TTHI / Transition Therapeutics Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Transition Therapeutics Inc.
US ˙ NASDAQ
HINDI NA ACTIVE ANG SIMBONG ITO

Mga Batayang Estadistika
CIK 1399250
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Transition Therapeutics Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
September 13, 2016 15-12B

Transition Therapeutics 15-12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number: 001-33514 Transition Therapeutics Inc. (Exact name of registrant as specifi

September 13, 2016 S-8 POS

Transition Therapeutics S-8 POS

As filed with the Securities and Exchange Commission on September 13, 2016 Registration No.

September 9, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by ch

September 9, 2016 EX-99.1

FORM 51-102F3 MATERIAL CHANGE REPORT

EX-99.1 2 v448583ex99-1.htm MATERIAL CHANGE REPORT FILED SEPTEMBER 9, 2016. Exhibit 99.1 FORM 51-102F3 MATERIAL CHANGE REPORT Item 1: Name and Address of Company Transition Therapeutics Inc. (“Transition”) Suite 220 – 101 College Street Toronto, ON M5G 1L7 Item 2: Date of Material Change August 31, 2016 Item 3: News Release A news release announcing the material change was disseminated on August 3

August 31, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

August 26, 2016 EX-99.1

Transition Therapeutics Announces Special Shareholder Meeting Voting Results Including Shareholder Approval of the Plan of Arrangement with OPKO Health, Inc.

EX-99.1 2 v447747ex99-1.htm PRESS RELEASE DATED AUGUST 25, 2016 Exhibit 99.1 Transition Therapeutics Announces Special Shareholder Meeting Voting Results Including Shareholder Approval of the Plan of Arrangement with OPKO Health, Inc. TORONTO, ON, August 25, 2016 – Transition Therapeutics Inc. (“Transition” or the “Company”) (NASDAQ: TTHI, TSX: TTH) is pleased to announce that the Company has rece

August 26, 2016 EX-99.1

Transition Therapeutics Announces Special Shareholder Meeting Voting Results Including Shareholder Approval of the Plan of Arrangement with OPKO Health, Inc.

EX-99.1 2 v447747ex99-1.htm PRESS RELEASE DATED AUGUST 25, 2016 Exhibit 99.1 Transition Therapeutics Announces Special Shareholder Meeting Voting Results Including Shareholder Approval of the Plan of Arrangement with OPKO Health, Inc. TORONTO, ON, August 25, 2016 – Transition Therapeutics Inc. (“Transition” or the “Company”) (NASDAQ: TTHI, TSX: TTH) is pleased to announce that the Company has rece

August 26, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

August 26, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

August 4, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

August 4, 2016 EX-99.1

NOTICE OF SPECIAL MEETING OF SHAREHOLDERS to be held August 25, 2016 NOTICE OF APPLICATION TO THE ONTARIO SUPERIOR COURT OF JUSTICE (COMMERCIAL LIST) INFORMATION CIRCULAR and PROXY STATEMENT with respect to a PROPOSED PLAN OF ARRANGEMENT TRANSITION T

EX-99.1 2 v445986ex99-1.htm NOTICE OF SPECIAL MEETING OF SHAREHOLDERS Exhibit 99.1 NOTICE OF SPECIAL MEETING OF SHAREHOLDERS to be held August 25, 2016 and NOTICE OF APPLICATION TO THE ONTARIO SUPERIOR COURT OF JUSTICE (COMMERCIAL LIST) and INFORMATION CIRCULAR and PROXY STATEMENT with respect to a PROPOSED PLAN OF ARRANGEMENT involving TRANSITION THERAPEUTICS INC. and OPKO HEALTH, INC. and OPKO G

July 13, 2016 EX-99.1

Date: July 13, 2016

EX-99.1 2 v444207ex99-1.htm NOTICE OF SPECIAL MEETING Exhibit 99.1 Date: July 13, 2016 100 University Avenue, 8th floor Toronto ON, M5J 2Y1 www.computershare.com To: All Canadian Securities Regulatory Authorities Subject: TRANSITION THERAPEUTICS INC Dear Sir/Madam: We advise of the following with respect to the upcoming Meeting of Security Holders for the subject Issuer: Meeting Type : Special Mee

July 13, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

July 6, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

6-K 1 v4437926k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executiv

July 6, 2016 EX-99.1

MATERIAL CHANGE REPORT

EX-99.1 2 v443792ex99-1.htm MATERIAL CHANGE REPORT DATED JULY 6, 2016 Exhibit 99.1 MATERIAL CHANGE REPORT Item 1. Name and Address of Reporting Issuer: Transition Therapeutics Inc. (“Transition”) 101 College Street, Suite 220 Toronto, Ontario M5G 1L7 Item 2. Date of Material Change: June 29, 2016 Item 3. News Release: A joint news release disclosing the material change described below was issued b

June 30, 2016 6-K

Transition Therapeutics 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

June 30, 2016 EX-99.1

OPKO Health to Acquire Transition Therapeutics

Exhibit 99.1 OPKO Health to Acquire Transition Therapeutics ? All-stock transaction valued at approximately US$60 million, or US$1.55 per Transition Therapeutics share ? OPKO to gain potential first-to-market GLP-1/Glucagon dual agonist for type 2 diabetes and obesity and phase 2 drug candidate for the treatment of androgen deficiency MIAMI and TORONTO (June 30, 2016) ? OPKO Health, Inc. (NASDAQ:

June 3, 2016 EX-99.1

Transition Therapeutics Receives Notification From NASDAQ

EX-99.1 2 ex991.htm NEWS RELEASE DATED JUNE 3, 2016 Exhibit 99.1 Transition Therapeutics Receives Notification From NASDAQ TORONTO, June 3, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced that it received written notification from the NASDAQ Stock Market ("NASDAQ") on May 31, 2016 advising the Company that because the bid price of

June 3, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

May 11, 2016 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.5 6 v439356ex99-5.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF FINANCIAL OFFICER Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therap

May 11, 2016 EX-99.1

Transition Therapeutics Announces Third Quarter Fiscal 2016 Financial Results

EX-99.1 2 v439356ex99-1.htm PRESS RELEASE DATED MAY 11, 2016 Exhibit 99.1 Transition Therapeutics Announces Third Quarter Fiscal 2016 Financial Results TORONTO, ON, May 11, 2016 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS, metabolic disease and androgen deficiency indications,

May 11, 2016 EX-99.3

As At March 31, 2016

EX-99.3 4 v439356ex99-3.htm CONSOLIDATED FINANCIAL STATEMENTS Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the nine and three months ended March 31, 2016 and 2015 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As At March 31, 2016 As at June 30, 2015 Assets Current assets Cash 24,768,772 40,510,75

May 11, 2016 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.4 5 v439356ex99-4.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF EXECUTIVE OFFICER Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeut

May 11, 2016 EX-99.6

To Our Shareholders,

EX-99.6 7 v439356ex99-6.htm LETTER TO SHAREHOLDERS Exhibit 99.6 To Our Shareholders, Fiscal Q3 2016 is highlighted by the announcement of top-line results from our diabetes drug candidate TT401. In parallel, the Company has commenced an interaction with the FDA to assess the future development plan for the ELND005 program. Subsequent to the quarter end, the Company also announced the start of the

May 11, 2016 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT?S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company?s unaudited consolidated financial statements for the three and nine month periods ended March 31, 2016 and the related notes, which are prepared in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board for interi

May 11, 2016 6-K

Transition Therapeutics 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 9, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 9, 2016 EX-99.1

Transition Therapeutics to Hold Conference Call on Third Quarter Fiscal 2016 Financial Results on Wednesday, May 11th, at 4:30 P.M. EST

EX-99.1 2 ex991.htm NEWS RELEASE DATED MAY 9, 2016 Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Third Quarter Fiscal 2016 Financial Results on Wednesday, May 11th, at 4:30 P.M. EST TORONTO, May 9, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Wednesday, May 11th, 2016 at 4:30 P.M. EST to discuss

April 26, 2016 EX-99.1

Transition Therapeutics Announces Dosing of First Patient in Phase 2 Study of Drug Candidate TT701

Exhibit 99.1 Transition Therapeutics Announces Dosing of First Patient in Phase 2 Study of Drug Candidate TT701 TORONTO, April 25, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced the dosing of the first patient of a Phase 2 study of selective androgen receptor modulator (SARM) drug candidate TT701. The Phase 2 study will evaluate t

April 26, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

April 18, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

April 18, 2016 EX-99.1

Transition Therapeutics Provides Update on Type 2 Diabetes Drug Candidate TT401

EX-99.1 2 ex991.htm NEWS RELEASE DATED APRIL 18, 2016 Exhibit 99.1 Transition Therapeutics Provides Update on Type 2 Diabetes Drug Candidate TT401 TORONTO, April 18, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced that it has received notification that Eli Lilly and Co. ("Lilly") will not elect to advance diabetes drug candidate, T

March 24, 2016 EX-99.1

Transition Therapeutics Receives Notification From NASDAQ

EX-99.1 2 ex991.htm NEWS RELEASE DATED MARCH 17, 2016 Exhibit 99.1 Transition Therapeutics Receives Notification From NASDAQ TORONTO, March 17, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced that it received written notification from The NASDAQ Stock Market ("NASDAQ") on March 15, 2016 advising the Company that because the bid pri

March 24, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

March 1, 2016 EX-99.1

Transition Therapeutics to Present at the 36th Annual Cowen Healthcare Conference

EX-99.1 2 ex991.htm NEWS RELEASE DATED MARCH 1, 2016 Exhibit 99.1 Transition Therapeutics to Present at the 36th Annual Cowen Healthcare Conference TORONTO, March 1, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the Cowen Healthcare Confe

March 1, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

February 11, 2016 EX-99.1

JOINT FILING AGREEMENT

CUSIP No. 893716209 EXHIBIT 1 JOINT FILING AGREEMENT This Joint Filing Agreement is entered into as of February 11, 2016, by the undersigned, who hereby agree that the Statement on Amendment No. 3 to Schedule 13D in respect of the common shares of Transition Therapeutics Inc. is filed on behalf of each of the undersigned pursuant to and in accordance with the provisions of Rule 13d-1(k) under the

February 11, 2016 SC 13D/A

TTHI / Transition Therapeutics Inc. / SCHULER JACK W - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) TRANSITION THERAPEUTICS INC. (Name of Issuer) Common Shares (Title of Class of Securities) 893716209 (CUSIP Number) Jack W. Schuler c/o Crabtree Partners LLC 100 N. Field Drive, #360 Lake Forest, Illinois 60045 (224) 880-1211 (Name, Address and Telephone

February 9, 2016 EX-99.2

1

Exhibit 99.2 MANAGEMENT?S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company?s unaudited consolidated financial statements for the three and six month periods ended December 31, 2015 and the related notes, which are prepared in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board for inte

February 9, 2016 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the ?interim filings?) of Transition Therapeutics Inc. (the ?issuer?) for the interim period ended December 31, 2015. 2. No misrepresentations: B

February 9, 2016 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.5 6 v430769ex99-5.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF FINANCIAL OFFICER Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therap

February 9, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 9, 2016 EX-99.1

Transition Therapeutics Announces Second Quarter Fiscal 2016 Financial Results

Exhibit 99.1 Transition Therapeutics Announces Second Quarter Fiscal 2016 Financial Results TORONTO, ON, February 9, 2016 ? Transition Therapeutics Inc. (?Transition? or the ?Company?) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the three and six month periods end

February 9, 2016 EX-99.3

Consolidated Financial Statements

EX-99.3 4 v430769ex99-3.htm CONSOLIDATED FINANCIAL STATEMENTS Exhibit 99.3 Consolidated Financial Statements (Unaudited) Transition Therapeutics Inc. For the three and six months ended December 31, 2015 and 2014 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As At December 31, 2015 As at June 30, 2015 Assets Current assets Cash 29,070,189 40,510,758 O

February 9, 2016 EX-99.6

To Our Shareholders

EX-99.6 7 v430769ex99-6.htm LETTER TO SHAREHOLDERS Exhibit 99.6 To Our Shareholders In the second quarter of fiscal 2016 and shortly thereafter, the Company announced important findings that will guide the future of its two lead development programs. For ELND005, the Company held an Investor Day in November to provide an update on the analysis of the Phase 2/3 study completed in June 2015. This up

February 5, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 5, 2016 EX-99.1

Transition Therapeutics to Hold Conference Call on Second Quarter Fiscal 2016 Financial Results on Tuesday, February 9th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Second Quarter Fiscal 2016 Financial Results on Tuesday, February 9th, at 4:30 P.M. EST TORONTO, Feb. 5, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Tuesday, February 9th, 2016 at 4:30 P.M. EST to discuss Second Quarter Fiscal 2016 financial results.

February 3, 2016 SC 13G/A

TTHI / Transition Therapeutics Inc. / FEINBERG LARRY N - SCHEDULE 13G/A, #9 Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Amendment No. 9) Under the Securities Exchange Act of 1934 Transition Therapeutics, Inc. (Name of Issuer) Common Shares, no par value (Title of Class of Securities) 893716209 (CUSIP Number) December 31, 2015 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

February 1, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 1, 2016 EX-99.1

Transition Therapeutics Announces Top Line Phase 2 Clinical Study Results of Diabetes Drug Candidate TT401

Exhibit 99.1 Transition Therapeutics Announces Top Line Phase 2 Clinical Study Results of Diabetes Drug Candidate TT401 TORONTO, Feb. 1, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced the results of a Phase 2 clinical study of drug candidate TT401 (LY2944876) for the treatment of type 2 diabetes. TT401 is a once-weekly administere

January 19, 2016 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2016 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by chec

January 19, 2016 EX-99.1

Transition Therapeutics Announces Annual General Meeting Voting Results

Exhibit 99.1 Transition Therapeutics Announces Annual General Meeting Voting Results TORONTO, Jan. 6, 2016 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announces that the following five directors were elected at the Annual General Meeting of shareholders of the Company held on December 10, 2015 (the "Meeting"): NOMINEE VOTES IN FAVOR % VOTES WITHHEL

December 11, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

December 11, 2015 EX-99.1

TRANSITION THERAPEUTICS INC. ANNUAL GENERAL MEETING OF SHAREHOLDERS HELD ON DECEMBER 10, 2015 PREPARED BY COMPUTERSHARE INVESTOR SERVICES INC. TRANSITION THERAPEUTICS INC. ANNUAL GENERAL MEETING OF SHAREHOLDERS HELD ON DECEMBER 10, 2015 FINAL SCRUTIN

Exhibit 99.1 TRANSITION THERAPEUTICS INC. ANNUAL GENERAL MEETING OF SHAREHOLDERS HELD ON DECEMBER 10, 2015 PREPARED BY COMPUTERSHARE INVESTOR SERVICES INC. TORONTO TRANSITION THERAPEUTICS INC. ANNUAL GENERAL MEETING OF SHAREHOLDERS HELD ON DECEMBER 10, 2015 FINAL SCRUTINEERS' REPORT 2 SHAREHOLDERS IN PERSON, REPRESENTING 15,822 SHARES 67 SHAREHOLDERS BY PROXY, REPRESENTING 30,988,319 SHARES 69 TOT

November 19, 2015 EX-99.1

TRANSITION THERAPEUTICS INC. Annual Meeting of Shareholders Management Information Circular

Exhibit 99.1 TRANSITION THERAPEUTICS INC. Annual Meeting of Shareholders Management Information Circular This Management Information Circular (?Circular?) is furnished in connection with the solicitation of proxies by and on behalf of the management of Transition Therapeutics Inc. (the ?Corporation?) for use at the Annual Meeting of the Corporation?s shareholders to be held on December 10, 2015 at

November 19, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 19, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 19, 2015 EX-99.1

Live Webcast Beginning at 12 PM Eastern Time

Exhibit 99.1 Transition Therapeutics to Host Investor Day November 23 in New York Live Webcast Beginning at 12 PM Eastern Time TORONTO, Nov. 19, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that it will host an Investor Day on Monday, November 23rd in New York City. An industry key opinion leader, Jacobo Mintzer, MD, and Transit

November 19, 2015 EX-99.2

EX-99.2

Exhibit 99.2

November 10, 2015 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.4 5 v424095ex99-4.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF EXECUTIVE OFFICER Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeut

November 10, 2015 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT?S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company?s unaudited consolidated financial statements for the three-month period ended September 30, 2015 and the related notes, which are prepared in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board for interim fina

November 10, 2015 EX-99.3

As At September 30, 2015

Exhibit 99.3 Consolidated Financial Statements (Unaudited) Transition Therapeutics Inc. For the three months ended September 30, 2015 and 2014 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As At September 30, 2015 As at June 30, 2015 Assets Current assets Cash 31,803,201 40,510,758 Other receivables 330,160 265,189 Income tax and investment tax credi

November 10, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 10, 2015 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the ?interim filings?) of Transition Therapeutics Inc. (the ?issuer?) for the interim period ended September 30, 2015. 2. No misrepresentation

November 10, 2015 EX-99.6

To Our Shareholders,

Exhibit 99.6 To Our Shareholders, The first quarter of fiscal 2015 is highlighted by the completion of the data analysis from the ELND005 Phase 2/3 study, Lilly?s advancement of the TT401 study and the progress of TT701 toward commencing a Phase 2 study. Neuropsychiatric Drug Candidate ELND005 Subsequent to the quarter-end, Transition?s subsidiary Transition Therapeutics Ireland Limited (?TTIL?) c

November 10, 2015 EX-99.1

Transition Therapeutics Announces First Quarter Fiscal 2016 Financial Results

Exhibit 99.1 Transition Therapeutics Announces First Quarter Fiscal 2016 Financial Results TORONTO, ON, November 10, 2015 ? Transition Therapeutics Inc. (?Transition? or the ?Company?) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the three month period ended Septem

November 4, 2015 EX-99.1

Transition Therapeutics to Hold Conference Call on First Quarter Fiscal 2016 Financial Results on Tuesday, November 10th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on First Quarter Fiscal 2016 Financial Results on Tuesday, November 10th, at 4:30 P.M. EST TORONTO, Nov. 2, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Tuesday, November 10th, 2015 at 4:30 P.M. EST to discuss First Quarter Fiscal 2016 financial results.

November 4, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

October 29, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by chec

October 29, 2015 EX-99.1

Transition Therapeutics Announces Agreement for Phase 2 Study of TT701 Drug Candidate

Exhibit 99.1 Transition Therapeutics Announces Agreement for Phase 2 Study of TT701 Drug Candidate TORONTO, Oct. 29, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Transition Therapeutics Ireland Limited ("TTIL") has entered into an agreement for an investigator-led clinical study of drug candidate, TT701, with Brigham and Wo

October 28, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by chec

October 28, 2015 EX-99.1

Transition Therapeutics Announces Presentation of ELND005 Phase 2/3 Clinical Study Results at Clinical Trials in Alzheimer's Disease (CTAD) Conference

Exhibit 99.1 Transition Therapeutics Announces Presentation of ELND005 Phase 2/3 Clinical Study Results at Clinical Trials in Alzheimer's Disease (CTAD) Conference TORONTO, Oct. 28, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that data from the Phase 2/3 clinical study of ELND005 in Alzheimer's disease patients with moderate an

October 15, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by chec

October 15, 2015 EX-99.1

Transition Therapeutics Announces Results of Data Analysis from ELND005 Phase 2/3 Clinical Study in Agitation and Aggression in Alzheimer's Disease Patients

Exhibit 99.1 Transition Therapeutics Announces Results of Data Analysis from ELND005 Phase 2/3 Clinical Study in Agitation and Aggression in Alzheimer's Disease Patients Primary efficacy endpoint not achieved in overall study ELND005 significantly (p value < .05) improved agitation and aggression in a sub-population of Alzheimer's disease patients with severe agitation and aggression In this popul

September 15, 2015 EX-99.3

MANAGEMENT’S RESPONSIBILITY FOR FINANCIAL STATEMENTS

Exhibit 99.3 MANAGEMENT?S RESPONSIBILITY FOR FINANCIAL STATEMENTS The accompanying consolidated financial statements of Transition Therapeutics Inc. have been prepared by management and have been approved by the Board of Directors. Management is responsible for the information and representation contained in these consolidated financial statements. The consolidated financial statements have been p

September 15, 2015 EX-99.5

FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE

Exhibit 99.5 FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify that: 1. Review: I have reviewed the AIF, annual financial statements and annual MD&A, including, for greater certainty, all documents and information that are incorporated by reference in the AIF (together, the ?annual filings?) of Transitio

September 15, 2015 EX-99.6

To Our Shareholders:

Exhibit 99.6 To Our Shareholders: The focus of fiscal 2015 was on the clinical development of our lead drug candidates. Our Irish subsidiary, Transition Therapeutics Ireland Limited (TTIL), focused its efforts on the development of neuropsychiatric drug candidate, ELND005. Transition?s other development subsidiary, Waratah Pharmaceuticals Inc., supported the clinical development of lead diabetes c

September 15, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by ch

September 15, 2015 EX-99.7

Transition Therapeutics Announces Fiscal 2015 Financial Results

Exhibit 99.7 Transition Therapeutics Announces Fiscal 2015 Financial Results TORONTO, ON, September 15, 2015 ? Transition Therapeutics Inc. (?Transition? or the ?Company?) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the year ended June 30, 2015. Investors are invi

September 15, 2015 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT?S DISCUSSION AND ANALYSIS The following is a discussion and analysis of the operating results and financial position of Transition Therapeutics Inc. for the year ended June 30, 2015. This document should be read in conjunction with the Company?s audited consolidated financial statements and the accompanying notes, which have been prepared in accordance with International Fi

September 15, 2015 EX-99.4

FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE

Exhibit 99.4 FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the AIF, annual financial statements and annual MD&A, including, for greater certainty, all documents and information that are incorporated by reference in the AIF (together, the ?annual filings?) of Tra

September 15, 2015 EX-99.1

TRANSITION THERAPEUTICS INC. ANNUAL INFORMATION FORM For the year ended June 30, 2015 September 14, 2015 TABLE OF CONTENTS

Exhibit 99.1 TRANSITION THERAPEUTICS INC. ANNUAL INFORMATION FORM For the year ended June 30, 2015 September 14, 2015 TABLE OF CONTENTS PRELIMINARY 1 CAUTION REGARDING FORWARD-LOOKING STATEMENTS 1 CORPORATE STRUCTURE 2 Name, Address and Incorporation 2 Intercorporate Relationships 3 GENERAL DEVELOPMENT OF THE BUSINESS 3 Three Year History 3 Trends 7 BUSINESS OF THE CORPORATION 7 General 7 Technolo

September 15, 2015 20-F

Transition Therapeutics FORM 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F [Mark One] ? REGISTRATION STATEMENT PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13(a) OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: June 30, 2015 Commission File Number: 001-33514 TRANSITION THERAPEUTICS INC. (Exact name of Registra

September 14, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by ch

September 14, 2015 EX-99.1

Transition Therapeutics to Hold Conference Call on Fiscal 2015 Financial Results on Tuesday, September 15th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Fiscal 2015 Financial Results on Tuesday, September 15th, at 4:30 P.M. EST TORONTO, Sept. 14, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Tuesday, September 15th, 2015 at 4:30 P.M. EST to discuss full year Fiscal 2015 financial results. Dr. Tony Cruz

August 10, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

August 10, 2015 EX-99.1

Transition Therapeutics to Present at the Canaccord Genuity 35th Annual Growth Conference

Exhibit 99.1 Transition Therapeutics to Present at the Canaccord Genuity 35th Annual Growth Conference TORONTO, Aug. 10, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the Canaccord Genuity 35th Annual Growth Conference on Thursday, August

June 24, 2015 EX-99.1

Transition Therapeutics Announces Results of Clinical Study of ELND005 in Agitation and Aggression in Patients with Alzheimer's Disease

Exhibit 99.1 Transition Therapeutics Announces Results of Clinical Study of ELND005 in Agitation and Aggression in Patients with Alzheimer's Disease TORONTO, June 24, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced that a Phase 2/3 clinical study of neuropsychiatric drug candidate ELND005 did not meet its primary efficacy endpoint. In th

June 24, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

June 16, 2015 EX-99.1

Transition Therapeutics Appoints Carl Damiani as President

Exhibit 99.1 Transition Therapeutics Appoints Carl Damiani as President TORONTO, June 16, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) Chairman and Chief Executive Officer, Dr. Tony Cruz is pleased to announce the appointment of Carl Damiani as President and Chief Operating Officer of Transition. "Carl has worked closely with me over many years

June 16, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

May 26, 2015 EX-99.1

Transition Therapeutics to Present at the Jefferies 2015 Healthcare Conference

Exhibit 99.1 Transition Therapeutics to Present at the Jefferies 2015 Healthcare Conference TORONTO, May 26, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the Jefferies 2015 Healthcare Conference on Tuesday, June 2 at 4:00pm Eastern time

May 26, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 12, 2015 EX-99.1

Transition Therapeutics Announces Third Quarter Fiscal 2015 Financial Results

Exhibit 99.1 Transition Therapeutics Announces Third Quarter Fiscal 2015 Financial Results TORONTO, ON, May 12, 2015 ? Transition Therapeutics Inc. (?Transition? or the ?Company?) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the three and nine month periods ended M

May 12, 2015 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT?S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company?s unaudited consolidated financial statements for the nine and three month periods ended March 31, 2015 and the related notes, which are prepared in accordance with International Financial Reporting Standards as issued by the International Accounting Standards Board for interi

May 12, 2015 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the ?interim filings?) of Transition Therapeutics Inc. (the ?issuer?) for the interim period ended March 31, 2015. 2. No misrepresentations: Base

May 12, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 12, 2015 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the ?interim filings?) of Transition Therapeutics Inc. (the ?issuer?) for the interim period ended March 31, 2015. 2. No misrepresentations: B

May 12, 2015 EX-99.6

To Our Shareholders

EX-99.6 7 v410180ex99-6.htm LETTER TO SHAREHOLDERS Exhibit 99.6 To Our Shareholders The third quarter marks an important milestone in the advancement of lead neuropsychiatric drug candidate, ELND005, and lead diabetes drug candidate, TT401 (LY2944876), with each completing enrolment of a large Phase 2 clinical study. For ELND005, 350 Alzheimer’s disease (“AD”) patients with moderate to severe leve

May 12, 2015 EX-99.3

As at March 31, 2015

Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the nine and three months ended March 31, 2015 and 2014 1 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As at March 31, 2015 As at June 30, 2014 Assets Current assets Cash 50,248,469 57,212,004 Short term investments 6 - 3,059,562 Other receivables 1,3

May 11, 2015 EX-99.1

LICENSE AGREEMENT by and among TRANSITION THERAPEUTICS IRELAND LIMITED ELI LILLY and COMPANY LICENSE AGREEMENT

Exhibit 99.1 LICENSE AGREEMENT by and among TRANSITION THERAPEUTICS IRELAND LIMITED and ELI LILLY and COMPANY LICENSE AGREEMENT This Agreement (the ?Agreement?), effective as of May 5, 2015 (the ?Effective Date?), is entered into by and among Transition Therapeutics Ireland Limited, an Irish company with its registered office at Arthur Cox Building, Earlsfort Terrace, Dublin 2 Ireland (hereinafter

May 11, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 8, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 8, 2015 EX-99.1

Transition Therapeutics to Hold Conference Call on Third Quarter Fiscal 2015 Financial Results on Tuesday, May 12th, at 4:30 P.M. EST

EX-99.1 2 ex991.htm NEWS RELEASE DATED MAY 7, 2015 Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Third Quarter Fiscal 2015 Financial Results on Tuesday, May 12th, at 4:30 P.M. EST TORONTO, May 7, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Tuesday, May 12th, 2015 at 4:30 P.M. EST to discuss Thir

May 6, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 6, 2015 EX-99.1

Transition Therapeutics In-Licenses Phase 2 Drug Candidate from Lilly

Exhibit 99.1 Transition Therapeutics In-Licenses Phase 2 Drug Candidate from Lilly TORONTO, May 6, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced its wholly-owned subsidiary, Transition Therapeutics Ireland Limited ("TTIL"), has exclusively licensed worldwide rights to a novel small molecule drug candidate ("TT701") from Eli Lilly

March 27, 2015 EX-99.1

Transition Therapeutics Announces Results from Phase 1 AME & Renal Clearance Clinical Studies of Neuropsychiatric Drug Candidate ELND005

Exhibit 99.1 Transition Therapeutics Announces Results from Phase 1 AME & Renal Clearance Clinical Studies of Neuropsychiatric Drug Candidate ELND005 TORONTO, March 26, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX:TTH) today announced results from two phase 1 clinical studies of neuropsychiatric drug candidate ELND005. These studies, an absorption-me

March 27, 2015 6-K

Transition Therapeutics FORM 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

March 2, 2015 EX-99.1

Transition Therapeutics Announces Enrolment Completion of ELND005 Phase 2 Clinical Study in Agitation and Aggression in Patients with Alzheimer's Disease

Exhibit 99.1 Transition Therapeutics Announces Enrolment Completion of ELND005 Phase 2 Clinical Study in Agitation and Aggression in Patients with Alzheimer's Disease TORONTO, March 2, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced that its wholly owned subsidiary, Transition Therapeutics Ireland Limited ("TTIL") completed enrolment of

March 2, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

February 19, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 19, 2015 EX-99.1

Transition Therapeutics to Present at the Cowen and Company 35th Annual Healthcare Conference

Exhibit 99.1 Transition Therapeutics to Present at the Cowen and Company 35th Annual Healthcare Conference TORONTO, Feb. 19, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the Cowen and Company 35th Annual Healthcare Conference on Monday,

February 18, 2015 EX-99.1

Transition Therapeutics Inc. Announces Closing of Public Offering of US$23 Million of Common Shares

Exhibit 99.1 Transition Therapeutics Inc. Announces Closing of Public Offering of US$23 Million of Common Shares TORONTO, ON, February 18, 2015 – Transition Therapeutics Inc. (“Transition” or the “Company”) (NASDAQ: TTHI, TSX: TTH) today announced the closing of its underwritten public offering of an aggregate of 3,538,461 common shares at a price to the public of US$6.50 per share, including 461,

February 18, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 v4021456k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Exec

February 17, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 v4020066k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Exec

February 12, 2015 424B5

3,076,923 Shares Common Shares Cowen and Company TABLE OF CONTENTS ABOUT THIS PROSPECTUS SUPPLEMENT SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS SUMMARY THE OFFERING RISK FACTORS USE OF PROCEEDS CAPITALIZATION PRICE RANGE OF COMMON SHARES EXCHAN

Filed pursuant to Rule 424(b)(5) Registration Statement Number 333-189879 PROSPECTUS SUPPLEMENT (To the Prospectus dated July 19, 2013) 3,076,923 Shares Common Shares We are offering 3,076,923 of our common shares pursuant to this prospectus supplement and accompanying prospectus.

February 12, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 12, 2015 EX-99.1

Transition Therapeutics Inc. Announces Public Offering of Common Shares

Exhibit 99.1 Transition Therapeutics Inc. Announces Public Offering of Common Shares TORONTO, ON, February 11, 2015 – Transition Therapeutics Inc. (“Transition” or the “Company”) (NASDAQ: TTHI, TSX: TTH) announced today that it has commenced an underwritten public offering of its common shares. The Company expects to use net proceeds from the sale of the common shares for general corporate purpose

February 12, 2015 EX-1.1

3,076,923 Shares TRANSITION THERAPEUTICS INC. Common Shares UNDERWRITING AGREEMENT

Exhibit 1.1 3,076,923 Shares TRANSITION THERAPEUTICS INC. Common Shares UNDERWRITING AGREEMENT February 11, 2015 Cowen and Company, LLC As Representative of the several Underwriters named in Schedule A hereto 599 Lexington Avenue New York, New York 10022 Dear Sirs: 1. Introductory. Transition Therapeutics Inc., a corporation organized under the laws of the Province of Ontario, Canada (the “Company

February 12, 2015 EX-99.2

Transition Therapeutics Inc. Announces Pricing of Public Offering of US$20 Million of Common Shares

Exhibit 99.2 Transition Therapeutics Inc. Announces Pricing of Public Offering of US$20 Million of Common Shares TORONTO, ON, February 12, 2015 – Transition Therapeutics Inc. (“Transition” or the “Company”) (NASDAQ: TTHI, TSX: TTH) today announced the pricing of its underwritten public offering of 3,076,923 common shares at a price to the public of US$6.50 per share for total gross proceeds of US$

February 11, 2015 EX-99.1

Transition Therapeutics Inc. Announces Public Offering of Common Shares

EX-99.1 2 ex991.htm NEWS RELEASE DATED FEBRUARY 11, 2015 Exhibit 99.1 Transition Therapeutics Inc. Announces Public Offering of Common Shares TORONTO, Feb. 11, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that it has commenced an underwritten public offering of its common shares. The Company expects to use net proceeds from the

February 11, 2015 424B5

Shares Common Shares Cowen and Company TABLE OF CONTENTS ABOUT THIS PROSPECTUS SUPPLEMENT SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS SUMMARY THE OFFERING RISK FACTORS USE OF PROCEEDS CAPITALIZATION PRICE RANGE OF COMMON SHARES EXCHANGE RATES D

Filed pursuant to Rule 424(b)(5) Registration Statement Number 333-189879 This preliminary prospectus supplement and the accompanying prospectus relate to an effective registration statement under the Securities Act of 1933, as amended, but the information in this preliminary prospectus supplement is not complete and may be changed.

February 11, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 9, 2015 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.5 6 v400635ex99-5.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF FINANCIAL OFFICER Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therap

February 9, 2015 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

EX-99.2 3 v400635ex99-2.htm MANAGEMENT'S DISCUSSION AND ANALYSIS Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company’s unaudited consolidated financial statements for the three and six month periods ended December 31, 2014 and the related notes, which are prepared in accordance with International Financial Reporting Standards a

February 9, 2015 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended December 31, 2014. 2. No misrepresentations: B

February 9, 2015 EX-99.6

To Our Shareholders

EX-99.6 7 v400635ex99-6.htm LETTER TO SHAREHOLDERS Exhibit 99.6 To Our Shareholders The second quarter of fiscal 2015 is highlighted by continued progress toward the completion of enrolment for our Phase 2 studies of both neuropsychiatric drug candidate ELND005 and diabetes drug candidate TT401 (LY2944876). During the quarter, there were also multiple ELND005 presentations of data from the study i

February 9, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 v4006356k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Exec

February 9, 2015 EX-99.3

Consolidated Interim Financial Statements

Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the three and six months ended December 31, 2014 and 2013 1 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As at December 31, 2014 As at June 30, 2014 Assets Current assets Cash 26,756,324 57,212,004 Short term investments 6 - 3,059,562 Other receivable

February 9, 2015 EX-99.1

Transition Therapeutics Announces Second Quarter Fiscal 2015 Financial Results

Exhibit 99.1 Transition Therapeutics Announces Second Quarter Fiscal 2015 Financial Results TORONTO, ON, February 9, 2015 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the three and six month periods end

February 5, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 5, 2015 EX-99.1

Transition Therapeutics to Hold Conference Call on Second Quarter Fiscal 2015 Financial Results on Monday, February 9th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Second Quarter Fiscal 2015 Financial Results on Monday, February 9th, at 4:30 P.M. EST TORONTO, Feb. 5, 2015 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Monday, February 9th, 2015 at 4:30 P.M. EST to discuss Second Quarter Fiscal 2015 financial results. D

January 30, 2015 SC 13G/A

TTHI / Transition Therapeutics Inc. / FEINBERG LARRY N - AMENDMENT NO. 8 Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Amendment No. 8) Under the Securities Exchange Act of 1934 Transition Therapeutics, Inc. (Name of Issuer) Common Shares, no par value (Title of Class of Securities) 893716209 (CUSIP Number) December 31, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pu

January 6, 2015 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2015 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by chec

January 6, 2015 EX-1.1

TRANSITION THERAPEUTICS INC. COMMON shares Having an aggregate offering price of up to US$25 million SALES AGREEMENT

Exhibit 1.1 TRANSITION THERAPEUTICS INC. COMMON shares Having an aggregate offering price of up to US$25 million SALES AGREEMENT January 5, 2015 Cowen and Company, LLC 599 Lexington Avenue New York, NY 10022 Ladies and Gentlemen: Transition Therapeutics Inc., a corporation organized under the laws of Ontario, Canada (the “Company”), confirms its agreement (this “Agreement”) with Cowen and Company,

January 6, 2015 424B5

$25,000,000 Common Shares Cowen and Company TABLE OF CONTENTS ABOUT THIS PROSPECTUS SUPPLEMENT SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS SUMMARY THE OFFERING RISK FACTORS USE OF PROCEEDS CAPITALIZATION PRICE RANGE OF COMMON SHARES EXCHANGE RA

Filed pursuant to Rule 424(b)(5) Registration No. 333-189879 PROSPECTUS SUPPLEMENT (To Prospectus dated July 19, 2013) $25,000,000 Common Shares We have entered into a sales agreement with Cowen and Company, LLC, or Cowen, relating to the sale of our common shares, no par value per share, offered by this prospectus supplement and the accompanying prospectus. In accordance with the terms of the sal

December 10, 2014 EX-99.1

EX-99.1

Exhibit 99.1

December 10, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

December 8, 2014 EX-99.1

Transition Therapeutics to Present at the Oppenheimer 25th Annual Healthcare Conference

Exhibit 99.1 Transition Therapeutics to Present at the Oppenheimer 25th Annual Healthcare Conference TORONTO, Dec. 8, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the Oppenheimer 25th Annual Healthcare Conference on Wednesday, December 1

December 8, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 24, 2014 EX-99.1

Transition Therapeutics' ELND005 Showed No Prolongation of QT Interval

Exhibit 99.1 Transition Therapeutics' ELND005 Showed No Prolongation of QT Interval TORONTO, Nov. 24, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX:TTH) today announced results from a thorough QT (tQT) study in which no QT effects were observed at supra-therapeutic single doses of neuropsychiatric drug candidate, ELND005. A tQT study is a specialized

November 24, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 transitionthera6k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Princi

November 20, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 20, 2014 EX-99.1

Transition Therapeutics Announces Results from ELND005 Clinical Study in Adults with Down Syndrome

Exhibit 99.1 Transition Therapeutics Announces Results from ELND005 Clinical Study in Adults with Down Syndrome TORONTO, Nov. 20, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced the results of a clinical study of neuropsychiatric drug candidate ELND005 in young adults with Down syndrome. Transition's wholly-owned subsidiary, Transi

November 14, 2014 EX-99.1

TRANSITION THERAPEUTICS INC. Annual Meeting of Shareholders Management Information Circular

Exhibit 99.1 TRANSITION THERAPEUTICS INC. Annual Meeting of Shareholders Management Information Circular This Management Information Circular (“Circular”) is furnished in connection with the solicitation of proxies by and on behalf of the management of Transition Therapeutics Inc. (the “Corporation”) for use at the Annual Meeting of the Corporation’s shareholders to be held on December 9, 2014 at

November 14, 2014 EX-99.2

EX-99.2

Exhibit 99.2

November 14, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 12, 2014 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company’s unaudited consolidated financial statements for the three-month period ended September 30, 2014 and the related notes, which are prepared in accordance with International Financial Reporting Standards for interim financial statements, including IAS 34, Interim Reporting (IFR

November 12, 2014 EX-99.3

Consolidated Interim Financial Statements

Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the three months ended September 30, 2014 and 2013 1 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As at September 30, 2014 As at June 30, 2014 Assets Current assets Cash 42,782,040 57,212,004 Short term investments 6 3,073,551 3,059,562 Other receivab

November 12, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 12, 2014 EX-99.6

To our shareholders

Exhibit 99.6 To our shareholders The first quarter of fiscal 2015 is highlighted by the continued advancement of lead neuropsychiatric drug candidate ELND005 and diabetes drug candidate TT401 (LY2944876). Our wholly owned subsidiary, Transition Therapeutics Ireland Limited (“TTIL”) has been focused on the execution of the ELND005 Phase 2 study of agitation and aggression in Alzheimer’s disease (AD

November 12, 2014 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended September 30, 2014. 2. No misrepresentations:

November 12, 2014 EX-99.1

Transition Therapeutics Announces First Quarter Fiscal 2015 Financial Results

Exhibit 99.1 Transition Therapeutics Announces First Quarter Fiscal 2015 Financial Results TORONTO, ON, November 12, 2014 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the three month period ended Septem

November 12, 2014 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended September 30, 2014. 2. No misrepresentation

November 10, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 10, 2014 EX-99.1

Transition Therapeutics to Hold Conference Call on First Quarter Fiscal 2015 Financial Results on Wednesday, November 12th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on First Quarter Fiscal 2015 Financial Results on Wednesday, November 12th, at 4:30 P.M. EST TORONTO, Nov. 10, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Wednesday, November 12th, 2014 at 4:30 P.M. EST to discuss First Quarter Fiscal 2015 financial res

November 4, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 4, 2014 EX-99.1

Transition Therapeutics Reports Findings from Bipolar Disorder Phase 2 Study

Exhibit 99.1 Transition Therapeutics Reports Findings from Bipolar Disorder Phase 2 Study TORONTO, Nov. 4, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced findings from a Phase 2 study of neuropsychiatric drug candidate, ELND005, as an adjunctive maintenance treatment for bipolar disorder type I patients (BPD). Transition's wholly-

September 25, 2014 EX-99.4

CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a)

Exhibit 99.4 CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a) I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify that: 1. I have reviewed this annual report on Form 40-F of Transition Therapeutics Inc. (the issuer) for the year ended June 30, 2014; 2. Based on my knowledge, this report does not contain any untrue sta

September 25, 2014 EX-99.6

CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO 18 U.S.C. SECTION 1350

Exhibit 99.6 CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO 18 U.S.C. SECTION 1350 I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc. (the “Company”), in compliance with 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, hereby certify, in connection with the Company’s Annual Report as filed on Form 40-F for the fiscal year ending

September 25, 2014 EX-99.1

Transition Therapeutics Announces Fiscal 2014 Year End Financial Results

Exhibit 99.1 Transition Therapeutics Announces Fiscal 2014 Year End Financial Results TORONTO, ON, September 25, 2014 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a biopharmaceutical development company advancing novel therapeutics for CNS and metabolic disease indications, today announced its financial results for the year ended June 30, 2014. Selected

September 25, 2014 40-F

TTHI / Transition Therapeutics Inc. 40-F - - ANNUAL REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 40-F [Check one] ¨ REGISTRATION STATEMENT PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13(a) OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: June 30, 2014 Commission File Number: 001-33514 TRANSITION THERAPEUTICS INC. (Exact name of Registr

September 25, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by ch

September 25, 2014 EX-99.8

Consent of Independent Auditor

Exhibit 99.8 Consent of Independent Auditor We hereby consent to the incorporation by reference in this Annual Report on Form 40-F for the year ended June 30, 2014 of Transition Therapeutics Inc. of our report dated September 19, 2014, relating to the consolidated financial statements and the effectiveness of internal control over financial reporting, which appears in the Exhibit incorporated by r

September 25, 2014 EX-99.3

MANAGEMENT’S RESPONSIBILITY FOR FINANCIAL STATEMENTS

Exhibit 99.3 MANAGEMENT’S RESPONSIBILITY FOR FINANCIAL STATEMENTS The accompanying consolidated financial statements of Transition Therapeutics Inc. have been prepared by management and have been approved by the Board of Directors. Management is responsible for the information and representation contained in these consolidated financial statements. The consolidated financial statements have been p

September 25, 2014 EX-99.7

CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350

Exhibit 99.7 CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350 I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc. (the “Company”), in compliance with 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, hereby certify, in connection with the Company’s Annual Report as filed on Form 40-F for the fiscal year end

September 25, 2014 EX-99.1

TRANSITION THERAPEUTICS INC. ANNUAL INFORMATION FORM For the year ended June 30, 2014 September 19, 2014 TABLE OF CONTENTS

Exhibit 99.1 TRANSITION THERAPEUTICS INC. ANNUAL INFORMATION FORM For the year ended June 30, 2014 September 19, 2014 TABLE OF CONTENTS PRELIMINARY 1 CAUTION REGARDING FORWARD-LOOKING STATEMENTS 1 CORPORATE STRUCTURE 2 Name, Address and Incorporation 2 Intercorporate Relationships 3 GENERAL DEVELOPMENT OF THE BUSINESS 3 Three Year History 3 Recent Developments 7 Trends 7 BUSINESS OF THE CORPORATIO

September 25, 2014 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following is a discussion and analysis of the operating results and financial position of Transition Therapeutics Inc. for the year ended June 30, 2014. This document should be read in conjunction with the Company’s audited consolidated financial statements and the accompanying notes, which have been prepared in accordance with International Fi

September 25, 2014 EX-99.2

Dear Shareholders,

Exhibit 99.2 Dear Shareholders, It is with great enthusiasm that I report to you on our fiscal year 2014 which is highlighted by an important acquisition, advancement of our partnered diabetes asset, multiple private placement financings and activities to expand the core strategy of our business. The acquisition of the neuropsychiatric drug candidate, ELND005, from Perrigo Company plc (“Perrigo”)

September 25, 2014 EX-99.5

CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a)

Exhibit 99.5 CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a) I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify that: 1. I have reviewed this annual report on Form 40-F of Transition Therapeutics Inc. (the issuer) for the year ended June 30, 2014; 2. Based on my knowledge, this report does not contain any untrue

September 22, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

6-K 1 transitionthera6k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Princ

September 22, 2014 EX-99.1

Transition Therapeutics to Hold Conference Call on Full Year Fiscal 2014 Financial Results on Thursday, September 25th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Full Year Fiscal 2014 Financial Results on Thursday, September 25th, at 4:30 P.M. EST TORONTO, Sept. 22, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Thursday, September 25th, 2014 at 4:30 P.M. EST to discuss Full Year Fiscal 2014 financial results. D

July 11, 2014 6-K

TTHI / Transition Therapeutics Inc. 6-K - Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

July 11, 2014 EX-99.1

Transition Therapeutics Appoints Carl Damiani as Chief Operating Officer

Exhibit 99.1 Transition Therapeutics Appoints Carl Damiani as Chief Operating Officer TORONTO, July 11, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) Chairman and Chief Executive Officer, Dr. Tony Cruz is pleased to announce that Carl Damiani has been appointed to the role of Chief Operating Officer of Transition. "This appointment reflects Mr.

July 2, 2014 EX-99.3

TRANSITION THERAPEUTICS INC. (Existing under the Business Corporations Act (Ontario)) Common Share Purchase Warrants CERTIFICATE NO. 2014 - WARRANTS

EX-99.3 EXHIBIT 3 These Warrants shall not be exercisable by the holder, in whole or in part, and Transition Therapeutics Inc. (the Corporation) shall not give effect to any such exercise, if, after giving effect to such exercise, the holder, together with any person or company acting jointly or in concert with the holder (the Joint Actors) would in the aggregate beneficially own, or exercise cont

July 2, 2014 EX-99.2

SUBSCRIPTION AGREEMENT FOR UNITS

EX-99.2 EXHIBIT 2 UNITED STATES SUBSCRIPTION AGREEMENT FOR UNITS INSTRUCTIONS: To properly complete this Subscription Agreement: (1) All subscribers must complete all boxes on this face page. (2) All subscribers must complete and sign Exhibit 1 and Exhibit 2. (3) All subscribers should return their completed documents by email or fax to the Corporation at [email protected] or 416-2

July 2, 2014 EX-99.1

Joint Filing Agreement

EX-99.1 EXHIBIT 1 Joint Filing Agreement This Joint Filing Agreement is entered into as of July 1, 2014, by the undersigned, who hereby agree that the Statement on Amendment No. 2 to Schedule 13D in respect of the common shares ofTransition Therapeutics Inc. is, and any amendment subsequently signed by each of the undersigned shall be, filed on behalf of each of the undersigned pursuant to and in

July 2, 2014 SC 13D/A

TTHI / Transition Therapeutics Inc. / SCHULER JACK W - SCHEDULE 13D AMENDMENT NO. 2 Activist Investment

SCHEDULE 13D AMENDMENT NO. 2 SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13D (Rule 13d-101) Information To Be Included in Statements Filed Pursuant to § 240.13d-1(a) and Amendments Thereto Filed Pursuant to § 240.13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 2)* TRANSITION THERAPEUTICS INC. (Name of Issuer) Common Shares (Title of Class of Securities) 893

June 26, 2014 EX-99.1

Transition Therapeutics Announces Closing of Private Placement Equity Financing

Exhibit 99.1 Transition Therapeutics Announces Closing of Private Placement Equity Financing TORONTO, June 23, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI) (TSX: TTH) announced that it has closed its previously announced private placement through which 3,195,487 units of the Company were purchased by Jack W. Schuler, Larry N. Feinberg, Oracle Investment

June 26, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

June 6, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check m

June 6, 2014 EX-99.1

Transition Therapeutics Enters Into a Private Placement with Investors to Receive up to US$30.8 Million in Equity Financing

Exhibit 99.1 Transition Therapeutics Enters Into a Private Placement with Investors to Receive up to US$30.8 Million in Equity Financing Company to Receive Upfront US$17 Million Upon Closing TORONTO, June 6, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced that Jack W. Schuler, Larry N. Feinberg, Oracle Investment Management, certain Tran

May 27, 2014 EX-99.1

Transition Therapeutics to Host Investor Day and Webcast on May 28th in New York City

Exhibit 99.1 Transition Therapeutics to Host Investor Day and Webcast on May 28th in New York City Live Webcast Beginning at 8am Eastern Time on May 28th TORONTO, May 27, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI) (TSX: TTH) announced today that it will host an Investor Day on Wednesday, May 28th in New York City. An industry key opinion leader, Consta

May 27, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 23, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 23, 2014 EX-99.1

Transition Therapeutics to Present at Jefferies 2014 Global Healthcare Conference

Exhibit 99.1 Transition Therapeutics to Present at Jefferies 2014 Global Healthcare Conference TORONTO, May 22, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the Jefferies 2014 Global Healthcare Conference on Monday, June 2nd, at 8:30 a.m

May 15, 2014 EX-99.1

Transition Therapeutics Diabetes Drug Candidate, TT-401, Commences Phase 2 Clinical Study

Exhibit 99.1 Transition Therapeutics Diabetes Drug Candidate, TT-401, Commences Phase 2 Clinical Study TORONTO, May 15, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) today announced the dosing of the first patient in a Phase 2 clinical study of TT-401 (LY2944876), a drug candidate for the treatment of type 2 diabetes. The study is expected to en

May 15, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 13, 2014 EX-99.3

Consolidated Interim Financial Statements

Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the nine and three month periods ended March 31, 2014 and 2013 1 CONSOLIDATED BALANCE SHEETS (Unaudited) As at In Canadian Dollars Note March 31, 2014 June 30, 2013 Assets Current assets Cash 48,834,630 23,067,937 Short term investments 7 4,063,819 5,057,702 Other receivables 33,366 35,792 Investmen

May 13, 2014 6-K

Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

May 13, 2014 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.4 5 v378191ex99-4.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF EXECUTIVE OFFICER Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeut

May 13, 2014 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

EX-99.2 3 v378191ex99-2.htm MANAGEMENTS DISCUSSION AND ANALYSIS Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company’s unaudited consolidated financial statements for the three and nine month periods ended March 31, 2014 and the related notes, which are prepared in accordance with International Financial Reporting Standards (IFR

May 13, 2014 EX-99.6

To Our Shareholders

EX-99.6 7 v378191ex99-6.htm LETTER TO SHAREHOLDERS Exhibit 99.6 To Our Shareholders The third quarter of fiscal 2014 is highlighted by the Company’s acquisition of the development and commercialization rights to neuropsychiatric drug candidate, ELND005. This transaction broadened the Company’s development pipeline with an un-partnered late-stage clinical asset, coupled with Transition’s core strat

May 13, 2014 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

EX-99.5 6 v378191ex99-5.htm CERTIFICATION OF INTERIM FILINGS SIGNED BY THE CHIEF FINANCIAL OFFICER Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therap

May 13, 2014 EX-99.1

Transition Therapeutics Announces Third Quarter Fiscal 2014 Financial Results

EX-99.1 2 v378191ex99-1.htm PRESS RELEASE DATED MAY 13, 2014 Exhibit 99.1 FOR IMMEDIATE RELEASE Transition Therapeutics Announces Third Quarter Fiscal 2014 Financial Results TORONTO, ON, May 13, 2014 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a product-focused biopharmaceutical company developing therapeutics for disease indications with large markets,

May 12, 2014 EX-99.1

Transition Therapeutics to Hold Conference Call on Third Quarter Fiscal 2014 Financial Results on Tuesday, May 13th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Third Quarter Fiscal 2014 Financial Results on Tuesday, May 13th, at 4:30 P.M. EST TORONTO, May 12, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Tuesday, May 13th, 2014 at 4:30 P.M. EST to discuss Third Quarter Fiscal 2014 financial results. Dr. Tony

May 12, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check ma

April 16, 2014 EX-99.1

Transition Therapeutics Announces No Material Change

Exhibit 99.1 Transition Therapeutics Announces No Material Change TORONTO, April 15, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) reports today that there are no undisclosed material changes or corporate developments involving the Company to account for its recent change in stock price. About Transition Transition is a biopharmaceutical company

April 16, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

April 7, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

6-K 1 transitionthera6k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal

April 7, 2014 EX-99.1

Transition Therapeutics Announces Development Update

Exhibit 99.1 Transition Therapeutics Announces Development Update TORONTO, April 7, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI) (TSX: TTH) provided an update on the development of its drug candidates and plans for future growth. The addition of the neuropsychiatric drug candidate ELND005 has broadened the Company's development pipeline with an un-partne

March 7, 2014 SC 13G

TTHI / Transition Therapeutics Inc. / PERRIGO Co plc - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Transition Therapeutics Inc. (Name of Issuer) Common Shares, no par value (Title of Class of Securities) 893716209 (CUSIP Number) February 28, 2014 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the r

March 3, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by check

March 3, 2014 EX-99.1

Perrigo Company plc and Transition Therapeutics Modify Development and Commercialization Rights of ELND005 Program

Exhibit 99.1 Perrigo Company plc and Transition Therapeutics Modify Development and Commercialization Rights of ELND005 Program · All development and commercialization rights of ELND005 drug candidate have been transferred to an Irish-domiciled company ("Irish Subsidiary") · Transition has acquired 100% of the common shares of Irish Subsidiary · Irish Subsidiary will be responsible for the future

March 3, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

March 3, 2014 EX-99.1

Transition Therapeutics to Present at the 34th Annual Cowen & Co. Healthcare Conference

Exhibit 99.1 Transition Therapeutics to Present at the 34th Annual Cowen & Co. Healthcare Conference TORONTO, March 3, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI) (TSX: TTH) announced today that Dr. Tony Cruz, Chairman and Chief Executive Officer of Transition will be presenting at the 34th Annual Cowen & Co. Healthcare Conference on Tuesday, March 4th,

February 18, 2014 CORRESP

-

February 18, 2014 Mr. Jeffrey Riedler United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N. E. Washington, D.C. 20549 Re: Transition Therapeutics Inc. Form 20-F for the Fiscal Year Ended June 30, 2013 Filed September 11, 2013 File No. 001-33514 Dear Mr. Riedler: We are writing in response to your comment letter dated February 12, 2014 relating to Transit

February 12, 2014 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company’s unaudited consolidated financial statements for the three and six month periods ended December 31, 2013 and the related notes, which are prepared in accordance with International Financial Reporting Standards (IFRS) for interim financial statements, as well as the audited co

February 12, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2014 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 12, 2014 EX-99.1

Transition Therapeutics Announces Second Quarter Fiscal 2014 Financial Results

Exhibit 99.1 FOR IMMEDIATE RELEASE Transition Therapeutics Announces Second Quarter Fiscal 2014 Financial Results TORONTO, ON, February 12, 2014 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a product-focused biopharmaceutical company developing therapeutics for disease indications with large markets, today announced its financial results for the three an

February 12, 2014 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended December 31, 2013. 2. No misrepresentations

February 12, 2014 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended December 31, 2013. 2. No misrepresentations: B

February 12, 2014 EX-99.3

Consolidated Interim Financial Statements

Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the six and three month periods ended December 31, 2013 and 2012 1 CONSOLIDATED BALANCE SHEETS (Unaudited) As at In Canadian Dollars Note December 31, 2013 June 30, 2013 Assets Current assets Cash and cash equivalents 32,341,634 23,067,937 Short term investments 6 4,045,573 5,057,702 Other receivabl

February 12, 2014 EX-99.6

To Our Shareholders

Exhibit 99.6 To Our Shareholders This fiscal quarter is highlighted by advancement of our multiple programs in development. The two large Phase 2 studies of our lead neuropsychiatric drug candidate, ELND005, in bipolar disorder and agitation and aggression associated with Alzheimer’s disease are continuing to progress toward completion. Our lead metabolic drug candidate, TT401, is in preparation f

February 7, 2014 EX-99.1

Transition Therapeutics to Hold Conference Call on Second Quarter Fiscal 2014 Financial Results on Wednesday, February 12th, at 4:30 P.M. EST

Exhibit 99.1 Transition Therapeutics to Hold Conference Call on Second Quarter Fiscal 2014 Financial Results on Wednesday, February 12th, at 4:30 P.M. EST TORONTO, Feb. 7, 2014 /CNW/ - Transition Therapeutics Inc. ("Transition" or the "Company") (NASDAQ: TTHI, TSX: TTH) will hold a conference call on Wednesday, February 12th, 2014 at 4:30 P.M. EST to discuss Second Quarter Fiscal 2014 financial re

February 7, 2014 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

February 7, 2014 SC 13G/A

TTHI / Transition Therapeutics Inc. / FEINBERG LARRY N - SC 13G/A Passive Investment

SC 13G/A 1 v367681sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Amendment No. 7) Under the Securities Exchange Act of 1934 Transition Therapeutics, Inc. (Name of Issuer) Common Shares, no par value (Title of Class of Securities) 893716209 (CUSIP Number) December 31, 2013 (Date of Event Which Requires Filing of this Statement) Check the ap

December 16, 2013 EX-99.1

TRANSITION THERAPEUTICS INC ANNUAL GENERAL MEETING OF SHAREHOLDERS HELD ON DECEMBER 13, 2013 FINAL SCRUTINEERS' REPORT

Exhibit 99.1 TRANSITION THERAPEUTICS INC ANNUAL GENERAL MEETING OF SHAREHOLDERS HELD ON DECEMBER 13, 2013 FINAL SCRUTINEERS' REPORT 0 SHAREHOLDERS IN PERSON, REPRESENTING 0 SHARES 73 SHAREHOLDERS BY PROXY, REPRESENTING 24,820,638 SHARES 73 TOTAL SHAREHOLDERS, HOLDING 24,820,638 SHARES TOTAL ISSUED AND OUTSTANDING AS AT RECORD DATE: 29,619,456 PERCENTAGE OF OUTSTANDING SHARES REPRESENTED AT THE MEE

December 16, 2013 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 21, 2013 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 21, 2013 EX-99.2

EX-99.2

Exhibit 99.2

November 21, 2013 EX-99.1

TRANSITION THERAPEUTICS INC. Annual Meeting of Shareholders Management Information Circular

Exhibit 99.1 TRANSITION THERAPEUTICS INC. Annual Meeting of Shareholders Management Information Circular This Management Information Circular (“Circular”) is furnished in connection with the solicitation of proxies by and on behalf of the management of Transition Therapeutics Inc. (the “Corporation”) for use at the Annual Meeting of the Corporation’s shareholders to be held on December 13, 2013 at

November 18, 2013 EX-99.1

Transition Therapeutics Announces ELND005 Presentations at the Clinical Trials in Alzheimer’s Disease (CTAD) Meeting

Exhibit 99.1 FOR IMMEDIATE RELEASE Transition Therapeutics Announces ELND005 Presentations at the Clinical Trials in Alzheimer’s Disease (CTAD) Meeting TORONTO, ON, November 18th, 2013 – Transition Therapeutics Inc. (“Transition” or the “Company”) (NASDAQ: TTHI, TSX: TTH) announced ELND005 (scyllo-inositol) was featured in an oral and two poster presentations at the recently completed 6th Annual C

November 18, 2013 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 12, 2013 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by che

November 12, 2013 EX-99.5

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.5 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended September 30, 2013. 2. No misrepresentation

November 12, 2013 EX-99.1

Transition Therapeutics Announces First Quarter Fiscal 2014 Financial Results

Exhibit 99.1 FOR IMMEDIATE RELEASE Transition Therapeutics Announces First Quarter Fiscal 2014 Financial Results TORONTO, ON, November 12, 2013 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a product-focused biopharmaceutical company developing therapeutics for disease indications with large markets, today announced its financial results for the three mon

November 12, 2013 EX-99.6

To Our Shareholders

Exhibit 99.6 To Our Shareholders This fiscal quarter was highlighted by important milestones in the advancement of our development candidates and the addition of a new program through a collaboration with Lilly. Our lead neuropsychiatric drug candidate, ELND005, received FDA “Fast Track” designation for the treatment of agitation and aggression in Alzheimer’s disease and an additional Phase 2A stu

November 12, 2013 EX-99.3

Consolidated Interim Financial Statements

Exhibit 99.3 Consolidated Interim Financial Statements (Unaudited) Transition Therapeutics Inc. For the three months ended September 30, 2013 and 2012 1 Transition Therapeutics Inc. CONSOLIDATED BALANCE SHEETS (Unaudited) In Canadian Dollars Note As at September 30, 2013 As at June 30, 2013 Assets Current assets Cash and cash equivalents 32,173,444 23,067,937 Short term investments 6 5,080,203 5,0

November 12, 2013 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following information should be read in conjunction with the Company’s unaudited consolidated financial statements for the three-month period ended September 30, 2013 and the related notes, which are prepared in accordance with International Financial Reporting Standards (IFRS) for interim financial statements, as well as the audited consolidat

November 12, 2013 EX-99.4

Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE

Exhibit 99.4 Form 52-109F2 Certification of Interim Filings FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the interim financial report and interim MD&A (together, the “interim filings”) of Transition Therapeutics Inc. (the “issuer”) for the interim period ended September 30, 2013. 2. No misrepresentations:

September 11, 2013 6-K

Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by ch

September 11, 2013 EX-4.11

SUBSCRIPTION AGREEMENT FOR UNITS

Exhibit 4.11 UNITED STATES SUBSCRIPTION AGREEMENT FOR UNITS INSTRUCTIONS: To properly complete this Subscription Agreement: (1) All subscribers must complete all boxes on this face page. (2) All subscribers must complete and sign Exhibit 1 and Exhibit 2. (3) All subscribers should return their completed documents by email or fax to the Corporation at [email protected] or 416-260-28

September 11, 2013 EX-99.7

Transition Therapeutics Announces Fiscal 2013 Year End Financial Results

Exhibit 99.7 Transition Therapeutics Announces Fiscal 2013 Year End Financial Results TORONTO, ON, September 11, 2013 – Transition Therapeutics Inc. (“Transition” or the “Company”) (TSX: TTH; NASDAQ: TTHI), a product-focused biopharmaceutical company developing therapeutics for disease indications with large markets, today announced its financial results for the year ended June 30, 2013. Selected

September 11, 2013 EX-99.3

MANAGEMENT’S RESPONSIBILITY FOR FINANCIAL STATEMENTS

Exhibit 99.3 MANAGEMENT’S RESPONSIBILITY FOR FINANCIAL STATEMENTS The accompanying consolidated financial statements of Transition Therapeutics Inc. have been prepared by management and have been approved by the Board of Directors. Management is responsible for the information and representation contained in these consolidated financial statements. The consolidated financial statements have been p

September 11, 2013 EX-2.2

TRANSITION THERAPEUTICS INC. (Existing under the Business Corporations Act (Ontario)) Common Share Purchase Warrants

Exhibit 2.2 THESE WARRANTS WILL BE VOID AND OF NO VALUE UNLESS EXERCISED BEFORE TIME OF EXPIRY (AS DEFINED HEREIN). Unless permitted under securities legislation, the holder of this security must not trade the security before [DECEMBER ·], 2013. THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE "U.S. SECURITIES ACT") OR ANY S

September 11, 2013 EX-2.1

TRANSITION THERAPEUTICS INC. (Existing under the Business Corporations Act (Ontario)) Common Share Purchase Warrants

Exhibit 2.1 THESE WARRANTS WILL BE VOID AND OF NO VALUE UNLESS EXERCISED BEFORE TIME OF EXPIRY (AS DEFINED HEREIN). Unless permitted under securities legislation, the holder of this security must not trade the security before [DECEMBER ·], 2013. THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE "U.S. SECURITIES ACT") OR ANY S

September 11, 2013 EX-99.4

FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE

Exhibit 99.4 FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify the following: 1. Review: I have reviewed the AIF, annual financial statements and annual MD&A, including, for greater certainty, all documents and information that are incorporated by reference in the AIF (together, the “annual filings”) of Tra

September 11, 2013 EX-15.1

Consent of Independent Auditor

Exhibit 15.1 Consent of Independent Auditor We hereby consent to the incorporation by reference in the Registration Statements on Form F-3 (No. 333-189879) and on Form S-8 (No. 333-157279) of Transition Therapeutics Inc. of our report dated September 6, 2013 relating to the consolidated financial statements, which appears as an Exhibit in this Form 20-F, which is incorporated in this Annual Report

September 11, 2013 EX-99.1

TRANSITION THERAPEUTICS INC. ANNUAL INFORMATION FORM For the year ended June 30, 2013 September 6, 2013 TABLE OF CONTENTS

Exhibit 99.1 TRANSITION THERAPEUTICS INC. ANNUAL INFORMATION FORM For the year ended June 30, 2013 September 6, 2013 TABLE OF CONTENTS PRELIMINARY 1 CAUTION REGARDING FORWARD-LOOKING STATEMENTS 1 CORPORATE STRUCTURE 2 Name, Address and Incorporation 2 Intercorporate Relationships 2 GENERAL DEVELOPMENT OF THE BUSINESS 3 Three Year History 3 Recent Developments 6 Trends 7 BUSINESS OF THE CORPORATION

September 11, 2013 EX-99.2

MANAGEMENT’S DISCUSSION AND ANALYSIS

Exhibit 99.2 MANAGEMENT’S DISCUSSION AND ANALYSIS The following is a discussion and analysis of the operating results and financial position of Transition Therapeutics Inc. for the year ended June 30, 2013. This document should be read in conjunction with the Company’s audited consolidated financial statements and the accompanying notes, which have been prepared in accordance with International Fi

September 11, 2013 EX-4.10

SUBSCRIPTION AGREEMENT FOR UNITS

Exhibit 4.10 CANADA/OFFSHORE SUBSCRIPTION AGREEMENT FOR UNITS INSTRUCTIONS: To properly complete this Subscription Agreement: (1) All subscribers must complete all boxes on these two face pages. (2) All subscribers should return their completed documents by email or fax to the Corporation at [email protected] or 416-260-2886, Attention: N. Nicole Rusaw This Subscription Agreement i

September 11, 2013 EX-13.2

CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350

Exhibit 13.2 CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO 18 U.S.C. SECTION 1350 I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc. (the “Company”), in compliance with 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, hereby certify, in connection with the Company’s Annual Report as filed on Form 20-F for the fiscal year end

September 11, 2013 20-F

- FORM 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F [Mark One] ¨ REGISTRATION STATEMENT PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 OR x ANNUAL REPORT PURSUANT TO SECTION 13(a) OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: June 30, 2013 Commission File Number: 001-33514 TRANSITION THERAPEUTICS INC. (Exact name of Registra

September 11, 2013 EX-99.5

FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE

Exhibit 99.5 FORM 52-109F1 CERTIFICATION OF ANNUAL FILINGS FULL CERTIFICATE I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify that: 1. Review: I have reviewed the AIF, annual financial statements and annual MD&A, including, for greater certainty, all documents and information that are incorporated by reference in the AIF (together, the “annual filings”) of Transitio

September 11, 2013 EX-13.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO 18 U.S.C. SECTION 1350

Exhibit 13.1 CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO 18 U.S.C. SECTION 1350 I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc. (the “Company”), in compliance with 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, hereby certify, in connection with the Company’s Annual Report as filed on Form 20-F for the fiscal year ending

September 11, 2013 EX-12.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a)

Exhibit 12.1 CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a) I, Tony Cruz, Chief Executive Officer of Transition Therapeutics Inc., certify that: 1. I have reviewed this annual report on Form 20-F of Transition Therapeutics Inc. (the “company” ) for the year ended June 30, 2013; 2. Based on my knowledge, this report does not contain any untrue

September 11, 2013 EX-99.6

Dear Shareholders,

Exhibit 99.6 Dear Shareholders, The goal of every biotechnology company is to ultimately offer a product of medical benefit to patients. With that goal always firmly in mind, Transition’s strategy has been to (a) leverage our internal strengths, (b) partner to access expertise and infrastructure for later stage development, and (c) expand our development pipeline with new drug candidates. From the

September 11, 2013 EX-12.2

CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a)

Exhibit 12.2 CERTIFICATION OF CHIEF FINANCIAL OFFICER PURSUANT TO SECURITIES AND EXCHANGE COMMISSION RULE 13a-14(a) I, Nicole Rusaw, Chief Financial Officer of Transition Therapeutics Inc., certify that: 1. I have reviewed this annual report on Form 20-F of Transition Therapeutics Inc. (the “company”) for the year ended June 30, 2013; 2. Based on my knowledge, this report does not contain any untr

September 4, 2013 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2013 Commission File No.: 001-33514 TRANSITION THERAPEUTICS INC. 101 College Street, Suite 220, Toronto, Ontario, Canada M5G 1L7 (Address of Principal Executive Office) Indicate by ch

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