ZVSA / ZyVersa Therapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

ZyVersa Therapeutics, Inc.
US ˙ OTCPK ˙ US98987D1028

Mga Batayang Estadistika
CIK 1859007
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to ZyVersa Therapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41184 ZYVERSA TH

August 1, 2025 S-1/A

As filed with the Securities and Exchange Commission on August 1, 2025

As filed with the Securities and Exchange Commission on August 1, 2025 Registration No.

July 28, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 25, 2025 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction of incorporation) (Commissio

July 18, 2025 S-1/A

As filed with the Securities and Exchange Commission on July 18, 2025

As filed with the Securities and Exchange Commission on July 18, 2025 Registration No.

July 18, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-1/A (Form Type) 333-288470 ZyVersa Therapeutics, Inc.

July 16, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 15, 2025 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction of incorporation) (Commissio

July 9, 2025 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 8, 2025 ZyVersa Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction of incorporation) (Commission

July 9, 2025 EX-10.2

Financial Advisory Agreement, dated July 8, 2025 (incorporated by reference to Exhibit 10.2 to the Company Current Report on Form 8-K, filed with the SEC on July 9, 2025).

Exhibit 10.2 CONFIDENTIAL July 8, 2025 ZyVersa Therapeutics, Inc. Attention: Stephen C. Glover 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 The purpose of this financial advisory agreement (this “Agreement”) is to confirm the engagement of A.G.P./Alliance Global Partners (“A.G.P.”) by ZyVersa Therapeutics, Inc. (the “Company”) to render Financial Services (as defined below) to the Company.

July 9, 2025 EX-4.1

Form of Series A-4 Warrant (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K, filed with the SEC on July 9, 2025).

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

July 9, 2025 EX-10.1

Inducement Letter, dated July 8, 2025 (incorporated by reference to Exhibit 10.1 to the Company Current Report on Form 8-K, filed with the SEC on July 9, 2025).

Exhibit 10.1 ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 July 8, 2025 To the Holders of Series A-2 Warrants and Series A-3 Warrants Re: Inducement Offer to Exercise Existing Common Stock Purchase Warrants Dear Holders: ZYVERSA THERAPEUTICS, INC. (the “Company”) is pleased to offer (this “Inducement Offer”) to you (“Holder”, “you” or similar terminology) the oppo

July 2, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

July 2, 2025 EX-10.36

Form of Registration Rights Agreement.

Exhibit 10.36 Execution Version REGISTRATION RIGHTS AGREEMENT REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of June , 2025 (the “Execution Date”), is entered into by and between ZyVersa Therapeutics Inc., a Delaware corporation (the “Company”), and Williamsburg Venture Holdings, LLC, a Nevada limited liability company (together with its permitted assigns, the “Buyer”). Capitalized ter

July 2, 2025 EX-10.35

Form of Equity Purchase Agreement.

Exhibit 10.35 EQUITY PURCHASE AGREEMENT THIS EQUITY PURCHASE AGREEMENT (this “Agreement”) is entered into as of June, 2025 the “Execution Date”), by and between ZyVersa Therapeutics, Inc, a Delaware corporation (the “Company”), and Williamsburg Venture Holdings, LLC, a Nevada limited liability company (the “Investor”). RECITALS WHEREAS, the parties desire that, upon the terms and subject to the co

July 2, 2025 S-1

As filed with the Securities and Exchange Commission on July 1, 2025

As filed with the Securities and Exchange Commission on July 1, 2025 Registration No.

June 25, 2025 EX-10.1

Form of Equity Purchase Agreement, dated June 24, 2025, by and between ZyVersa Therapeutics, Inc. and Williamsburg Venture Holdings, LLC

Exhibit 10.1 EQUITY PURCHASE AGREEMENT THIS EQUITY PURCHASE AGREEMENT (this “Agreement”) is entered into as of June, 2025 the “Execution Date”), by and between ZyVersa Therapeutics, Inc, a Delaware corporation (the “Company”), and Williamsburg Venture Holdings, LLC, a Nevada limited liability company (the “Investor”). RECITALS WHEREAS, the parties desire that, upon the terms and subject to the con

June 25, 2025 EX-99.1

ZyVersa Therapeutics Announces Share Purchase Agreement for up to $10 Million in Partnership with Williamsburg Venture Holdings to Fund Clinical Development of Cholesterol Efflux Mediator

Exhibit 99.1 ZyVersa Therapeutics Announces Share Purchase Agreement for up to $10 Million in Partnership with Williamsburg Venture Holdings to Fund Clinical Development of Cholesterol Efflux MediatorTM VAR 200 Weston, FL (June 25, 2025) – ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA; “ZyVersa”), a clinical stage specialty biopharmaceutical company developing first-in-class drugs for treatment of pati

June 25, 2025 EX-10.2

Form of Registration Rights Agreement, dated June 24, 2025, by and between ZyVersa Therapeutics, Inc. and Williamsburg Venture Holdings, LLC

Exhibit 10.2 Execution Version REGISTRATION RIGHTS AGREEMENT REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of June , 2025 (the “Execution Date”), is entered into by and between ZyVersa Therapeutics Inc., a Delaware corporation (the “Company”), and Williamsburg Venture Holdings, LLC, a Nevada limited liability company (together with its permitted assigns, the “Buyer”). Capitalized term

June 25, 2025 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 24, 2025 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction of incorporation) (Commissio

June 12, 2025 EX-10.1

Amended and Restated ZyVersa Therapeutics, Inc. 2022 Omnibus Equity Incentive Plan

Exhibit 10.1 ZYVERSA THERAPEUTICS, INC. 2022 OMNIBUS EQUITY INCENTIVE PLAN (as amended and restated on June 11, 2025) 1. Establishment and Purpose 1.1 The purpose of the ZyVersa Therapeutics, Inc. 2022 Omnibus Equity Incentive Plan (the “Plan”) is to provide a means whereby eligible employees, officers, non-employee directors and other individual service providers develop a sense of proprietorship

June 12, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 11, 2025 ZYVERSA THERAPEUTICS, INC.

May 30, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 27, 2025 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction of incorporation) (Commission

May 12, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41184 ZYVERSA T

April 17, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities and Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities and Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy S

April 17, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

April 8, 2025 CORRESP

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 April 8, 2025

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 April 8, 2025 VIA EDGAR SUBMISSION U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-3 (File No. 333-286396) (the “Registration Statement”) Ladies and Gentl

April 7, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

April 7, 2025 EX-16.1

Letter dated April 7, 2025 from Marcum LLP to the U.S. Securities and Exchange Commission (incorporated by reference to Exhibit 16.1 to the Company’s Form 8-K, filed with the SEC on April 7, 2025).

Exhibit 16.1

April 7, 2025 8-K

Changes in Registrant's Certifying Accountant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 4, 2025 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction of incorporation) (Commissio

April 4, 2025 S-3

As filed with the Securities and Exchange Commission on April 4, 2025

As filed with the Securities and Exchange Commission on April 4, 2025 Registration No.

April 4, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) ZyVersa Therapeutics, Inc.

March 27, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41184 ZYVERSA THERAP

March 27, 2025 EX-19.1

Insider Trading Policies and Procedures.

Exhibit 19.1 ZYVERSA THERAPEUTICS, INC. STATEMENT OF COMPANY POLICY ON INSIDER TRADING AND POLICY REGARDING SPECIAL TRADING PROCEDURES Approved by the Board of Directors on December 12, 2022 Two copies of this Statement of Company Policy on Insider Trading and Policy Regarding Special Trading Procedures (collectively, this “Policy”) are being provided to you. You should read this Policy, address q

March 7, 2025 EX-4.1

Form of Pre-Funded Warrant to Purchase Shares of Common Stock (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K, filed with the SEC on March 7, 2025).

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

March 7, 2025 EX-10.2

Placement Agency Agreement, dated March 5, 2025, between the Company and A.G.P./Alliance Global Partners (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, filed with the SEC on March 7, 2025).

Exhibit 10.2 March 5, 2025 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as sole placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (the

March 7, 2025 EX-4.2

Form of Series A-3 Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.2 to the Company’s Current Report on Form 8-K, filed with the SEC on March 7, 2025).

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

March 7, 2025 EX-10.1

Form of Securities Purchase Agreement, dated March 5, 2025 (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, filed with the SEC on March 7, 2025).

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of March 5, 2025, between ZyVersa Therapeutics Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condition

March 7, 2025 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Other Events, Submission of Matters to a Vote of Security Holders, Shareholder Director Nominations, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 4, 2025 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction (Commission (IRS employer of

March 7, 2025 EX-4.3

Form of Amendment to Common Share Purchase Warrant, dated March 5, 2025 (incorporated by reference to Exhibit 4.3 to the Company’s Current Report on Form 8-K, filed with the SEC on March 7, 2025).

Exhibit 4.3 AMENDMENT TO COMMON Share PURCHASE WARRANT This AMENDMENT TO COMMON SHARE PURCHASE WARRANT (this “Amendment”) is entered into as of March 5, 2025, by and between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and Armistice Capital Master Fund Ltd. (the “Holder”). WHEREAS, the Holder is the holder of Common Share Purchase Warrants, issued by the Company on November

January 24, 2025 EX-FILING FEES

Filing fee table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) ZyVersa Therapeutics, Inc.

January 24, 2025 S-8

As filed with the Securities and Exchange Commission on January 24, 2025

As filed with the Securities and Exchange Commission on January 24, 2025 Registration No.

January 17, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

December 30, 2024 424B3

1,637,000 Shares of Common Stock

Filed pursuant to Rule 424(b)(3) File No. 333-283993 PROSPECTUS 1,637,000 Shares of Common Stock This prospectus relates to the offer and resale of up to an aggregate of 1,637,000 shares of common stock, par value $0.0001 per share (the “Common Stock”) of ZyVersa Therapeutics, Inc. (the “Company,” “we,” “our” or “us”), held by the selling stockholder listed in this prospectus or its permitted tran

December 26, 2024 CORRESP

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 December 23, 2024

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 December 23, 2024 VIA EDGAR SUBMISSION U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-3 (File No. 333-283993) (the “Registration Statement”) Ladies and G

December 20, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) ZyVersa Therapeutics, Inc.

December 20, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

December 20, 2024 S-3

As filed with the Securities and Exchange Commission on December 20, 2024

As filed with the Securities and Exchange Commission on December 20, 2024 Registration No.

November 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2024 ZYVERSA THERAPE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2024 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction (Commission (IRS employe

November 14, 2024 EX-99.1

ZyVersa Therapeutics Reports Third Quarter, 2024 Financial Results and Provides Business Update

Exhibit 99.1 ZyVersa Therapeutics Reports Third Quarter, 2024 Financial Results and Provides Business Update KEY BUSINESS HIGHLIGHTS ● Phase 2a clinical trial for Cholesterol Efflux MediatorTM VAR 200 in patients with diabetic kidney disease expected to begin Q1-2025. ● New Obesity, Metabolic & Inflammatory Disease Scientific Advisory Board (SAB) was formed in October 2024 to support development o

November 14, 2024 SC 13G/A

ZVSA / ZyVersa Therapeutics, Inc. / Anson Funds Management LP - SC 13G/A Passive Investment

SC 13G/A 1 d886582dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G (Rule 13d-102) (Amendment No.1) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) ZYVERSA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 98987D300 (

November 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41184 ZYVER

November 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2024 ZYVERSA THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2024 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction (Commission (IRS employer

November 6, 2024 EX-10.2

Financial Advisory Agreement, dated November 6, 2024 (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, filed with the SEC on November 6, 2024).

Exhibit 10.2 CONFIDENTIAL November 5, 2024 ZyVersa Therapeutics, Inc. Attention: Stephen C. Glover 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 The purpose of this financial advisory agreement (this “Agreement”) is to confirm the engagement of A.G.P./Alliance Global Partners (“A.G.P.”) by ZyVersa Therapeutics, Inc. (the “Company”) to render Financial Services (as defined below) to the Comp

November 6, 2024 EX-10.1

Inducement Letter, dated November 5, 2024 (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, filed with the SEC on November 6, 2024).

Exhibit 10.1 ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 November 5, 2024 To the Holders of December 2023 Common Stock Purchase Warrants and August 2024 Common Stock Purchase Warrants Re: Inducement Offer to Exercise Existing Common Stock Purchase Warrants Dear Holder: ZYVERSA THERAPEUTICS, INC. (the “Company”) is pleased to offer (this “Inducement Offer”) to yo

November 6, 2024 EX-4.1

Form of Series A-2 Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K, filed with the SEC on November 6, 2024).

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

October 30, 2024 EX-10.1

Amended and Restated ZyVersa Therapeutics, Inc. 2022 Omnibus Equity Incentive Plan

Exhibit 10.1 ZYVERSA THERAPEUTICS, INC. 2022 OMNIBUS EQUITY INCENTIVE PLAN (as amended and restated on October 29, 2024) 1. Establishment and Purpose 1.1 The purpose of the ZyVersa Therapeutics, Inc. 2022 Omnibus Equity Incentive Plan (the “Plan”) is to provide a means whereby eligible employees, officers, non-employee directors and other individual service providers develop a sense of proprietors

October 30, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 29, 2024 ZYVERSA THERAPEUTICS, INC.

September 16, 2024 8-K

8-K, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 16, 2024 ZYVERSA THERAPEUTICS, INC.

September 16, 2024 EX-1.1

Sales Agreement dated September 16, 2024 by and between Zyversa Therapeutics, Inc., and A.G.P./Alliance Global Partners

September 16, 2024 424B5

424B5

424B5 1 form424b5.htm

September 10, 2024 424B3

478,600 Shares of Common Stock

Filed pursuant to Rule 424(b)(3) File No. 333-281913 PROSPECTUS 478,600 Shares of Common Stock This prospectus relates to the offer and resale of up to an aggregate of 478,600 shares of common stock, par value $0.0001 per share (the “Common Stock”) of ZyVersa Therapeutics, Inc. (the “Company,” “we,” “our” or “us”), held by the selling stockholder listed in this prospectus or its permitted transfer

September 10, 2024 424B3

Common Stock Preferred Stock Debt Securities Purchase Contracts Subscription Rights

Filed pursuant to Rule 424(b)(3) File No. 333-281914 PROSPECTUS $100,000,000 Common Stock Preferred Stock Debt Securities Warrants Purchase Contracts Units Subscription Rights From time to time, we may offer and sell up to an aggregate amount of $100,000,000 of any combination of the securities described in this prospectus, either individually or in combination with other securities, in one or mor

September 9, 2024 CORRESP

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 September 9, 2024

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 September 9, 2024 VIA EDGAR SUBMISSION U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-3 (File No. 333-281913) (the “Registration Statement”) Ladies and G

September 9, 2024 CORRESP

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 September 9, 2024

ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, Florida 33326 (754) 231-1688 September 9, 2024 VIA EDGAR SUBMISSION U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-3 (File No. 333-281914) (the “Registration Statement”) Ladies and G

September 9, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities and Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities and Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy S

September 9, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

September 3, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) ZyVersa Therapeutics, Inc.

September 3, 2024 S-3

As filed with the Securities and Exchange Commission on September 3, 2024

As filed with the Securities and Exchange Commission on September 3, 2024 Registration No.

September 3, 2024 S-3

As filed with the Securities and Exchange Commission on September 3, 2024

As filed with the Securities and Exchange Commission on September 3, 2024 Registration No.

September 3, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) ZYVERSA THERAPEUTICS, INC.

August 30, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

August 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41184 ZYVERSA TH

August 9, 2024 EX-3.1

Second Amended and Restated Certificate of Incorporation of ZyVersa Therapeutics, Inc. (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 10-Q filed with the SEC on August 9, 2024).

Exhibit 3.1

August 1, 2024 EX-10.2

Financial Advisory Agreement, dated August 1, 2024, between the Company and A.G.P./Alliance Global Partners (incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, filed with the SEC on August 1, 2024).

Exhibit 10.2 CONFIDENTIAL August 1, 2024 ZyVersa Therapeutics, Inc. Attention: Stephen C. Glover 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 The purpose of this financial advisory agreement (this “Agreement”) is to confirm the engagement of A.G.P./Alliance Global Partners (“A.G.P.”) by ZyVersa Therapeutics, Inc. (the “Company”) to render Financial Services (as defined below) to the Compan

August 1, 2024 EX-4.2

Form of Series B-1 Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.2 to the Company’s Current Report on Form 8-K, filed with the SEC on August 1, 2024).

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

August 1, 2024 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 1, 2024 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-41184 86-2685744 (State or other jurisdiction (Commission (IRS employer o

August 1, 2024 EX-4.1

Form of Series A-1 Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.1 to the Company’s Current Report on Form 8-K, filed with the SEC on August 1, 2024).

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

August 1, 2024 EX-10.1

Inducement Letter, dated August 1, 2024 (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, filed with the SEC on August 1, 2024).

Exhibit 10.1 ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 August 1, 2024 To the Holder of December 2023 Common Stock Purchase Warrants Re: Inducement Offer to Exercise Existing Common Stock Purchase Warrants Dear Holder: ZYVERSA THERAPEUTICS, INC. (the “Company”) is pleased to offer (this “Inducement Offer”) to you (“Holder”, “you” or similar terminology) the opp

July 12, 2024 POS AM

Form S-1

As filed with the U.S. Securities and Exchange Commission on July 11, 2024 Registration No. 333-275320 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Post-Effective Amendment No. 1 to FORM S-1 REGISTRATION STATEMENT under the Securities Act of 1933 ZYVERSA THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 2834 86-2685744 (State or other jur

May 15, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A Amendment No. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A Amendment No. 1 (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41

May 15, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-41184 ZYVERSA T

May 15, 2024 EX-97.1

Compensation Recovery Policy.

Exhibit 97.1 ZYVERSA THERAPEUTICS, INC. COMPENSATION RECOVERY POLICY (Adopted as of November 21, 2023) 1. Introduction. Zyversa Therapeutics, Inc. (the “Company”) has adopted this Compensation Recovery Policy (the “Policy”), which provides for the recovery of certain executive compensation in the event of an accounting restatement resulting from material noncompliance with financial reporting requ

April 25, 2024 EX-3.1

Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation of ZyVersa Therapeutics, Inc., filed with the Delaware Secretary of State on April 25, 2024 (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K, filed with the SEC on April 25, 2024).

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF SECOND AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ZYVERSA THERAPEUTICS, INC. (Pursuant to Section 242 of the General Corporation Law of the State of Delaware) ZyVersa Therapeutics, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify as follow

April 25, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 ZYVERSA THERAPEUTICS, INC.

April 17, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2024 ZYVERSA THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2024 ZYVERSA THERAPEUTICS, INC.

March 27, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. 1) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

March 25, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41184 ZYVERSA THERAP

March 25, 2024 EX-4.8

Exhibit 4.8

Exhibit 4.8 DESCRIPTION OF REGISTRANT’S SECURITIES The following is a description of the securities of ZyVersa Therapeutics, Inc. (“us,” “our,” “we” or the “Company”) as set forth in certain provisions of our Second Amended and Restated Certificate of Incorporation (the “Charter”) and our Second Amended and Restated Bylaws (the “Bylaws”), Series A Certificate of Designation, Series B Certificate o

March 19, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

March 8, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 6, 2024 ZYVERSA THERAPEUTICS, INC.

March 8, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

March 1, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 29, 2024 ZYVERSA THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 29, 2024 ZYVERSA THERAPEUTICS, INC.

February 14, 2024 S-8

As filed with the Securities and Exchange Commission on February 14, 2024

As filed with the Securities and Exchange Commission on February 14, 2024 Registration No.

February 14, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d764036dex991.htm EX-99.1 EXHIBIT 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including any and all amendments thereto) with respect to the Common Stock, $0.0001 par value, of Zyversa Therapeutics, Inc., a Delaware cor

February 14, 2024 EX-FILING FEES

Filing fee table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) ZyVersa Therapeutics, Inc.

February 14, 2024 SC 13G

ZVSA / ZyVersa Therapeutics, Inc. / Anson Funds Management LP - SC 13G Passive Investment

SC 13G 1 d764036dsc13g.htm SC 13G SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G (Rule 13d-102) (Amendment No. ) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) ZYVERSA THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 98987D102 (CUSIP

February 14, 2024 SC 13G/A

ZVSA / ZyVersa Therapeutics, Inc. / Ionic Ventures, LLC - SC 13G/A Passive Investment

SC 13G/A 1 g084053sch13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* ZyVersa Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D201 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the a

February 9, 2024 SC 13G/A

ZVSA / ZyVersa Therapeutics, Inc. / L1 Capital Global Opportunities Master Fund, Ltd. - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 l1cap13ga.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Amendment No. 1 Under the Securities Exchange Act of 1934 ZyVersa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 per share (Title of Class of Securities) 98987D 102 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate bo

January 19, 2024 SC 13G/A

ZVSA / ZyVersa Therapeutics, Inc. / INCON Co., Ltd. Passive Investment

SECURITIES AND EXCHANGE COMMISSION UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

December 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 ZYVERSA THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 ZYVERSA THERAPEUTICS, INC.

December 22, 2023 EX-16.1

Letter dated December 22, 2023 from Ernst & Young LLP to the U.S. Securities and Exchange Commission (incorporated by reference to Exhibit 16.1 to the Company’s Form 8-K filed with the SEC on December 22, 2023).

Exhibit 16.1 December 22, 2023 Securities and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read Item 4.01 of Form 8-K dated December 22, 2023, of ZyVersa Therapeutics, Inc. and are in agreement with the statements contained in the third paragraph on page 2 therein. We have no basis to agree or disagree with other statements of the registrant contained therein.

December 11, 2023 EX-10.1

Form of Securities Purchase Agreement, dated as of December 6, 2023, between the Company and each purchaser named in the signature pages thereto (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K, filed with the SEC on December 11, 2023).

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of December 6, 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condi

December 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 6, 2023 ZYVERSA THERAPEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 6, 2023 ZYVERSA THERAPEUTICS, INC.

December 11, 2023 EX-4.2

Form of Series A Warrant (incorporated by reference to Exhibit 4.2 to the Company’s Form 8-K filed with the SEC on December 11, 2023).

Exhibit 4.2 Series A COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Issue Date: [December ], 2023 THIS Series A COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after

December 11, 2023 EX-4.1

Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Company’s Form 8-K filed with the SEC on December 11, 2023).

Exhibit 4.1 Pre-Funded WARRANT To purchase Shares of Common Stock ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Initial Exercise Date: [●], 2023 THIS Pre-Funded WARRANT to Purchase Shares of Common Stock (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth,

December 11, 2023 EX-10.2

Placement Agency Agreement, dated as of December 6, 2023, between the Company and A.G.P./Alliance Global Partners (incorporated by reference to Exhibit 10.2 of the Company’s Current Report on Form 8-K, filed with the SEC on December 11, 2023).

Exhibit 10.2 December 6, 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as sole placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (t

December 11, 2023 EX-99.1

ZyVersa Therapeutics, Inc. Announces Pricing of $5.0 Million Public Offering

Exhibit 99.1 ZyVersa Therapeutics, Inc. Announces Pricing of $5.0 Million Public Offering WESTON, Fla., Dec. 06, 2023 (GLOBE NEWSWIRE) - ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA, or “ZyVersa” or “the Company”), a clinical stage specialty biopharmaceutical company developing first-in-class drugs for treatment of inflammatory and renal diseases with high unmet needs, announced today the pricing of a

December 11, 2023 EX-4.3

Form of Series B Warrant (incorporated by reference to Exhibit 4.3 to the Company’s Form 8-K filed with the SEC on December 11, 2023).

Exhibit 4.3 Series B COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Issue Date: [December ], 2023 THIS Series B COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after

December 8, 2023 424B4

400,000 Shares of Common Stock Pre-Funded Warrants to Purchase up to 3,600,000 Shares of Common Stock Series A Common Warrants to purchase up to 4,000,000 Shares of Common Stock Series B Common Warrants to purchase up to 4,000,000 Shares of Common St

PROSPECTUS  Filed Pursuant to Rule 424(b)(4) Registration No. 333-275320 400,000 Shares of Common Stock Pre-Funded Warrants to Purchase up to 3,600,000 Shares of Common Stock Series A Common Warrants to purchase up to 4,000,000 Shares of Common Stock Series B Common Warrants to purchase up to 4,000,000 Shares of Common Stock 8,000,000 Shares of Common Stock underlying the Common Warrants 3,600,000

December 6, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

December 6, 2023 EX-10.29

Form of Securities Purchase Agreement

Exhibit 10.29 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of December 6, 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and cond

December 6, 2023 EX-4.15

Form of Series A Common Warrant

Exhibit 4.15 Series A COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Issue Date: [December ], 2023 THIS Series A COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after

December 6, 2023 EX-10.30

Form of Placement Agent Agreement

Exhibit 10.30 December [], 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as sole placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware

December 6, 2023 CORRESP

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 December 6, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1, as amended File No. 333-275320 (the “Registration Statement”) Dear Ladies and Gentlemen

December 6, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 December 6, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333-275320 (the “Registration Statement”) Ladies and Gentlemen: In accordance with Rul

December 6, 2023 S-1/A

As filed with the Securities and Exchange Commission on December 6, 2023

As filed with the Securities and Exchange Commission on December 6, 2023 Registration No.

December 6, 2023 EX-4.16

Form of Series B Common Warrant

Exhibit 4.16 Series B COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Issue Date: [December ], 2023 THIS Series B COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after

December 5, 2023 S-1/A

As filed with the Securities and Exchange Commission on December 4, 2023

As filed with the Securities and Exchange Commission on December 4, 2023 Registration No.

November 30, 2023 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 30, 2023 ZYVERSA THERAPEUTICS, INC.

November 30, 2023 EX-3.1

Certificate of Amendment to the Second Amended and Restated Certificate of Incorporation of ZyVersa Therapeutics, Inc., filed with the Delaware Secretary of State on November 30, 2023 (incorporated by reference to Exhibit 3.1 to the Company’s Current Report on Form 8-K, filed with the SEC on November 30, 2023).

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF SECOND AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF ZYVERSA THERAPEUTICS, INC. (Pursuant to Section 242 of the General Corporation Law of the State of Delaware) ZyVersa Therapeutics, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify as follow

November 30, 2023 EX-99.1

ZyVersa Therapeutics, Inc. Announces Reverse Stock Split and Increase in Authorized Shares of Common Stock

Exhibit 99.1 ZyVersa Therapeutics, Inc. Announces Reverse Stock Split and Increase in Authorized Shares of Common Stock WESTON, FL (November 30, 2023) - ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA, or “ZyVersa” or the “Company”), a clinical stage specialty biopharmaceutical company developing first-in-class drugs for treatment of renal and inflammatory diseases with high unmet needs, announces that i

November 21, 2023 EX-4.14

Form of Pre-Funded Warrant

Exhibit 4.14 Pre-Funded WARRANT To purchase Shares of Common Stock ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Initial Exercise Date: [ November ●], 2023 THIS Pre-Funded WARRANT to Purchase Shares of Common Stock (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter

November 21, 2023 EX-4.15

Form of Common Warrant

Exhibit 4.15 COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: [●] Issue Date: [November ], 2023 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after [November ], 2023

November 21, 2023 EX-10.30

Form of Placement Agent Agreement

Exhibit 10.30 November [], 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as sole placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware

November 21, 2023 CORRESP

November 21, 2023

November 21, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

November 21, 2023 S-1/A

As filed with the Securities and Exchange Commission on November 21, 2023

As filed with the Securities and Exchange Commission on November 21, 2023 Registration No.

November 21, 2023 EX-10.31

Form of Lock-Up Agreement

Exhibit 10.31 LOCK-UP AGREEMENT November [], 2023 A.G.P./Alliance Global Partners 590 Madison Avenue, 28th Floor New York, New York 10022 Re: ZyVersa Therapeutics, Inc.—Proposed Offering of Securities Ladies and Gentlemen: The undersigned, a holder of common stock, par value $0.0001 per share (“Shares”), or rights to acquire Shares, of ZyVersa Therapeutics, Inc., a company incorporated under the l

November 21, 2023 EX-10.29

Form of Securities Purchase Agreement

Exhibit 10.29 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of [], 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions s

November 20, 2023 424B3

ZYVERSA THERAPEUTICS, INC. 5,858,714 Shares of Common Stock 723,234 Shares of Common Stock Underlying Series B Preferred Stock 4,878,875 Shares of Common Stock Underlying PIPE Warrants 5,825,358 Shares of Common Stock Underlying Public Warrants 240,2

PROSPECTUS SUPPLEMENT Filed pursuant to Rule 424(b)(3) Registration Number 333-268934 ZYVERSA THERAPEUTICS, INC.

November 17, 2023 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 ZYVERSA THERAPEUTICS, INC.

November 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41184 ZYVERSA

November 3, 2023 S-1

As filed with the Securities and Exchange Commission on November 3, 2023

As filed with the Securities and Exchange Commission on November 3, 2023 Registration No.

November 3, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

November 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2023 ZYVERSA THERAPEUTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2023 ZYVERSA THERAPEUTICS, INC.

October 24, 2023 424B3

ZYVERSA THERAPEUTICS, INC. 5,858,714 Shares of Common Stock 723,234 Shares of Common Stock Underlying Series B Preferred Stock 4,878,875 Shares of Common Stock Underlying PIPE Warrants 5,825,358 Shares of Common Stock Underlying Public Warrants 240,2

PROSPECTUS Filed pursuant to Rule 424(b)(3) Registration Number 333-268934 ZYVERSA THERAPEUTICS, INC.

October 17, 2023 CORRESP

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 October 17, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1, as amended File No. 333-268934 (the “Registration Statement”) Dear Ladies and Gentlemen

October 17, 2023 S-1/A

As filed with the Securities and Exchange Commission on October 17, 2023

As filed with the Securities and Exchange Commission on October 17, 2023 Registration No.

October 5, 2023 CORRESP

VIA EDGAR

VIA EDGAR October 5, 2023 Joshua Gorsky and Laura Crotty Securities and Exchange Commission 100 F Street, N.

October 5, 2023 S-1/A

As filed with the Securities and Exchange Commission on October 5, 2023

As filed with the Securities and Exchange Commission on October 5, 2023 Registration No.

October 5, 2023 EX-FILING FEES

Filing Fee Table

EXHIBIT 107 CALCULATION OF REGISTRATION FEE Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

September 20, 2023 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K/A (AmeNDment NO. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K/A (AmeNDment NO.

September 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2023 ZYVERSA THERAPEU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 13, 2023 ZYVERSA THERAPEUTICS, INC.

September 14, 2023 EX-4.1

Form of Inducement Warrant (incorporated by reference to Exhibit 4.1 to the Company’s Current Report to Form 8-K filed with the SEC on September 14, 2023).

Exhibit 4.1 COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: Issue Date: September [], 2023 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, [] or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after [], 2023 (the “Ini

September 14, 2023 EX-10.1

Form of Inducement Letter (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 14, 2023).

Exhibit 10.1 ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 September 13, 2023 To the Holder of July 2023 Common Stock Purchase Warrants Re: Inducement Offer to Exercise Existing Common Stock Purchase Warrants Dear Holder: ZYVERSA THERAPEUTICS, INC. (the “Company”) is pleased to offer (this “Inducement Offer”) to you (“Holder”, “you” or similar terminology) the opp

September 13, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive

September 13, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities and Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities and Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy S

September 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 ZYVERSA THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 1, 2023 ZYVERSA THERAPEUTICS, INC.

September 1, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

August 21, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41184 ZYVERSA THERA

August 18, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2023 ZYVERSA THERAPEUTICS

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 7, 2023 ZYVERSA THERAPEUTICS, INC.

August 15, 2023 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: June 30, 2023 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition Period

July 26, 2023 EX-4.8_1

Warrant Amendment (incorporated by reference to Exhibit 4.8.1 to the Company’s Post-Effective Amendment No. 1 to Form S-1 Registration Statement, File No. 333-272657, filed with the SEC on July 26, 2023).

Exhibit 4.8.1 AMENDMENT TO COMMON STOCK PURCHASE WARRANT This AMENDMENT TO COMMON STOCK PURCHASE WARRANT (this “Amendment”) is entered into as of July 26, 2023, by and between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and the holder signatory hereto (the “Holder”). WHEREAS, the Holder is the holder of a Common Stock Purchase Warrant, issued as of April 28, 2023 and a Term

July 26, 2023 POS EX

As filed with the Securities and Exchange Commission on July 26, 2023

As filed with the Securities and Exchange Commission on July 26, 2023 Registration No.

July 26, 2023 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 5, 2023 ZYVERSA THERAPEUTICS, INC.

July 26, 2023 EX-99.1

ZyVersa Therapeutics, Inc. Announces Pricing of $2.1 Million Public Offering

Exhibit 99.1 ZyVersa Therapeutics, Inc. Announces Pricing of $2.1 Million Public Offering WESTON, FL (July 24, 2023) - ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA, or “ZyVersa” or “the Company”), a clinical stage specialty biopharmaceutical company developing first-in-class drugs for treatment of inflammatory and renal diseases with high unmet needs, announced today the pricing of a “reasonable best

July 26, 2023 424B4

3,256,060 Shares of Common Stock Pre-Funded Warrants to Purchase 9,471,213 Shares of Common Stock Warrants to purchase 12,727,273 Shares of Common Stock 22,198,486 Shares of Common Stock underlying the Warrants and Pre-Funded Warrants

Filed Pursuant to Rule 424(b)(4) Registration No. 333-272657 PROSPECTUS 3,256,060 Shares of Common Stock Pre-Funded Warrants to Purchase 9,471,213 Shares of Common Stock Warrants to purchase 12,727,273 Shares of Common Stock 22,198,486 Shares of Common Stock underlying the Warrants and Pre-Funded Warrants We are offering on a “reasonable best efforts” basis 3,256,060 shares of our common stock, pa

July 26, 2023 EX-10.1

Placement Agency Agreement (incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K filed with the SEC on July 26, 2023).

Exhibit 10.1 July 24, 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as sole placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (the

July 18, 2023 SC 13G

ZVSA / ZyVersa Therapeutics Inc / L1 Capital Global Opportunities Master Fund, Ltd. - SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 ZyVersa Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 98987D 102 (CUSIP Number) June 26, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is f

July 14, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 July 14, 2023 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Division of Corporation Finance Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 272657 (the “Registration Statement”) Ladies and Gentlemen: In accordance with Rule

July 14, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 July 14, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 272657 (the “Registration Statement”) Ladies and Gentlemen: Reference is made to our

July 14, 2023 CORRESP

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 July 14, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1, as amended File No. 333-272657 (the “Registration Statement”) Dear Ladies and Gentlemen: P

July 14, 2023 CORRESP

July 14, 2023

July 14, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

July 11, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 July 11, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 272657 (the “Registration Statement”) Ladies and Gentlemen: Reference is made to our

July 11, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 July 11, 2023 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Division of Corporation Finance Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333-272657 (the “Registration Statement”) Ladies and Gentlemen: In accordance with Rule 4

July 11, 2023 CORRESP

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 July 11, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1, as amended File No. 333-272657 (the “Registration Statement”) Dear Ladies and Gentlemen: P

July 11, 2023 CORRESP

July 11, 2023

July 11, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

July 7, 2023 EX-10.24

Form of Securities Purchase Agreement (incorporated by reference to Exhibit 10.24 to the Company’s Registration Statement on Form S-1/A filed with the SEC on July 7, 2023).

Exhibit 10.24 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of July [●], 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condit

July 7, 2023 EX-4.10

Form of Common Warrant (incorporated by reference to Exhibit 4.10 to the Company’s Amendment No. 2 to Form S-1 Registration Statement, File No. 333-272657, filed with the SEC on July 7, 2023).

Exhibit 4.10 COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: Issue Date: July [●], 2023 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after July [●], 2023 (the “Ini

July 7, 2023 EX-4.11

Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.11 to the Company’s Amendment No. 2 to Form S-1 Registration Statement, File No. 333-272657, filed with the SEC on July 7, 2023).

Exhibit 4.11 Pre-Funded WARRANT To purchase Shares of Common Stock ZYVERSA THERAPEUTICS, INC. Warrant Shares: Initial Exercise Date: July [●], 2023 THIS Pre-Funded WARRANT to Purchase Shares of Common Stock (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth

July 7, 2023 EX-1.1

Form of Placement Agency Agreement.

Exhibit 1.1 July [●], 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as sole placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (the

July 7, 2023 CORRESP

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 (754) 231-1688

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 (754) 231-1688 July 7, 2023 VIA EDGAR Joshua Gorsky Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. Registration Statement on Form S-1 Filed June 15, 2023 File No. 333-272657 (the “Registration Statement”) Dear Mr. Gorsky: ZyVersa Therapeutics, Inc., a Delawar

July 7, 2023 CORRESP

July 7, 2023

July 7, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Mail Stop 4720 100 F Street, N.

July 7, 2023 S-1/A

As filed with the Securities and Exchange Commission on July 7, 2023

As filed with the Securities and Exchange Commission on July 7, 2023 Registration No.

July 7, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 July 7, 2023 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Division of Corporation Finance Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 272657 (the “Registration Statement”) Ladies and Gentlemen: In accordance with Rule 4

June 30, 2023 CORRESP

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 (754) 231-1688

ZYVERSA THERAPEUTICS, INC. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 (754) 231-1688 June 30, 2023 VIA EDGAR Joshua Gorsky Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. Registration Statement on Form S-1 Filed June 15, 2023 File No. 333-272657 (the “Registration Statement”) Dear Mr. Gorsky: ZyVersa Therapeutics, Inc., a Delawa

June 30, 2023 EX-4.10

Form of Warrant in connection with this Offering.

Exhibit 4.10 COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: Issue Date: [●], 2023 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after [●], 2023 (the “Initial Exerc

June 30, 2023 S-1/A

As filed with the Securities and Exchange Commission on June 30, 2023

As filed with the Securities and Exchange Commission on June 30, 2023 Registration No.

June 30, 2023 EX-4.11

Form of Pre-Funded Warrant in connection with this Offering.

Exhibit 4.11 Pre-Funded WARRANT To purchase Shares of Common Stock ZYVERSA THERAPEUTICS, INC. Warrant Shares: Initial Exercise Date: [●], 2023 THIS Pre-Funded WARRANT to Purchase Shares of Common Stock (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at

June 30, 2023 EX-10.24

Form of Securities Purchase Agreement.

Exhibit 10.24 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of [●], 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions

June 30, 2023 EX-1.1

Form of Placement Agency Agreement.

Exhibit 1.1 [●], 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as lead placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (the “Comp

June 30, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

June 15, 2023 S-1

Power of Attorney (included on the signature page of this Registration Statement)

As filed with the Securities and Exchange Commission on June 14, 2023 Registration No.

June 15, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

June 12, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2023 ZYVERSA THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 9, 2023 ZYVERSA THERAPEUTICS, INC.

June 12, 2023 424B3

11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants

Filed Pursuant to Rule 424(b)(3) Registration No. 333-269442 Prospectus Supplement No. 4 Dated June 9, 2023 (To Prospectus Dated April 26, 2023) 11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants This Prospectus Supplement No. 4 (this “Prospectus Supplement”) supplements the prospectus of ZyVersa

May 19, 2023 EX-99.1

ZyVersa Therapeutics Announces Changes to ZyVersa Board of Directors

Exhibit 99.1 ZyVersa Therapeutics Announces Changes to ZyVersa Board of Directors Weston, FL (May 19, 2023) – ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA, or “ZyVersa”), a clinical stage specialty biopharmaceutical company developing first-in-class drugs for the treatment of renal and inflammatory diseases with high unmet medical needs, announces that two members of the Board of Directors have steppe

May 19, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2023 ZYVERSA THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 17, 2023 ZYVERSA THERAPEUTICS, INC.

May 19, 2023 S-8

As filed with the Securities and Exchange Commission on May 19, 2023

As filed with the Securities and Exchange Commission on May 19, 2023 Registration No.

May 19, 2023 424B3

11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants

Filed Pursuant to Rule 424(b)(3) Registration No. 333-269442 Prospectus Supplement No. 3 Dated May 19, 2023 (To Prospectus Dated April 26, 2023) 11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants This Prospectus Supplement No. 3 (this “Prospectus Supplement”) supplements the prospectus of ZyVersa

May 19, 2023 EX-FILING FEES

Calculation of filing fee table.

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) ZyVersa Therapeutics, Inc.

May 15, 2023 424B3

11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants

Filed Pursuant to Rule 424(b)(3) Registration No. 333-269442 Prospectus Supplement No. 2 Dated May 12, 2023 (To Prospectus Dated April 26, 2023) 11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants This Prospectus Supplement No. 2 (this “Prospectus Supplement”) supplements the prospectus of ZyVersa

May 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2023 ZYVERSA THERAPEUTICS,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 12, 2023 ZYVERSA THERAPEUTICS, INC.

May 15, 2023 EX-99.1

ZYVERSA THERAPEUTICS, INC. CONDENSED CONSOLIDATED BALANCE SHEETS

EX-99.1 2 ex99-1.htm Exhibit 99.1 ZyVersa Therapeutics Reports First Quarter 2023 Corporate and Financial Results Key Highlights: ● Continued progress has been made in advancing an investigator-initiated clinical trial to gain human proof-of-concept for Cholesterol Efflux Mediator™ VAR 200 in patients with renal disease ● Announced publication of several peer-reviewed journal articles supporting A

May 12, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41184 ZYVERSA THER

May 12, 2023 424B3

11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants

Filed Pursuant to Rule 424(b)(3) Registration No. 333-269442 Prospectus Supplement No. 1 Dated May 12, 2023 (To Prospectus Dated April 26, 2023) 11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants This Prospectus Supplement No. 1 supplements the prospectus of ZyVersa Therapeutics, Inc. (the “Compan

May 12, 2023 SC 13D/A

ZVSA / ZyVersa Therapeutics Inc / O'Connor Daniel J. Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* ZyVersa Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D 102 (CUSIP Number) Jared Kelly Lowenstein Sandler LLP One Lowenstein Drive Roseland, NJ 07068 (212) 419-5974 (Name, Address and Te

May 12, 2023 SC 13D/A

ZVSA / ZyVersa Therapeutics Inc / Glover Stephen C. Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* ZyVersa Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D 102 (CUSIP Number) Jared Kelly Lowenstein Sandler LLP One Lowenstein Drive Roseland, NJ 07068 (212) 419-5974 (Name, Address and Te

May 3, 2023 SC 13G

ZVSA / ZyVersa Therapeutics Inc / Ionic Ventures, LLC - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Zyversa Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D102 (CUSIP Number) April 28, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

April 28, 2023 424B4

11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants

Filed Pursuant to Rule 424(b)(4) Registration No. 333-269442 PROSPECTUS 11,015,500 Shares of Common Stock Warrants to Purchase up to 11,015,500 Shares of Common Stock 11,015,500 Shares of Common Stock underlying the Warrants We are offering on a “reasonable best efforts” basis 11,015,500 shares of our common stock, par value $0.0001 per share (“Common Stock”) and warrants to purchase 11,015,500 sh

April 28, 2023 POS EX

As filed with the Securities and Exchange Commission on April 28, 2023

As filed with the Securities and Exchange Commission on April 28, 2023 Registration No.

April 25, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 April 25, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 269442 (the “Registration Statement”) Ladies and Gentlemen: Reference is made to ou

April 25, 2023 CORRESP

April 25, 2023

April 25, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.

April 24, 2023 CORRESP

April 24, 2023

CORRESP 1 filename1.htm April 24, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Mail Stop 4720 100 F Street, N.E. Washington, D.C. 20549 Attn: Lauren Hamill Laura Crotty Re: ZyVersa Therapeutics, Inc. Registration Statement on Form S-1, as amended File No. 333-269442 Acceleration Request Requested Date: April 26, 2023 Reques

April 24, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 April 24, 2023 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Division of Corporation Finance Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 269442 (the “Registration Statement”) Ladies and Gentlemen: In accordance with Rule

April 24, 2023 S-1/A

As filed with the Securities and Exchange Commission on April 21, 2023

As filed with the Securities and Exchange Commission on April 21, 2023 Registration No.

April 21, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 April 21, 2023 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Division of Corporation Finance Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 269442 (the “Registration Statement”) Ladies and Gentlemen: In accordance with Rule

April 21, 2023 CORRESP

April 21, 2023

April 21, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Mail Stop 4720 100 F Street, N.

April 18, 2023 EX-4.9

Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.9 to the Company’s Registration Statement filed with the SEC on April 24, 2023).

Exhibit 4.9 Pre-Funded WARRANT To purchase Shares of Common Stock ZYVERSA THERAPEUTICS, INC. Warrant Shares: Initial Exercise Date: April [●], 2023 THIS Pre-Funded WARRANT to Purchase Shares of Common Stock (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth

April 18, 2023 EX-10.23

Form of Escrow Agreement (incorporated by reference to Exhibit 10.23 to Company’s Registration Statement on Form S-1 filed with the SEC on April 24, 2023)

Exhibit 10.23 ESCROW AGREEMENT This ESCROW AGREEMENT (this “Agreement”) made as of [●], 2023, by and among ZyVersa Therapeutics, Inc. (the “Issuer”), whose address and other information appears on the Information Sheet (as defined herein) attached to this Agreement, and Continental Stock Transfer & Trust Company, 1 State Street, 30th Floor, New York, NY 10004 (the “Escrow Agent”). WITNESSETH: WHER

April 18, 2023 EX-4.8

Form of Warrant (incorporated by reference to Exhibit 4.8 to the Company’s Registration Statement filed with the SEC on April 24, 2023).

Exhibit 4.8 COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: Issue Date: April [●], 2023 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after April [●], 2023 (the “In

April 18, 2023 S-1/A

As filed with the Securities and Exchange Commission on April 17, 2023

As filed with the Securities and Exchange Commission on April 17, 2023 Registration No.

April 18, 2023 EX-10.22

Form of Securities Purchase Agreement (incorporated by reference to Exhibit 10.22 to Company’s Registration Statement on Form S-1 filed with the SEC on April 24, 2023)

Exhibit 10.22 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of April [●], 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and condi

April 18, 2023 EX-1.1

Form of Placement Agency Agreement (incorporated by reference to Exhibit 1.1 to Company’s Registration Statement on Form S-1 filed with the SEC on April 24, 2023)

Exhibit 1.1 April [●], 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as lead placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (the

April 17, 2023 CORRESP

Jared Kelly

Jared Kelly 1251 6th Avenue, 17th Floor New York, NY 10020 T: (212) 419-5974 F: (212) 262-7402 E: JKelly@lowenstein.

April 12, 2023 S-1/A

As filed with the Securities and Exchange Commission on April 11, 2023

S-1/A 1 forms-1a.htm As filed with the Securities and Exchange Commission on April 11, 2023 Registration No. 333-268934 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 ZYVERSA THERAPEUTICS, INC. (Exact name of Registrant as specified in its charter) Delaware 2834 86-2685744 (State or other j

April 11, 2023 CORRESP

Jared Kelly

Jared Kelly 1251 6th Avenue, 17th Floor New York, NY 10020 T: (212) 419-5974 F: (212) 262-7402 E: JKelly@lowenstein.

April 5, 2023 S-1/A

As filed with the Securities and Exchange Commission on April 4, 2023

As filed with the Securities and Exchange Commission on April 4, 2023 Registration No.

April 3, 2023 8-K

Results of Operations and Financial Condition, Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 3, 2023 ZYVERSA THERAPEUTICS, INC.

April 3, 2023 EX-99.1

ZyVersa Therapeutics Reports Fourth Quarter and Year-End 2022 Corporate and Financial Results

Exhibit 99.1 ZyVersa Therapeutics Reports Fourth Quarter and Year-End 2022 Corporate and Financial Results April 3, 2023 Key Highlights: ● Closed business combination with Larkspur Health Acquisition Corp. in December 2022 and began trading on Nasdaq Global Market under the ticker symbol “ZVSA” ● Planning underway with nephrologists for an investigator-initiated clinical trial in focal segmental g

March 31, 2023 EX-4.8

Description of the Company’s Securities.

Exhibit 4.8 DESCRIPTION OF REGISTRANT’S SECURITIES The following is a description of the securities of ZyVersa Therapeutics, Inc. (“us,” “our,” “we” or the “Company”) as set forth in certain provisions of our Second Amended and Restated Certificate of Incorporation (the “Charter”) and our Second Amended and Restated Bylaws (the “Bylaws”), Series A Certificate of Designation, Series B Certificate o

March 31, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-41184 ZYVERSA THERAP

March 10, 2023 8-K

Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 ZYVERSA THERAPEUTICS, INC.

March 10, 2023 EX-99.1

IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE

Exhibit 99.1 IN THE COURT OF CHANCERY OF THE STATE OF DELAWARE IN RE ZYVERSA THERAPEUTICS, INC. C.A. No. 2023- VERIFIED PETITION FOR RELIEF PURSUANT TO 8 DEL. C. § 205 Petitioner ZyVersa Therapeutics, Inc. (“ZyVersa” or the “Company”), by and through its undersigned counsel, brings this petition pursuant to 8 Del. C. § 205 (the “Petition”), seeking to have this Court validate corporate acts descri

March 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2023 ZYVERSA THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2023 ZYVERSA THERAPEUTICS, INC.

March 3, 2023 EX-10.1

Amendment and Restatement Agreement, by and between L&F Research LLC and ZyVersa Therapeutics, Inc. (incorporated by reference to Exhibit 10.1 to the Company’s Form 8-K filed with the SEC on February 3, 2023).

EX-10.1 2 ex10-1.htm Exhibit 10.1 AMENDMENT AND RESTATEMENT WITH RESPECT TO WAIVER OF CERTAIN RIGHTS UNDER LICENSE AGREEMENT This Amendment and Restatement Agreement (this “Restatement”), effective as of February 28, 2023 (the “Effective Date”), is made by and among ZyVersa Therapeutics, Inc., a Delaware corporation (“Company” or “Licensee”), and L&F Research, LLC, a Florida limited liability comp

February 15, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

CORRESP 1 filename1.htm A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 February 15, 2023 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 269442 (the “Registration Statement”) Ladies and Gentlem

February 15, 2023 CORRESP

February 15, 2023

CORRESP 1 filename1.htm February 15, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Lauren Hamill Laura Crotty Re: ZyVersa Therapeutics, Inc. Registration Statement on Form S-1, as amended File No. 333-269442 Ladies and Gentlemen: ZyVersa Therapeutics, Inc. hereby requests that

February 14, 2023 SC 13G

ZVSA / ZyVersa Therapeutics Inc / A.G.P. / ALLIANCE GLOBAL PARTNERS, LLC - SC 13G Passive Investment

SC 13G 1 zyversasc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Act of 1934 (Amendment No. )* ZYVERSA THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D102 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appro

February 14, 2023 SC 13G/A

ZVSA / ZyVersa Therapeutics Inc / Oaktree Capital Group, LLC - SC 13G/A Passive Investment

SC 13G/A 1 brhc10048172sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Zyversa Therapeutics, Inc. (formerly known as Larkspur Health Acquisition Corp.) (Name of Issuer) Class A Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D102 (CUSIP Number) Decem

February 14, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 brhc10048172ex1.htm EXHIBIT 1 EXHIBIT 1 JOINT FILING AGREEMENT Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, each of the undersigned acknowledges and agrees that the foregoing statement on this Schedule 13G is filed on behalf of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf o

February 14, 2023 SC 13G/A

US51724W2061 / Larkspur Health Acquisition Corp. / Lighthouse Investment Partners, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

February 14, 2023 SC 13G

ZVSA / ZyVersa Therapeutics Inc / INCON Co., Ltd. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(b) (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )* ZyVersa Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 98987D102 (CUSIP Number) December 31, 2022 (Date of E

February 13, 2023 EX-1.1

Form of Placement Agency Agreement

Exhibit 1.1 February [●], 2023 Attn: Chief Executive Officer ZyVersa Therapeutics, Inc. 2200 N. Commerce Parkway, Suite 208 Weston, FL 33326 Dear Mr. Glover: This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners, as lead placement agent (the “Placement Agent”), and ZyVersa Therapeutics, Inc., a company incorporated under the laws of the State of Delaware (

February 13, 2023 CORRESP

A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022

CORRESP 1 filename1.htm A.G.P./ALLIANCE GLOBAL PARTNERS 590 Madison Avenue 28th Floor New York, New York 10022 February 13, 2023 VIA EDGAR Securities and Exchange Commission 100 F Street, N.E. Division of Corporation Finance Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. (the “Company”) Registration Statement on Form S-1 File No. 333- 269442 (the “Registration Statement”) Ladies and Gentlem

February 13, 2023 CORRESP

February 13, 2023

February 13, 2023 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Mail Stop 4720 100 F Street, N.

February 13, 2023 EX-4.9

Form of Pre-Funded Warrant in connection with this Offering.

EX-4.9 4 ex4-9.htm Exhibit 4.9 Pre-Funded WARRANT To purchase Shares of Common Stock ZYVERSA THERAPEUTICS, INC. Warrant Shares: Initial Exercise Date: February [●], 2023 THIS Pre-Funded WARRANT to Purchase Shares of Common Stock (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions

February 13, 2023 CORRESP

Jared Kelly

CORRESP 1 filename1.htm Jared Kelly 1251 6th Avenue, 17th Floor New York, NY 10020 T: (212) 419-5974 F: (212) 262-7402 E: [email protected] February 13, 2023 VIA EDGAR Lauren Hamill and Laura Crotty Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: ZyVersa Therapeutics, Inc. Registration Statement on Form S-1 Filed January 27, 2023 File No. 333-269442 Dear Ms. Ha

February 13, 2023 EX-4.8

Form of Warrant in connection with this Offering.

Exhibit 4.8 COMMON STOCK PURCHASE WARRANT ZYVERSA THERAPEUTICS, INC. Warrant Shares: Issue Date: February [●], 2023 THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time or times on or after February [●], 2023 (t

February 13, 2023 S-1/A

As filed with the Securities and Exchange Commission on February 13, 2023

As filed with the Securities and Exchange Commission on February 13, 2023 Registration No.

February 13, 2023 EX-10.22

Form of Securities Purchase Agreement

EX-10.22 6 ex10-22.htm Exhibit 10.22 SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of February [●], 2023, between ZyVersa Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subj

February 9, 2023 SC 13G/A

ZVSA / ZyVersa Therapeutics Inc / Hudson Bay Capital Management LP - ZSVA 13GA Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* ZyVersa Therapeutics, Inc. (f/k/a Larkspur Health Acquisition Corp.) (Name of Issuer) Class A Common Stock, par value $0.0001 per share (Title of Class of Securities) 98987D102 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement)

February 1, 2023 S-1/A

As filed with the Securities and Exchange Commission on February 1, 2023

As filed with the Securities and Exchange Commission on February 1, 2023 Registration No.

February 1, 2023 CORRESP

Jared Kelly

Jared Kelly 1251 6th Avenue, 17th Floor New York, NY 10020 T: (212) 419-5974 F: (212) 262-7402 E: JKelly@lowenstein.

January 31, 2023 SC 13G/A

US51724W2061 / Larkspur Health Acquisition Corp. / Yakira Capital Management, Inc. - 13GA Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Larkspur Health Acquisition Corp. (Name of Issuer) Units, each consisting of one share of common stock and three-fourths of one warrant (Title of Class of Securities) 51724W206 (CUSIP Number) NICHOLAS SABATINI, CFO & CCO; 1555 POST ROAD EAST, SUITE 202,

January 27, 2023 EX-99.6

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION

Exhibit 99.6 UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL INFORMATION Explanatory Note: The unaudited pro forma condensed combined financial information previously reflected management’s estimates based on information available at the consummation of the Business Combination and was subject to change as additional information became available and analysis was performed. The Company is updating

January 27, 2023 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 27, 2023 ZYVERSA THERAPEUTICS, INC.

January 27, 2023 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-1 (Form Type) ZyVersa Therapeutics, Inc.

January 27, 2023 S-1

As filed with the Securities and Exchange Commission on January 27, 2023

As filed with the Securities and Exchange Commission on January 27, 2023 Registration No.

January 27, 2023 8-K/A

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 12, 2022 ZYVERSA THERAPEUTICS, INC.

January 27, 2023 EX-99.1

ZyVersa Therapeutics Reports Inducement Grant to Newly Appointed Chief Medical Officer Under Nasdaq Listing Rule 5635(c)(4)

Exhibit 99.1 ZyVersa Therapeutics Reports Inducement Grant to Newly Appointed Chief Medical Officer Under Nasdaq Listing Rule 5635(c)(4) Jan 27, 2023 WESTON, FL., (Jan. 27, 2023) — ZyVersa Therapeutics, Inc. (Nasdaq: ZVSA, or “ZyVersa”), a clinical-stage specialty biopharmaceutical company developing first-in-class drugs for treatment of renal and inflammatory diseases with high unmet medical need

January 27, 2023 EX-10.21

Executive Employment Agreement, by and between the Company and Pablo Guzman, M.D.

Exhibit 10.21 EXECUTIVE EMPLOYMENT AGREEMENT This EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) is entered into effective as of January 26, 2023 (the “Effective Date”), by and between Pablo Guzman, M.D. (“Executive”) and ZyVersa Therapeutics Inc., a Florida corporation (the “Company”). Each of the Company and Executive is a “Party” and, collectively, they are the “Parties.” WHEREAS, the Parties

Fintel data has been cited in the following publications:
Daily Mail Fox Business Business Insider Wall Street Journal The Washington Post Bloomberg Financial Times Globe and Mail
NASDAQ.com Reuters The Guardian Associated Press FactCheck.org Snopes Politifact
Federal Register The Intercept Forbes Fortune Magazine TheStreet Time Magazine Canadian Broadcasting Corporation International Business Times
Cambridge University Press Investopedia MarketWatch NY Daily News Entrepreneur Newsweek Barron's El Economista