OLMA / Olema Pharmaceuticals, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Olema Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US68062P1066

Mga Batayang Estadistika
CIK 1750284
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Olema Pharmaceuticals, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
September 2, 2025 8-K

FORM 8-K Item 7.01 Regulation FD Disclosure. Item 8.01 Other Events. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 02, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Com

September 2, 2025 EX-99.1

Olema Oncology Announces New Clinical Trial Agreement with Pfizer to Combine Palazestrant with Atirmociclib in ER+/HER2-

Exhibit 99.1 Olema Oncology Announces New Clinical Trial Agreement with Pfizer to Combine Palazestrant with Atirmociclib in ER+/HER2- Metastatic Breast Cancer • Study to explore the palazestrant-atirmociclib combination in approximately 35 patients with initiation anticipated in H2 2025 • Results to inform potential pivotal Phase 3 trial of novel combination in frontline metastatic breast cancer s

August 11, 2025 10-Q

Item 1. Financial Statements. Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations. Item 4. Controls and Procedures. Item 1. Legal Proceedings. Item 1A. Risk Factors. Item 2. Unregistered Sales of Equity Secur

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

August 11, 2025 EX-10.2

Second Amendment to Loan and Security Agreement by and between the Registrant and Silicon Valley Bank, a division of First-Citizens Bank & Trust Company, dated June 27, 2025

Exhibit 10.2  SECOND amendment to Loan and security agreement This Second Amendment to Loan and Security Agreement (this “Amendment”) is entered into this 27th day of June, 2025, by and between Silicon Valley Bank, a division of First-Citizens Bank & Trust Company (“Bank”) and OLEMA PHARMACEUTICALS, INC., a Delaware corporation (“Borrower”). Recitals A. Bank and Borrower have entered into that ce

August 11, 2025 EX-99.2

Advancing medicines for breast cancer and beyond Corporate Overview August 2025

Advancing medicines for breast cancer and beyond Corporate Overview August 2025 Forward-looking statements and legal disclaimer This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

August 11, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 7.01 Regulation FD Disclosure. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commis

August 11, 2025 EX-10.1

Olema Pharmaceuticals, Inc. Amended and Restated Non-Employee Director Compensation Policy

Exhibit 10.1 Olema Pharmaceuticals, Inc. Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) of Olema Pharmaceuticals, Inc. (the “Company”) who is not also serving as an employee of the Company or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy (thi

August 11, 2025 EX-99.1

Olema Oncology Reports Second Quarter 2025 Financial and Operating Results

Exhibit 99.1 Olema Oncology Reports Second Quarter 2025 Financial and Operating Results • Selected 90 mg once-daily palazestrant for Part 2 of the OPERA-01 Phase 3 monotherapy trial and for the OPERA-02 Phase 3 trial in combination with ribociclib • OPERA-01 enrollment ongoing with top-line data expected in the second half of 2026; OPERA-02 on track to initiate in Q3 2025 • Mature data from the Ph

June 13, 2025 8-K

FORM 8-K Item 5.07 Submission of Matters to a Vote of Security Holders.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 10, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commissi

May 13, 2025 EX-99.1

Olema Oncology Reports First Quarter 2025 Financial and Operating Results

Exhibit 99.1 Olema Oncology Reports First Quarter 2025 Financial and Operating Results • Pivotal Phase 3 OPERA-02 trial of palazestrant in combination with ribociclib in frontline metastatic breast cancer on track for initiation in 2025, supported by promising updated efficacy data from ongoing Phase 1b/2 study • Pivotal Phase 3 OPERA-01 trial of palazestrant monotherapy in 2/3L metastatic breast

May 13, 2025 10-Q

Item 1. Financial Statements. Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations. Item 4. Controls and Procedures. Item 1. Legal Proceedings. Item 1A. Risk Factors. Item 2. Unregistered Sales of Equity Secur

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

May 13, 2025 EX-10.1

Olema Pharmaceuticals, Inc. Amended and Restated Non-Employee Director Compensation Policy

Exhibit 10.1 Olema Pharmaceuticals, Inc. Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) of Olema Pharmaceuticals, Inc. (the “Company”) who is not also serving as an employee of the Company or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy (thi

May 13, 2025 8-K

FORM 8-K Item 2.02 Results of Operations and Financial Condition. Item 9.01 Financial Statements and Exhibits.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commissio

April 28, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitte

April 28, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant þ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

March 18, 2025 EX-10.25

Clinical Trial Collaboration and Supply Agreement by and between the Registrant and Novartis Pharma AG, dated November 29, 2024.

Exhibit 10.25 Certain identified information has been excluded from this exhibit because it is both not material and is the type that the registrant treats as private or confidential. Information that was omitted has been noted in this document with a placeholder identified by the mark “[***]”. CLINICAL TRIAL COLLABORATION AND SUPPLY AGREEMENT (FOR PHASE III CLINICAL STUDY OF OP-1250 IN COMBINATIO

March 18, 2025 EX-97.1

Olema Pharmaceuticals, Inc. Incentive Compensation Recoupment Policy

Exhibit 97.1 Olema Pharmaceuticals, Inc. Incentive Compensation Recoupment Policy 1. Introduction The Compensation Committee (the “Compensation Committee”) of the Board of Directors (the “Board”) of Olema Pharmaceuticals, Inc., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment

March 18, 2025 S-8

As filed with the Securities and Exchange Commission on March 18, 2025

As filed with the Securities and Exchange Commission on March 18, 2025 Registration No.

March 18, 2025 EX-19.1

Olema Pharmaceuticals, Inc. Insider Trading Policy

EXHIBIT 19.1 Olema Pharmaceuticals, Inc. Insider Trading Policy 1. Introduction During the course of your relationship with Olema Pharmaceuticals, Inc. (the “Company”), you may receive material information that is not yet public (“material nonpublic information”) about the Company or about other publicly traded companies with which the Company has business relationships. Material nonpublic informa

March 18, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Olema Pharmaceuticals, Inc.

March 18, 2025 EX-10.26

Amendment Number No. 1 to the Drug Discovery Collaboration and License Agreement by and between the Registrant and Aurigene Oncology Limited, dated May 2, 2024

Exhibit 10.26 [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Amendment Number No. 1 to Drug Discovery Collaboration and License Agreement THIS AMENDMENT NO. 1 (the “Amendment”), is made and entered into as of the date of the last

March 18, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commiss

March 18, 2025 EX-99.1

Olema Oncology Reports Fourth Quarter and Full Year 2024 Financial and Operating Results

Exhibit 99.1 Olema Oncology Reports Fourth Quarter and Full Year 2024 Financial and Operating Results • Pivotal Phase 3 OPERA-01 trial of palazestrant as a monotherapy in patients with second- and third-line metastatic breast cancer on track for top-line data in 2026 • Pivotal Phase 3 OPERA-02 trial of palazestrant in combination with ribociclib in patients with frontline metastatic breast cancer

March 18, 2025 EX-10.18

Offer Letter by and between the Registrant and Shawnte Mitchell, dated January 27, 2025

EXHIBIT 10.18 January 27, 2025 Shawnte Mitchell EMAIL/DOCUSIGN Re: Employment Terms Dear Shawnte: Olema Pharmaceuticals, Inc. (the “Company”) is pleased to offer you employment as its Chief Legal Officer and Corporate Secretary, pursuant to the terms of this offer letter agreement (the “Agreement”). 1. Position; Duties. You will have overall responsibility for legal, corporate governance and compl

March 18, 2025 EX-10.27

Amendment Number No. 2 to the Drug Discovery Collaboration and License Agreement by and between the Registrant and Aurigene Oncology Limited, dated November 15, 2024

Exhibit 10.27 [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. Amendment Number No. 2 to Drug Discovery Collaboration and License Agreement THIS AMENDMENT NO. 2 (the “Amendment”), is made and entered into as of the date of the last

March 18, 2025 EX-1.1

OLEMA PHARMACEUTICALS, INC. COMMON STOCK SALES AGREEMENT

Exhibit 1.1 OLEMA PHARMACEUTICALS, INC. $100,000,000 COMMON STOCK SALES AGREEMENT March 9, 2023 Oppenheimer & Co. Inc. 85 Broad Street New York, New York 10004 Ladies and Gentlemen: Olema Pharmaceuticals, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Oppenheimer & Co. Inc. (the “Agent”), as follows: 1. Issuance and Sale of Shares. The Company agrees that, from time to time d

March 18, 2025 EX-21.1

Olema Pharmaceuticals, Inc.

Exhibit 21.1 Olema Pharmaceuticals, Inc. Subsidiaries Name of Subsidiary Jurisdiction of Incorporation Olema Oncology Australia PTY LTD Australia

March 18, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents ` UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 18, 2025 EX-10.14

Olema Pharmaceuticals, Inc. 2022 Inducement Plan, as amended December 5, 2024.

Exhibit 10.14 Olema Pharmaceuticals, Inc. 2022 Inducement Plan Adopted by the Board of Directors: January 19, 2022 Amended by the Compensation Committee of the Board of Directors: December 5, 2024 Effective: January 1, 2025 1. General. (a) Eligible Award Recipients. The only persons eligible to receive grants of Awards under this Plan are individuals who satisfy the standards for inducement grants

March 5, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 05, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commiss

March 5, 2025 EX-99.1

Forward-looking statements This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Statements in this presentation that are not statements of historica

Advancing medicines for breast cancer and beyond Corporate Overview March 2025 EXHIBIT 99.

January 15, 2025 424B3

27,533,038 Shares of Common Stock

424B3 1 d842969d424b3.htm 424B3 Table of Contents Filed Pursuant to Rule 424(b)(3) Registration No. 333-284131 PROSPECTUS 27,533,038 Shares of Common Stock This prospectus relates to the resale by the selling stockholders identified in this prospectus from time to time of up to an aggregate of 27,533,038 shares of our common stock, which consists of (i) 19,928,875 shares of our common stock and (i

January 15, 2025 424B5

Up to $150,000,000 Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-284146 PROSPECTUS Up to $150,000,000 Common Stock We have entered into a sales agreement, dated January 6, 2025, or the Sales Agreement, with TD Securities (USA) LLC, or TD Cowen, relating to shares of our common stock offered by this prospectus. In accordance with the terms of the Sales Agreement, we may offer and sell shares

January 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commi

January 13, 2025 EX-99.1

Forward-looking statements This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Statements in this presentation that are not statements of historica

Advancing medicines for breast cancer and beyond Corporate Overview January 2025 EXHIBIT 99.

January 13, 2025 CORRESP

OLEMA PHARMACEUTICALS, INC. 780 Brannan Street San Francisco, California 94103

CORRESP OLEMA PHARMACEUTICALS, INC. 780 Brannan Street San Francisco, California 94103 January 13, 2025 VIA EDGAR Securities and Exchange Commission Office of Finance Division of Corporation Finance 100 F. Street N.E. Washington, D.C. 20549-3010 RE: Olema Pharmaceuticals, Inc.   Registration Statement on Form S-3 (File No. 333-284146)   Request for Acceleration of Effective Date Ladies and Gentlem

January 13, 2025 CORRESP

OLEMA PHARMACEUTICALS, INC. 780 Brannan Street San Francisco, California 94103

CORRESP OLEMA PHARMACEUTICALS, INC. 780 Brannan Street San Francisco, California 94103 January 13, 2025 VIA EDGAR Securities and Exchange Commission Office of Finance Division of Corporation Finance 100 F. Street N.E. Washington, D.C. 20549-3010 RE: Olema Pharmaceuticals, Inc. Registration Statement on Form S-3 (File No. 333-284131) Request for Acceleration of Effective Date Ladies and Gentlemen:

January 10, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 10, 2025 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commi

January 10, 2025 EX-4.1

Form of Exchange Warrant

Exhibit 4.1 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY OTHER APPLICABLE SECURITIES LAWS AND HAVE BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND SUCH OTHER APPLICABLE SECURITIES LAWS. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE

January 6, 2025 EX-4.3

Form of Indenture

Exhibit 4.3 Olema Pharmaceuticals, Inc., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20 Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificate 8

January 6, 2025 EX-4.6

Form of Preferred Stock Warrant Agreement and Warrant Certificate

Exhibit 4.6 OLEMA PHARMACEUTICALS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF OLEMA PHARMACEUTICALS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between OLEMA PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] orga

January 6, 2025 S-3

As filed with the Securities and Exchange Commission on January 6, 2025

Table of Contents As filed with the Securities and Exchange Commission on January 6, 2025 Registration No.

January 6, 2025 EX-1.2

Sales Agreement between Olema Pharmaceuticals, Inc. and TD Securities (USA) LLC, dated January 6, 2025

Exhibit 1.2 OLEMA PHARMACEUTICALS, INC. $150,000,000 SALES AGREEMENT January 6, 2025 TD Securities (USA) LLC 1 Vanderbilt Avenue New York, New York 10017 Ladies and Gentlemen: Olema Pharmaceuticals, Inc. (the “Company”), confirms its agreement (this “Agreement”) with TD Securities (USA) LLC (“TD Cowen”), as follows: 1. Issuance and Sale of Shares. The Company agrees that, from time to time during

January 6, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Olema Pharmaceuticals, Inc.

January 6, 2025 EX-4.7

Form of Debt Securities Warrant Agreement and Warrant Certificate

Exhibit 4.7 OLEMA PHARMACEUTICALS, INC. AND        , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF       OLEMA PHARMACEUTICALS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [•], between OLEMA PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking asso

January 6, 2025 EX-4.5

Form of Common Stock Warrant Agreement and Warrant Certificate

Exhibit 4.5 OLEMA PHARMACEUTICALS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF OLEMA PHARMACEUTICALS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between OLEMA PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] organized and

January 3, 2025 EX-FILING FEES

Filing Fee Table.

EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Olema Pharmaceuticals, Inc.

January 3, 2025 S-3

As filed with the Securities and Exchange Commission on January 3, 2025

S-3 Table of Contents As filed with the Securities and Exchange Commission on January 3, 2025 Registration No.

December 11, 2024 SC 13G

OLMA / Olema Pharmaceuticals, Inc. / Bain Capital Life Sciences Opportunities IV, L.P. - SC 13G Passive Investment

SC 13G 1 d904837dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G (Rule 13d-102) Information to be Included in Statements Filed Pursuant to § 240.13d-1(b), (c) and (d) and Amendments Thereto Filed Pursuant to § 240.13d-2 Under the Securities Exchange Act of 1934 (Amendment No. ) OLEMA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock, $0.0001 pa

December 10, 2024 EX-99.3

Legal disclaimer This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Statements in this presentation that are not statements of historical fact are

Palazestrant in Combination with Ribociclib Clinical Update SABCS 2024 December 10, 2024 EXHIBIT 99.

December 10, 2024 EX-99.1

Olema Oncology Announces FDA Clearance of Investigational New Drug Application for OP-3136, a Potent KAT6 Inhibitor

EX-99.1 2 olma-ex991.htm EX-99.1 PRESS RELEASE, DATED DECEMBER 9, 2024, OF OLEMA PHARMACEUTICALS, INC. EXHIBIT 99.1 Olema Oncology Announces FDA Clearance of Investigational New Drug Application for OP-3136, a Potent KAT6 Inhibitor • Phase 1 clinical trial for OP-3136 to initiate in early 2025 SAN FRANCISCO, CA - (GLOBE NEWSWIRE) - December 9, 2024 - Olema Pharmaceuticals, Inc. (“Olema” or “Olema

December 10, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 09, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Comm

December 10, 2024 EX-99.2

# # #

EXHIBIT 99.2 Olema Oncology Presents Updated Clinical Results for Palazestrant in Combination with Ribociclib at the San Antonio Breast Cancer Symposium • Palazestrant, in combination with ribociclib, demonstrated promising clinical activity, a safety profile consistent with ribociclib and endocrine therapy, and favorable tolerability in patients with ER+/HER2- advanced or metastatic breast cancer

December 4, 2024 SC 13D/A

OLMA / Olema Pharmaceuticals, Inc. / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 3 TO SCHEDULE 13D Activist Investment

SC 13D/A 1 sc13da307422olma12042024.htm AMENDMENT NO. 3 TO SCHEDULE 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 3)1 Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 pe

December 2, 2024 EX-10.1

Form of 2024 Purchase Agreement, dated November 29, 2024 (incorporated by reference to Exhibit 10.1 of the Issuer’s Current Report on Form 8-K filed with the Securities and Exchange Commission on December 2, 2024).

EXHIBIT 10.1 OLEMA PHARMACEUTICALS, INC. SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (the “Agreement”) is made as of November 29, 2024 (the “Effective Date”), by and among Olema Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and the purchasers whose names and addresses are set forth on the signature pages hereof (each, a “Purchaser” and, collectively, the “Purc

December 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 29, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Comm

December 2, 2024 EX-99.1

Olema Oncology Announces New Clinical Trial Collaboration and Supply Agreement with Novartis in Frontline Metastatic Breast Cancer as well as $250 Million Equity Private Placement

EXHIBIT 99.1 Olema Oncology Announces New Clinical Trial Collaboration and Supply Agreement with Novartis in Frontline Metastatic Breast Cancer as well as $250 Million Equity Private Placement • Clinical trial collaboration and supply agreement enables pivotal Phase 3 OPERA-02 clinical trial of palazestrant in combination with ribociclib in frontline ER+/HER2- metastatic breast cancer; trial initi

December 2, 2024 EX-4.1

Form of Pre-Funded and Exchange Warrant

EXHIBIT 4.1 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY OTHER APPLICABLE SECURITIES LAWS AND HAVE BEEN ISSUED IN RELIANCE UPON AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND SUCH OTHER APPLICABLE SECURITIES LAWS. NEITHER THIS SECURITY NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE

November 14, 2024 SC 13G/A

OLMA / Olema Pharmaceuticals, Inc. / Paradigm Biocapital Advisors LP - SC 13G/A Passive Investment

SC 13G/A 1 tm2427604d9sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 68062P106 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this state

November 14, 2024 SC 13G/A

OLMA / Olema Pharmaceuticals, Inc. / Deep Track Capital, LP Passive Investment

SC 13G/A 1 deeptrack-olma093024a1.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

November 12, 2024 EX-99.1

Olema Oncology Reports Third Quarter 2024 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Olema Oncology Reports Third Quarter 2024 Financial Results and Provides Corporate Update • Presented compelling new preclinical data demonstrating anti-tumor activity for OP-3136, a novel KAT6 inhibitor, with enhanced activity of palazestrant combinations at EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (ENA 2024) • New clinical data for palazestrant (OP-1250)

November 12, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Comm

September 27, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 27, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Com

September 27, 2024 EX-99.1

Advancing medicines for breast cancer and beyond Corporate Overview September 2024

Advancing medicines for breast cancer and beyond Corporate Overview September 2024 Forward-looking statements This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

August 6, 2024 EX-10.1

First Amendment to Loan and Security Agreement by and between the Registrant and Silicon Valley Bank, a division of First-Citizens Bank & Trust Company, dated June 28, 2024

[ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL.

August 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

August 6, 2024 EX-10.2

Olema Pharmaceuticals, Inc. Amended and Restated Non-Employee Director Compensation Policy

Exhibit 10.2 Olema Pharmaceuticals, Inc. Amended and Restated Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) of Olema Pharmaceuticals, Inc. (the “Company”) who is not also serving as an employee of the Company or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Com

August 6, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 06, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commis

August 6, 2024 EX-99.1

Olema Oncology Reports Second Quarter 2024 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports Second Quarter 2024 Financial Results and Provides Corporate Update • Presented promising interim clinical results from the ongoing study of palazestrant in combination with ribociclib at the 2024 ESMO Breast Cancer Congress. Updated results expected to be presented at a future medical meeting • Successfully completed Investigational New Drug (IND)-enabling stud

July 2, 2024 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 28, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commissi

June 14, 2024 EX-99

JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)

EX-99 2 p24-2172exhibit99.htm JOINT FILING AGREEMENT PURSUANT TO RULE 13D-1(K) EXHIBIT 99.1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without t

June 14, 2024 SC 13G

OLMA / Olema Pharmaceuticals, Inc. / Point72 Asset Management, L.P. - OLEMA PHARMACEUTICALS INC. Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) June 4, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant

June 14, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commissi

June 6, 2024 SC 13D/A

OLMA / Olema Pharmaceuticals, Inc. / Logos Global Management LP Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2) Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 60862P106 (CUSIP Number) Derek Gould Logos Global Management LP One Letterman Drive, Building D, Suite D3-700 San Francisco, CA 94129 Tel

May 15, 2024 EX-99.1

Olema Oncology Announces Promising New Data for Palazestrant in Combination with Ribociclib Presented at the 2024 ESMO Breast Cancer Congress

Exhibit 99.1 Olema Oncology Announces Promising New Data for Palazestrant in Combination with Ribociclib Presented at the 2024 ESMO Breast Cancer Congress • Across 50 treated patients, palazestrant (OP-1250) in combination with ribociclib was well tolerated with no new safety signals or increased toxicity and no clinically meaningful impact on drug exposure of either therapy • 85% clinical benefit

May 15, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commissio

May 15, 2024 EX-99.2

ESMO Breast Cancer 2024 Palazestrant-Ribociclib Combination Interim Results May 15, 2024

ESMO Breast Cancer 2024 Palazestrant-Ribociclib Combination Interim Results May 15, 2024 Forward-Looking Statements This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

May 8, 2024 EX-99.1

Olema Oncology Reports First Quarter 2024 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports First Quarter 2024 Financial Results and Provides Corporate Update • Completed enrollment in 60-patient Phase 1b/2 clinical studies of palazestrant in combination with each of ribociclib and palbociclib • New clinical data from palazestrant-ribociclib combination study to be presented at the ESMO Breast Cancer Annual Congress 2024 in Berlin, Germany. Olema will

May 8, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 08, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commissio

May 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

May 8, 2024 EX-10.1

Amendment No. 2 to Amended and Restated Clinical Collaboration and Supply Agreement, by and between the Company and Novartis Institutes for BioMedical Research, Inc., dated March 22, 2024.

Exhibit 10.1 Amendment No. 2 to Amended and Restated Clinical Collaboration and Supply Agreement Reference is hereby made to the Clinical Collaboration and Supply Agreement, dated July 22, 2020, as amended via the Amended and Restated Clinical Collaboration and Supply Agreement, dated January 13, 2022, and the Amendment No. 1 to Amended and Restated Clinical Collaboration and Supply Agreement, dat

April 26, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☑ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitte

April 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant þ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

March 22, 2024 SC 13G

OLMA / Olema Pharmaceuticals, Inc. / Deep Track Capital, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

March 11, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 11, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commiss

March 11, 2024 EX-1.1

OLEMA PHARMACEUTICALS, INC. COMMON STOCK SALES AGREEMENT

Exhibit 1.1 OLEMA PHARMACEUTICALS, INC. $100,000,000 COMMON STOCK SALES AGREEMENT March 9, 2023 Oppenheimer & Co. Inc. 85 Broad Street New York, New York 10004 Ladies and Gentlemen: Olema Pharmaceuticals, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Oppenheimer & Co. Inc. (the “Agent”), as follows: 1. Issuance and Sale of Shares. The Company agrees that, from time to time d

March 11, 2024 EX-21.1

Subsidiaries of the Registrant.

Exhibit 21.1 Olema Pharmaceuticals, Inc. Subsidiaries Name of Subsidiary Jurisdiction of Incorporation Olema Oncology Australia PTY LTD Australia

March 11, 2024 S-8

As filed with the Securities and Exchange Commission on March 11, 2024

As filed with the Securities and Exchange Commission on March 11, 2024 Registration No.

March 11, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents ` UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 11, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Olema Pharmaceuticals, Inc.

March 11, 2024 EX-99.1

Olema Oncology Reports Fourth Quarter and Full-Year 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports Fourth Quarter and Full-Year 2023 Financial Results and Provides Corporate Update • Presented compelling clinical results for palazestrant both as a monotherapy and in combination with CDK4/6 inhibitors, ribociclib and palbociclib, in Q4 2023 • Initiated OPERA-01 pivotal Phase 3 monotherapy trial in Q4 2023; top-line results expected in 2026 • 60-patient Phase 2

March 11, 2024 EX-97.1

Incentive Compensation Recoupment Policy.

Exhibit 97.1 Olema Pharmaceuticals, Inc. Incentive Compensation Recoupment Policy 1. Introduction The Compensation Committee (the “Compensation Committee”) of the Board of Directors (the “Board”) of Olema Pharmaceuticals, Inc., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment

February 14, 2024 SC 13G/A

OLMA / Olema Pharmaceuticals, Inc. / Kynam Capital Management, LP - KYNAM CAPITAL MANAGEMENT, LP Passive Investment

SC 13G/A 1 olmaa221424.htm KYNAM CAPITAL MANAGEMENT, LP UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* OLEMA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the

February 14, 2024 SC 13G/A

OLMA / Olema Pharmaceuticals, Inc. / Cormorant Asset Management, LP Passive Investment

SC 13G/A 1 schedule13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

February 14, 2024 SC 13G/A

OLMA / Olema Pharmaceuticals, Inc. / Paradigm Biocapital Advisors LP - SC 13G/A Passive Investment

SC 13G/A 1 tm245955d9sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this stateme

February 12, 2024 424B3

13,211,381 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) Registration No. 333-276787 PROSPECTUS 13,211,381 Shares of Common Stock This prospectus relates to the resale from time to time of up to 13,211,381 shares of our common stock held by the selling stockholders identified in this prospectus, which were issued by us in a private placement on September 12, 2023. We are not selling any shares of common stock under this

February 7, 2024 CORRESP

Olema Pharmaceuticals, Inc. 780 Brannan Street San Francisco, California 94103

Olema Pharmaceuticals, Inc. 780 Brannan Street San Francisco, California 94103 February 7, 2024 VIA EDGAR Securities and Exchange Commission Office of Finance Division of Corporation Finance 100 F. Street N.E. Washington, D.C. 20549-3010 RE: Olema Pharmaceuticals, Inc. Registration Statement on Form S-3 (File No. 333-276787) Request for Acceleration of Effective Date Ladies and Gentlemen: Olema Ph

January 31, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Olema Pharmaceuticals, Inc.

January 31, 2024 S-3

As filed with the Securities and Exchange Commission on January 31, 2024

As filed with the Securities and Exchange Commission on January 31, 2024 Registration No.

January 8, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 08, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commi

January 8, 2024 EX-99.1

Olema Oncology JP Morgan Conference January 2024

Olema Oncology JP Morgan Conference January 2024 Forward-Looking Statements This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

January 8, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 08, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commi

January 8, 2024 EX-99.1

Olema Oncology Nominates OP-3136, an Orally Bioavailable KAT6 Inhibitor, as a Development Candidate OP-3136 demonstrated potent anti-tumor activity alone and in combination with both palazestrant and CDK4/6 inhibitors in preclinical ER+ breast cancer

Exhibit 99.1 Olema Oncology Nominates OP-3136, an Orally Bioavailable KAT6 Inhibitor, as a Development Candidate OP-3136 demonstrated potent anti-tumor activity alone and in combination with both palazestrant and CDK4/6 inhibitors in preclinical ER+ breast cancer models Initiating IND-enabling studies with goal to advance into clinical development by end of 2024 SAN FRANCISCO, Jan. 08, 2024 – Olem

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 05, 2024 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Commi

January 5, 2024 EX-1.1

Sales Agreement by and between Registrant and Cowen and Company, LLC, dated January 5, 2024

Exhibit 1.1 Olema Pharmaceuticals, inc. 150,000,000 SHARES COMMON STOCK SALES AGREEMENT January 5, 2024 Cowen and Company, LLC 599 Lexington Avenue New York, NY 10022 Ladies and Gentlemen: Olema Pharmaceuticals, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Cowen and Company, LLC (“TD Cowen”), as follows: 1. Issuance and Sale of Shares. The Company agrees that, from time to

January 5, 2024 424B5

$150,000,000 Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-263117 PROSPECTUS SUPPLEMENT (To prospectus dated May 2, 2022) $150,000,000 Common Stock We have entered into a sales agreement, dated January 5, 2024, or the ATM Agreement, with Cowen and Company, LLC, or TD Cowen, relating to shares of our common stock offered by this prospectus supplement and accompanying prospectus.

December 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 06, 2023 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Comm

December 6, 2023 EX-99.1

Olema SABCS December 2023 Presentation December 6, 2023

Olema SABCS December 2023 Presentation December 6, 2023 Forward-Looking Statements This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

December 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 05, 2023 Olema Pharmaceuticals, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39712 30-0409740 (State or Other Jurisdiction of Incorporation) (Comm

December 5, 2023 EX-99.1

Olema Oncology Announces Palazestrant Demonstrates Attractive Combinability with CDK4/6 Inhibitors Ribociclib and Palbociclib in Phase 1b/2 Studies

Exhibit 99.1 Olema Oncology Announces Palazestrant Demonstrates Attractive Combinability with CDK4/6 Inhibitors Ribociclib and Palbociclib in Phase 1b/2 Studies • Palazestrant (OP-1250) in combination with the CDK 4/6 inhibitors, ribociclib and palbociclib, demonstrated no significant drug-drug interaction, no dose-limiting toxicities and a tolerability profile consistent with the FDA-approved lab

November 28, 2023 SC 13D/A

OLMA / Olema Pharmaceuticals Inc / Logos Global Management LP Activist Investment

SC 13D/A 1 olma13da.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1) Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 60862P106 (CUSIP Number) Derek Gould Logos Global Management LP One Letterman Drive, Building D, Suite D3-700 San

November 7, 2023 EX-99.1

Olema Oncology Reports Third Quarter 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports Third Quarter 2023 Financial Results and Provides Corporate Update ● OPERA-01 pivotal Phase 3 monotherapy clinical trial on track, with clinical site activation ongoing and first patient expected to be enrolled in fourth quarter ● New clinical data for palazestrant (OP-1250) in combination with CDK4/6 inhibitors to be presented at the 2023 San Antonio Breast Can

November 7, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Empl

November 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

October 23, 2023 EX-99.2

2 Forward-Looking Statements and Other Disclaimers This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Statements in this presentation that are not

Exhibit 99.2 1 ESMO 2023 Palazestrant Phase 2 Monotherapy Clinical Study Results October 23, 2023 2 Forward-Looking Statements and Other Disclaimers This presentation contains forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Statements in this presentation that are not statements of historical fact are forward-looking s

October 23, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 22, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Empl

October 23, 2023 EX-99.1

Olema Oncology Announces Positive Phase 2 Monotherapy Clinical Study Results for Palazestrant

Exhibit 99.1 Olema Oncology Announces Positive Phase 2 Monotherapy Clinical Study Results for Palazestrant · Across all 86 heavily pretreated patients, the median PFS was 4.6 months with a CBR of 40%; in patients with ESR1 mutations at baseline, the median PFS was 5.6 months with a CBR of 52% · In an analysis of 49 second- and third-line patients, the median PFS was 7.2 months with a CBR of 48%; t

October 18, 2023 8-K/A

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Em

October 18, 2023 EX-99.1

Olema Oncology Appoints Oncology Biotech Executive Scott Garland to Board of Directors Mr. Garland brings significant industry expertise with a long track record of successful launches

Exhibit 99.1 Olema Oncology Appoints Oncology Biotech Executive Scott Garland to Board of Directors Mr. Garland brings significant industry expertise with a long track record of successful launches SAN FRANCISCO, October 17, 2023 – Olema Pharmaceuticals, Inc. (“Olema” or “Olema Oncology,” Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development and commercial

October 17, 2023 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 13, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Empl

October 17, 2023 EX-99.1

Olema Oncology Appoints Oncology Biotech Executive Scott Garland to Board of Directors Mr. Garland brings significant industry expertise with a long track record of successful launches

Exhibit 99.1 Olema Oncology Appoints Oncology Biotech Executive Scott Garland to Board of Directors Mr. Garland brings significant industry expertise with a long track record of successful launches SAN FRANCISCO, October 17, 2023 – Olema Pharmaceuticals, Inc. (“Olema” or “Olema Oncology,” Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on the discovery, development and commercial

October 10, 2023 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 9, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Emplo

October 10, 2023 EX-99.1

Olema Oncology Announces Expansion of Collaboration Agreement with Novartis Amended clinical collaboration and supply agreement increases the palazestrant/ribociclib combination Phase 1/2 clinical study size to approximately 60 patients Expanded stud

Exhibit 99.1 Olema Oncology Announces Expansion of Collaboration Agreement with Novartis Amended clinical collaboration and supply agreement increases the palazestrant/ribociclib combination Phase 1/2 clinical study size to approximately 60 patients Expanded study supports the potential late-stage development of palazestrant in first-line advanced or metastatic breast cancer in combination with ri

October 10, 2023 EX-10.1

Amendment No. 1 to Amended and Restated Clinical Collaboration and Supply Agreement, by and between the Company and Novartis Institutes for BioMedical Research, Inc., dated October 9, 2023.

Exhibit 10.1 Amendment No. 1 to Amended and Restated Clinical Collaboration and Supply Agreement Reference is hereby made to the Clinical Collaboration and Supply Agreement, dated July 22, 2020, as amended via the Amended and Restated Clinical Collaboration and Supply Agreement, dated January 13, 2022 (collectively the “Agreement”), by and between Olema Pharmaceuticals, Inc., a Delaware corporatio

September 14, 2023 SC 13D/A

OLMA / Olema Pharmaceuticals Inc / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 2 TO SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 2)1 Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) JAMES KR

September 13, 2023 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / Paradigm Biocapital Advisors LP - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 68062P106 (CUSIP Number) September 12, 2023 (Date of Event Which Requires Filing of this statement) Check the appropriate box to designa

September 5, 2023 EX-99.1

Olema Oncology Announces Combined Financing for Up to $180 Million $130 million equity private placement led by Paradigm BioCapital with participation by Lightspeed Venture Partners, Deep Track Capital, BVF Partners L.P., Cormorant Asset Management,

Exhibit 99.1 Olema Oncology Announces Combined Financing for Up to $180 Million $130 million equity private placement led by Paradigm BioCapital with participation by Lightspeed Venture Partners, Deep Track Capital, BVF Partners L.P., Cormorant Asset Management, Vivo Capital, Logos Capital, and Woodline Partners LP Senior secured credit facility for up to $50 million provided by Silicon Valley Ban

September 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2023 Olema Pharmaceu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Emp

September 5, 2023 EX-10.1

Stock Purchase Agreement by and among the Registrant and the Purchasers named therein, dated September 5, 2023

Exhibit 10.1 OLEMA PHARMACEUTICALS, INC. STOCK PURCHASE AGREEMENT This Stock Purchase Agreement (the “Agreement”) is made as of September 5, 2023 (the “Effective Date”), by and among Olema Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and the purchasers whose names and addresses are set forth on the signature pages hereof (each, a “Purchaser” and, collectively, the “Purchasers”).

September 5, 2023 EX-10.2

Loan and Security Agreement by and between the Registrant and Silicon Valley Bank, a division of First-Citizens Bank & Trust Company, dated September 5, 2023

Exhibit 10.2 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as of the Effective Date between SILICON VALLEY BANK, a division of First-Citizens Bank & Trust Company (“Bank”) and OLEMA PHARMACEUTICALS, INC., a Delaware corporation (“Borrower”). The parties agree as follows. The parties agree as follows: 1LOAN AND TERMS OF PAYMENT 1.1Term Loan. (a)Availabilit

August 8, 2023 EX-99.1

Olema Oncology Reports Second Quarter 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports Second Quarter 2023 Financial Results and Provides Corporate Update ● Initiation of OPERA-01 pivotal Phase 3 monotherapy clinical trial on track; expecting to enroll first patient in fourth quarter ● New clinical data for palazestrant (OP-1250) to be presented in the fourth quarter including both monotherapy and CDK4/6 inhibitor combination updates ● Cash, cash

August 8, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employ

August 8, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

June 21, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 Olema Pharmaceutica

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employe

May 11, 2023 EX-99.1

Olema Oncology Announces OP-1250 Continues to Demonstrate Attractive Combinability with CDK4/6 Inhibitor Palbociclib in Phase 1b/2 Study

Olema Oncology Announces OP-1250 Continues to Demonstrate Attractive Combinability with CDK4/6 Inhibitor Palbociclib in Phase 1b/2 Study ● OP-1250 in combination with palbociclib was well-tolerated in patients with ER+/HER2- metastatic breast cancer, with no dose-limiting toxicities, and no observed drug-drug interaction ● Overall tolerability profile of the combination is consistent with the FDA-approved label of palbociclib plus an endocrine agent ● Tumor responses have been observed in patients previously treated with CDK4/6 inhibitors SAN FRANCISCO, May 11, 2023 – Olema Pharmaceuticals, Inc.

May 11, 2023 EX-99.2

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Exhibit 99.2  -           -  $&+&2 $$ #(("#(' ( %'(#))$# $#)#( $','8!$$ # ())"#)( " %*'(*#) )$ ) ( '$' %'$+($#( $ ) '+) *')( ))$# $'" -) $ BJJF3 ))"#)( # )( %'(#))$# )) ' #$) ())"#)( $ ()$'! ) ' $','8!$$ # ())"#)(3 * $','8!$$ # ())"#)(

May 11, 2023 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employer

May 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employer

May 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

May 9, 2023 EX-99.1

Olema Oncology Reports First Quarter 2023 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports First Quarter 2023 Financial Results and Provides Corporate Update ● Initiation of first pivotal Phase 3 monotherapy clinical trial of OP-1250 in second- and third-line metastatic breast cancer planned for the second half of 2023 ● Interim Phase 2 clinical results of OP-1250 in combination with palbociclib to be presented at the 2023 ESMO Breast Cancer Annual Co

May 9, 2023 EX-10.3

Separation Agreement by and between the Registrant and Kinney Horn, dated March 8, 2023

Exhibit 10.3 March 8, 2023 Kinney Horn VIA EMAIL Dear Kinney: This letter sets forth the substance of the separation and consulting agreement (the “Agreement”) that Olema Pharmaceuticals, Inc. (the “Company”) is offering to you to aid in your employment transition. 1.SEPARATION. Your employment termination date will be March 24, 2023 (the “Separation Date”). 2.ACCRUED SALARY. On the Separation Dat

May 9, 2023 EX-10.2

Separation Agreement by and between the Registrant and Cyrus Harmon, dated March 21, 2023

Exhibit 10.2 March 21, 2023 Cyrus Harmon VIA EMAIL Dear Cyrus: This letter sets forth the substance of the separation agreement (the “Agreement”) that Olema Pharmaceuticals, Inc. (the “Company”) is offering to you to aid in your employment transition. 1.SEPARATION. Your employment termination date will be March 24, 2023 (the “Separation Date”). Notwithstanding the termination of your employment re

May 9, 2023 EX-10.1

Amended and Restated Clinical Collaboration and Supply Agreement by and between the Registrant and Novartis Institutes for BioMedical Research, Inc., dated January 13, 2022.

Exhibit 10.1 Certain confidential information contained in this document, marked by [***], has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed. AMENDED AND RESTATED CLINICAL COLLABORATION AND SUPPLY AGREEMENT This AMENDED AND RESTATED CLINICAL COLLABORATION AND SUPPLY AGREEMENT (the “Agreement”) is made and entered into effective as of

April 28, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 tmb-20230428xdefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant þ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Com

April 28, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant þ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitte

April 10, 2023 SC 13G

OLMA / Olema Pharmaceuticals Inc / Paradigm Biocapital Advisors LP - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 68062P106 (CUSIP Number) March 29, 2023 (Date of Event Which Requires Filing of this statement) Check the appropriate box to designate th

March 22, 2023 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / Kynam Capital Management, LP - KYNAM CAPITAL MANAGEMENT, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* OLEMA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 30, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

March 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Olema Pharmaceutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employ

March 9, 2023 S-8

As filed with the Securities and Exchange Commission on March 9, 2023

As filed with the Securities and Exchange Commission on March 9, 2023 Registration No.

March 9, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Olema Pharmaceuticals, Inc.

March 9, 2023 424B5

$100,000,000 Common Stock

TABLE OF CONTENTS  Filed Pursuant to Rule 424(b)(5)  Registration No. 333-263117 PROSPECTUS SUPPLEMENT (To prospectus dated May 2, 2022) $100,000,000 Common Stock We have entered into a sales agreement, dated March 9, 2023, or the ATM Agreement, with Oppenheimer & Co. Inc., or Oppenheimer, relating to shares of our common stock offered by this prospectus supplement and accompanying prospectus. In

March 9, 2023 EX-1.1

Sales Agreement by and between Registrant and Oppenheimer & Co. Inc., dated March 9, 2023.

EX-1.1 2 olma-20221231xex1d1.htm EX-1.1 Exhibit 1.1 OLEMA PHARMACEUTICALS, INC. $100,000,000 COMMON STOCK SALES AGREEMENT March 9, 2023 Oppenheimer & Co. Inc. 85 Broad Street New York, New York 10004 Ladies and Gentlemen: Olema Pharmaceuticals, Inc. (the “Company”), confirms its agreement (this “Agreement”) with Oppenheimer & Co. Inc. (the “Agent”), as follows: 1.Issuance and Sale of Shares. The C

March 9, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-39712 OLEMA P

March 9, 2023 EX-21.1

Subsidiaries of the Registrant as of December 31, 2022.

Exhibit 21.1 Olema Pharmaceuticals, Inc. Subsidiaries Name of Subsidiary Jurisdiction of Incorporation Olema Oncology Australia PTY LTD Australia

March 9, 2023 EX-99.1

Olema Oncology Reports Fourth Quarter and Full-Year 2022 Financial Results and Provides Strategic Update

Exhibit 99.1 Olema Oncology Reports Fourth Quarter and Full-Year 2022 Financial Results and Provides Strategic Update ● Significant progress made advancing lead program, OP-1250, with more than 170 patients treated to date ● Initiating first pivotal Phase 3 monotherapy clinical trial of OP-1250 in second- and third-line metastatic breast cancer in the second half of 2023 ● Corporate restructuring

March 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 Olema Pharmaceutica

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 9, 2023 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employe

February 14, 2023 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / Fairmount Funds Management LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, Par Value $0.0001 (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate the rule

February 14, 2023 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / Cormorant Asset Management, LP Passive Investment

SC 13G/A 1 schedule13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate

February 10, 2023 SC 13G

OLMA / Olema Pharmaceuticals Inc / Kynam Capital Management, LP - KYNAM CAPITAL MANAGEMENT, LP Passive Investment

SC 13G 1 olma21023.htm KYNAM CAPITAL MANAGEMENT, LP UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 OLEMA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 30, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to desi

February 9, 2023 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 1)* Name of issuer: Olema Pharmaceuticals Inc. Title of Class of Securities: Common Stock CUSIP Number: 68062P106 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to designate the rule pursuant to which this Schedule is f

February 6, 2023 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / WELLINGTON MANAGEMENT GROUP LLP - SEC SCHEDULE 13G Passive Investment

SC 13G/A 1 SEC13GFiling.htm SEC SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2 )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 30, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriat

December 16, 2022 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 15, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Emp

December 16, 2022 EX-3.1

Amended and Restated Bylaws.

EXHIBIT 3.1 AMENDED AND RESTATED BYLAWS ? OF ? OLEMA PHARMACEUTICALS, INC. (A DELAWARE CORPORATION) AS AMENDED AND RESTATED ON DECEMBER 15, 2022 ARTICLE I ? OFFICES Section 1.Registered Office. The registered office of Olema Pharmaceuticals, Inc. (the ?Corporation?) in the State of Delaware shall as set forth in the certificate of incorporation of the Corporation, as the same may be amended or res

November 14, 2022 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* OLEMA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) November 14, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to design

November 8, 2022 EX-99.1

Olema Oncology Reports Third Quarter 2022 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports Third Quarter 2022 Financial Results and Provides Corporate Update ● Presented preliminary results from OP-1250 Phase 1/2 dose expansion study demonstrating favorable tolerability, high drug exposure, and strong anti-tumor activity at the 34th EORTC-NCI-AACR Symposium ● Initial clinical data for OP-1250 in combination with CDK 4/6 inhibitor, palbociclib, to be p

November 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 8, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Empl

November 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

August 9, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2022 Olema Pharmaceuticals, Inc. s(Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ? (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

August 9, 2022 EX-10.1

Drug Discovery Collaboration and License Agreement by and between the Registrant and Aurigene Discovery Technologies Limited, dated June 7, 2022.

Exhibit 10.1 [ * ] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL. DRUG DISCOVERY COLLABORATION AND LICENSE AGREEMENT THIS DRUG DISCOVERY COLLABORATION AND LICENSE AGREEMENT (the ?Agreement?) is entered into as of June 7, 2022 (the ?Eff

August 9, 2022 EX-99.1

Olema Oncology Reports Second Quarter 2022 Financial Results and Provides Corporate Update

Exhibit 99.1 Olema Oncology Reports Second Quarter 2022 Financial Results and Provides Corporate Update ? Received Fast Track designation from U.S. FDA for OP-1250 for the treatment of ER+/HER2- metastatic breast cancer ? Reported progress across OP-1250 clinical development program, including selection of the recommended Phase 2 dose, initiation of Phase 2 monotherapy enrollment, and continued do

August 9, 2022 EX-99.2

Olema Oncology Advances OP-1250 into Phase 2 Monotherapy Expansion in Patients with ER+/HER2- Advanced Breast Cancer

Exhibit 99.2 Olema Oncology Advances OP-1250 into Phase 2 Monotherapy Expansion in Patients with ER+/HER2- Advanced Breast Cancer SAN FRANCISCO, August 9, 2022 ? Olema Pharmaceuticals, Inc. (?Olema? or ?Olema Oncology,? Nasdaq: OLMA), today announced the advancement of OP-1250, a complete estrogen receptor (ER) antagonist (CERAN) and a selective ER degrader (SERD), into Phase 2 clinical developmen

June 23, 2022 8-K

Submission of Matters to a Vote of Security Holders

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 16, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.

June 9, 2022 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 7, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employer

May 16, 2022 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2 )* OLEMA PHARMACEUTICALS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) May 16, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate th

May 9, 2022 EX-99.1

Olema Oncology Reports First Quarter 2022 Financial Results and Provides Corporate Update

Exhibit 99.1 ? ? ? Olema Oncology Reports First Quarter 2022 Financial Results and Provides Corporate Update ? ? Phase 1/2 trial of OP-1250 continues to enroll patients in the dose expansion stage, with selection of Recommended Phase 2 Dose expected in Q2 2022 ? Phase 1b combination study with palbociclib ongoing; Additional combination trials with CDK4/6 and PI3K? inhibitors planned to initiate i

May 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employer

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ? (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

April 28, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 tmb-20220428xdefa14a.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant þ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Com

April 28, 2022 CORRESP

April 28, 2022

CORRESP 1 filename1.htm April 28, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Olema Pharmaceuticals, Inc. Registration Statement on Form S-3 File No. 333-263117 Acceleration Request Requested Date:May 2, 2022 Requested Time:4:00 PM Eastern Daylight Time Ladies and Gentlemen: In accordance with Rule 461 under t

April 28, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEF 14A 1 tmb-20220616xdef14a.htm DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant þ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, f

March 14, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employ

March 3, 2022 DEL AM

Olema Pharmaceuticals, Inc. 512 2nd Street, 4th Floor San Francisco, California 94107

DEL AM 1 tmb-20220303xdelam.htm DEL AM Olema Pharmaceuticals, Inc. 512 2nd Street, 4th Floor San Francisco, California 94107 March 3, 2022 Via Edgar United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re:Olema Pharmaceuticals, Inc. Registration Statement on Form S-3 (File No. 333-263117) Ladies and Gentlemen: Reference is made to

March 1, 2022 EX-4.6

Form of Preferred Stock Warrant Agreement and Warrant Certificate

? Exhibit 4.6 ? ? ? OLEMA PHARMACEUTICALS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF ? ? ? ? ? OLEMA PHARMACEUTICALS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between OLEMA PHARMACEUTICALS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking

March 1, 2022 EX-4.7

Form of Debt Securities Warrant Agreement and Warrant Certificate

? Exhibit 4.7 ? ? OLEMA PHARMACEUTICALS, INC. ? AND ? , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT ? DATED AS OF ? ? ? ? OLEMA PHARMACEUTICALS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between OLEMA PHARMACEUTICALS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banki

March 1, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables ? Form S-8 ? Olema Pharmaceuticals, Inc.

March 1, 2022 S-8

As filed with the Securities and Exchange Commission on February 28, 2022

S-8 1 tmb-20220228xs8.htm S-8 As filed with the Securities and Exchange Commission on February 28, 2022 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 30-0409740 (State or other jurisdiction of in

March 1, 2022 EX-4.5

Form of Common Stock Warrant Agreement and Warrant Certificate

? Exhibit 4.5 ? ? OLEMA PHARMACEUTICALS, INC. ? AND ? , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT ? DATED AS OF ? ? ? ? OLEMA PHARMACEUTICALS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between OLEMA PHARMACEUTICALS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking associ

March 1, 2022 S-3

As filed with the Securities and Exchange Commission on February 28, 2022

Table of Contents As filed with the Securities and Exchange Commission on February 28, 2022 Registration No.

March 1, 2022 EX-FILING FEES

Filing Fee Table.

EX-FILING FEES 8 tmb-20220228xexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Olema Pharmaceuticals, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Share M

March 1, 2022 EX-4.3

Form of Indenture

Exhibit 4.3 ? Olema Pharmaceuticals, Inc., Issuer ? AND [TRUSTEE], Trustee INDENTURE ? Dated as of [?], 20 Debt Securities ? ? ? ? ? ? TABLE OF CONTENTS ? ? Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and T

February 28, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2022 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (

February 28, 2022 EX-10.19

Offer Letter by and between the Registrant and Naseem Zojwalla, dated December 15, 2021.

? ? Exhibit 10.19 ? ? December 15, 2021 ? Naseem Zojwalla, M.D. VIA EMAIL/DOCUSIGN ? Re:Employment Terms ? Dear Naseem: ? Olema Pharmaceuticals, Inc. (the ?Company?) is pleased to offer you employment as its Chief Medical Officer, pursuant to the terms of this offer letter agreement (the ?Agreement?). ? 1.Position; Duties. You will serve as Chief Medical Officer, reporting directly to the Company?

February 28, 2022 EX-10.18

Form of Stock Option Agreement and Option Grant Notice under the Inducement Plan.

? Exhibit 10.18 Olema Pharmaceuticals, Inc. Stock Option Grant Notice (2022 Inducement Plan) Olema Pharmaceuticals, Inc. (the ?Company?), pursuant to its 2022 Inducement Plan (the ?Plan?), has granted to you (?Optionholder?) an option to purchase the number of shares of the Common Stock set forth below (the ?Option?). Your Option is subject to all of the terms and conditions as set forth herein an

February 28, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 28, 2022 EX-21.1

Subsidiaries of the Registrant as of December 31, 2021.

Exhibit 21.1 ? Olema Pharmaceuticals, Inc. Subsidiaries ? ? ? Name of Subsidiary Jurisdiction of Incorporation Olema Oncology Australia PTY LTD ? Australia ?

February 28, 2022 EX-10.17

Olema Pharmaceuticals, Inc. 2022 Inducement Plan

? Exhibit 10.17 Olema Pharmaceuticals, Inc. 2022 Inducement Plan Adopted by the Board of Directors: January 19, 2022 ? 1.General. (a)Eligible Award Recipients. The only persons eligible to receive grants of Awards under this Plan are individuals who satisfy the standards for inducement grants under NASDAQ Marketplace Rule 5635(c)(4) or 5635(c)(3), if applicable, and the related guidance under NASD

February 28, 2022 EX-99.1

Olema Oncology Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 ? ? ? Olema Oncology Reports Fourth Quarter and Full Year 2021 Financial Results and Provides Corporate Update ? ? Presented Phase 1a proof-of-concept data for OP-1250 in metastatic, ER+ / HER2- breast cancer, with demonstrated attractive pharmacokinetics, favorable tolerability and encouraging anti-tumor activity in a heavily pretreated patient population ? Enrollment in Phase 1b dos

February 14, 2022 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to desig

February 14, 2022 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / Cormorant Asset Management, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 11, 2022 SC 13G

OLMA / Olema Pharmaceuticals Inc / Fairmount Funds Management LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, Par Value $0.0001 (Title of Class of Securities) 68062P106 (CUSIP Number) Erin O?Connor Fairmount Funds Management LLC 2001 Market Street, Suite 2501 Philadelphia, PA 19103 (267) 229-2730 (Name, A

February 10, 2022 SC 13G

OLMA / Olema Pharmaceuticals Inc / VANGUARD GROUP INC - SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 Name of issuer: Olema Pharmaceuticals Inc. Title of Class of Securities: Common Stock CUSIP Number: 68062P106 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ??Rule 13d-1(b

February 4, 2022 SC 13G/A

OLMA / Olema Pharmaceuticals Inc / WELLINGTON MANAGEMENT GROUP LLP - SEC SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1 )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

December 2, 2021 SC 13D/A

OLMA / Olema Pharmaceuticals Inc / BIOTECHNOLOGY VALUE FUND L P - AMENDMENT NO. 1 TO THE SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 1)1 Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) JAMES KR

November 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents ? ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ? (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

November 10, 2021 EX-99.1

Olema Oncology Reports Third Quarter 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 ? ? ? Olema Oncology Reports Third Quarter 2021 Financial Results and Provides Corporate Update ? ? Completed dose-escalation stage of Phase 1/2 clinical trial of OP-1250 in patients with metastatic, ER+ / HER2- breast cancer ? Interim safety, tolerability, pharmacokinetic and initial efficacy data from Phase 1 dose escalation to be presented at 2021 San Antonio Breast Cancer Symposiu

November 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2021 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (

August 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2021 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.

August 10, 2021 EX-99.1

Olema Oncology Reports Second Quarter 2021 Financial Results and Provides Corporate Update

Exhibit 99.1 ? ? ? Olema Oncology Reports Second Quarter 2021 Financial Results and Provides Corporate Update ? ? Presentation of preliminary Phase 1/2 dose-escalation data for OP-1250 in patients with metastatic, ER+ / HER2- breast cancer planned for Q4 2021 ? Strong cash, cash equivalents and marketable securities position of $318.1 million as of June 30, 2021 sufficient to support execution of

August 10, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

Table of Contents ? ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ? (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

June 9, 2021 8-K

Submission of Matters to a Vote of Security Holders

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 8, 2021 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) ? ? ? ? Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S

May 11, 2021 10-Q

Quarterly Report - 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q ? (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ? For the transition period from to Commission File Number: 001-39712 OLEMA PHARMACEUTICALS, INC.

May 11, 2021 EX-99.1

Olema Oncology Reports First Quarter 2021 Financial Results and Provides Corporate Update

? Olema Oncology Reports First Quarter 2021 Financial Results and Provides Corporate Update ? ? OP-1250 continues to advance in dose-escalation stage of Phase 1/2 clinical trial in patients with metastatic, ER+ / HER2- breast cancer; Initial data anticipated in 2H 2021 ? Cash, cash equivalents, and marketable securities of $327.

May 11, 2021 EX-10.1

Consulting Agreement by and between the Company and Frank McCormick Ph.D., F.R.S., D.Sc. (Hon), dated April 5, 2021.

? DocuSign Envelope ID: DCF0D6AC-6E2F-4DD0-AB52-5A3A0B54EBBF CONSULTING AGREEMENT Effective Date: April 5, 2021 This Consulting Agreement (the ?Agreement?) is made as of the Effective Date set forth above by and between Olema Pharmaceuticals, Inc.

May 11, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

8-K 1 tmb-20210511x8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 11, 2021 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdictio

April 27, 2021 DEF 14A

- DEF 14A

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 27, 2021 DEFA14A

- DEFA14A

? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ? SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 ? (Amendment No. ) ? ? ? Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitte

April 6, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 5, 2021 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction (Commission (I.R.S. Employe

March 17, 2021 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF THE REGISTRANT?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 ? Olema Pharmaceuticals, Inc. (?we,? ?our,? ?us,? or the ?Company?) has one class of securities registered under Section 12 of the Securities Exchange Act of 1934, as amended (the ?Exchange Act?): our common stock. The following summary of the terms of our common stock is

March 17, 2021 S-8

- S-8

S-8 1 tmb-20210317xs8.htm S-8 As filed with the Securities and Exchange Commission on March 17, 2021 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 30-0409740 (State or other jurisdiction of incor

March 17, 2021 EX-21.1

Subsidiaries of the Registrant as of December 31, 2020.

Exhibit 21.1 ? Olema Pharmaceuticals, Inc. Subsidiaries ? None.

March 17, 2021 EX-99.1

Olema Oncology Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Corporate Updates

Exhibit 99.1 Olema Oncology Reports Fourth Quarter and Full Year 2020 Financial Results and Provides Corporate Updates ? ? Advancing OP-1250 in metastatic, ER+ / HER2- breast cancer Phase 1/2 clinical trial ? Clinical trial agreements announced with Novartis and Pfizer to explore combination of OP-1250 with CDK4/6 inhibitors and PI3K? inhibitor ? Approximately $382 million in gross proceeds raised

March 17, 2021 10-K

Annual Report - 10-K

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 17, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 17, 2021 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) ? Delaware 001-39712 30-0409740 (State or other jurisdiction ? (Commission ? (I

February 16, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

February 4, 2021 SC 13G

SCHEDULE 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which t

December 3, 2020 SC 13D

OLMA / Olema Pharmaceuticals, Inc. / Logos Global Management LP Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. ) Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 60862P106 (CUSIP Number) Virginia Yee Logos Global Management LP One Letterman Drive, Building D, Suite D3-700 San Francisco, CA 94129 Tel

November 23, 2020 SC 13G

OLMA / Olema Pharmaceuticals, Inc. / Cormorant Asset Management, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 68062P106 (CUSIP Number) November 23, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which t

November 23, 2020 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of November 23, 2020, is by and among Cormorant Global Healthcare Master Fund, LP, Cormorant Global Healthcare GP, LLC, Cormorant Private Healthcare Fund II, LP, Cormorant Private Healthcare GP II, LLC, Cormorant Private Healthcare Fund III, LP, Cormorant Private Healthcare GP III, LLC, Cormorant Asset Management, LP and Bih

November 23, 2020 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 23, 2020 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39712 30-0409740 (State or other jurisdiction of incorporation) (Comm

November 23, 2020 EX-3.1

Amended and Restated Certificate of Incorporation

EX-3.1 2 tm2027048d18ex3-1.htm EXHIBIT 3.1 Exhibit 3.1 SEVENTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF OLEMA PHARMACEUTICALS, INC. Olema Pharmaceuticals, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of the Delaware (the “DGCL”), hereby certifies that: ONE: The name of this corporation is Olema Pharmaceuticals, Inc. The orig

November 23, 2020 EX-3.2

Amended and Restated Bylaws

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF Olema pharmaceuticals, inC. (A DELAWARE CORPORATION) November 23, 2020 Table of Contents Page ARTICLE I Offices 1 Section 1. Registered Office 1 Section 2. Other Offices 1 ARTICLE II Corporate Seal 1 Section 3. Corporate Seal 1 ARTICLE III Stockholders’ Meetings 1 Section 4. Place of Meetings 1 Section 5. Annual Meetings 2 Section 6. Special Meetings 6 Se

November 20, 2020 EX-99.2

Joint Filing Agreement by and among Biotechnology Value Fund, L.P., BVF I GP LLC, Biotechnology Value Fund II, L.P., BVF II GP, LLC, Biotechnology Value Trading Fund OS LP, BVF Partners OS Ltd., BVF GP Holdings LLC, BVF Partners L.P., BVF Inc., Mark N. Lampert and Gorjan Hrustanovic, dated November 20, 2020.

Exhibit 99.2 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D dated November 20, 2020 (including amendments thereto) with respect to the shares of Common Stock, $0.0001 par value per share, of Olema Pharmaceuticals, Inc. Th

November 20, 2020 SC 13D

OLMA / Olema Pharmaceuticals, Inc. / BIOTECHNOLOGY VALUE FUND L P - THE SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. )1 Olema Pharmaceuticals, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 68062P106 (CUSIP Number) JAMES KRA

November 19, 2020 S-8

As filed with the Securities and Exchange Commission on November 19, 2020

As filed with the Securities and Exchange Commission on November 19, 2020 Registration No.

November 19, 2020 EX-99.3

Olema Pharmaceuticals, Inc. 2020 Equity Incentive Plan.

Exhibit 99.3 Olema Pharmaceuticals, Inc. 2020 Equity Incentive Plan Adopted by the Board of Directors: October 30, 2020 Approved by the Stockholders: November 12, 2020 1. General. (a) Plan Purpose. The Company, by means of the Plan, seeks to secure and retain the services of Employees, Directors and Consultants, to provide incentives for such persons to exert maximum efforts for the success of the

November 19, 2020 424B4

(in thousands, except share and per share data)

TABLE OF CONTENTS ?Filed Pursuant to Rule 424(b)(4)? ?Registration No. 333-249748? Prospectus 11,000,000 shares Common stock This is an initial public offering of shares of common stock by Olema Pharmaceuticals, Inc. We are offering 11,000,000 shares of our common stock to be sold in the offering. The initial public offering price is $19.00 per share. Prior to this offering, there has been no publ

November 19, 2020 EX-99.6

Olema Pharmaceuticals, Inc. 2020 Employee Stock Purchase Plan.

Exhibit 99.6 Olema Pharmaceuticals, Inc. 2020 Employee Stock Purchase Plan Adopted by the Board of Directors: October 30, 2020 Approved by the Stockholders: November 12, 2020 IPO Date: November 18, 2020 1. General; Purpose. (a) The Plan provides a means by which Eligible Employees of the Company and certain Designated Companies may be given an opportunity to purchase shares of Common Stock. The Pl

November 18, 2020 S-1MEF

- FORM S-1MEF

As filed with the Securities and Exchange Commission on November 18, 2020 Registration No.

November 17, 2020 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Olema Pharmaceuticals, Inc. (Exact name of registrant as specified in its charter) Delaware 30-0409740 (State of Incorporation or Organization) (I.R.S. Employer Identification No.) 512 2nd Street,

November 16, 2020 EX-1.1

Form of Underwriting Agreement.

Exhibit 1.1 Underwriting Agreement Olema Pharmaceuticals, Inc. [·] Shares of Common Stock , 2020 J.P. Morgan Securities LLC Jefferies LLC Cowen and Company, LLC As Representatives of the several Underwriters listed in Schedule 1 hereto c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, NY 10179 Jefferies LLC 520 Madison Avenue New York, NY 10022 c/o Cowen and Company, LLC 599 Lexington Av

November 16, 2020 EX-10.12

Amended and Restated Offer Letter by and between the Registrant and Shane Kovacs, dated November 13, 2020.

Exhibit 10.12 November 13, 2020 Shane W. Kovacs VIA EMAIL Re: Employment Terms Dear Shane: As you know, you are currently employed by Olema Pharmaceuticals, Inc. (the “Company”) as its Chief Financial Officer and Chief Operating Officer, pursuant to the terms of an offer letter from the Company dated June 15, 2020 (the “Offer Letter”). In connection with your continuing employment, you and the Com

November 16, 2020 EX-10.13

Amended and Restated Offer Letter by and between the Registrant and Peter Kushner, dated November 13, 2020.

Exhibit 10.13 November 13, 2020 Peter Kushner VIA EMAIL Re: Employment Terms Dear Peter: As you know, you are currently employed by Olema Pharmaceuticals, Inc. (the “Company”) as its Chief Scientific Officer, pursuant to the terms of an offer letter from the Company dated June 15, 2020 (the “Offer Letter”). In connection with your continuing employment, you and the Company are hereby agreeing to t

November 16, 2020 EX-10.3

Olema Pharmaceuticals, Inc. 2020 Equity Incentive Plan.

Exhibit 10.3 Olema Pharmaceuticals, Inc. 2020 Equity Incentive Plan Adopted by the Board of Directors: October 30, 2020 Approved by the Stockholders: November 12, 2020 1. General. (a) Plan Purpose. The Company, by means of the Plan, seeks to secure and retain the services of Employees, Directors and Consultants, to provide incentives for such persons to exert maximum efforts for the success of the

November 16, 2020 EX-10.7

Olema Pharmaceuticals, Inc. 2020 Non-Employee Director Compensation Policy.

Exhibit 10.7 Olema Pharmaceuticals, Inc. Non-Employee Director Compensation Policy Each member of the Board of Directors (the “Board”) of Olema Pharmaceuticals, Inc. (the “Company”) who is not also serving as an employee of the Company or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy (thi

November 16, 2020 S-1/A

- S-1/A

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on November 16, 2020 Registration No.

November 16, 2020 EX-4.1

Form of Common Stock Certificate

Exhibit 4.1 .ZQ|CERT#|COY|CLS|RGSTRY|ACCT#|TRANSTYPE|RUN#|TRANS# COMMON STOCK PAR VALUE $0.0001 COMMON STOCK Certificate Number ZQ00000000 THIS CERTIFIES THAT OLEMA PHARMACEUTICALS, INC. INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE ** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **

November 16, 2020 EX-10.9

Amended and Restated Offer Letter by and between the Registrant and Sean Bohen, dated November 13, 2020.

Exhibit 10.9 November 13, 2020 Sean Bohen, M.D., Ph.D. VIA EMAIL Re: Employment Terms Dear Sean: As you know, you are currently employed by Olema Pharmaceuticals, Inc. (the “Company”) as its Chief Executive Officer, pursuant to the terms of an offer letter from the Company dated September 1, 2020 (the “Offer Letter”). In connection with your continuing employment, you and the Company are hereby ag

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