STRO / Sutro Biopharma, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Sutro Biopharma, Inc.
US ˙ NasdaqGM ˙ US8693671021

Mga Batayang Estadistika
LEI 5493005U6P15VD25P851
CIK 1382101
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Sutro Biopharma, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 7, 2025 EX-10.1

Offer Letter, dated June 2, 2025, by and between Registrant and Gregory K. Chow.

Exhibit 10.1 May 22, 2025 Gregory K. Chow (415) 218-4035 [email protected] Dear Gregory: We are pleased to offer you a position with Sutro Biopharma, Inc. (the “Company”), as Chief Financial Officer, reporting to Jane Chung, Chief Executive Officer, effective 6/2/2025, or such earlier date as may be mutually agreed between you and the Company. The Company is excited to have you join our excepti

August 7, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIOP

August 7, 2025 EX-99.1

Sutro Biopharma Reports Second Quarter 2025 Financial Results and Business Highlights About Sutro Biopharma Forward-Looking Statements

Exhibit 99.1 Sutro Biopharma Reports Second Quarter 2025 Financial Results and Business Highlights – On track to initiate FIH study with STRO-004, potential best-in-class Tissue Factor ADC, in the second half of 2025 – – Expanded breadth of preclinical data across pipeline, including STRO-006 and dual-payload ADCs – – Entered research collaboration with the FDA to advance regulatory standards for

August 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2025 SUTRO BIOPHARMA, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2025 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

June 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2025 SUTRO BIOPHARMA, IN

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2025 SUTRO BIOPHARMA, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-38662 47-0926186 (State or Other Jurisdiction of Incorporation) (Commission Fil

June 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2025 SUTRO BIOPHARMA, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2025 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

June 2, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2025 SUTRO BIOPHARMA, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 2, 2025 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 30, 2025 S-8

As filed with the Securities and Exchange Commission on May 30, 2025

As filed with the Securities and Exchange Commission on May 30, 2025 Registration No.

May 30, 2025 EX-99.1

Amended and Restated 2021 Equity Inducement Plan.

EXHIBIT 99.1 SUTRO BIOPHARMA, INC. AMENDED AND RESTATED 2021 EQUITY INDUCEMENT PLAN 1. PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible employees whose potential contributions are important to the success of the Company, and any Parents, Subsidiaries and Affiliates that exist now or in the future, by offering them an opportunity to participate in

May 30, 2025 EX-FILING FEES

Calculation of Registration Fees.

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Sutro Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities CALCULATION OF REGISTRATION FEE Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity C

May 30, 2025 EX-99.2

Amended Form of Restricted Stock Unit Award Agreement under the Amended and Restated 2021 Equity Inducement Plan.

Exhibit 99.2 SUTRO BIOPHARMA, INC. 2021 Equity INDUCEMENT Plan GLOBAL NOTICE OF RESTRICTED STOCK UNIT AWARD Unless otherwise defined herein, the terms defined in the Sutro Biopharma, Inc. (the “Company”) 2021 Equity Inducement Plan (the “Plan”) will have the same meanings in this Global Notice of Restricted Stock Unit Award and the electronic representation of this Global Notice of Restricted Stoc

May 30, 2025 EX-99.3

Amended Form of Stock Option Award Agreement under the Amended and Restated 2021 Equity Inducement Plan.

Exhibit 99.3 SUTRO BIOPHARMA, INC. 2021 EQUITY INDUCEMENT PLAN GLOBAL NOTICE OF STOCK OPTION GRANT Unless otherwise defined herein, the terms defined in the Sutro Biopharma, Inc. (the “Company”) 2021 Equity Inducement Plan (the “Plan”) will have the same meanings in this Global Notice of Stock Option Grant and the electronic representation of this Global Notice of Stock Option Grant established an

May 8, 2025 EX-10.3

Transition and Separation Agreement, dated as of March 13, 2025, by and between Sutro Biopharma, Inc. and Edward C. Albini.

Exhibit 10.3 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. March 13, 2025 Via Docusign Edward Albini Re: Terms of Transition and Separation Dear Edward: This letter confirms the agreement (“Agreement”) between you and Sutro Biopharma, Inc

May 8, 2025 EX-10.2

Offer Letter, dated as of March 13, 2025, by and between Sutro Biopharma, Inc. and Jane Chung.

Exhibit 10.2 March 13, 2025 Jane Chung Appointment Letter Dear Jane: We are pleased to offer you a position with Sutro Biopharma, Inc. (the “Company”), as Chief Executive Officer (“CEO”), reporting to Connie Matsui, the Chair of the Company’s Board of Directors (the “Board”), effective March 13, 2025 (the “Effective Date”). While you serve as Chief Executive Officer, you will also serve on the Boa

May 8, 2025 EX-99.1

Exhibit 99.1 Sutro Biopharma Reports First Quarter 2025 Financial Results and Business Highlights Forward-Looking Statements

Exhibit 99.1 Sutro Biopharma Reports First Quarter 2025 Financial Results and Business Highlights - Sharpened product candidate focus on its next-generation ADC portfolio, following strategic review and pipeline reprioritization - - Promising preclinical results with STRO-004 and dual-payload ADC, as well as STRO-006 programs presented at AACR 2025 and PEGS, respectively - - Three INDs for wholly-

May 8, 2025 EX-10.1

Transition and Separation Agreement, dated as of March 13, 2025, by and between Sutro Biopharma, Inc. and William J. Newell.

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. March 13, 2025 Via Docusign William Newell Re: Terms of Transition and Separation Dear Bill: This letter confirms the agreement (“Agreement”) between you and Sutro Biopharma, Inc.

May 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIO

May 8, 2025 EX-10.4

Transition and Separation Agreement, dated as of March 13, 2025, by and between Sutro Biopharma, Inc. and Anne Borgman.

Exhibit 10.4 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. March 13, 2025 Via Docusign Anne Borgman Re: Terms of Transition and Separation Dear Anne: This letter confirms the agreement (“Agreement”) between you and Sutro Biopharma, Inc. (

May 8, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2025 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

April 25, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 25, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 14, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 14, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2025 SUTRO BIOPHARMA, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2025 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

March 13, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Costs Associated with Exit or Disposal Activities, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2025 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

March 13, 2025 10-K

w, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

w, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-38662 SUTRO BIOPHA

March 13, 2025 EX-99.1

Sutro Biopharma Reports Full Year 2024 Financial Results and Business Highlights –Sutro announced a strategic portfolio review resulting in prioritization of wholly-owned next-generation ADC programs; Key management changes announced as part of trans

Exhibit 99.1 Sutro Biopharma Reports Full Year 2024 Financial Results and Business Highlights –Sutro announced a strategic portfolio review resulting in prioritization of wholly-owned next-generation ADC programs; Key management changes announced as part of transition– – Cash, cash equivalents and marketable securities as of December 31, 2024 of $316.9 million, with cash runway expected into at le

March 13, 2025 EX-19.1

Insider Trading Policy

Exhibit 19.1 I. PURPOSE Sutro Biopharma, Inc. (collectively with its subsidiaries, the “Company”) is committed to promoting high standards of honest and ethical business conduct and compliance with laws, rules and regulations. As part of this commitment, the Company has adopted this Insider Trading Policy (as adopted and amended from time to time by the Board, this “Policy”) governing the purchase

March 13, 2025 EX-99.2

Sutro Biopharma Announces Strategic Portfolio Review Resulting in the Prioritization of its Next-Generation ADC Pipeline – Sutro will rapidly advance next-generation exatecan and dual-payload ADC programs; luveltamab tazevibulin development to be dep

Exhibit 99.2 Sutro Biopharma Announces Strategic Portfolio Review Resulting in the Prioritization of its Next-Generation ADC Pipeline – Sutro will rapidly advance next-generation exatecan and dual-payload ADC programs; luveltamab tazevibulin development to be deprioritized as Sutro continues to seek a partner – – Three INDs for wholly-owned programs expected in the next 3 years, beginning with nov

February 27, 2025 EX-FILING FEES

Calculation of Registration Fees.

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Sutro Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common stock, par value $0.001 p

February 27, 2025 S-8

As filed with the Securities and Exchange Commission on February 27, 2025

As filed with the Securities and Exchange Commission on February 27, 2025 Registration No.

December 10, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 10, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 14, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 2 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 sc13ga207422stro11142024.htm AMENDMENT NO. 2 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 2)1 Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par va

November 14, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / Point72 Asset Management, L.P. - SUTRO BIOPHARMA, INC. Passive Investment

SC 13G/A 1 p24-3182sc13ga.htm SUTRO BIOPHARMA, INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 869367102 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Che

November 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 13, 2024 EX-99.1

Sutro Biopharma Reports Third Quarter 2024 Financial Results and Business Highlights

Exhibit 99.1 Sutro Biopharma Reports Third Quarter 2024 Financial Results and Business Highlights - Expects to deliver three Investigational New Drug (IND) applications in next three years based on next-generation ADC technology - - Two new clinical trials, REFRαME-P1, a registration-enabling trial of luvelta for pediatric patients with rare leukemia, and REFRαME-L1, a Phase 2 trial of luvelta for

November 13, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / Rubric Capital Management LP - SC 13G/A Passive Investment

SC 13G/A 1 tm2427812d14sc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367102 (CUSIP Number) September 30, 2024 (Date of event which requires filing of this statement) Check the ap

November 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO

November 12, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / Adage Capital Management, L.P. Passive Investment

SC 13G/A 1 p24-3036sc13ga.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 869367102 (CUSIP Number) September 30, 2024** (Date of Event Which Requires Filing of This Statement) Check the appropriate b

November 4, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / INTEGRATED CORE STRATEGIES (US) LLC Passive Investment

SC 13G/A 1 STROSC13GA12024.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (AMENDMENT NO. 1) SUTRO BIOPHARMA, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 PER SHARE (Title of Class of Securities) 869367102 (CUSIP Number) SEPTEMBER 30, 2024 (Date of event which requires filing of this statement) Check the app

August 13, 2024 EX-10.1

Amended 2018 Employee Stock Purchase Plan

Exhibit 10.1 SUTRO BIOPHARMA, INC. SUTRO BIOPHARMA, INC. AMENDED 2018 EMPLOYEE STOCK PURCHASE PLAN 1. Purpose. Sutro Biopharma, Inc. adopted the Plan effective as of the date of the IPO. The purpose of this Plan is to provide eligible employees of the Company and the Participating Corporations with a means of acquiring an equity interest in the Company through payroll deductions, to enhance such e

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIOP

August 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

August 13, 2024 EX-99.1

Sutro Biopharma Reports Second Quarter 2024 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Second Quarter 2024 Financial Results, Business Highlights and Select Anticipated Milestones - Sutro will present updated data from the ongoing Phase 1b study of luvelta in combination with bevacizumab in a poster presentation at ESMO 2024; expansion study is ongoing with data expected in the first half of 2025 - - REFRαME-O1 Part 2 (randomized portion) of the

August 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2024 SUTRO BIOPHARMA, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

June 10, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2024 SUTRO BIOPHARMA, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 17, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Ru

May 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 13, 2024 EX-10.1

Exclusive License Agreement between the Registrant and Ipsen Pharma SAS.

Execution Version Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. EXCLUSIVE LICENSE AGREEMENT dated as of March 29, 2024 by and between Sutro Biopharma, Inc. and Ipsen Pharma SAS i EXCLUSIVE LICENSE AGREEMENT This Exclusive Lic

May 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIO

May 13, 2024 EX-99.1

Sutro Biopharma Reports First Quarter 2024 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports First Quarter 2024 Financial Results, Business Highlights and Select Anticipated Milestones - Investigational New Drug application for non-small cell lung cancer trial with luvelta cleared by U.S. Food and Drug Administration; Phase 2 on track to begin dosing in the second half of 2024 - - Patient expansion phase well underway in Phase 2 study of luvelta in com

April 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Ru

April 26, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 5, 2024 EX-99.1

JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)

EX-99.1 2 p24-1385exhibit99.htm JOINT FILING AGREEMENT PURSUANT TO RULE 13D-1(K) EXHIBIT 99.1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without

April 5, 2024 SC 13G

STRO / Sutro Biopharma, Inc. / Point72 Asset Management, L.P. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 869367102 (CUSIP Number) April 4, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whi

April 2, 2024 EX-1.1

Underwriting Agreement dated April 2, 2024

Exhibit 1.1 14,478,764 Shares SUTRO BIOPHARMA, INC. Common Stock UNDERWRITING AGREEMENT April 2, 2024 BofA Securities, Inc. As Representative of the several Underwriters c/o BofA Securities, Inc. One Bryant Park New York, NY 10036 1. Introductory. Sutro Biopharma, Inc., a Delaware corporation (the “Company”), proposes to sell, pursuant to the terms of this Agreement, to the several underwriters na

April 2, 2024 EX-99.1

Ipsen and Sutro Biopharma announce exclusive global licensing agreement for an ADC targeting solid tumors

Press release Intended for international media and investor audiences only Exhibit 99.

April 2, 2024 424B5

14,478,764 Shares Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-275525 PROSPECTUS SUPPLEMENT (To prospectus dated November 21, 2023) 14,478,764 Shares Common Stock We are offering 14,478,764 shares of our common stock in this offering. Our common stock is listed on The Nasdaq Global Market under the symbol “STRO.” On April 1, 2024, the last reported sale price of our common stock on The Na

April 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

April 2, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 2, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fil

March 25, 2024 10-K

w, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

w, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-38662 SUTRO BIOPHA

March 25, 2024 EX-99.1

Sutro Biopharma Reports Full Year 2023 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Full Year 2023 Financial Results, Business Highlights and Select Anticipated Milestones - Sutro highlighted luveltamab tazevibulin (luvelta) in a January 2024 investor webcast, describing the broad opportunity to address unmet needs in multiple FolRα-expressing cancers - - Compelling anti-leukemic activity of luvelta in pediatric patients with relapsed/refracto

March 25, 2024 EX-10.30

Offer Letter, dated January 18, 2023, by and between the Registrant and Anne E. Borgman.

Exhibit 10.30 January 18, 2023 Anne E. Borgman, M.D. [Private address] Dear Anne: We are pleased to offer you a position with Sutro Biopharma, Inc. (the “Company”), as Chief Medical Officer, reporting to Bill Newell, CEO, effective 2/28/2023. The Company is excited to have you join our exceptional team and we look forward to a purposeful and productive relationship. You should note that the Compan

March 25, 2024 EX-10.14

Offer Letter, dated August 28, 2013, by and between the Registrant and Hans-Peter Gerber.

Exhibit 10.14 August 28, 2023 Han-Peter Gerber, PhD [private address] Dear Hans-Peter: We are pleased to offer you a position with Sutro Biopharma, Inc. (the “Company”), as Chief Scientific Officer, reporting to Bill Newell, Chief Executive Officer, effective 9/18/2023. The Company is excited to have you join our exceptional team and we look forward to a purposeful and productive relationship. You

March 25, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 25, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

March 25, 2024 EX-10.43

Manufacturing Rights Agreement between the Registrant and Vaxcyte, Inc.

Execution Version Exhibit 10.43 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. MANUFACTURING RIGHTS AGREEMENT This MANUFACTURING RIGHTS AGREEMENT (this “Agreement”), effective as of the Effective Date, is entered into by and between Vaxcyte

March 25, 2024 EX-10.34

Amended and Restated 2021 Equity Inducement Plan and forms of award agreements thereunder.

EXHIBIT 10.34 SUTRO BIOPHARMA, INC. AMENDED AND RESTATED 2021 EQUITY INDUCEMENT PLAN 1.PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible employees whose potential contributions are important to the success of the Company, and any Parents, Subsidiaries and Affiliates that exist now or in the future, by offering them an opportunity to participate in

March 25, 2024 EX-97.1

Compensation Recovery Policy

exhibit 97.1 Sutro Biopharma, Inc. Compensation Recovery Policy (Adopted November 12, 2023) The Board has determined that it is in the best interests of the Company and its stockholders to adopt this Policy enabling the Company to recover from specified current and former Company executives certain incentive-based compensation in the event of an accounting restatement resulting from material nonco

March 25, 2024 EX-10.24

Severance and Change in Control Plan of the Company

Exhibit 10.24 SUTRO BIOPHARMA, INC. SEVERANCE AND CHANGE IN CONTROL PLAN Section 1 PURPOSE The Board of Sutro Biopharma, Inc., a Delaware corporation (together with its subsidiaries, the “Company”), considers it in the best interests of the stockholders of the Company to reinforce the continued attention and dedication of certain key employees of the Company to their duties of employment without p

March 25, 2024 EX-4.2

Description of Registrant’s Securities.

Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK General Our authorized capital stock consists of 300,000,000 shares of common stock, $0.001 par value per share, and 10,000,000 shares of undesignated preferred stock, $0.001 par value per share. The following description summarizes the most important terms of our capital stock. Because it is only a summary, it does not contain all the information that may

February 27, 2024 EX-FILING FEES

Calculation of Registration Fees.

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Sutro Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common stock, par value $0.001 pe

February 27, 2024 S-8

As filed with the Securities and Exchange Commission on February 27, 2024

As filed with the Securities and Exchange Commission on February 27, 2024 Registration No.

February 13, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / SUVRETTA CAPITAL MANAGEMENT, LLC Passive Investment

SC 13G/A 1 d1096317013g-a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box

February 12, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / Rubric Capital Management LP - SC 13G/A Passive Investment

SC 13G/A 1 tm245464d19sc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2023 (Date of event which requires filing of this statement) Check the appr

February 9, 2024 EX-1.1

Open Market Sale AgreementSM, dated April 2, 2021, by and between Sutro Biopharma, Inc. and Jefferies LLC.

Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM April 2, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Sutro Biopharma, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s common stoc

February 9, 2024 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 9, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

February 9, 2024 424B5

Up to $100,000,000 Common Stock

Table of Contents As Filed Pursuant to Rule 424(b)(5) Registration No. 333-275525 PROSPECTUS SUPPLEMENT (to Prospectus dated November 21, 2023) Up to $100,000,000 Common Stock We have previously entered into an Open Market Sale AgreementSM, or Sales Agreement, with Jefferies LLC, or Jefferies, relating to shares of our common stock offered by this prospectus supplement. In accordance with the term

February 7, 2024 SC 13G/A

STRO / Sutro Biopharma, Inc. / ADAGE CAPITAL PARTNERS GP, L.L.C. - SUTRO BIOPHARMA, INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursuant

January 17, 2024 SC 13G

STRO / Sutro Biopharma, Inc. / INTEGRATED CORE STRATEGIES (US) LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 SUTRO BIOPHARMA, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 PER SHARE (Title of Class of Securities) 869367102 (CUSIP Number) JANUARY 10, 2024 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to whic

January 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 4, 2024 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

January 8, 2024 EX-99.1

Forward-Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

Company Overview January 2024 Sutro Biopharma NASDAQ: STRO Exhibit 99.1 Forward-Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other than statements of historical fact con

November 27, 2023 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 21, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 21, 2023 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 21, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 21, 2023 EX-99.1

Sutro Biopharma Promotes Jane Chung to President and Chief Operating Officer

Exhibit 99.1 Sutro Biopharma Promotes Jane Chung to President and Chief Operating Officer SOUTH SAN FRANCISCO, Calif., November 21, 2023 – Sutro Biopharma, Inc. (Sutro or the Company) (NASDAQ: STRO), a clinical-stage oncology company pioneering site-specific and novel-format antibody drug conjugates (ADCs), today announced the promotion of Jane Chung to President and Chief Operating Officer, a new

November 17, 2023 CORRESP

* * *

SUTRO BIOPHARMA, INC. 111 Oyster Point Blvd. South San Francisco, CA 94080 November 17, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Attention: Office of Life Sciences Re: Sutro Biopharma, Inc. Registration Statement on Form S-3 Filed November 13, 2023 File No. 333-275525 Requested Date: November 21, 2023 Re

November 13, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 13, 2023 S-3

As filed with the Securities and Exchange Commission on November 13, 2023

S-3 Table of Contents As filed with the Securities and Exchange Commission on November 13, 2023 Registration No.

November 13, 2023 EX-3.1

Amended and Restated Certificate of Incorporation of the Registrant.

Exhibit 3.1 SUTRO BIOPHARMA, INC. RESTATED CERTIFICATE OF INCORPORATION Sutro Biopharma, Inc., a Delaware corporation, hereby certifies as follows: 1. The name of the corporation is Sutro Biopharma, Inc. The date of the filing of its original Certificate of Incorporation with the Secretary of State was April 21, 2003, under the name Fundamental Applied Biology, Inc. 2. The Restated Certificate of

November 13, 2023 EX-99.1

Sutro Biopharma Reports Third Quarter 2023 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Third Quarter 2023 Financial Results, Business Highlights and Select Anticipated Milestones - Updated luvelta data from Compassionate Use Access demonstrating anti-leukemic activity in pediatric patients with relapsed/refractory CBF2AT3-GLIS2 AML to be presented in a poster at ASH 2023 - - Luvelta demonstrated encouraging preliminary anti-tumor activity in init

November 13, 2023 EX-10.1

Third Amendment to the Vaxcyte License Agreement between the Registrant and Vaxcyte, Inc.

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. THIRD AMENDMENT TO AMENDED AND RESTATED SUTROVAX AGREEMENT This Third Amendment (“Amendment No. 3”) to the Amended and Restated SutroVax Agreement, dated as of October 12, 2015, as

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO

November 13, 2023 EX-4.2

Form of Debt Security

Exhibit 4.2 FORM OF DEBT SECURITY [Face of Security] SUTRO BIOPHARMA, INC. [If applicable, insert–FOR PURPOSES OF THE ORIGINAL ISSUE DISCOUNT PROVISIONS OF THE INTERNAL REVENUE CODE OF 1986, THE ISSUE PRICE OF THIS SECURITY IS % OF ITS PRINCIPAL AMOUNT AT STATED MATURITY SET FORTH BELOW (ITS “PRINCIPAL AMOUNT”), THE AMOUNT OF ORIGINAL ISSUE DISCOUNT IS % OF ITS PRINCIPAL AMOUNT, THE YIELD TO MATUR

November 13, 2023 EX-FILING FEES

Filing Fee Table

EXHIBIT 107 Calculation Of Filing Fee Tables Form S-3 (Form Type) Sutro Biopharma, Inc.

November 13, 2023 EX-4.3

Form of Indenture

Exhibit 4.3 SUTRO BIOPHARMA, INC. And , as Trustee INDENTURE Dated as of , TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS AND INCORPORATION BY REFERENCE 1 1.1 DEFINITIONS 1 1.2 OTHER DEFINITIONS 4 1.3 INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT 4 1.4 RULES OF CONSTRUCTION 5 ARTICLE 2 THE SECURITIES 5 2.1 ISSUABLE IN SERIES 5 2.2 ESTABLISHMENT OF TERMS OF SERIES OF SECURITIES 5 2.3 EXECUTION AN

October 10, 2023 SC 13G

STRO / Sutro Biopharma Inc / ADAGE CAPITAL PARTNERS GP, L.L.C. - SUTRO BIOPHARMA, INC. Passive Investment

SC 13G 1 p23-2557sc13g.htm SUTRO BIOPHARMA, INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 869367102 (CUSIP Number) September 28, 2023 (Date of Event Which Requires Filing of This Statement) Check the

October 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2023 SUTRO BIOPHARM

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 28, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commissio

August 10, 2023 EX-99.1

Sutro Biopharma Reports Second Quarter 2023 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Second Quarter 2023 Financial Results, Business Highlights and Select Anticipated Milestones - Enrollment is underway for REFRaME-O1, the Phase 2/3 pivotal study of luveltamab tazevibulin, or luvelta, for patients with platinum-resistant ovarian cancer - - Sutro will present data from the Phase 1 dose expansion for luvelta for patients with endometrial cancers

August 10, 2023 EX-10.1

Purchase Agreement, dated June 21, 2023, between the Registrant and an affiliate of Blackstone Life Sciences.

Confidential Execution Version Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. PURCHASE AND SALE AGREEMENT dated as of June 21, 2023 between SUTRO BIOPHARMA, INC. and BXLS V – VAULT L.P. Table of Contents Page Article I DEFINED

August 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIOP

August 10, 2023 EX-10.2

Consent and Fifth Amendment to Loan and Security Agreement among Oxford Finance LLC, the Lenders (as defined in the certain Loan and Security Agreement, dated as of February 28, 2020) and the Registrant.

Exhibit 10.2 CONSENT AND FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS CONSENT AND FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into as of June 21, 2023, by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314, as collateral agent (in its individual capacity, “Oxfor

August 10, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

June 26, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2023 SUTRO BIOPHARMA, IN

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 21, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fil

June 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 SUTRO BIOPHARMA, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 15, 2023 EX-10.1

Consent and Second Amendment to the Loan and Security Agreement among Oxford Finance LLC, the Lenders (as defined in the certain Loan and Security Agreement, dated as of February 28, 2020) and the Registrant.

Exhibit 10.1 CONSENT AND SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS CONSENT AND SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into as of September 15, 2022, by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314, as collateral agent (in its individual capacity,

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIO

May 15, 2023 EX-99.1

Sutro Biopharma Reports First Quarter 2023 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports First Quarter 2023 Financial Results, Business Highlights and Select Anticipated Milestones - Data from the Phase 1 dose-expansion study for luveltamab tazevibulin, or luvelta, for patients with advanced ovarian cancer will be featured as an oral presentation at ASCO 2023 - - As presented at AACR 2023, STRO-003 demonstrated potent anti-tumor activity and immune

May 15, 2023 EX-10.3

Consent and Fourth Amendment to Loan and Security Agreement among Oxford Finance LLC, the Lenders (as defined in the certain Loan and Security Agreement, dated as of February 28, 2020) and the Registrant.

Exhibit 10.3 CONSENT AND FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS CONSENT AND FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into as of April 14, 2023, by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314, as collateral agent (in its individual capacity, “Ox

May 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2023 SUTRO BIOPHARMA, INC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 15, 2023 EX-10.2

Consent and Third Amendment to Loan and Security Agreement among Oxford Finance LLC, the Lenders (as defined in the certain Loan and Security Agreement, dated as of February 28, 2020) and the Registrant.

Exhibit 10.2 CONSENT AND THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS CONSENT AND THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into as of March 28, 2023, by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314, as collateral agent (in its individual capacity, “Oxfo

April 28, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (a

April 28, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Ru

April 27, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2023 SUTRO BIOPHARMA, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

April 14, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (AMENDMENT NO. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (a

April 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2023 SUTRO BIOPHARMA, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 10, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

March 30, 2023 EX-10

Letter Agreement, dated December 19, 2022, by and between the Registrant and Vaxcyte, Inc.

Exhibit 10.35 EXECUTION VERSION CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. December 19, 2022 Sutro Biopharma, Inc. 111 Oyster Point Boulevard South San Francisco, California 94080 Attention: William J. Newell, CEO, Sutro Biopharma, Inc. [

March 30, 2023 10-K

w, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

w, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-38662 SUTRO BIOPHA

March 30, 2023 EX-99

Sutro Biopharma Reports Full Year 2022 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Full Year 2022 Financial Results, Business Highlights and Select Anticipated Milestones - Sutro plans to initiate a Phase 2/3 registration-directed study of luvelta for patients with platinum resistant ovarian cancer in the second quarter - - Dr. Anne Borgman joined Sutro as Chief Medical Officer in February 2023 - - Sutro expanded its relationship with Vaxcyte

March 30, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 30, 2023 SUTRO BIOPHARMA, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 30, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

February 27, 2023 S-8

As filed with the Securities and Exchange Commission on February 27, 2023

As filed with the Securities and Exchange Commission on February 27, 2023 Registration No.

February 27, 2023 EX-FILING FEES

Calculation of Registration Fees.

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Sutro Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity Common stock, par value $0.001 pe

February 27, 2023 EX-99

Amended and Restated 2021 Equity Inducement Plan

EXHIBIT 99.5 SUTRO BIOPHARMA, INC. AMENDED AND RESTATED 2021 EQUITY INDUCEMENT PLAN 1. PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible employees whose potential contributions are important to the success of the Company, and any Parents, Subsidiaries and Affiliates that exist now or in the future, by offering them an opportunity to participate in

February 24, 2023 EX-3

Amended and Restated Bylaws of Sutro Biopharma, Inc.

Exhibit 3.1 SUTRO BIOPHARMA, INC. (a Delaware corporation) AMENDED AND RESTATED BYLAWS Amended and Restated on February 24, 2023 SUTRO BIOPHARMA, INC. (a Delaware corporation) AMENDED AND RESTATED BYLAWS Article I: STOCKHOLDERS 1 Section 1.1: Annual Meetings 1 Section 1.2: Special Meetings 1 Section 1.3: Notice of Meetings 1 Section 1.4: Adjournments 1 Section 1.5: Quorum 2 Section 1.6: Organizati

February 24, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 24, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

February 14, 2023 SC 13G/A

STRO / Sutro Biopharma Inc / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 1 TO THE SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367102 (CUSIP Number) De

February 14, 2023 SC 13G/A

STRO / Sutro Biopharma Inc / EVENTIDE ASSET MANAGEMENT, LLC - SC 13G/A Passive Investment

SC 13G/A 1 sutrobio13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Sutro Biopharma, Inc. (Name of Issuer – as specified in its charter) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) C

February 13, 2023 SC 13G/A

STRO / Sutro Biopharma Inc / SUVRETTA CAPITAL MANAGEMENT, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 10, 2023 SC 13G

STRO / Sutro Biopharma Inc / Rubric Capital Management LP - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2022 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to

February 1, 2023 SC 13G/A

STRO / Sutro Biopharma Inc / FRANKLIN RESOURCES INC Passive Investment

sutr22a11.htm - Generated by SEC Publisher for SEC Filing CUSIP NO. 869367102 13G Page 1 of 13 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* SUTRO BIOPHARMA, INC. (Name of Issuer) Common stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2022 (Date of Event

January 23, 2023 SC 13G/A

STRO / Sutro Biopharma Inc / MILLENNIUM MANAGEMENT LLC Passive Investment

SC 13G/A 1 STROSC13GA2023.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (AMENDMENT NO. 1) SUTRO BIOPHARMA, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 PER SHARE (Title of Class of Securities) 869367102 (CUSIP Number) DECEMBER 31, 2022 (Date of event which requires filing of this statement) Check the appro

January 9, 2023 EX-99.1

Forward-Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

EX-99.1 2 stro-ex991.htm EX-99.1 Company Overview January 9, 2023 Sutro Biopharma NASDAQ: STRO Exhibit 99.1 Forward-Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other th

January 9, 2023 EX-99.2

Sutro Biopharma Announces Update from STRO-002, Luveltamab Tazevibulin (Luvelta), Phase 1 Dose-Expansion Study and Registrational Plans in Advanced Ovarian Cancer - Results from the STRO-002 (luvelta) Phase 1 dose-expansion study demonstrate that Fol

Exhibit 99.2 Sutro Biopharma Announces Update from STRO-002, Luveltamab Tazevibulin (Luvelta), Phase 1 Dose-Expansion Study and Registrational Plans in Advanced Ovarian Cancer - Results from the STRO-002 (luvelta) Phase 1 dose-expansion study demonstrate that FolRα-selected patients experienced meaningful clinical benefit, with 43.8% ORR, median DOR of 5.4 months, and median PFS of 6.6 months at t

January 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 9, 2023 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

January 9, 2023 EX-99.3

Agenda for Today January 9, 2023 Topic Speaker Welcome and Introduction Forward-Looking Statements Ed Albini, Chief Financial Officer, Sutro Biopharma Bill Newell, Chief Executive Officer, Sutro Biopharma Luvelta (STRO-002) Phase 1 Dose-Expansion S

Luveltamab Tazevibulin (Luvelta, STRO-002) Phase 1 Data and Regulatory Strategy January 9, 2023 Exhibit 99.

December 20, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 19, 2022 SUTRO BIOPHARMA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 19, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 8, 2022 EX-99.1

Sutro Biopharma Reports Third Quarter 2022 Financial Results, Business Highlights and Select Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Third Quarter 2022 Financial Results, Business Highlights and Select Anticipated Milestones - STRO-002 data demonstrating anti-leukemic activity in pediatric patients with relapsed/refractory CBF2AT3-GLIS2 AML are accepted for oral presentation at ASH 2022 - - STRO-002 data from the Phase 1 ovarian cancer dose-expansion cohort and the trial design of the Phase

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO

October 24, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 SUTRO BIOPHARMA,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 18, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

August 31, 2022 EX-FILING FEES

Calculation of Registration Fees

Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Sutro Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities CALCULATION OF REGISTRATION FEE Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Equity C

August 31, 2022 EX-99.1

Amended and Restated 2021 Equity Inducement Plan

Exhibit 99.1 SUTRO BIOPHARMA, INC. AMENDED AND RESTATED 2021 EQUITY INDUCEMENT PLAN 1. PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible employees whose potential contributions are important to the success of the Company, and any Parents, Subsidiaries and Affiliates that exist now or in the future, by offering them an opportunity to participate in

August 31, 2022 S-8

As filed with the Securities and Exchange Commission on August 31, 2022

As filed with the Securities and Exchange Commission on August 31, 2022 Registration No.

August 8, 2022 EX-99.1

Sutro Biopharma Reports Second Quarter 2022 Financial Results, Business Highlights and Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports Second Quarter 2022 Financial Results, Business Highlights and Anticipated Milestones - Collaboration with Astellas on discovery and development of iADCs for up to three targets, includes an upfront payment of $90 million and $422.5 million in potential milestones per product candidate - - A $10 million milestone payment from Merck was triggered upon first pati

August 8, 2022 EX-10.3

First amendment to the Loan and Security Agreement among Oxford Finance LLC, Silicon Valley Bank, and the Registrant.

Exhibit 10.3 FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT THIS FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (this ?Amendment?) is entered into as of June 23, 2022, by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314, as collateral agent (in its individual capacity, ?Oxford?; and in its capacity

August 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIOP

August 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

August 8, 2022 EX-10.1

First Amendment to the Tasly License Agreement dated April 18, 2022.

Exhibit 10.1 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. AMENDMENT TO LICENSE AGREEMENT This ?Amendment? is entered into by and between Sutro Biopharma, Inc. (?Sutro?) and Tasly Biopharmaceuticals Co., Ltd. (?Licensee?; together with Su

August 8, 2022 EX-10.2

License and Collaboration Agreement, dated June 27, 2022, by and between the Registrant and Astellas Pharma Inc.

Exhibit 10.2 Execution Version Confidential CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. LICENSE AND COLLABORATION AGREEMENT by and between Sutro Biopharma, Inc. and astellas pharma Inc. June 27, 2022 i Confidential TABLE OF CONTENTS Art

July 26, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fil

July 8, 2022 SC 13G

STRO / Sutro Biopharma Inc / MILLENNIUM MANAGEMENT LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 SUTRO BIOPHARMA, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 PER SHARE (Title of Class of Securities) 869367102 (CUSIP Number) JULY 1, 2022 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which th

June 28, 2022 EX-99.1

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

Company Overview June 2022 Sutro Biopharma NASDAQ: STRO Exhibit 99.1 Forward Looking Statements This presentation and the accompanying oral presentation contain ?forward-looking? statements that are based on our management?s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other than statements of historical fact contai

June 28, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 27, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fil

June 16, 2022 EX-99.1

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

Company Overview June 2022 Sutro Biopharma NASDAQ: STRO Exhibit 99.1 Forward Looking Statements This presentation and the accompanying oral presentation contain ?forward-looking? statements that are based on our management?s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other than statements of historical fact contai

June 16, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fil

June 7, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 18, 2022 POS EX

As filed with the Securities and Exchange Commission on May 18, 2022

POS EX 1 stro-posex.htm POS EX As filed with the Securities and Exchange Commission on May 18, 2022 Registration No. 333-255014 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 3 TO FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Sutro Biopharma, Inc. (Exact name of registrant as specified in its charter) Delaware 47-0926186 (Sta

May 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 9, 2022 EX-99.1

Sutro Biopharma Reports First Quarter 2022 Financial Results, Business Highlights, and Anticipated Milestones

Exhibit 99.1 Sutro Biopharma Reports First Quarter 2022 Financial Results, Business Highlights, and Anticipated Milestones - Cash, cash equivalents and marketable securities totaled $192.1 million as of March 31, 2022, with projected cash runway into the second half of 2023 - - Meetings with regulatory agencies for STRO-002 are planned for mid-year 2022 and near-final dose expansion data are expec

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIO

April 25, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

DEFA14A 1 stro-defa14a-2022.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of

April 25, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Ru

April 20, 2022 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 18, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

March 1, 2022 POS AM

As filed with the Securities and Exchange Commission on February 28, 2022

Table of Contents As filed with the Securities and Exchange Commission on February 28, 2022 Registration No.

March 1, 2022 S-8

As filed with the Securities and Exchange Commission on February 28, 2022

As filed with the Securities and Exchange Commission on February 28, 2022 Registration No.

March 1, 2022 EX-FILING FEES

Calculation of Registration Fees.

EX-FILING FEES 4 d52521dexfilingfees.htm EX-FILING FEES Exhibit 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Sutro Biopharma, Inc. (Exact Name of Registrant as Specified in its Charter) Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of R

February 28, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

February 28, 2022 POSASR

Power of Attorney

Table of Contents As filed with the Securities and Exchange Commission on February 28, 2022 Registration No.

February 28, 2022 EX-10.30

Offer Letter, dated May 23, 2021, by and between the Registrant and Jane Chung.

Exhibit 10.30 May 23, 2021 Jane Chung, RPh [Private Address] Dear Jane: We are pleased to offer you a position with Sutro Biopharma, Inc. (the ?Company?), as Chief Commercial Officer, reporting to William Newell, Chief Executive Officer, effective August 1, 2021. The Company is excited to have you join our exceptional team and we look forward to a purposeful and productive relationship. You should

February 28, 2022 EX-10.29

License Agreement, dated December 24, 2021, by and between the Registrant and Tasly Biopharmaceuticals Co., Ltd.

Exhibit 10.29 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. LICENSE AGREEMENT BY AND BETWEEN SUTRO BIOPHARMA, INC. AND TASLY BIOPHARMACEUTICALS CO., LTD. December 20, 2021 LICENSE AGREEMENT This License Agreement (the ?Agreement?) is ente

February 28, 2022 EX-10.31

Offer Letter, dated December 11, 2015, by and between the Registrant and Arturo Molina.

Exhibit 10.31 December 11, 2015 Arturo Molina, M.D [Private Address] Dear Arturo, We are very pleased to present this revised offer of employment to you for the position of Chief Medical Officer at Sutro Biopharma (the ?Company?), reporting to William J. Newell, Chief Executive Officer. This letter sets forth the terms and conditions of our proposal for your employment. You may accept this offer b

February 28, 2022 10-K

, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-38662 SUTRO BIOPHAR

February 28, 2022 EX-FILING FEES

Filing Fee Table.

EXHIBIT 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Sutro Biopharma, Inc.

February 28, 2022 EX-10.11

Offer Letter, dated December 11, 2012, by and between the Registrant and Edward C. Albini.

Exhibit 10.11 Biologics by Design. Imagine. December 11, 2012 Edward Albini [Private Address] Dear Ed: I am pleased to offer you a position with Sutro Biopharma, Inc. (the ?Company?), as a Chief Financial Officer reporting to Bill Newell, CEO. If you decide to join us, you will receive an annual salary of $260,000, which will be paid semi-monthly in accordance with the Company?s normal payroll pro

February 28, 2022 EX-10.28

Option Agreement, dated October 9, 2021, by and between the Registrant and BioNova Pharmaceuticals Limited.

Execution Version CONFIDENTIAL Exhibit 10.28 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [*], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO SUTRO BIOPHARMA, INC. IF PUBLICLY DISCLOSED. OPTION AND LICENSE AGREEMENT THIS OPTION AND LICENSE AGREEMENT (this ?Agreement?), entered into as of October 9, 2021 (the ?Effective Date?), is en

February 28, 2022 EX-99.1

Sutro Biopharma Reports Full Year 2021 Financial Results, Business Highlights, and Anticipated 2022 Milestones

Exhibit 99.1 Sutro Biopharma Reports Full Year 2021 Financial Results, Business Highlights, and Anticipated 2022 Milestones - Promising STRO-002 initial data on Phase 1 dose-expansion cohort were reported in January 2022, providing initial insights on a go-forward dosing regimen and biomarker enrichment strategy - - Cash, cash equivalents and marketable securities totaled $229.5 million as of Dece

February 14, 2022 SC 13G/A

STRO / Sutro Biopharma Inc / EVENTIDE ASSET MANAGEMENT, LLC - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Sutro Biopharma, Inc. (Name of Issuer ? as specified in its charter) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

February 11, 2022 SC 13G/A

STRO / Sutro Biopharma Inc / SUVRETTA CAPITAL MANAGEMENT, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 4, 2022 SC 13G

STRO / Sutro Biopharma Inc / FRANKLIN RESOURCES INC Passive Investment

sutr21in.htm - Generated by SEC Publisher for SEC Filing CUSIP NO. 869367102 13G Page 1 of 14 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SUTRO BIOPHARMA, INC. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2021 (Date of Event Wh

January 18, 2022 EX-99.1

Joint Filing Agreement

Exhibit 99.1 Joint Filing Agreement The undersigned hereby agree that the Statement on Schedule 13G dated January 18, 2022 with respect to the Common Stock, $0.001 par value per share of Sutro Biopharma, Inc., a Delaware corporation, and any further amendments thereto executed by each and any of the undersigned shall be filed on behalf of each of the undersigned pursuant to and in accordance with

January 18, 2022 SC 13G

STRO / Sutro Biopharma Inc / BIOTECHNOLOGY VALUE FUND L P - THE SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )1 Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367102 (CUSIP Number) Jan

January 10, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 7, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

January 10, 2022 EX-99.1

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

NON-CONFIDENTIAL Company Overview January 2022 Sutro Biopharma NASDAQ: STRO Exhibit 99.

January 5, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2022 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

January 5, 2022 EX-99.1

Sutro Biopharma Announces Interim Data from Dose-Expansion Cohort of STRO-002 Phase 1 Study for Patients with Advanced Ovarian Cancer

Exhibit 99.1 Sutro Biopharma Announces Interim Data from Dose-Expansion Cohort of STRO-002 Phase 1 Study for Patients with Advanced Ovarian Cancer - 33% Objective Response Rate (ORR) was observed in 33 RECIST evaluable patients across all FolR? expression levels and both dose levels. - Dose response was observed, with a 47% ORR in 17 patients who started at the 5.2 mg/kg dose level. - Tumor propor

January 5, 2022 EX-99.2

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

NON-CONFIDENTIAL 2022 KOL Discussion of STRO-002 Phase 1 Interim Dose Expansion Data January 5, 2022 5:00pm ET / 2:00pm PT Sutro Biopharma ?NASDAQ: STRO Exhibit 99.

December 27, 2021 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 24, 2021 SUTRO BIOPHARMA, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-38662 47-0926186 (State or Other Jurisdiction of Incorporation) (Commission

December 10, 2021 SC 13G

STRO / Sutro Biopharma Inc / SUVRETTA CAPITAL MANAGEMENT, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

November 17, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 10, 2021 EX-10.2

Second Amendment to the Exclusive Patent License and Research Collaboration Agreement

Exhibit 10.2 Execution Copy Second Amendment to the Exclusive Patent License and Research Collaboration Agreement This Second Amendment to the Exclusive Patent License and Research Collaboration Agreement between the Parties, effective as of July 23, 2018, and as subsequently amended by Amendment #1, effective as of August 26, 2020 (the ?Agreement?), is entered into and effective as of the date of

November 10, 2021 EX-99.2

Forward Looking Statements NON-CONFIDENTIAL 2 This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to managemen

NON-CONFIDENTIAL Company Overview November 2021 Sutro Biopharma NASDAQ: STRO Exhibit 99.

November 10, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 10, 2021 EX-99.1

Sutro Biopharma Reports Third Quarter 2021 Financial Results, Business Highlights, and Anticipated 2021 Milestones

Exhibit 99.1 Sutro Biopharma Reports Third Quarter 2021 Financial Results, Business Highlights, and Anticipated 2021 Milestones - Patient enrollment has been completed for the STRO-002 Phase 1 ovarian cancer dose-expansion cohort, and an interim data update is expected in the second half of 2021 ? - STRO-001 Phase 1 dose escalation for non-Hodgkin?s lymphoma and multiple myeloma is ongoing to achi

November 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO

October 12, 2021 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 9, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission F

September 30, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 30, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commissio

August 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIOP

August 9, 2021 EX-99.1

2021 Equity Inducement Plan Document

Exhibit 99.1 SUTRO BIOPHARMA, INC. 2021 EQUITY INDUCEMENT PLAN 1.PURPOSE. The purpose of this Plan is to provide incentives to attract, retain and motivate eligible employees whose potential contributions are important to the success of the Company, and any Parents, Subsidiaries and Affiliates that exist now or in the future, by offering them an opportunity to participate in the Company?s future p

August 9, 2021 EX-10.2

Third Amendment to Lease 888-894 Industrial Road, San Carlos, CA

Exhibit 10.2 Third Amendment to Lease 888-894 Industrial Road, San Carlos, CA LESSEE: Sutro Biopharma, Inc., a Delaware Corporation Subject Property: 888-894 Industrial Road San Carlos, CA 94070 LESSOR: Alemany Plaza LLC, a California Limited Liability CompanyDated: June 11, 2021 This Third Amendment to Lease is dated this 11th day of June 2021 by and between Sutro Biopharma, Inc., a Delaware Corp

August 9, 2021 EX-99.1

Sutro Biopharma Reports Second Quarter 2021 Financial Results, Business Highlights and Anticipated Second Half 2021 Milestones

Exhibit 99.1 Sutro Biopharma Reports Second Quarter 2021 Financial Results, Business Highlights and Anticipated Second Half 2021 Milestones - - Additional follow-up data on STRO-002 from the Phase 1 dose-escalation cohort were presented at ASCO June 2021; enrollment for the Phase 1 dose-expansion cohort is ongoing - Milestone payment earned from Merck for initiation of IND-enabling study and from

August 9, 2021 S-8

As filed with the Securities and Exchange Commission on August 6, 2021

As filed with the Securities and Exchange Commission on August 6, 2021 Registration No.

August 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

June 17, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fil

June 4, 2021 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 3, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 19, 2021 EX-99.1

Maturing data from the Phase 1 dose-escalation cohort for STRO-002 showed a median progression-free survival of 7.2 months

EX-99.1 2 stro-ex9916.htm EX-99.1 Exhibit 99.1 Sutro Biopharma Announces Additional Data for Dose-Escalation Phase 1 Study of STRO-002 to be Presented at ASCO 2021 • Maturing data from the Phase 1 dose-escalation cohort for STRO-002 showed a median progression-free survival of 7.2 months • One patient achieved a CR and nine patients achieved a PR, of which four were confirmed PRs. Median duration

May 19, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 19, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

May 19, 2021 EX-99.2

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

Company Overview May 19, 2021 Sutro Biopharma NASDAQ: STRO Exhibit 99.2 Forward Looking Statements This presentation and the accompanying oral presentation contain ?forward-looking? statements that are based on our management?s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other than statements of historical fact con

May 7, 2021 EX-99.1

Sutro Biopharma Reports First Quarter 2021 Financial Results, Business Highlights and 2021 Anticipated Milestones

EX-99.1 2 stro-ex9916.htm EX-99.1 Exhibit 99.1 Sutro Biopharma Reports First Quarter 2021 Financial Results, Business Highlights and 2021 Anticipated Milestones - Additional follow-up data on STRO-002 from the Phase 1 dose-escalation will be presented at ASCO 2021; enrollment for the dose-expansion is ongoing - Merck initiated IND-enabling toxicology studies for the first program under the cytokin

May 7, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO BIO

May 7, 2021 EX-10.1

Severance and Change in Control Plan

EX-10.1 2 stro-ex1019.htm EX-10.1 Exhibit 10.1 SUTRO BIOPHARMA, INC. SEVERANCE AND CHANGE IN CONTROL PLAN SECTION 1 PURPOSE The Board of Sutro Biopharma, Inc., a Delaware corporation (together with its subsidiaries, the “Company”), considers it in the best interests of the stockholders of the Company to reinforce the continued attention and dedication of certain key employees of the Company to the

May 7, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission File

April 29, 2021 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Ru

April 15, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 14, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

April 5, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule pursua

April 5, 2021 EX-99.1

Joint Filing Agreement

EX-99.1 2 brhc10022785ex99-1.htm JOINT FILING AGREEMENT Exhibit 99.1 Joint Filing Agreement The persons below hereby agree that the Schedule 13G to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13G, shall be filed jointly on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securitie

April 2, 2021 EX-4.4

Form of Indenture

EX-4.4 4 d130369dex44.htm EX-4.4 Exhibit 4.4 SUTRO BIOPHARMA, INC. And , as Trustee INDENTURE Dated as of , TABLE OF CONTENTS ARTICLE 1 – DEFINITIONS AND INCORPORATION BY REFERENCE 1 1.1 DEFINITIONS 1 1.2. OTHER DEFINITIONS 4 1.3. INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT 4 1.4. RULES OF CONSTRUCTION 4 ARTICLE 2 – THE SECURITIES 5 2.1. ISSUABLE IN SERIES 5 2.2. ESTABLISHMENT OF TERMS OF SE

April 2, 2021 EX-4.3

Form of Debt Security

Exhibit 4.3 FORM OF DEBT SECURITY [Face of Security] SUTRO BIOPHARMA, INC. [If applicable, insert?FOR PURPOSES OF THE ORIGINAL ISSUE DISCOUNT PROVISIONS OF THE INTERNAL REVENUE CODE OF 1986, THE ISSUE PRICE OF THIS SECURITY IS % OF ITS PRINCIPAL AMOUNT AT STATED MATURITY SET FORTH BELOW (ITS ?PRINCIPAL AMOUNT?), THE AMOUNT OF ORIGINAL ISSUE DISCOUNT IS % OF ITS PRINCIPAL AMOUNT, THE YIELD TO MATUR

April 2, 2021 EX-1.2

Open Market Sale AgreementSM, dated April 2, 2021, by and between the Registrant and Jefferies LLC

Exhibit 1.2 OPEN MARKET SALE AGREEMENTSM April 2, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Sutro Biopharma, Inc., a Delaware corporation (the ?Company?), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the ?Agent?), shares of the Company?s common stoc

April 2, 2021 S-3ASR

- S-3ASR

Table of Contents As filed with the Securities and Exchange Commission on April 2, 2021 Registration No.

March 18, 2021 10-K

Annual Report - 10-K

, UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-38662 SUTRO BIOPHAR

March 18, 2021 EX-10.24

Severance and Change in Control Plan of the Company

EX-10.24 3 stro-ex1024531.htm EX-10.24 Exhibit 10.24 SUTRO BIOPHARMA, INC. SEVERANCE AND CHANGE IN CONTROL PLAN SECTION 1 PURPOSE The Board of Sutro Biopharma, Inc., a Delaware corporation (together with its subsidiaries, the “Company”), considers it in the best interests of the stockholders of the Company to reinforce the continued attention and dedication of certain key employees of the Company

March 18, 2021 EX-99.1

Sutro Biopharma Reports Full Year 2020 Financial Results and Provides Business Highlights and 2021 Anticipated Milestones - Year-end 2020 cash, cash equivalents and marketable securities of $326.5 million, with projected runway into the second half o

EX-99.1 2 stro-ex9917.htm EX-99.1 Exhibit 99.1 Sutro Biopharma Reports Full Year 2020 Financial Results and Provides Business Highlights and 2021 Anticipated Milestones - Year-end 2020 cash, cash equivalents and marketable securities of $326.5 million, with projected runway into the second half of 2023 - Four antibody-drug conjugate programs are now in the clinic that were discovered through Sutro

March 18, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 18, 2021 Registration No.

March 18, 2021 EX-10.11

Offer Letter, dated August 8, 2018, by and between the Registrant and Linda Fitzpatrick.

EX-10.11 2 stro-ex1011205.htm EX-10.11 Exhibit 10.11 August 8, 2018 Linda Fitzpatrick 720 Endfield Way Hillsborough, CA 940 l 0 Dear Linda, We are very pleased to present this offer of employment to you for the position of Chief People and Communications Officer at Sutro Biopharma (the "Company"), reporting to William Newell, CEO. This letter sets forth the terms and conditions of our proposal for

March 18, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2021 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission Fi

February 16, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) (CUSIP

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367 10 2 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Amendment No. 1) UNDER THE SECURITIES EXCHANGE ACT OF 19341 Sutro Biopharma, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) (CUSI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Amendment No.

February 16, 2021 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 tm214737d22ex99-1.htm EXHIBIT 99.1 EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G/A filed herewith (and any amendments thereto), relating to the common stock of Sutro Biopharma, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of

February 16, 2021 SC 13G/A

December 31, 2020

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) Under the Securities Exchange Act of 1934 (Amendment No. 3)* Sutro Biopharma, Inc. (Name of Issuer) Common stock, par value $0.001 per share (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2020 Date of Event Which Requires Filing of the Statement Check the appropriate box to des

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CUS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuan

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendm

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 869367102 (CUSIP Number) De

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (CU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursua

December 9, 2020 EX-1.1

Underwriting Agreement dated December 8, 2020

EX-1.1 2 stro-ex1134.htm EX-1.1 EXHIBIT 1.1 6,000,000 Shares SUTRO BIOPHARMA, INC. Common Stock UNDERWRITING AGREEMENT December 8, 2020 Cowen and Company, LLC Piper Sandler & Co. Wells Fargo Securities, LLC As Representatives of the several Underwriters c/o Cowen and Company, LLC 599 Lexington Avenue New York, New York 10022 c/o Piper Sandler & Co. 800 Nicollet Mall, Suite 1000 Minneapolis, Minnes

December 9, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 8, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

December 9, 2020 424B5

6,000,000 Shares Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-234101 and 333-251206 Prospectus supplement (To prospectus dated October 11, 2019) 6,000,000 Shares Common Stock We are offering 6,000,000 shares of our common stock pursuant to this prospectus supplement and the accompanying prospectus. Our common stock is quoted on The Nasdaq Global Market under the symbol “STRO.” On

December 9, 2020 S-3MEF

- S-3MEF

S-3MEF As filed with the Securities and Exchange Commission on December 8, 2020 Registration No.

December 7, 2020 424B5

5,000,000 Shares Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-234101 This preliminary prospectus supplement and the accompanying prospectus relate to an effective registration statement under the Securities Act of 1933, as amended, but the information in this prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospe

December 7, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 7, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

December 7, 2020 EX-99.1

Sutro Biopharma Presents Data from Ongoing Phase 1 Dose-Escalation Study for STRO-001 for the Treatment of B-cell Non-Hodgkin Lymphoma at the 62nd American Society of Hematology Annual Meeting - STRO-001 was generally well-tolerated in patients with

Exhibit 99.1 Sutro Biopharma Presents Data from Ongoing Phase 1 Dose-Escalation Study for STRO-001 for the Treatment of B-cell Non-Hodgkin Lymphoma at the 62nd American Society of Hematology Annual Meeting - STRO-001 was generally well-tolerated in patients with late-line NHL with no ocular or neuropathy toxicity signals; MTD has not been reached - - 1 CR & 2 PRs observed in heavily pretreated pat

December 4, 2020 EX-99.1

Sutro Biopharma Announces Encouraging Interim Data on STRO-002 Phase 1 Dose-Escalation Study for Patients with Ovarian Cancer

EX-99.1 2 stro-ex9916.htm EX-99.1 Exhibit 99.1 Sutro Biopharma Announces Encouraging Interim Data on STRO-002 Phase 1 Dose-Escalation Study for Patients with Ovarian Cancer - Responses observed in 32% (10/31) of evaluable patients treated at clinically active dose levels-including 1 CR, 3 cPRs and 6 uPRs - Disease control rate at 12 weeks is 74% (23/31) and 10 patients remained on treatment - Dose

December 4, 2020 EX-99.2

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

Lainie P. Martin, M.D. Leader, Gynecology/Oncology Program and Associate Professor of Medicine at Hospital of the University of Pennsylvania KOL Discussion of STRO-002 Data December 3, 2020 5:00pm ET | 2:00pm PT R. Wendel Naumann, M.D. Professor & Director of Gynecologic Oncology Research and Associate Medical Director of Clinical Trials at Levine Cancer Institute, Atrium Health Exhibit 99.2 Forwa

December 4, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 3, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

December 1, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 30, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of incorporation) (Commission

November 5, 2020 EX-99.1

Sutro Biopharma Reports Third Quarter 2020 Financial Results and Provides Business Highlights and Developments - KOL Discussion of STRO-002 Data Event scheduled for December 3rd - Interim Phase 1 data from STRO-001 for patients with NHL will be prese

Exhibit 99.1 Sutro Biopharma Reports Third Quarter 2020 Financial Results and Provides Business Highlights and Developments - KOL Discussion of STRO-002 Data Event scheduled for December 3rd - Interim Phase 1 data from STRO-001 for patients with NHL will be presented at ASH - Milestone payment received from EMD Serono collaboration on MUC1-EGFR bispecific ADC - Honored as Best New Drug Developer a

November 5, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

November 5, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-38662 SUTRO

November 5, 2020 EX-10.1

Sublease Agreement, dated September 3, 2020, by and between the Company and Five Prime Therapeutics, Inc.

SUBLEASE THIS SUBLEASE (this “Sublease”) is made and entered into this 3rd day of September, 2020, by and between Five Prime Therapeutics, Inc.

September 9, 2020 EX-99.1

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

Company Overview 2020 Wells Fargo Virtual Healthcare Conference NASDAQ: STRO Bill Newell, CEO Exhibit 99.

September 9, 2020 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 9, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

September 9, 2020 EX-99.2

Forward Looking Statements This presentation and the accompanying oral presentation contain “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking

FolRα – Targeting ADC Phase 1 Potential Best-in-Class ADC for Ovarian and Endometrial Cancers STRO 002 Exhibit 99.

September 4, 2020 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 3, 2020 SUTRO BIOPHARMA, INC. (Exact name of registrant as specified in its charter) Delaware 001-38662 47-0926186 (State or other jurisdiction of Incorporation) (Commission

August 28, 2020 SC 13G

STRO / SUTRO BIOPHARMA INC / EcoR1 Capital, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ) Sutro Biopharma, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 869367102 (CUSIP Number) August 19, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant t

August 25, 2020 SC 13G

STRO / SUTRO BIOPHARMA INC / Ridgeback Capital Investments L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Amendment No.

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