ISPC / iSpecimen Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

iSpecimen Inc.

Mga Batayang Estadistika
CIK 1558569
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to iSpecimen Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
September 4, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 4, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 4, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

September 4, 2025 EX-99.1

iSpecimen Approached by Crypto Currency Companies for $200 Million Treasury Discussions

Exhibit 99.1 iSpecimen Approached by Crypto Currency Companies for $200 Million Treasury Discussions Woburn, MA – September 4, 2025 – iSpecimen Inc. (NASDAQ: ISPC), (the “Company”), a technology-enabled company modernizing the way human biospecimens are sourced for scientific research, today announced an update on its major strategic initiative aimed at integrating digital assets into its business

August 25, 2025 S-1/A

As filed with the Securities and Exchange Commission on August 25, 2025

As filed with the Securities and Exchange Commission on August 25, 2025 Registration No.

August 21, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 21, 2025 iSpecimen Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 21, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Num

August 21, 2025 EX-99.1

iSpecimen Announces Completion of Milestone 1 in Digital Transformation Journey with Salestack Platform

Exhibit 99.1 iSpecimen Announces Completion of Milestone 1 in Digital Transformation Journey with Salestack Platform Woburn, MA – August 21, 2025 – iSpecimen Inc. (NASDAQ: ISPC), an online marketplace for human biospecimens, today announced the successful completion of Milestone 1 in its digital transformation program powered by Salestack Solutions. This critical achievement marks the installation

August 20, 2025 S-1

As filed with the Securities and Exchange Commission on August 20, 2025

As filed with the Securities and Exchange Commission on August 20, 2025 Registration No.

August 20, 2025 EX-FILING FEES

Filing Fee Table

Ex-Filing Fees CALCULATION OF FILING FEE TABLES S-1 iSpecimen Inc. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Common Stock, $0.0001

August 14, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2025 ☐ TRANSITION REPORT PU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen Inc. (E

August 13, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive

August 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 7, 2025 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 7, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numb

August 7, 2025 EX-99.1

iSpecimen to Establish $200M Corporate Treasury Built Around Solana Cryptocurrency with BlockArrow

Exhibit 99.1 iSpecimen to Establish $200M Corporate Treasury Built Around Solana Cryptocurrency with BlockArrow Woburn, MA – August 7, 2025 – iSpecimen Inc. (NASDAQ: ISPC), a technology-enabled company modernizing the way human biospecimens are sourced for scientific research, today announced a major strategic initiative aimed at integrating digital assets into its business model. The company is l

August 5, 2025 EX-99.2

iSpecimen Inc. Announces Closing of Approximately $1.75 Million Private Placement Priced At-the-Market

Exhibit 99.2 iSpecimen Inc. Announces Closing of Approximately $1.75 Million Private Placement Priced At-the-Market WOBURN, Mass., Aug. 04, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today announced that it clo

August 5, 2025 EX-10.1

Form of Securities Purchase Agreement.

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 31, 2025, between iSpecimen Inc., a Delaware corporation (the “Company”), and each of the purchasers identified on the signature pages hereto (each, including its successors and assigns, an “Purchaser” and collectively the “Purchasers”). RECITALS A. The Company and each Purchaser is

August 5, 2025 EX-4.1

Form of Pre-Funded Warrant.

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

August 5, 2025 EX-10.3

Investor Relations Agreement by and between the Company and IR Agency LLC.

Exhibit 10.3 ADDENDUM TO CONSULTING AGREEMENT Dated August 1, 2025 This Addendum to Consulting Agreement (this “Addendum”) is entered into for the purpose of amending the Consulting Agreement between IR Agency LLC (the “Consultant” or “IR Agency”) and iSpecimen Inc. (“you,” the “Client” or the “Company”) dated as of July 25, 2025, to provide for the purchase of additional Services by the Company u

August 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 31, 2025 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 31, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

August 5, 2025 EX-99.1

iSpecimen Inc. Announces Pricing of Approximately $1.75 Million Private Placement Priced At-the-Market

Exhibit 99.1 iSpecimen Inc. Announces Pricing of Approximately $1.75 Million Private Placement Priced At-the-Market WOBURN, Mass., July 31, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today announced that it ent

August 5, 2025 EX-10.2

Form of Registration Rights Agreement.

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT THIS REGISTRATION RIGHTS AGREEMENT (“Agreement”) is entered into as of July 31, 2025 by and among iSpecimen Inc., a Delaware corporation (the “Company”), and the purchasers from time to time party hereto (each, a “Purchaser” and collectively, the “Purchasers”). This Agreement is made pursuant to the Securities Purchase Agreement, dated as of the date here

July 25, 2025 EX-99.1

iSpecimen Inc. Announces Pricing of $4 Million Underwritten Offering

Exhibit 99.1 iSpecimen Inc. Announces Pricing of $4 Million Underwritten Offering WOBURN, Mass., July 24, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the pricing of an underwritten public offerin

July 25, 2025 EX-99.2

iSpecimen Inc. Announces Closing of $4 Million Underwritten Offering

Exhibit 99.2 iSpecimen Inc. Announces Closing of $4 Million Underwritten Offering WOBURN, Mass., July 25, 2025 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the closing of its previously announced under

July 25, 2025 424B4

1,482,644 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 4,231,639 SHARES OF COMMON STOCK 4,231,639 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc.

PROSPECTUS Filed pursuant to Rule 424(b)(4) Registration No. 333-286958 1,482,644 SHARES OF COMMON STOCK PRE-FUNDED WARRANTS TO PURCHASE 4,231,639 SHARES OF COMMON STOCK 4,231,639 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc. We are offering on an underwritten basis 1,482,644 shares of our common stock, par value $0.0001 per share (the “Shares”) and 4,

July 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 23, 2025 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 23, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

July 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 9, 2025 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 9, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

July 10, 2025 EX-3.1

Third Amended and Restated Bylaws of iSpecimen Inc.

Exhibit 3.1 THIRD AMENDED AND RESTATED BY-LAWS OF ISPECIMEN INC. (as amended through July 9, 2025) ARTICLE I OFFICES Section 1.01 Registered Office. The registered office of iSpecimen Inc. (the “Corporation”) will be fixed in the Certificate of Incorporation of the Corporation, as may be amended from time to time (the “Certificate of Incorporation”). Section 1.02 Other Offices. The Corporation may

July 8, 2025 S-1/A

As filed with the Securities and Exchange Commission on July 8, 2025.

As filed with the Securities and Exchange Commission on July 8, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 4 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or org

June 27, 2025 S-1/A

As filed with the Securities and Exchange Commission on June 27, 2025.

As filed with the Securities and Exchange Commission on June 27, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or or

June 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 18, 2025 iSpecimen Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 18, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

June 11, 2025 EX-10.45

Consulting Agreement by and between the Company and IR Agency LLC.

Exhibit 10.45 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to iSpecimen Inc. (“you,” “Client” or “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services. 1. Consulting Services. (a) Commenc

June 11, 2025 S-1/A

As filed with the Securities and Exchange Commission on June 11, 2025.

As filed with the Securities and Exchange Commission on June 11, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 2 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or or

June 11, 2025 EX-10.46

Definitive Software Purchase and Services Agreement by and between the Company and Sales Stack Solutions Corp., a British Columbia Company.

Exhibit 10.46 Definitive Service Agreement for the Development of the SalesStack This Definitive Software Purchase and Services Agreement (the “Agreement”) is made and entered into as of the Effective Date (defined in Section 1.3 below), by and between: iSpecimen Inc., a Delaware corporation with its principal place of business at 8 Cabot Road, Woburn MA 01801 (the “Purchaser”), AND Sales Stack So

June 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 4, 2025 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 4, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 23, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables FORM S-1 (Form Type) ISPECIMEN INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price(1)(3) Fee Rate Amount of Registration Fee Fees to Be Paid Equity Common Stock,

May 23, 2025 EX-10.46

Form of Definitive Software Purchase and Services Agreement by and between the Company and Sales Stack Solutions Corp., a British Columbia Company.

Exhibit 10.46 Definitive Service Agreement for the Development of the SalesStack This Definitive Software Purchase and Services Agreement (the “Agreement”) is made and entered into as of the Effective Date (defined in Section 1.3 below), by and between: iSpecimen Inc., a Delaware corporation with its principal place of business at 8 Cabot Road, Woburn MA 01801 (the “Purchaser”), AND Sales Stack So

May 23, 2025 S-1/A

As filed with the Securities and Exchange Commission on May 23, 2025.

As filed with the Securities and Exchange Commission on May 23, 2025. Registration No. 333-286958 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1/A Amendment No. 1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or org

May 19, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2025 ☐ TRANSITION REPORT P

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2025 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501 iSpecimen Inc. (

May 15, 2025 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: March 31, 2025 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition Perio

May 2, 2025 EX-10.45

Form of Consulting Agreement by and between the Company and IR Agency LLC.

Exhibit 10.45 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to iSpecimen Inc (“you,” “Client” or “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which Company engages Consultant to provide such services. 1. Consulting Services. (a) Commenci

May 2, 2025 S-1

As filed with the Securities and Exchange Commission on May 2, 2025.

As filed with the Securities and Exchange Commission on May 2, 2025. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-0480143 (State or other jurisdiction of incorporation or organization) (Primary Stand

May 2, 2025 EX-1.1

Form of Underwriting Agreement between the Company and WestPark Capital, Inc.

Exhibit 1.1 ISPECIMEN INC. UNDERWRITING AGREEMENT [*], 2025 WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 As Representative of the Several underwriters, if any, named in Schedule I hereto Ladies and Gentlemen: The undersigned, ISPECIMEN INC., a corporation formed under the laws of the State of Delaware (the “Company”), hereby confirms its agreement (this “Agreement

May 2, 2025 EX-4.5

Form of Pre-Funded Warrant for Investors in this Offering.

Exhibit 4.5 PRE-FUNDED COMMON STOCK PURCHASE WARRANT ISPECIMEN INC. Warrant Shares: Issue Date: , 2025 Initial Exercise Date: , 2025 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after th

May 2, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables FORM S-1 (Form Type) ISPECIMEN INC. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price(1)(3) Fee Rate Amount of Registration Fee Fees to Be Paid Equity Common Stock,

May 2, 2025 EX-10.46

Form of Software Agreement by and between the Company and Sales Stack Solutions Corp., a British Columbia Company.

Exhibit 10.46 BETWEEN: iSpecimen Inc., a Delaware corporation, with its principal place of business at 8 Cabot Road, Woburn MA 01801 (the “Purchaser”) AND: Sales Stack Solutions Corp., a British Columbia Company, with a registered address at 25th Floor – 700 West Georgia Street, Vancouver B.C. V7Y 1K8 (the “Vendor”) WHEREAS: 1. The Purchaser has recently experienced technological challenges associ

April 14, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-40501 iSpecimen Inc. (Exact nam

March 26, 2025 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check One): ☒ Form 10-K ☐ Form 20-F ☐ Form 11-K ☐ Form 10-Q ☐ Form 10-D ☐ Form N-SAR ☐ Form N-CSR For Period Ended: December 31, 2024 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-K ☐ Transition Report o

March 11, 2025 EX-16.1

Letter from Wolf & Company, P.C., dated March 11, 2025.

Exhibit 16.1 March 11, 2025 Securities and Exchange Commission Washington, DC 20549 Commissioners: We have read iSpecimen Inc.’s statements included under Item 4.01 of its Form 8-K filed on March 11, 2025 and we agree with such statements concerning our firm. Boston, Massachusetts

March 11, 2025 8-K

Financial Statements and Exhibits, Changes in Registrant's Certifying Accountant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 7, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

February 28, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation

February 28, 2025 EX-10.1

Employment Agreement between iSpecimen Inc. and Katharyn Field, dated February 28, 2025

Exhibit 10.1 February 28th, 2025 Katharyn Field 22210 Woodset Lane Boca Raton, FL 33428 Dear Katie: I am pleased to confirm our offer to you of the position of President with iSpecimen Inc. (the “Company"), effective as of February 19, 2025 (your “Employment Date”). The purpose of this letter is to generally describe your employment with the Company and your agreement with the terms thereof. Job R

February 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19, 2025 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 19, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

January 16, 2025 EX-99.1

iSpecimen Secures Suppliers for COVID-style hMPV Outbreak

Exhibit 99.1 iSpecimen Secures Suppliers for COVID-style hMPV Outbreak WOBURN, Mass., Jan. 16, 2025 (Newsfile Corp.) - iSpecimen Inc. (NASDAQ: ISPC), a leading online marketplace for human biospecimens, has secured suppliers for the flu-like human metapneumovirus (hMPV). The virus has been causing hospitals in China to become overrun, raising the potential for another COVID-style pandemic. iSpecim

January 16, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 16, 2025 iSpecimen Inc. (

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 16, 2025 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

December 30, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 27, 2024 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 27, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

December 20, 2024 EX-10.1

Engagement Letter between iSpecimen Inc. and Yuying Liang Professional Corp., dated December 13, 2024 (incorporated by reference as Exhibit 10.1 to the Company’s Form 8-K filed with the SEC on December 20, 2024).

Exhibit 10.1 YUYING LIANG PROFESSIONAL CORP. Vancouver, British Columbia Canada Telephone +1 778 318 7278 Private and Confidential December 13, 2024 Ms. Katharyn Field Director iSpecimen Inc. 8 Cabot Road, Suite 1800 Woburn, MA 01801 United States Dear Board of Directors: We appreciate the opportunity to provide accounting services to iSpecimen Inc. the (“Company”) in connection with the bookkeepi

December 20, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

December 20, 2024 EX-99.1

iSpecimen will serve as a Preferred Provider of Cancer Biospecimens

Exhibit 99.1 iSpecimen will serve as a Preferred Provider of Cancer Biospecimens Woburn, MA, Dec. 20, 2024 (GLOBE NEWSWIRE) - iSpecimen Inc. (Nasdaq: ISPC), a leading online marketplace for human biospecimens, today announced its strategic initiatives for 2025, expanding services to procure high demand cancer biospecimens, enhancing its ability to support groundbreaking cancer research worldwide.

December 13, 2024 EX-99.1

iSpecimen Reports Positive Results on Next Day Quote Program for Researchers and Providers

Exhibit 99.1 iSpecimen Reports Positive Results on Next Day Quote Program for Researchers and Providers WOBURN, Mass., December 13, 2024 — iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today positive results attributed to its N

December 13, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2024 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 13, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

December 12, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 9, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

December 12, 2024 EX-10.1

Form of Independent Contractor Agreement, dated December 9, 2024, by and between iSpecimen Inc. and 1513932 B.C. Ltd., the personal corporation of Mr. Robert Bradley Lim.

Exhibit 10.1 INDEPENDENT CONTRACTOR AGREEMENT This Independent Contractor Agreement (the “Agreement”) is made and entered into as of this December 9, 2024, by and between iSpecimen Inc., a Delaware corporation, and Robert Bradley Lim (the “Contractor”) through his personal corporation, 1513932 B.C. Ltd., a company incorporated under the laws of the Province of British Columbia, Canada. 1. Engageme

December 12, 2024 EX-99.1

iSpecimen Appoints Robert Lim as CEO and Director

Exhibit 99.1 iSpecimen Appoints Robert Lim as CEO and Director WOBURN, Mass., December 12, 2024 — iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today that it has appointed Robert Lim as CEO and director. Mr. Lim is the principa

November 12, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 7, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-

October 31, 2024 EX-99.2

iSpecimen Inc. Announces Closing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants

Exhibit 99.2 iSpecimen Inc. Announces Closing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants WOBURN, Mass., October 31, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the closing of its previo

October 31, 2024 EX-4.1

Form of Pre-Funded Warrant (incorporated by reference as Exhibit 4.1 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 4.1 PRE-FUNDED COMMON STOCK PURCHASE WARRANT ISPECIMEN INC. Warrant Shares: Initial Exercise Date: , 2024 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (“Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Ini

October 31, 2024 424B4

132,814 SHARES OF COMMON STOCK        PRE-FUNDED WARRANTS TO PURCHASE 1,533,852 SHARES OF COMMON STOCK 1,533,852 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc.

TABLE OF CONTENTS  Filed pursuant to Rule 424(b)(4)  Registration No. 333-282736 PROSPECTUS 132,814 SHARES OF COMMON STOCK        PRE-FUNDED WARRANTS TO PURCHASE 1,533,852 SHARES OF COMMON STOCK 1,533,852 SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE OF THE PRE-FUNDED WARRANTS iSpecimen Inc. We are offering on a best-efforts basis 132,814 shares of our common stock, par value $0.0001 per share

October 31, 2024 EX-10.3

Form of Investor Relations Agreement (incorporated by reference as Exhibit 10.3 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 10.3 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to iSpecimen Inc. (“you,” the “Client” or the “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which the Company engages the Consultant to provide such services. 1. Consulting Servic

October 31, 2024 EX-10.1

Form of Placement Agency Agreement (incorporated by reference as Exhibit 10.1 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 10.1 WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 October 29, 2024 iSpecimen Inc. 8 Cabot Road Woburn, MA 01801 Attention: Tracy Curley Dear Ms. Curley: Subject to the terms and conditions of this letter agreement (the “Agreement”), between WestPark Capital, Inc., as lead placement agent (“Placement Agent”), and iSpecimen Inc., a company organized under th

October 31, 2024 EX-10.2

Form of Securities Purchase Agreement (incorporated by reference as Exhibit 10.2 to the Company’s Form 8-K filed with the SEC on October 31, 2024).

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of October 29, 2024, between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions set fo

October 31, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 29, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Nu

October 31, 2024 EX-99.1

iSpecimen Inc. Announces Pricing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants

Exhibit 99.1 iSpecimen Inc. Announces Pricing of $5 Million Public Offering of Common Stock and Pre-Funded Warrants WOBURN, Mass., October 29, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today the pricing of its public

October 28, 2024 CORRESP

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101

iSpecimen Inc. 8 Cabot Road, Suite 1800 Mt Woburn, WA 08101 October 28, 2024 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance Office of Industrial Applications and Services 100 F Street, N.E. Washington, D.C. 20549 Re: iSpecimen Inc. Request for Acceleration Registration Statement on Form S-1 File No. 333-282736 Ladies and Gentlemen: Pursuant to Rule 461 promulgate

October 28, 2024 CORRESP

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067

WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 October 28, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: iSpecimen Inc. Registration Statement on Form S-1 File No. 333-282736 REQUEST FOR ACCELERATION OF EFFECTIVENESS Requested Date:    Tuesday, October 29, 2024 Requested Ti

October 18, 2024 S-1

As filed with the Securities and Exchange Commission on October 18, 2024.

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on October 18, 2024.

October 18, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables S-1 (Form Type) iSpecimen Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price(1)(2) Fee Rate Amount of Registration Fee Fees to Be Paid Equity Co

October 18, 2024 EX-10.46

Form of Securities Purchase Agreement for this offering.

Exhibit 10.46 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of , 2024, between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditions set forth in th

October 18, 2024 EX-4.4

Form of Pre-Funded Warrant for Investors in this Offering.

Exhibit 4.4 PRE-FUNDED COMMON STOCK PURCHASE WARRANT ISPECIMEN INC. Warrant Shares: Initial Exercise Date: , 2024 THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (“Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Ini

October 18, 2024 EX-1.1

Form of Placement Agency Agreement between the Company and WestPark Capital, Inc.

Exhibit 1.1 WestPark Capital, Inc. 1800 Century Park East, Suite 220 Los Angeles, CA 90067 [ ] [ ], 2024 iSpecimen, Inc. 8 Cabot Road Woburn, MA 01801 Attention: Tracy Curley Dear Ms. Curley: Subject to the terms and conditions of this letter agreement (the “Agreement”), between WestPark Capital, Inc., as lead placement agent (“Placement Agent”), and iSpecimen, Inc., a company organized under the

October 18, 2024 EX-10.47

Form of Consulting Agreement by and between the Company and IR Agency LLC.

Exhibit 10.47 CONSULTING AGREEMENT IR Agency LLC (the “Consultant” or “IR Agency”) is pleased to provide certain consulting services to Ispecimen inc (“you,” the “Client” or the “Company”) as more fully described in this agreement (the “Agreement”). This Agreement sets forth the terms and conditions pursuant to which the Company engages the Consultant to provide such services. 1. Consulting Servic

October 2, 2024 8-K

Regulation FD Disclosure, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 25, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

September 25, 2024 EX-4.1

Senior Note, dated as of September 24, 2024 (incorporated by reference to Exhibit 4.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 25, 2024)

Exhibit 4.1 THIS SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAI

September 25, 2024 EX-10.1

Note Purchase Agreement, dated as of September 19, 2024 (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 25, 2024)

Exhibit 10.1 NOTE PURCHASE AGREEMENT This Note Purchase Agreement (this “Agreement”) is dated as of September 18, 2024 between iSpecimen Inc., a Delaware corporation (the “Company”), and the purchaser identified on the signature page (including its successors and assigns, the “Investor”. WHEREAS, the Investor wishes to purchase from the Company, and the Company wishes to issue and sell to the Inve

September 25, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 19, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File

September 11, 2024 EX-99.1

iSpecimen Announces 1-for-20 Reverse Stock Split

Exhibit 99.1 iSpecimen Announces 1-for-20 Reverse Stock Split WOBURN, Mass., September 11, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, announced today that it will effect a reverse stock split of its issued and outstanding share

September 11, 2024 8-K

Regulation FD Disclosure, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 11, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File

September 11, 2024 EX-3.1

Form of Certificate of Amendment to Fourth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 of the Company’s Current Report on Form 8-K filed with the SEC on September 11, 2024)

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF FOURTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF iSPECIMEN INC. A DELAWARE CORPORATION PURSUANT TO SECTION 242 OF THE GENERAL CORPORATION LAW OF THE STATE OF DELAWARE iSpecimen Inc., a corporation duly organized and existing under the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify that: First: That the na

August 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501

August 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 6, 2024 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 6, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

August 6, 2024 EX-99.1

iSpecimen Reports Second Quarter 2024 Results Revenue increased 76% year-over-year to approximately $2.86 million Brielan Smiechowski Named SVP of Sales and Business Development

Exhibit 99.1 iSpecimen Reports Second Quarter 2024 Results Revenue increased 76% year-over-year to approximately $2.86 million Brielan Smiechowski Named SVP of Sales and Business Development LEXINGTON, Mass., August 6, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network

August 6, 2024 EX-99.2

August 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement

Exhibit 99.2 August 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are characteri

July 22, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 17, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

July 8, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 5, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number

July 3, 2024 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 28, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

July 3, 2024 EX-10.2

Notice of Lease Termination, dated June 28, 2024 (incorporated by reference to Exhibit 10.2 of the Company’s Current Report on Form 8-K filed with the SEC on July 3, 2024)

Exhibit 10.2 450 Bedford Street | Lexington, MA 02420 | 781-301-6700 June 28, 2024 TO: BEDFORD STREET LLC: NOTICE OF LEASE TERMINATION This Notice of Lease Termination (the “Notice”) is in reference to the Seventh Amendment to the Lease Agreement (“Seventh Amendment”) dated September 27, 2023, by and between iSpecimen Inc. (“Tenant”) and Bedford Street LLC (“Landlord”). Date of Notice: June 28, 20

July 3, 2024 EX-10.1

Commercial Lease, dated July 2, 2024, between the Company and Cummings Properties, LLC (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on July 3, 2024)

Exhibit 10.1 CUMMINGS PROPERTIES, LLC COMMERCIAL LEASE Cummings Properties, LLC ("LESSOR") hereby leases to iSpecimen Inc. (a DE corp.), 450 Bedford Street, Suite 1010, Lexington, MA 02420 ("LESSEE"), the following premises, approximately 2,273 square feet (including 13% common area) at 8 Cabot Road, Suite 1800, Woburn, MA 01801 (“premises"), for an initial term of five years and two months commen

June 10, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

May 28, 2024 PRER14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 1) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION (Amendment No. 1) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as

May 17, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 16, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number

May 7, 2024 EX-99.2

This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterize

Exhibit 99.2 May 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by futur

May 7, 2024 EX-99.1

iSpecimen Reports First Quarter 2024 Results

Exhibit 99.1 iSpecimen Reports First Quarter 2024 Results LEXINGTON, Mass., May 7, 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results for the three-month period ended March 31, 2024. “

May 7, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 7, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number)

May 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-4050

April 11, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 9, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

March 28, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

March 26, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 21, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

March 14, 2024 EX-99.2

This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterize

Exhibit 99.2 March 2024 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by fut

March 14, 2024 EX-99.1

iSpecimen Reports Full Year 2023 Results

Exhibit 99.1 iSpecimen Reports Full Year 2023 Results LEXINGTON, Mass., March 14 2024 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results for the twelve-month period ended December 31, 2023.

March 14, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2024 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

March 13, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period fromto Commission file number: 001-40501 iSpecime

March 13, 2024 EX-97.1

iSpecimen Inc. Executive Compensation Clawback Policy (Adopted on October 27, 2023).

Exhibit 97.1 ISPECIMEN INC. EXECUTIVE COMPENSATION CLAWBACK POLICY Adopted as of October 27, 2023 The Board of Directors (the “Board”) of iSpecimen Inc. (the “Company”) has adopted the following executive compensation clawback policy (this “Policy”). This Policy shall supplement any other clawback or compensation recovery policy or policies adopted by the Company or included in any agreement betwe

March 5, 2024 EX-10.1

At the Market Offering Agreement, dated March 5, 2024, between the Company and Rodman & Renshaw LLC

Exhibit 10.1 AT THE MARKET OFFERING AGREEMENT March 5, 2024 Rodman & Renshaw LLC 600 Lexington Avenue, 32nd Floor New York, NY 10022 Ladies and Gentlemen: iSpecimen Inc., a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”) with Rodman & Renshaw LLC (the “Manager”) as follows: 1.             Definitions. The terms that follow, when used in t

March 5, 2024 424B5

iSpecimen Inc. Up to $1,500,000 of Common Stock

TABLE OF CONTENTS  Filed Pursuant to Rule 424(b)(5)  Registration Statement 333-265976 PROSPECTUS SUPPLEMENT (To Prospectus dated July 12, 2022) iSpecimen Inc.

March 5, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 5, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Numbe

February 15, 2024 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 13, 2024 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

February 15, 2024 EX-10.1

Form of Warrant Repurchase and Termination Agreements between the Company and certain Warrant Holders

Exhibit 10.1 WARRANT REPURCHASE AND TERMINATION AGREEMENT This WARRANT REPURCHASE AND TERMINATION AGREEMENT (this “Agreement”), dated and effective as of , 2024 (the “Effective Date”), is entered into by and between (“Warrant Holder”), and iSpecimen Inc., a Delaware corporation (the “Company”). The Warrant Holder and the Company are sometimes each referred to herein as a “Party” and collectively a

February 13, 2024 SC 13G/A

ISPC / iSpecimen Inc. / OBF Investments, LLC Passive Investment

SC 13G/A 1 tm61.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* iSpecimen Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

December 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 15, 2023 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 15, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File N

November 2, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-

November 2, 2023 EX-99.1

iSpecimen Reports Third Quarter 2023 Financial and Operating Results Sequential Quarterly Revenue Growth of 75% Driven by Enhanced Operational Efficiencies of iSpecimen Marketplace and Rollout of New Business Initiatives

Exhibit 99.1 iSpecimen Reports Third Quarter 2023 Financial and Operating Results Sequential Quarterly Revenue Growth of 75% Driven by Enhanced Operational Efficiencies of iSpecimen Marketplace and Rollout of New Business Initiatives LEXINGTON, Mass., November 2, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring bio

November 2, 2023 EX-99.2

November 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of

Exhibit 99.2 November 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are characte

November 2, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 2, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

October 23, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 23, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

October 23, 2023 EX-99.1

iSpecimen Preannounces Third Quarter 2023 Revenue Increase of 60-70% Sequentially Management to Host Third Quarter 2023 Conference Call on Thursday, November 2, 2023

Exhibit 99.1 iSpecimen Preannounces Third Quarter 2023 Revenue Increase of 60-70% Sequentially Management to Host Third Quarter 2023 Conference Call on Thursday, November 2, 2023 LEXINGTON, Mass., October 23, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of health

October 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 9, 2023 iSpecimen Inc. (E

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 9, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Num

September 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 6, 2023 iSpecimen Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 6, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File N

September 6, 2023 EX-99.1

iSpecimen Announces Organizational Changes to Enhance Operational Efficiencies and Drive Profitability Company to Focus on Core Revenue Drivers, New Revenue Growth Opportunities from Recently Launched Sequencing Procurement Program and Expense Reduct

Exhibit 99.1 iSpecimen Announces Organizational Changes to Enhance Operational Efficiencies and Drive Profitability Company to Focus on Core Revenue Drivers, New Revenue Growth Opportunities from Recently Launched Sequencing Procurement Program and Expense Reductions LEXINGTON, Mass., September 6, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace tha

August 2, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-40501

August 2, 2023 EX-99.2

August 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement

Exhibit 99.2 August 2023 Investor Presentation Nasdaq: ISPC The Online Marketplace for Human Biospecimens Transforming Biospecimen Procurement This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are characteri

August 2, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 2, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

August 2, 2023 EX-99.1

iSpecimen Reports Second Quarter 2023 Financial and Operating Results

Exhibit 99.1 iSpecimen Reports Second Quarter 2023 Financial and Operating Results LEXINGTON, Mass., August 2, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results for the three and six

July 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 7, 2023 iSpecimen Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 7, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 25, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 24, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of Incorporation) (Commission File Number

May 25, 2023 EX-10.1

Amendment No. 1 to iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan

AMENDMENT NO. 1 TO iSPECIMEN INC. AMENDED AND RESTATED 2021 STOCK INCENTIVE PLAN WHEREAS, iSpecimen Inc. (the “Company”) has adopted the 2021 Stock Incentive Plan, effective June 16, 2021, which was amended and restated twice since adoption and the Second Amended and Restated 2021 Stock Incentive Plan was approved by the of holders of the Company’s common stock (“Common Stock”), $0.0001 par value

May 4, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 4, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number)

May 4, 2023 EX-99.2

This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterize

Exhibit 99.2 May 2023 Investor Presentation Transforming Biospecimen Procurement An online marketplace for human biospecimens This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by future or condition

May 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-4050

May 4, 2023 EX-99.1

iSpecimen Reports First Quarter 2023 Results - Quarterly Revenue Increased 17% Year-Over-Year -

Exhibit 99.1 iSpecimen Reports First Quarter 2023 Results - Quarterly Revenue Increased 17% Year-Over-Year - LEXINGTON, MA, May 4, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists requiring biospecimens for medical research with a network of healthcare specimen providers, today reported its financial and operating results fo

April 17, 2023 SC 13D

ISPC / iSpecimen Inc / Ross Andrew L. - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* iSpecimen Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 45032V108 (CUSIP Number) Andrew L. Ross c/o iSpecimen Inc. 450 Bedford Street Lexington, MA 02420 (781) 301-6700 (Name, Address and Telephone Number of Person A

April 10, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 tm232091d5defa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (a

April 10, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

March 31, 2023 EX-10.2

Second Amendment to First Amended and Restated Executive Employment Agreement, dated March 31, 2023, by and between Tracy Wilson Curley and iSpecimen Inc.

Exhibit 10.2 SECOND AMENDMENT TO first amended and restated executive employment agreement This is a contractual amendment to the First Amended and Restated Executive Employment Agreement between iSpecimen, Inc. (the “Company”) and TRACY WILSON CURLEY (the “Executive”), executed on October 24th, 2022, as previously amended by the First Amendment to the First Amended and Restated Executive Employme

March 31, 2023 EX-10.1

Amendment No. 1 to iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan (incorporated by reference to Exhibit 10.1 of the Company’s Current Report on Form 8-K filed with the SEC on May 25, 2023)

Exhibit 10.1 first AMENDMENT TO first amended and restated executive employment agreement This is a contractual amendment to the First Amended and Restated Executive Employment Agreement between iSpecimen, Inc. (the “Company”) and TRACY WILSON CURLEY (the “Executive”), executed on October 24th, 2022 (the “Agreement”). WHEREAS, the Company and Executive do now mutually desire to amend the Agreement

March 31, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of the Commission Only (as permitted by Rule

March 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 31, 2023 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 31, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File Numb

March 30, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For The Transition Period FromTo Commission file number: 001-40501 iSpeci

March 21, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For The Transition Period FromTo Commission file number: 001-40501 iSpecimen Inc. (Exact name

March 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2023 iSpecimen Inc. (Ex

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 14, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

March 14, 2023 EX-99.2

CONNECT. INNOVATE. March 2023 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens

Exhibit 99.2 CONNECT. INNOVATE. March 2023 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are charac

March 14, 2023 EX-99.1

iSpecimen Reports Full Year 2022 Results - Reported Record Quarterly Revenue of $3.2 Million, Up 28% Year-Over-Year -

Exhibit 99.1 iSpecimen Reports Full Year 2022 Results - Reported Record Quarterly Revenue of $3.2 Million, Up 28% Year-Over-Year - LEXINGTON, MA, March 14, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists in need of biospecimens for medical research with a network of healthcare specimen providers, today reported its financia

February 13, 2023 SC 13G/A

ISPC / iSpecimen Inc. / OBF Investments, LLC Passive Investment

SC 13G/A 1 tm20.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* iSpecimen Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

January 12, 2023 SC 13G/A

ISPC / iSpecimen Inc. / Empery Asset Management, LP - ISPECIMEN INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* iSpecimen Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2022 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which this Sch

January 10, 2023 EX-99.1

iSpecimen Names Tracy Curley as Chief Executive Officer Previously Appointed Interim CEO in September 2022

Exhibit 99.1 iSpecimen Names Tracy Curley as Chief Executive Officer - Previously Appointed Interim CEO in September 2022 - LEXINGTON, Mass. – January 10, 2023 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists in need of biospecimens for medical research with a network of healthcare specimen providers, announced today that its Boa

January 10, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 9, 2023 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Num

December 30, 2022 424B3

Prospectus Supplement No. 1 to Reoffer Prospectus iSpecimen Inc.

Filed Pursuant to Rule 424(b)(3) Registration No. 333-261701 Prospectus Supplement No. 1 to Reoffer Prospectus of iSpecimen Inc. Up to 734,152 shares of Common Stock under the iSpecimen Inc. 2010 Stock Incentive Plan, the iSpecimen Inc. 2013 Stock Incentive Plan and the iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan. This Prospectus Supplement, dated December 30, 2022 (this ?

December 27, 2022 SC 13G/A

ISPC / iSpecimen Inc. / Wolf James G. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT §240.13d-2 (Amendment No. 1) iSPECIMEN INC. (Name of Issuer) Common Stock $.0001 Par Value (Title of Class of Securities) 45032V108 (CUSIP Number) December 23, 2022 (Date of

November 28, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 28, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File N

November 8, 2022 EX-99.1

iSpecimen Reports Third Quarter 2022 Financial and Operating Results - Reported Revenue of $2.6 Million, Comprised Of A Record 88% Non-COVID Revenue -

Exhibit 99.1 iSpecimen Reports Third Quarter 2022 Financial and Operating Results - Reported Revenue of $2.6 Million, Comprised Of A Record 88% Non-COVID Revenue - LEXINGTON, MA, November 8, 2022 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online global marketplace that connects scientists in need of biospecimens for medical research with a network of healthcare specimen pro

November 8, 2022 EX-99.2

Investor Presentation, dated November 2022.

Exhibit 99.2 CONNECT. INNOVATE. TRANSFORMING PROCUREMENT BIOSPECIMEN An online marketplace for human biospecimens November 2022 Investor Presentation Forward-Looking Statements This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking

November 8, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 8, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended September 30, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File No. 001-

October 28, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): October 24, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File Nu

October 28, 2022 EX-10.4

First Restated Noncompetition, Nonsolicitation, Nondisclosure and Inventions Agreement, dated October 24, 2022, by and between Benjamin Bielak and iSpecimen Inc. (incorporated by reference to Exhibit 10.4 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.4 iSpecimen, Inc. FIRST RESTATED NONCOMPETITION, NONSOLICITATION, NONDISCLOSURE AND INVENTIONS AGREEMENT The undersigned, BENJAMIN BIELAK, in consideration for and as a condition of employment as a senior executive officer (the ?Executive?) of iSpecimen, Inc. (the ?Company?), or for receiving stock or options, or any other form of compensation, salary, bonus, benefit or fringe benefits

October 28, 2022 EX-10.1

First Amended and Restated Executive Employment Agreement, dated October 24, 2022, by and between Tracy Wilson Curley and iSpecimen Inc. (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.1 iSpecimen, Inc. FIRST AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT This Amended and Restated Executive Employment Agreement (the ?Agreement?) made as of this 24 day of October, 2022, between Tracy Wilson Curley (the ?Executive?), and iSpecimen, Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?). Whereas, the Board of Directors of the Com

October 28, 2022 EX-10.5

Separation Agreement, dated October 24, 2022, by and between Christopher Ianelli and iSpecimen Inc. (incorporated by reference to Exhibit 10.5 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.5 October 24, 2022 Christopher Ianelli, MD, Ph.D. Re:??????Separation Agreement Dear Chris, This letter sets forth the substance of the separation agreement (the ?Agreement?) which ISPECIMEN INC. (the ?Company?) is offering to you to aid in your employment transition. Separation. Your last day of work with the Company and your employment termination date will be October 24, 2022 (the ?S

October 28, 2022 EX-10.3

First Amended and Restated Executive Employment Agreement, dated October 24, 2022, by and between Benjamin Bielak and iSpecimen Inc. (incorporated by reference to Exhibit 10.3 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.3 iSpecimen, Inc. FIRST AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT This Amended and Restated Executive Employment Agreement (the ?Agreement?) made as of this 24th day of October, 2022, between Benjamin Bielak (the ?Executive?), and iSpecimen, Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?). Whereas, the Board of Directors of the Compa

October 28, 2022 EX-10.6

Separation Agreement effective October 24, 2022, by and between Jill Mullan and iSpecimen Inc. (incorporated by reference to Exhibit 10.6 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.6 October 24, 2022 Jill Mullan Re:??????Separation Agreement Dear Jill, This letter sets forth the substance of the separation agreement (the ?Agreement?) which ISPECIMEN INC. (the ?Company?) is offering to you to aid in your employment transition. Separation. Your last day of work with the Company and your employment termination date will be October 24, 2022 (the ?Separation Date?). Th

October 28, 2022 EX-10.2

First Restated Noncompetition, Nonsolicitation, Nondisclosure and Inventions Agreement, dated October 24, 2022, by and between Tracy Wilson Curley and iSpecimen Inc. (incorporated by reference to Exhibit 10.2 of the Company’s Form 8-K filed with the SEC on October 28, 2022).

Exhibit 10.2 iSpecimen, Inc. FIRST RESTATED NONCOMPETITION, NONSOLICITATION, NONDISCLOSURE AND INVENTIONS AGREEMENT The undersigned, TRACY WILSON CURLEY, in consideration for and as a condition of employment as a senior executive officer (the ?Executive?) of iSpecimen, Inc. (the ?Company?), or for receiving stock or options, or any other form of compensation, salary, bonus, benefit or fringe benef

September 28, 2022 SC 13G

ISPC / iSpecimen Inc. / Wolf James G. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO §240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT §240.13d-2 (Amendment No. ) iSPECIMEN INC. (Name of Issuer) Common Stock $.0001 Par Value (Title of Class of Securities) 45032V108 (CUSIP Number) September 23, 2022 (Date of Ev

September 22, 2022 EX-99.1

iSpecimen Names Chief Financial Officer, Tracy Curley, Interim CEO Current President and CEO, Christopher Ianelli, to Leave Company

EX-99.1 2 tm2226424d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 iSpecimen Names Chief Financial Officer, Tracy Curley, Interim CEO - Current President and CEO, Christopher Ianelli, to Leave Company - LEXINGTON, Mass., September 22, 2022 – iSpecimen Inc. (Nasdaq: ISPC) (“iSpecimen” or the “Company”), an online global marketplace that connects scientists in need of biospecimens for medical research with a

September 22, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): September 19, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File

August 5, 2022 424B3

iSpecimen Inc. 2,598,473 Shares of Common Stock

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(3)? ?Registration No. 333-266384? PROSPECTUS iSpecimen Inc. 2,598,473 Shares of Common Stock This prospectus relates to the resale by the selling stockholders named herein, or their respective transferees, pledgees, donees or other successors-in-interest, from time to time, of up to an aggregate of 2,598,473 shares of common stock, par value $0.0001

August 4, 2022 EX-99.2

CONNECT. INNOVATE. August 2022 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens

Exhibit 99.2 CONNECT. INNOVATE. August 2022 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are chara

August 4, 2022 EX-99.1

iSpecimen Reports Second Quarter 2022 Financial and Operating Results - Enhanced iSpecimen Marketplace Platform® with Data Integration Capabilities to Simplify the Ingestion and Maintenance of Biospecimen Inventories for Providers -

Exhibit 99.1 iSpecimen Reports Second Quarter 2022 Financial and Operating Results - Enhanced iSpecimen Marketplace Platform? with Data Integration Capabilities to Simplify the Ingestion and Maintenance of Biospecimen Inventories for Providers - LEXINGTON, MA, August 4, 2022 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online global marketplace that connects scientists in nee

August 4, 2022 8-K

Results of Operations and Financial Condition, Results of Operations and Financial Condition, Regulation FD Disclosure, Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 4, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

August 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 3, 2022 CORRESP

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420 August 3, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Alyssa Wall Re: iSpecimen Inc. Registration Statement on Form S-3 Filed July 29, 2022 File No. 333-266384 Dear Ms. Wall: Pursuant to Rule 461 under the Securities Act of 1933, as amended,

July 29, 2022 S-3

As filed with the Securities and Exchange Commission on July 29, 2022

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on July 29, 2022 Registration No.

July 29, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) iSpecimen Inc. (Exact Name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered (1) Proposed Maximum Aggregate Offering Price Per Share (2) Maximum Aggregate Offering Price (2) Fee Rate Amount of Registration Fee (3) Equity Common Stock, $0.0001 par value per share Rule

July 8, 2022 CORRESP

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420

CORRESP 1 filename1.htm iSpecimen Inc. 450 Bedford Street Lexington, MA 02420 July 8, 2022 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Ryan Lichtenfels Re: iSpecimen Inc. Registration Statement on Form S-3 Filed July 1, 2022 File No. 333-265976 Dear Mr. Lichtenfels: Pursuant to Rule 461 under the Se

July 1, 2022 S-3

As filed with the Securities and Exchange Commission on July 1, 2022

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on July 1, 2022 Registration No.

July 1, 2022 EX-4.1

Form of Indenture

Exhibit 4.1 iSPECIMEN INC., as ISSUER and [ ], as INDENTURE TRUSTEE INDENTURE Dated as of [ ] TABLE OF CONTENTS Page ARTICLE I DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.01 Definitions 1 Section 1.02 Other Definitions 4 Section 1.03 Incorporation by Reference of Trust Indenture Act 4 Section 1.04 Rules of Construction 4 ARTICLE II THE SECURITIES 5 Section 2.01 Issuable in Series 5 Sect

July 1, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) iSpecimen Inc. (Exact Name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered (1)(2) Proposed Maximum Aggregate Offering Price Per Share (1)(2) Maximum Aggregate Offering Price (1)(2)(3) Fee Rate Amount of Registration Fee (3) Equity Common Stock, $0.0001 par value pe

June 21, 2022 EX-10.4

First Amendment to Executive Employment Agreement, dated as of June 20, 2022, between the Company and Benjamin Bielak (incorporated by reference to Exhibit 10.4 of the Company’s Form 8-K filed with the SEC on June 21, 2022).

Exhibit 10.4 iSpecimen Inc. first amendment to executive employment agreement This First Amendment to Executive Employment Agreement (this ?Amendment?) is made and entered into and effective as of June 20, 2022 (the ?Effective Date?), by and between iSpecimen Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?), and Benjamin Bielak (the ?Executive?). WHEREAS,

June 21, 2022 EX-10.2

First Amendment to Executive Employment Agreement, dated as of June 20, 2022, between the Company and Jill Mullan (incorporated by reference to Exhibit 10.2 of the Company’s Form 8-K filed with the SEC on June 21, 2022).

Exhibit 10.2 iSpecimen Inc. first amendment to executive employment agreement This First Amendment to Executive Employment Agreement (this ?Amendment?) is made and entered into and effective as of June 20, 2022 (the ?Effective Date?), by and between iSpecimen Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?), and Jill Mullan (the ?Executive?). WHEREAS, the

June 21, 2022 EX-10.1

First Amendment to Executive Employment Agreement, dated as of June 20, 2022, between the Company and Christopher Ianelli (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on June 21, 2022).

Exhibit 10.1 iSpecimen Inc. first amendment to executive employment agreement This First Amendment to Executive Employment Agreement (this ?Amendment?) is made and entered into and effective as of June 20, 2022 (the ?Effective Date?), by and between iSpecimen Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?), and Christopher Ianelli, MD, PhD (the ?Executiv

June 21, 2022 EX-10.3

First Amendment to Executive Employment Agreement, dated as of June 20, 2022, between the Company and Tracy Curley (incorporated by reference to Exhibit 10.3 of the Company’s Form 8-K filed with the SEC on June 21, 2022).

Exhibit 10.3 iSpecimen Inc. first amendment to executive employment agreement This First Amendment to Executive Employment Agreement (this ?Amendment?) is made and entered into and effective as of June 20, 2022 (the ?Effective Date?), by and between iSpecimen Inc., a Delaware corporation located at 450 Bedford St, Lexington, MA 02420 (the ?Company?), and Tracy Curley (the ?Executive?). WHEREAS, th

June 21, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 20, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File Numbe

June 7, 2022 424B3

iSpecimen Inc. 3,062,499 Shares of Common Stock

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(3)? ?Registration No. 333-261640? PROSPECTUS iSpecimen Inc. ? 3,062,499 Shares of Common Stock This prospectus relates to the offer and resale of up to an aggregate of 3,062,499 shares of common stock, par value $0.0001 per share, of iSpecimen Inc. held by selling stockholders, consisting of the following: (i) 1,749,999 shares of common stock (the ?

May 26, 2022 POS AM

As filed with the Securities and Exchange Commission on May 26, 2022

Table of Contents As filed with the Securities and Exchange Commission on May 26, 2022 Registration No.

May 26, 2022 EX-10.1

iSpecimen Inc. Second Amended and Restated 2021 Stock Incentive Plan (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on May 26, 2022).

Exhibit 10.1 iSPECIMEN INC. SECOND AMENDED AND RESTATED 2021 STOCK INCENTIVE PLAN 1. Purpose. The purpose of this 2021 Stock Incentive Plan, as amended from time to time (the ?Plan?) of iSpecimen Inc., a Delaware corporation (the ?Company?), is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who are expected to make

May 26, 2022 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 25, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or Other Jurisdiction of Incorporation) (Commission File Number

May 10, 2022 EX-99.1

iSpecimen Reports First Quarter 2022 Financial and Operating Results - Recently Launched Enhanced iSpecimen Marketplace Platform to Help Scientists More Efficiently Search for Biospecimens -

Exhibit 99.1 iSpecimen Reports First Quarter 2022 Financial and Operating Results - Recently Launched Enhanced iSpecimen Marketplace Platform to Help Scientists More Efficiently Search for Biospecimens - LEXINGTON, MA, May 10, 2022 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online global marketplace that connects scientists in need of biospecimens for medical research with

May 10, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): May 10, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Number

May 10, 2022 EX-99.2

CONNECT. INNOVATE. May 2022 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 19

Exhibit 99.2 CONNECT. INNOVATE. May 2022 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such forward-looking statements are characterized by

May 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 29, 2022 EX-10.1

Waiver Agreement, dated April 29, 2022, by and between the Company and Western Alliance Bank (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on April 29, 2022).

Exhibit 10.1 WAIVER AGREEMENT This Waiver Agreement (this ?Agreement?) is entered into this 29th day of April, 2022 by and between WESTERN ALLIANCE BANK, an Arizona corporation (?Bank?), and ISPECIMEN INC., a Delaware corporation (?Borrower?) whose address is 450 Bedford Street, Lexington, Massachusetts 02420. Recitals A. Among other indebtedness which may be owing by Borrower to Bank, Borrower is

April 29, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Triggering Events That Accelerate or Increase a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): April 25, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numb

April 14, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? Filed by the Registrant [X] ? ? Filed by a Party other than the Registrant [?] ? Check the appropriate box: [?] Preliminary Proxy Statement [?] Confidential, for Use of the Commission Only (as permitted

April 14, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 tm2210672d4defa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (

March 30, 2022 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

PRE 14A 1 tm2210672-1pre14a.htm PRE 14A TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [X] Preliminary Proxy Statement [ ] Confidential, for Use of t

March 22, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For The Transition Period FromTo Commission file number: 001-40501 iSpecimen Inc. (Exac

March 22, 2022 EX-4.3

Description of Securities (incorporated by reference to Exhibit 4.3 of the Company’s Form 10-K filed with the SEC on March 22, 2022).

? EXHIBIT 4.3 ? DESCRIPTION OF SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 ? Common Stock The following description is based on relevant portions of the Delaware General Corporation Law (the ?DGCL?) and our Fourth Amended and Restated Certificate of Incorporation (the ?Certificate of Incorporation?). This summary is a description of the material terms of, an

March 7, 2022 8-K

Shareholder Director Nominations

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): March 3, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

February 17, 2022 EX-99.2

CONNECT. INNOVATE. February 2022 Investor Presentation ( through Q4 2021) TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens

EX-99.2 3 tm227040d1ex99-2.htm EXHIBIT 99.2 Exhibit 99.2 CONNECT. INNOVATE. February 2022 Investor Presentation ( through Q4 2021) TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act o

February 17, 2022 EX-99.1

iSpecimen Reports Full Year 2021 Financial Results - Record FY 2021 Revenue of $11.1 Million, Surpassing FY 2020 Revenue of $8.2 Million by 36% -

Exhibit 99.1 iSpecimen Reports Full Year 2021 Financial Results - Record FY 2021 Revenue of $11.1 Million, Surpassing FY 2020 Revenue of $8.2 Million by 36% - LEXINGTON, MA, February 17, 2021 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online marketplace for human biospecimens, today reported its financial results for the three and twelve-month periods ended December 31, 202

February 17, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): February 17, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File N

February 14, 2022 SC 13G/A

ISPC / iSpecimen Inc. / Bleichroeder LP - ISPECIMEN - 13G/A Passive Investment

SC 13G/A 1 ispecimen13g.htm ISPECIMEN - 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) iSpecimen Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to desi

February 14, 2022 EX-99.1

Joint Filing Agreement

Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that this Schedule 13G (as so amended, the ?Schedule 13G?) with respect to the common stock of iSpecimen Inc. is, and any additional amendment thereto signed by each of the undersigned shall be, filed on behalf of each undersigned pursuant to and in accordance with the provisions of 13d-1(k) under the Securities Exchange Act of 1934,

February 14, 2022 SC 13G

ISPC / iSpecimen Inc. / OBF Investments, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 iSpecimen Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ? Rule 1

February 7, 2022 SC 13G

ISPC / iSpecimen Inc. / Ross Andrew L. - SC 13G Passive Investment

SC 13G 1 tm225639d1sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 iSpecimen Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to desi

January 24, 2022 SC 13G

ISPC / iSpecimen Inc. / Empery Asset Management, LP - ISPECIMEN INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* iSpecimen Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 45032V108 (CUSIP Number) December 31, 2021 (Date of event which requires filing of this statement) Check the appropriate box to designate the rule pursuant to which this Sche

January 10, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): January 10, 2022 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

December 23, 2021 424B3

The date of this prospectus is December 23, 2021.

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(3) ?Registration No. 333-261640? PROSPECTUS iSpecimen Inc. ? 3,062,499 Shares of Common Stock This prospectus relates to the offer and resale of up to an aggregate of 3,062,499 shares of common stock, par value $0.0001 per share, of iSpecimen Inc. held by selling stockholders, consisting of the following: (i) 1,749,999 shares of common stock (the ?S

December 21, 2021 CORRESP

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420 December 21, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Jennie Beysolow Re: iSpecimen Inc. Registration Statement on Form S-1 Filed December 14, 2021 File No. 333-261640 Dear Ms. Beysolow: Pursuant to Rule 461 under the Securities Act of 19

December 16, 2021 S-8

As filed with the Securities and Exchange Commission on December 16, 2021

As filed with the Securities and Exchange Commission on December 16, 2021 Registration No.

December 14, 2021 S-1

As filed with the Securities and Exchange Commission on December 14, 2021

Table of Contents ? As filed with the Securities and Exchange Commission on December 14, 2021 ? Registration No.

December 2, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 1, 2021 iSPECIMEN INC. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation or organizat

December 2, 2021 EX-99.1

iSpecimen Inc. Announces Closing of Approximately $21 Million Private Placement

Exhibit 99.1 iSpecimen Inc. Announces Closing of Approximately $21 Million Private Placement LEXINGTON, Mass., Dec. 1, 2021 /PRNewswire/ - iSpecimen Inc. (Nasdaq: ISPC) ("iSpecimen" or the "Company"), an online marketplace for human biospecimens, today announced that it has closed its previously announced private placement for the sale of 1,749,999 shares of common stock of iSpecimen together with

November 29, 2021 EX-10.1

Securities Purchase Agreement, dated November 28, 2021, by and between the Company and the purchasers named therein (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on November 29, 2021).

EX-10.1 3 tm2134042d1ex10-1.htm EXHIBIT 10.1 Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of November 28, 2021, between iSpecimen Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHER

November 29, 2021 EX-99.1

iSpecimen Inc. Announces $21 Million Private Placement

EX-99.1 6 tm2134042d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 iSpecimen Inc. Announces $21 Million Private Placement LEXINGTON, Mass., Nov. 28, 2021 /PRNewswire/ - iSpecimen Inc. (Nasdaq: ISPC) ("iSpecimen" or the "Company"), an online marketplace for human biospecimens, today announced that it has entered into a definitive securities purchase agreement for a private placement with three accredited in

November 29, 2021 EX-10.3

Placement Agency Agreement, dated November 28, 2021, by and between the Company and ThinkEquity LLC (incorporated by reference to Exhibit 10.3 of the Company’s Form 8-K filed with the SEC on November 29, 2021).

EX-10.3 5 tm2134042d1ex10-3.htm EXHIBIT 10.3 Exhibit 10.3 PLACEMENT AGENCY AGREEMENT November 28, 2021 ThinkEquity LLC 17 State Street, 22nd Floor New York, NY 10004 Ladies and Gentlemen: Introductory. This Placement Agency Agreement the (“Agreement”) sets forth the terms upon which ThinkEquity LLC, (“ThinkEquity” or the “Placement Agent”) shall be engaged by iSpecimen Inc., a corporation formed u

November 29, 2021 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 28, 2021 iSPECIMEN INC. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation or organiza

November 29, 2021 EX-10.2

Registration Rights Agreement, dated November 28, 2021, by and between the Company and the investors named therein (incorporated by reference to Exhibit 10.2 of the Company’s Form 8-K filed with the SEC on November 29, 2021).

Exhibit 10.2 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this ?Agreement?) is made and entered into as of November 28, 2021, by and between iSpecimen Inc., a Delaware corporation (the ?Company?), and each of the several purchasers signatory hereto (each such purchaser, a ?Purchaser? and, collectively, the ?Purchasers?). This Agreement is made pursuant to the Securities Purcha

November 29, 2021 EX-4.1

Form of Common Stock Purchase Warrant (incorporated by reference to Exhibit 4.1 of the Company’s Form 8-K filed with the SEC on November 29, 2021).

EX-4.1 2 tm2134042d1ex4-1.htm EXHIBIT 4.1 Exhibit 4.1 EXHIBIT C NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFF

November 4, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): November 4, 2021 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Nu

November 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 4, 2021 EX-99.1

CONNECT. INNOVATE. November 2021 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens

Exhibit 99.1 CONNECT. INNOVATE. November 2021 Investor Presentation TRANSFORMING BIOSPECIMEN PROCUREMENT An online marketplace for human biospecimens This presentation may contain forward - looking statements within the meaning of Section 27 A of the Securities Act of 1933 , as amended, and Section 21 E of the Securities Exchange Act of 1934 , as amended . Such forward - looking statements are cha

August 16, 2021 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 13, 2021 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Num

August 16, 2021 EX-10.1

Loan and Security Agreement (incorporated by reference to Exhibit 10.1 of the Company’s Form 8-K filed with the SEC on August 16, 2021).

Exhibit 10.1 ISPECIMEN INC., a DELAWARE corporation WESTERN ALLIANCE BANK, an arizona corporation LOAN AND SECURITY AGREEMENT This Loan And Security Agreement (this ?Agreement?) is entered into as of August 13, 2021, by and between Western Alliance Bank, an Arizona corporation (?Bank?) and ISPECIMEN INC., a Delaware corporation (?Borrower?). Recitals Borrower wishes to obtain credit from time to t

August 16, 2021 EX-10.2

Warrant to Purchase Common Stock issued to Western Alliance Bank on August 13, 2021 (incorporated by reference to Exhibit 10.2 of the Company’s Form 8-K filed with the SEC on August 16, 2021).

Exhibit 10.2 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE ?ACT?), AND MAY NOT BE SOLD, PLEDGED, OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER SUCH ACT OR PURSUANT TO RULE 144 OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY AND ITS COUNSEL, THAT SUCH REGISTRATION IS NOT REQUIRED.

August 10, 2021 EX-10.3

iSpecimen Inc. Amended and Restated 2021 Stock Incentive Plan (incorporated by reference to Exhibit 10.3 of the Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2021, with the SEC on August 10, 2021).

EXHIBIT 10.3 ? iSPECIMEN INC. AMENDED AND RESTATED 2021 STOCK INCENTIVE PLAN ? 1. Purpose. The purpose of this 2021 Stock Incentive Plan, as amended from time to time (the ?Plan?) of iSpecimen Inc., a Delaware corporation (the ?Company?), is to advance the interests of the Company?s stockholders by enhancing the Company?s ability to attract, retain and motivate persons who are expected to make imp

August 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): August 10, 2021 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Num

August 10, 2021 EX-99.1

iSpecimen Reports Second Quarter 2021 Financial Results -Delivered Revenue Growth of 93% Year-Over-Year- -Successfully Completed IPO Raising Total Gross Proceeds of $20.7 Million-

Exhibit 99.1 iSpecimen Reports Second Quarter 2021 Financial Results -Delivered Revenue Growth of 93% Year-Over-Year- -Successfully Completed IPO Raising Total Gross Proceeds of $20.7 Million- LEXINGTON, MA, August 10, 2021 ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online marketplace for human biospecimens, today reported its financial results for the three-month period en

August 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One)

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

July 9, 2021 SC 13G

ISPC / iSpecimen Inc. / Bleichroeder LP - ISPECIMEN - 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No. ) iSpecimen Inc. (Name of Issuer) Common Shares (Title of Class of Securities) 45032V108 (CUSIP Number) June 21, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is f

July 1, 2021 EX-99.1

iSpecimen Announces Closing of Over-Allotment Option in Connection with its Initial Public Offering

Exhibit 99.1 iSpecimen Announces Closing of Over-Allotment Option in Connection with its Initial Public Offering LEXINGTON, MA, July 1, 2021 /PRNewswire/ ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online marketplace for human biospecimens, today announced the closing of the issuance of an additional 337,500 shares of its common stock pursuant to the full exercise of the und

July 1, 2021 8-K

Financial Statements and Exhibits, Other Events

8-K 1 tm2121201d18k.htm FORM 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): July 1, 2021 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incor

June 22, 2021 EX-99.2

iSpecimen Announces Closing of Initial Public Offering

Exhibit 99.2 iSpecimen Announces Closing of Initial Public Offering LEXINGTON, MA, June 21, 2021 /PRNewswire/ ? iSpecimen Inc. (Nasdaq: ISPC) (?iSpecimen? or the ?Company?), an online marketplace for human biospecimens, today announced the closing of its previously announced initial public offering of 2,250,000 shares of its common stock at a price of $8.00 per share, for gross proceeds of $18,000

June 22, 2021 EX-1.1

Underwriting Agreement between the Company and ThinkEquity, a division of Fordham Financial Management, Inc.

Exhibit 1.1 UNDERWRITING AGREEMENT between iSPECIMEN INC. and THINKEQUITY A DIVISION OF FORDHAM FINANCIAL MANAGEMENT, INC. as Representative of the Several Underwriters iSPECIMEN INC. UNDERWRITING AGREEMENT New York, New York June 16, 2021 ThinkEquity A Division of Fordham Financial Management, Inc. As Representative of the several Underwriters named on Schedule 1 attached hereto 17 State Street,

June 22, 2021 EX-3.2

Second Amended and Restated Bylaws (incorporated by reference to Exhibit 3.2 of the Company’s Form 8-K filed with the SEC on June 22, 2021).

Exhibit 3.2 SECOND AMENDED AND RESTATED BY-LAWS OF ISPECIMEN INC. ARTICLE I OFFICES Section 1.01 Registered Office. The registered office of iSpecimen Inc. (the ?Corporation?) will be fixed in the Certificate of Incorporation of the Corporation, as may be amended from time to time (the ?Certificate of Incorporation?). Section 1.02 Other Offices. The Corporation may have other offices, both within

June 22, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): June 16, 2021 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 001-40501 27-0480143 (State or other jurisdiction of incorporation) (Commission File Numbe

June 22, 2021 EX-99.1

iSpecimen Announces Pricing of Initial Public Offering

Exhibit 99.1 iSpecimen Announces Pricing of Initial Public Offering LEXINGTON, Mass., June 16, 2021 /PRNewswire/ - iSpecimen Inc. ("iSpecimen" or the "Company"), an online marketplace for human biospecimens, today announced the pricing of its initial public offering of 2,250,000 shares of its common stock at a price of $8.00 per share, for gross proceeds of $18,000,000 before deducting underwritin

June 22, 2021 EX-3.1

Fourth Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 of the Company’s Form 8-K filed with the SEC on June 22, 2021).

Exhibit 3.1 Delaware Page 1 The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE RESTATED CERTIFICATE OF ?ISPECIMEN INC.?, FILED IN THIS OFFICE ON THE SEVENTEENTH DAY OF JUNE, A.D. 2021, AT 10:14 O`CLOCK A.M. AND I DO HEREBY FURTHER CERTIFY THAT THE EFFECTIVE DATE OF THE AFORESAID RESTATED CERTIFICATE I

June 18, 2021 424B4

Per Share

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(4) ?Registration No. 333-250198? PROSPECTUS 2,250,000 Shares Common Stock iSpecimen Inc. ? This is a firm commitment initial public offering of common stock of iSpecimen Inc. Prior to this offering, there has been no public market for our common stock. The initial public offering price of our common stock is $8.00 per share. Our common stock has bee

June 14, 2021 8-A12B

Form 8-A

8-A12B 1 tm2035427d238a12b.htm 8-A12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 iSpecimen Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 27-0480143 (State of Incorporation or Organization) (I.R.S. Employer Identific

June 14, 2021 CORRESP

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420

iSpecimen Inc. 450 Bedford Street Lexington, MA 02420 June 14, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Katherine Bagley Re: iSpecimen Inc. Registration Statement on Form S-1 Filed November 19, 2020, as amended File No. 333-250198 Dear Ms. Bagley: Pursuant to Rule 461 under the Securities Ac

June 14, 2021 CORRESP

ThinkEquity A division of Fordham Financial Management, Inc. 17 State Street, 22nd Floor New York, NY 10004

ThinkEquity A division of Fordham Financial Management, Inc. 17 State Street, 22nd Floor New York, NY 10004 June 14, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporate Finance 100 F St., NE Washington, D.C. 20549 Re: iSpecimen Inc. Registration Statement on Form S-1 Ladies and Gentlemen: Pursuant to Rule 461 of the General Rules and Regulations of the U.S. Securities and

May 28, 2021 FWP

Free Writing Prospectus iSpecimen Inc. Presentation

Filed Pursuant to Rule 433 Issuer Free Writing Prospectus Dated May 28, 2021 (To Preliminary Prospectus dated May 27, 2021) Registration Statement No.

May 27, 2021 S-1/A

As filed with the U.S. Securities and Exchange Commission on May 27, 2021.

S-1/A 1 tm2035427-18424b4.htm 424B4 TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on May 27, 2021. Registration No. 333-250198 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 6 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 iSpecimen Inc. (Exact name of registrant as specified in its charter) Delaware 8731 27-

May 13, 2021 S-1/A

As filed with the U.S. Securities and Exchange Commission on May 13, 2021.

TABLE OF CONTENTS As filed with the U.S. Securities and Exchange Commission on May 13, 2021. Registration No. 333-250198? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ? Amendment No. 5 to FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933? ? iSpecimen Inc. (Exact name of registrant as specified in its charter) ? ? Delaware ? ? 8731 ? ? 27-0480143 ? ? (S

April 27, 2021 EX-99.2

Form of Compensation Committee Charter.**

Exhibit 99.2 COMPENSATION COMMITTEE CHARTER OF ISPECIMEN INC. The responsibilities and powers of this Compensation Committee (the ?Committee?) as delegated by the Board of Directors (the ?Board?) of iSpecimen Inc. (the ?Company?) are set forth in this charter. Whenever the Committee takes an action, it shall exercise its independent judgment on an informed basis that the action is in the best inte

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