SNPHY / Santen Pharmaceutical Co., Ltd. - Depositary Receipt (Common Stock) - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Certification under Rule 466

Certification under Rule 466 The depositary, JPMorgan Chase Bank, N.A., represents and certifies the following: (1) That it previously had filed a registration statement on Form F-6 (Softbank Mobile Service Corp., 333-229175) that the Commission declared effective, with terms of deposit identical to the terms of deposit of this registration statement. (2) That its ability to designate the date and

DMLRY / Daimler AG F-6EF - -

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co Ltd (Exact name of Issuer of deposited securities as specified in its charter) Japan (Jurisdiction of Incorporation or organization of Issuer) JPMorgan Chase Bank, N.A. (Exact nam

Ziegler, Ziegler & Associates LLP Counselors at Law 570 Lexington Avenue, Suite 2405 New York, New York 10022 (212) 319-7600 Telecopier (212) 319-7605 October 15, 2019

Ziegler, Ziegler & Associates LLP Counselors at Law 570 Lexington Avenue, Suite 2405 New York, New York 10022 (212) 319-7600 Telecopier (212) 319-7605 October 15, 2019 JPMorgan Chase Bank, N.

JPMorgan Chase Bank, N.A. American Depositary Receipt American Depositary Shares Representing Shares of Common Stock of Santen Pharmaceutical Co Ltd (Incorporated under the laws of Japan)

SUBSCRIPTION RIGHTS: Under current Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

Certification under Rule 466

Certification under Rule 466 The depositary, Deutsche Bank Trust Company Americas, represents and certifies the following: (1) That it previously had filed a registration statement on Form F-6 (Uniper SE, 333-217999) that the Commission declared effective, with terms of deposit identical to the terms of deposit of this registration statement.

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT TO FORM F-6 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co., Ltd.

333-186313 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT TO FORM F-6 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co., Ltd. (Exact name of Issuer of deposited securities as specified in its charter) Japan (Jurisdiction of Incorporation or organization of Is

THE RELEASE OF THE SHARES OF STOCK OF THE ISSUER (AS HEREINAFTER DEFINED) UNDERLYING THE ADSs REPRESENTED BY THIS ADR MAY BE LIMITED TO A UNIT OF SUCH NUMBER OF SHARES OF STOCK AS THE ARTICLES OF INCORPORATION MAY FROM TIME TO TIME DESIGNATE AS A "UN

SUBSCRIPTION RIGHTS: Under current Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co Ltd (Exact name of Issuer of

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co Ltd (Exact name of Issuer of deposited securities as specified in its charter) Japan (Jurisdiction of Incorporation or organization of Issuer) JPMorgan Chase Bank, N.A. (Exact nam

Certification under Rule 466

Certification under Rule 466 The depositary, JPMorgan Chase Bank, N.A., represents and certifies the following: (1) That it previously had filed a registration statement on Form F-6 (Berkeley Group Holdings Plc, 333-198831) that the Commission declared effective, with terms of deposit identical to the terms of deposit of this registration statement. (2) That its ability to designate the date and t

Ziegler, Ziegler & Associates LLP Counselors at Law 570 Lexington Avenue, Suite 2405 New York, New York 10022 (212) 319-7600 Telecopier (212) 319-7605

Ziegler, Ziegler & Associates LLP Counselors at Law 570 Lexington Avenue, Suite 2405 New York, New York 10022 (212) 319-7600 Telecopier (212) 319-7605 March 7, 2016 JPMorgan Chase Bank, N.

THE RELEASE OF THE SHARES OF STOCK OF THE ISSUER (AS HEREINAFTER DEFINED) UNDERLYING THE ADSs REPRESENTED BY THIS ADR MAY BE LIMITED TO A UNIT OF SUCH NUMBER OF SHARES OF STOCK AS THE ARTICLES OF INCORPORATION MAY FROM TIME TO TIME DESIGNATE AS A "UN

SUBSCRIPTION RIGHTS: Under current Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT TO FORM F-6 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co. Ltd. (

333-186313 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT TO FORM F-6 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co. Ltd. (Exact name of Issuer of deposited securities as specified in its charter) Japan (Jurisdiction of Incorporation or organization of Iss

THE RELEASE OF THE SHARES OF STOCK OF THE ISSUER (AS HEREINAFTER DEFINED) UNDERLYING THE ADSs REPRESENTED BY THIS ADR MAY BE LIMITED TO A UNIT OF SUCH NUMBER OF SHARES OF STOCK AS THE ARTICLES OF INCORPORATION MAY FROM TIME TO TIME DESIGNATE AS A "UN

SUBSCRIPTION RIGHTS: Under current Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

Certification under Rule 466 The depositary, Deutsche Bank Trust Company Americas, represents and certifies the following: (1) That it previously had filed a registration statement on Form F-6 (Santen Pharmaceutical Co. Ltd. 333-186313) that the Comm

Certification under Rule 466 The depositary, Deutsche Bank Trust Company Americas, represents and certifies the following: (1) That it previously had filed a registration statement on Form F-6 (Santen Pharmaceutical Co.

As filed with the Securities and Exchange Commission on March 30, 2015 Registration No. 333-169312 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST EFFECTIVE AMENDMENT NO.1 TO THE FORM F-6 REGISTRATION STATEMENT THE SECURITIES ACT OF 19

As filed with the Securities and Exchange Commission on March 30, 2015 Registration No.

THE BANK OF NEW YORK MELLON AMERICAN DEPOSITARY RECEIPT FOR SHARES OF ORDINARY SHARES, OF SANTEN PHARMACEUTICAL CO., LTD. (INCORPORATED UNDER THE LAWS OF JAPAN)

AMERICAN DEPOSITARY SHARES (One (1) American Depositary Share represents One (1) Share) THE BANK OF NEW YORK MELLON AMERICAN DEPOSITARY RECEIPT FOR SHARES OF ORDINARY SHARES, OF SANTEN PHARMACEUTICAL CO.

As filed with the Securities and Exchange Commission on March 24, 2015 Registration No. 333-186418

As filed with the Securities and Exchange Commission on March 24, 2015 Registration No.

Rule 466 Certification The depositary, Citibank, N.A., represents and certifies the following:

Exhibit (e) Rule 466 Certification The depositary, Citibank, N.A., represents and certifies the following: 1. That it previously had filed a registration statement on Form F-6 (Registration No. 333-186418), which the U.S. Securities and Exchange Commission declared effective, with terms of deposit identical to the terms of deposit of this Post-Effective Amendment No. 1 to Form F-6 Registration Sta

AMERICAN DEPOSITARY SHARES

Exhibit (a) NUMBER AMERICAN DEPOSITARY SHARES CUSIP # Each American Depositary Share represents one (1) share of common stock of the Company SUBSCRIPTION RIGHTS: Under Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

FSGCF / First Gen Corp F-6EF - - FORM F-6EF

As filed with the Securities and Exchange Commission on October 16, 2014 Registration No.

ConvergEx Depositary, Inc. American Depositary Receipt American Depositary Shares For Common Stock of Santen Pharmaceutical Co., Ltd. (Incorporated under the laws of Japan [hereinafter the “Company”])

Exhibit (a) CUSIP # XXXXXX XX X Each American Depositary Share represents one-half (1/2) of one Share[s] SUBSCRIPTION RIGHTS: Under Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

LETTERHEAD OF THOMPSON HINE LLP

Exhibit (d) LETTERHEAD OF THOMPSON HINE LLP October 16, 2014 ConvergEx Depositary, Inc.

Rule 466 Certification

Exhibit (e) Rule 466 Certification The depositary, ConvergEx Depositary, Inc., represents and certifies the following: 1. That it previously had filed a registration statement on Form F-6 (Registration No. 333 – 197668), which the U.S. Securities and Exchange Commission declared effective, with terms of deposit identical to the terms of deposit of this Form F-6 Registration Statement except for th

AMERICAN DEPOSITARY SHARES

Exhibit (a) NUMBER AMERICAN DEPOSITARY SHARES CUSIP # Each American Depositary Share represents one-half (1/2) of one share of common stock of the Company SUBSCRIPTION RIGHTS: Under Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

LETTERHEAD OF PATTERSON BELKNAP WEBB & TYLER LLP

Exhibit (d) LETTERHEAD OF PATTERSON BELKNAP WEBB & TYLER LLP February 1, 2013 Citibank, N.

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F-6EF 1 e610442f6ef-santen.htm As filed with the Securities and Exchange Commission on February 1, 2013 Registration No. 333- SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 FOR DEPOSITARY SHARES EVIDENCED BY AMERICAN DEPOSITARY RECEIPTS SANTEN PHARMACEUTICAL CO., LTD. (Exact name of issuer of deposited securities as specif

Rule 466 Certification

Exhibit (e) Rule 466 Certification The depositary, Citibank, N.A., represents and certifies the following: 1. That it previously had filed a registration statement on Form F-6 (Registration No. 333-186245), which the U.S. Securities and Exchange Commission declared effective, with terms of deposit identical to the terms of deposit of this Form F-6 Registration Statement except for the shares repre

Ziegler, Ziegler & Associates LLP Counselors at Law 570 Lexington Avenue, 44th Floor New York, New York 10022 (212) 319-7600 Telecopier (212) 319-7605

Ziegler, Ziegler & Associates LLP Counselors at Law 570 Lexington Avenue, 44th Floor New York, New York 10022 (212) 319-7600 Telecopier (212) 319-7605 January 30, 2013 Deutsche Bank Trust Company Americas, as Depositary 60 Wall Street New York, New York 10005 American Depositary Shares evidenced by American Depositary Receipts for deposited shares of the foreign private issuer whose name appears o

Certification under Rule 466

Certification under Rule 466 The depositary, Deutsche Bank Trust Company Americas, represents and certifies the following: (1) That it previously had filed a registration statement on Form F-6 (Finmeccanica SpA 333-170944) that the Commission declared effective, with terms of deposit identical to the terms of deposit of this registration statement.

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F-6EF 1 e610413f6ef-santen.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT Under THE SECURITIES ACT OF 1933 For American Depositary Shares Evidenced by American Depositary Receipts Santen Pharmaceutical Co. Ltd. (Exact name of Issuer of deposited securities as specified in its charter) Japan (Jurisdiction of Incorporation or organization of Issuer) DEU

THE RELEASE OF THE SHARES OF STOCK OF THE ISSUER (AS HEREINAFTER DEFINED) UNDERLYING THE ADSs REPRESENTED BY THIS ADR MAY BE LIMITED TO A UNIT OF SUCH NUMBER OF SHARES OF STOCK AS THE ARTICLES OF INCORPORATION MAY FROM TIME TO TIME DESIGNATE AS A "UN

SUBSCRIPTION RIGHTS: Under current Japanese practice offerings of rights to subscribe to additional underlying securities are sometimes made, and in varying amounts, with a subscription price sometimes below the current market price of the security.

EMMET, MARVIN & MARTIN, LLP

Writer?s Direct Dial EXHIBIT 4 EMMET, MARVIN & MARTIN, LLP COUNSELLORS AT LAW 120 Broadway New York, New York 10271 (212) 238-3000 (212) 653-1760 Fax: (212) 238-3100 Fax: (212) 653-1730 http://www.

THE BANK OF NEW YORK MELLON AMERICAN DEPOSITARY RECEIPT FOR SHARES OF ORDINARY SHARES, OF SANTEN PHARMACEUTICAL CO., LTD. (INCORPORATED UNDER THE LAWS OF JAPAN)

AMERICAN DEPOSITARY SHARES (One (1) American Depositary Share represents One Half (1/2) Shares) THE BANK OF NEW YORK MELLON AMERICAN DEPOSITARY RECEIPT FOR SHARES OF ORDINARY SHARES, OF SANTEN PHARMACEUTICAL CO.

As filed with the Securities and Exchange Commission on September 10, 2010 Registration No. 333- SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-6 REGISTRATION STATEMENT THE SECURITIES ACT OF 1933 For Depositary Shares Evidenced by A

As filed with the Securities and Exchange Commission on September 10, 2010 Registration No.