENT and PROMISSORY NOTE

Exhibit 10.1 NORTHWEST BIOTHERAPEUTICS, INC. LOAN AGREEMENT and PROMISSORY NOTE US $ April 19, 2017 SECTION 1. GENERAL. (the “Holder”) hereby grants to Northwest Biotherapeutics, Inc., a Delaware company (the “Maker” or the “Company”) a loan of Three Hundred Fifty Thousand Dollars (US $) (the “Principal Amount”) on the terms and conditions set forth in this Loan Agreement and Promissory Note (this

August 15, 2017 NT 10-Q

Northwest Biotherapeutics NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 ? Form 10-K ? Form 20-F ? Form 11-K ? Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR For Period Ended: June 30, 2017 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on

August 8, 2017 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 3, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

August 7, 2017 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 1, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

August 7, 2017 424B5

18,843,692 Shares of Common Stock Class A Warrants to Purchase 21,632,769 Shares of Common Stock Class B Warrants to Purchase 21,632,769 Shares of Common Stock Class C Warrants to Purchase 10,000,000 Shares of Common Stock Series A Warrants to Purcha

Supplement No. 1 dated August 7, 2017 to Prospectus Supplement dated March 22, 2017 Filed Pursuant to Rule 424(b)(5) Registration No. 333-213777 (To the Prospectus dated September 23, 2016) 18,843,692 Shares of Common Stock Class A Warrants to Purchase 21,632,769 Shares of Common Stock Class B Warrants to Purchase 21,632,769 Shares of Common Stock Class C Warrants to Purchase 10,000,000 Shares of

August 7, 2017 EX-10.1

Form of Warrant Repricing Letter Agreement dated August 7, 2017 by and between Northwest Biotherapeutics, Inc. and a certain institutional investor (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on August 7, 2017).

Exhibit 10.1 August 7, 2017 [] [] [] [] Re: Reset Offer of Common Stock Purchase Warrants To Whom It May Concern: Northwest Biotherapeutics, Inc. (the ?Company?) is pleased to offer to you the opportunity to reprice the exercise of all of the Common Stock purchase warrants set forth on Annex I attached hereto (the ?Existing Warrants?) currently held by you (?Holder?). The Existing Warrants and the

August 7, 2017 EX-10.2

Form of Series A Common Stock Purchase Warrant (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on August 7, 2017).

Exhibit 10.2 EXHIBIT A COMMON STOCK PURCHASE WARRANT northwest biotherapeutics, inc. Warrant Shares: Initial Exercise Date: August , 2017 THIS COMMON STOCK PURCHASE WARRANT (the ?Warrant?) certifies that, for value received, or its assigns (the ?Holder?) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date

August 7, 2017 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): August 7, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

July 26, 2017 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 20, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

July 21, 2017 8-K

Unregistered Sales of Equity Securities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): July 17, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employer

June 27, 2017 EX-10.1

Securities Exchange Agreement (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on June 21, 2017).

Exhibit 10.1 EXECUTION VERSION SECURITIES EXCHANGE AGREEMENT This Securities Exchange Agreement (this ?Agreement?) is dated as of June 21, 2017, between Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Company?), and (?Holder?). WHEREAS, subject to the terms and conditions set forth in this Agreement and pursuant to Section 4(a)(2) of the Securities Act of 1933, as amended (the ?Secur

June 27, 2017 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

8-K 1 v4697568k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 21, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdict

June 27, 2017 EX-10.2

Note Purchase Agreement (incorporated by reference as Exhibit 10.2 filed with the Company’s Current Report on Form 8-K on June 21, 2017).

Exhibit 10.2 EXECUTION VERSION NOTE PURCHASE AGREEMENT This Note Purchase Agreement (this ?Agreement?) is dated as of June 21, 2017, between Northwest Biotherapeutics, Inc., a Delaware corporation (the ?Company?), and (?Investor?). WHEREAS, subject to the terms and conditions set forth in this Agreement and pursuant to Section 4(a)(2) of the Securities Act of 1933, as amended (the ?Securities Act?

June 19, 2017 8-K

Northwest Biotherapeutics 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 13, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 0-35737 (C

June 13, 2017 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): June 7, 2017 (June 13, 2017) Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organizat

June 13, 2017 EX-10.1

NORTHWEST BIOTHERAPEUTICS, INC. SECOND SUPPLEMENTAL INDENTURE

Exhibit 10.1 EXECUTION VERSION NORTHWEST BIOTHERAPEUTICS, INC. SECOND SUPPLEMENTAL INDENTURE THIS SECOND SUPPLEMENTAL INDENTURE (this ?Second Supplemental Indenture?), dated and effective as of June 7, 2017, between Northwest Biotherapeutics, Inc. (the ?Company?) and The Bank of New York Mellon, a New York banking corporation, as trustee (the ?Trustee?). Capitalized terms used herein and not other

May 31, 2017 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 31, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation or organization) 0-35737 (Co

May 31, 2017 EX-10.1

Securities Exchange Agreement (incorporated by reference as Exhibit 10.1 filed with the Company’s Current Report on Form 8-K on May 31, 2017).

Exhibit 10.1 SECURITIES EXCHANGE AGREEMENT This Securities Exchange Agreement (this “Agreement”) is dated as of May 31, 2017, between Northwest Biotherapeutics, Inc., a Delaware corporation (the “Company”), and each holder identified on the signature pages hereto (each, including its successors and assigns, a “Holder” and collectively the “Holders”). WHEREAS, subject to the terms and conditions se

May 26, 2017 8-K

Unregistered Sales of Equity Securities, Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement

8-K 1 v4679168k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): May 22, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdicti

May 15, 2017 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2017 OR ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS,

April 25, 2017 8-K

Northwest Biotherapeutics 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of report (Date of earliest event reported): April 19, 2017 Northwest Biotherapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 0-35737 94-3306718 (State or other jurisdiction (Commission (IRS Employe

April 17, 2017 424B5

1,384,615 Shares of Common Stock Class A Warrants to Purchase 1,038,461 Shares of Common Stock Class B Warrants to Purchase 1,038,461 Shares of Common Stock

PROSPECTUS SUPPLEMENT Filed Pursuant to Rule 424(b)(5) (To the Prospectus dated September 23, 2016) Registration No.

April 17, 2017 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K x ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2016 ¨ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-35737 NORTHWEST BIOTHERAPEUTICS, INC. (Exact n

April 17, 2017 EX-21.1

Subsidiaries of the Registrant

EXHIBIT 21.1 Subsidiaries of the Registrant Name: Jurisdiction Aracaris, Ltd. United Kingdom Aracaris Capital, Ltd. United Kingdom NW Bio Gmbh Germany NW Bio Europe S.A.R.L. Switzerland (closed June 2015)

April 7, 2017 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 7, 2017 NORTHWEST BIOTHERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction of incorporation or org

April 5, 2017 8-K

Northwest Biotherapeutics 8-K (Current Report/Significant Event)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 30, 2017 NORTHWEST BIOTHERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-35737 94-3306718 (State or other jurisdiction of incorporation or or

March 31, 2017 NT 10-K

Northwest Biotherapeutics NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 SEC FILE NUMBER 001-35737 CUSIP NUMBER NOTIFICATION OF LATE FILING 66737P600 ? Form 10-K Form 20-F ? Form 11-K ? Form 10-Q ? Form 10-D ? Form N-SAR ? Form N-CSR ? For Period Ended: December 31, 2016 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Repor

March 24, 2017 SC 13G

NWBO / Northwest Biotherapeutics, Inc. / INTRACOASTAL CAPITAL, LLC - SCHEDULE 13G Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Northwest Biotherapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 6673P600 (CUSIP Number) March 17, 2017 (Date of Event Which Requires Filing of this Statement) Check the appropriate box

March 24, 2017 SC 13G/A

NWBO / Northwest Biotherapeutics, Inc. / INTRACOASTAL CAPITAL, LLC - SCHEDULE 13G AMENDMENT NO. 2 Passive Investment

Schedule 13G Amendment No. 2 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Northwest Biotherapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 6673P600 (CUSIP Number) March 24, 2017 (Date of Event Which Requires Filing of this Statement) Check the

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