OMIC / Singular Genomics Systems, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Singular Genomics Systems, Inc.
HINDI NA ACTIVE ANG SIMBONG ITO

Mga Batayang Estadistika
CIK 1850906
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Singular Genomics Systems, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
February 27, 2025 EX-99.1

Singular Genomics Announces Closing of Acquisition by Deerfield Management

EX-99.1 Exhibit 99.1 Singular Genomics Announces Closing of Acquisition by Deerfield Management February 21, 2025 SAN DIEGO, Feb. 21, 2025 (GLOBE NEWSWIRE) — Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and spatial multiomics technologies to empower researchers and clinicians, announced today the closing of its acquisition by an affili

February 27, 2025 8-K

Changes in Control of Registrant, Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 21, 2025 Singular Genomics Systems, Inc. (Exact name of registrant as specified in charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

February 27, 2025 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION SINGULAR GENOMICS SYSTEMS, INC. (a Delaware corporation)

EX-3.1 Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF SINGULAR GENOMICS SYSTEMS, INC. (a Delaware corporation) Singular Genomics Systems, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “GCL”), DOES HEREBY CERTIFY: 1. That the name of this corporation is Singular Genomics Systems, Inc.,

February 27, 2025 EX-3.2

AMENDED AND RESTATED BYLAWS SINGULAR GENOMICS SYSTEMS, INC. ARTICLE I

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF SINGULAR GENOMICS SYSTEMS, INC. ARTICLE I OFFICES SECTION 1.1. Registered Offices; Other Offices. The registered office of the Corporation in the State of Delaware shall be in the City of Wilmington and County of New Castle. The Corporation may have such other offices, either within or outside of the State of Delaware, as the business of the Corporation m

February 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on February 21, 2025

As filed with the Securities and Exchange Commission on February 21, 2025 Registration No.

February 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on February 21, 2025

As filed with the Securities and Exchange Commission on February 21, 2025 Registration No.

February 21, 2025 POS AM

As filed with the Securities and Exchange Commission on February 21, 2025

POS AM As filed with the Securities and Exchange Commission on February 21, 2025 Registration No.

February 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on February 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on February 21, 2025 Registration No.

February 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on February 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on February 21, 2025 Registration No.

February 21, 2025 S-8 POS

As filed with the Securities and Exchange Commission on February 21, 2025

S-8 POS As filed with the Securities and Exchange Commission on February 21, 2025 Registration No.

February 19, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 19, 2025 Singular Genomics Systems, Inc. (Exact name of registrant as specified in charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

February 13, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒         Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a

February 13, 2025 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2025 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

January 15, 2025 DEFM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (RULE 14a-101) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (RULE 14a-101) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒        Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (a

December 31, 2024 PREM14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (RULE 14a-101) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (RULE 14a-101) Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒        Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (a

December 31, 2024 EX-FILING FEES

CALCULATION OF FILING FEE TABLES Schedule 14A (Form Type) Singular Genomics Systems, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1—Transaction Valuation  Proposed Maximum  Aggregate Value of Transaction  Fee Rate   Amount of  Fi

EX-FILING FEES Exhibit 107 CALCULATION OF FILING FEE TABLES Schedule 14A (Form Type) Singular Genomics Systems, Inc.

December 23, 2024 EX-2.1

AGREEMENT AND PLAN OF MERGER SINGULAR GENOMICS PARENT, LLC, SATURN MERGER SUB, INC. SINGULAR GENOMICS SYSTEMS, INC. Dated as of December 22, 2024

Exhibit 2.1 AGREEMENT AND PLAN OF MERGER Among SINGULAR GENOMICS PARENT, LLC, SATURN MERGER SUB, INC. and SINGULAR GENOMICS SYSTEMS, INC. Dated as of December 22, 2024 TABLE OF CONTENTS Article 1 Definitions 3 1.1 Definitions 3 Article 2 The Merger 15 2.1 The Merger 15 2.2 Effective Time; Closing 15 2.3 Effect of the Merger 16 2.4 Certificate of Incorporation; Bylaws 16 2.5 Directors and Officers

December 23, 2024 EX-10.1

VOTING AND SUPPORT AGREEMENT

Exhibit 10.1 VOTING AND SUPPORT AGREEMENT This VOTING AND SUPPORT AGREEMENT (this “Agreement”), dated as of [•], is entered into by and among Singular Genomics Systems, Inc., a Delaware corporation (the “Company”), and [•], a [•] (the “Stockholder”). Capitalized terms used but not defined herein shall have the meanings given to them in the Merger Agreement (as defined below). RECITALS WHEREAS, con

December 23, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2024 Singular Genomi

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

December 23, 2024 EX-99.1

Singular Genomics Enters into Agreement to be Acquired by Deerfield for $20.00 in Cash per Share

Exhibit 99.1 Singular Genomics Enters into Agreement to be Acquired by Deerfield for $20.00 in Cash per Share San Diego, CA. – December 23, 2024 - Singular Genomics Systems, Inc. (Nasdaq: OMIC) (“Singular Genomics” or the “Company”), a company leveraging novel next-generation sequencing (NGS) and spatial multiomics technologies to empower researchers and clinicians, today announced that it has ent

December 23, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

December 23, 2024 EX-10.2

LIMITED GUARANTEE

Exhibit 10.2 LIMITED GUARANTEE This Limited Guarantee, dated as of December 22, 2024 (this “Limited Guarantee”), is made by Deerfield Private Design Fund IV, L.P., a Delaware limited partnership, the “Guarantor”), in favor of Singular Genomics Systems, Inc., a Delaware corporation (the “Company”). Reference is hereby made to that certain Agreement and Plan of Merger, dated as of the date hereof (a

November 22, 2024 SC 13D/A

OMIC / Singular Genomics Systems, Inc. / CRCM LP - SC 13D/A Activist Investment

SC 13D/A 1 sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 82933R308 (CUSIP Number) Chun R. Ding c/o CRCM LP 475 Sansome Street, Suite 730 San Francisco, CA 941

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 Singular Genomics

November 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

November 12, 2024 EX-99.1

Singular Genomics Reports Recent Updates and Third Quarter 2024 Financial Results

Singular Genomics Reports Recent Updates and Third Quarter 2024 Financial Results San Diego, CA, November 12, 2024 – Singular Genomics Systems, Inc.

November 5, 2024 SC 13D

OMIC / Singular Genomics Systems, Inc. / CRCM LP - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 82933R308 (CUSIP Number) Chun R. Ding c/o CRCM LP 475 Sansome Street, Suite 730 San Francisco, CA 94111 (415) 578-5700 (Name, Address

November 4, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

November 1, 2024 SC 13D/A

OMIC / Singular Genomics Systems, Inc. / Flynn James E Activist Investment

SC 13D/A 1 e663986sc13da-sgs.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D [Rule 13d-101] INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 24.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13D-2(a) (Amendment No. 1)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 82933R308 (

September 19, 2024 EX-99.1

Singular Genomics Receives Non-Binding Acquisition Proposal from Concentra Biosciences and Tang Capital

Singular Genomics Receives Non-Binding Acquisition Proposal from Concentra Biosciences and Tang Capital San Diego, CA, September 19, 2024 – Singular Genomics Systems, Inc.

September 19, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 19, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation)

September 18, 2024 SC 13D

OMIC / Singular Genomics Systems, Inc. / TANG CAPITAL MANAGEMENT LLC Activist Investment

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13D Under the securities exchange act of 1934 (amendment no.

September 12, 2024 EX-1

Joint Filing Agreement dated as of March 5, 2018 by and among the Reporting Persons.*

EX-1 2 e663885ex1.htm Exhibit 1 JOINT FILING AGREEMENT Pursuant to and in accordance with the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder (the “Exchange Act”) the undersigned hereby agree to the joint filing on behalf of each of them of any filing required by such party under Section 13 of the Exchange Act or any rule or regulation thereunder (including an

September 12, 2024 EX-99.1

Singular Genomics Receives Non-Binding Acquisition Proposal from Deerfield

Singular Genomics Receives Non-Binding Acquisition Proposal from Deerfield San Diego, CA, September 12, 2024 – Singular Genomics Systems, Inc.

September 12, 2024 SC 13D

OMIC / Singular Genomics Systems, Inc. / Flynn James E Activist Investment

SC 13D 1 e663885sc13d-sgs.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D [Rule 13d-101] INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 24.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13D-2(a) (Amendment No. )* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 82933R308 (CUSI

September 12, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 12, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation)

September 12, 2024 EX-3

Non-binding Indication of Interest, submitted September 5, 2024*

EX-3 3 e663885ex3.htm Exhibit 3 Deerfield Mgmt IV, L.P. Deerfield Management Company, L.P. Deerfield Private Design Fund IV, L.P. 345 Park Avenue South New York, NY 10010 September 4, 20241 Special Committee of Independent Directors Singular Genomics Systems, Inc. 3010 Science Park Road San Diego, CA 92121 Re: Non-Binding Indication of Interest Dear Special Committee of Independent Directors (the

August 13, 2024 EX-99.1

Singular Genomics Reports Recent Highlights and Second Quarter 2024 Financial Results

Singular Genomics Reports Recent Highlights and Second Quarter 2024 Financial Results San Diego, CA, August 13, 2024 – Singular Genomics Systems, Inc.

August 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 Singular Genomics Syst

August 13, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Co

August 7, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 2, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Com

August 7, 2024 EX-10.1

Third Amendment to Lease Agreement, dated August 2, 2024, by and between ARE-SD Region No. 27, LLC and the Registrant

3010 Science Park/Singular - Page 1 THIRD AMENDMENT TO LEASE AGREEMENT THIS THIRD AMENDMENT TO LEASE AGREEMENT (this “Third Amendment”) is made this 2 day of August, 2024 (the “Effective Date”), between ARE-SD REGION NO.

July 15, 2024 EX-99.1

Singular Genomics Regains Compliance with Nasdaq Minimum Bid Price Requirement

Singular Genomics Regains Compliance with Nasdaq Minimum Bid Price Requirement San Diego, CA, July 15, 2024 – Singular Genomics Systems, Inc.

July 15, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 12, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

June 27, 2024 EX-3.1

Certificate of Amendment to Amended and Restated Certificate of Incorporation

Exhibit 3.1 CERTIFICATE OF AMENDMENT to the AMENDED AND RESTATED CERTIFICATE OF INCORPORATION of SINGULAR GENOMICS SYSTEMS, INC. Singular Genomics Systems, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), DOES HEREBY CERTIFY: FIRST: The name of the Corporation is Singular Genomics Systems, Inc. The Amended a

June 27, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 26, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

May 30, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 29, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commi

May 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 Singular Genomics Sys

May 14, 2024 EX-99.1

Singular Genomics Reports Recent Highlights and First Quarter 2024 Financial Results

Singular Genomics Reports Recent Highlights and First Quarter 2024 Financial Results San Diego, CA, May 14, 2024 – Singular Genomics Systems, Inc.

May 14, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 14, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commi

April 18, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☒ Defin

April 18, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☐ Defin

April 5, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☐ Defin

March 18, 2024 EX-FILING FEES

Calculation of Filing Fee Tables

Calculation of Filing Fee Table Form S-8 (Form Type) Singular Genomics Systems, Inc.

March 18, 2024 EX-99.1

Singular Genomics Reports Recent Highlights and Fourth Quarter and Full Year 2023 Financial Results

Singular Genomics Reports Recent Highlights and Fourth Quarter and Full Year 2023 Financial Results San Diego, CA, March 18, 2024 – Singular Genomics Systems, Inc.

March 18, 2024 S-8

As filed with the Securities and Exchange Commission on March 18, 2024

As filed with the Securities and Exchange Commission on March 18, 2024 Registration No.

March 18, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023. ☐ TRANSITION REPORT PURSUANT TO SECT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023. ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 001-40443 Singular Genomics Systems,

March 18, 2024 EX-97.1

Policy for Recovery of Erroneously Awarded Compensation.

Exhibit 97.1 SINGULAR GENOMICS SYSTEMS, INC. POLICY FOR THE RECOVERY OF ERRONEOUSLY AWARDED COMPENSATION 1. Purpose. The purpose of this Policy is to describe the circumstances in which Executive Officers will be required to repay or return Erroneously Awarded Compensation to members of the Company Group. This Policy is designed to comply with, and shall be interpreted to be consistent with, Secti

March 18, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Com

February 14, 2024 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Glezer Eli N. - SC 13G/A Passive Investment

SC 13G/A 1 eg2024sc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. 2)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value of $0.0001 per share (Title of Class of Securities) 82933R100 (CUSIP Number) December 31, 2023 (Date of

February 14, 2024 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Spaventa Andrew - SC 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Information Statement Pursuant to Rules 13d-1 and 13d-2 Under the Securities Exchange Act of 1934 (Amendment No.

February 12, 2024 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Flynn James E Passive Investment

SC 13G/A 1 e619251sc13ga-sgs.htm SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 3)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 82933R100 (CUSIP Number) Decem

January 25, 2024 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Domain Partners IX, L.P. Passive Investment

SC 13G/A 1 s13ga012524-singular.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)1 Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securities) 82933R

January 19, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 16, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

January 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 7, 2024 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Co

January 8, 2024 EX-99.1

Singular Genomics Reports Instrument Shipments and Preliminary Unaudited Fourth Quarter 2023 Revenue

EX-99.1 Singular Genomics Reports Instrument Shipments and Preliminary Unaudited Fourth Quarter 2023 Revenue San Diego, CA, January 7, 2024 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today announced instrument shipments and preliminary unaudited revenue for the four

November 14, 2023 EX-10.9

Agreement for Termination of Lease, dated July 19, 2023, by and between ARE-10933 North Torrey Pines, LLC and the Registrant.

AGREEMENT FOR TERMINATION OF LEASE This Agreement for Termination of Lease (this “Agreement”) is made and entered into as of July 19, 2023, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC.

November 14, 2023 EX-10.4

Second Amendment to Lease Agreement, dated May 7, 2020, by and between ARE-SD Region No. 35, LLC and the Registrant.

SECOND AMENDMENT TO LEASE THIS SECOND AMENDMENT TO LEASE (this "Second Amendment") is made as of May 7, 2020, by and between ARE-SD REGION NO.

November 14, 2023 EX-10.3

First Amendment to Lease Agreement, dated February 24, 2020, by and between ARE-SD Region No. 35, LLC and the Registrant.

FIRST AMENDMENT TO LEASE THIS FIRST AMENDMENT TO LEASE (this "First Amendment") is made as of February 24, 2020, by and between ARE.

November 14, 2023 EX-10.10

Second Amendment to Agreement for Termination of Lease, dated August 31, 2023, by and between ARE-10933 North Torrey Pines, LLC and the Registrant.

FIRST AMENDMENT TO AGREEMENT FOR TERMINATION OF LEASE THIS FIRST AMENDMENT TO AGREEMENT FOR TERMINATION OF LEASE (this “First Amendment”) is made as of August 31, 2023, by and between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC.

November 14, 2023 EX-10.1

Second Amendment to Lease Agreement, dated July 19, 2023, by and between ARE-SD Region No. 27, LLC and the Registrant.

Page 1 SECOND AMENDMENT TO LEASE AGREEMENT THIS SECOND AMENDMENT TO LEASE AGREEMENT (this “Second Amendment”) is made this 19 day of July, 2023 (the “Effective Date”), between ARE-SD REGION NO.

November 14, 2023 EX-10.2

Lease Agreement, dated November 15, 2019, by and between ARE-SD Region No. 35, LLC and the Registrant.

LEASE AGREEMENT THIS LEASE AGREEMENT (this "Lease") is made this 15 day of November, 2019, between ARE-SD REGION NO.

November 14, 2023 EX-10.5

Third Amendment to Lease Agreement, dated June 19, 2020, by and between ARE-SD Region No. 35, LLC and the Registrant.

THIRD AMENDMENT TO LEASE THIS THIRD AMENDMENT TO LEASE (this "Third Amendment") is made as of June 19, 2020, by and between ARE-SD REGION NO.

November 14, 2023 EX-99.1

Singular Genomics Reports Recent Highlights and Third Quarter 2023 Financial Results

EX-99.1 Singular Genomics Reports Recent Highlights and Third Quarter 2023 Financial Results San Diego, CA, November 14, 2023 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for the third quar

November 14, 2023 EX-10.8

Sixth Amendment to Lease Agreement, dated July 19, 2023, by and between ARE-SD Region No. 35, LLC and the Registrant.

SIXTH AMENDMENT TO LEASE THIS SIXTH AMENDMENT TO LEASE (this “Sixth Amendment”) is made as of July 19, 2023, by and between ARE-SD REGION NO.

November 14, 2023 EX-10.6

Fourth Amendment to Lease Agreement, dated April 20, 2021, by and between ARE-SD Region No. 35, LLC and the Registrant.

FOURTH AMENDMENT TO LEASE THIS FOURTH AMENDMENT TO LEASE (this “Fourth Amendment”) is made as of April 20, 2021, by and between ARE-SD REGION NO.

November 14, 2023 EX-10.7

Fifth Amendment to Lease Agreement, dated January 19, 2022, by and between ARE-SD Region No. 35, LLC and the Registrant.

FIFTH AMENDMENT TO LEASE THIS FIFTH AMENDMENT TO LEASE (this “Fifth Amendment”) is made as of January 19, 2022, by and between ARE-SD REGION NO.

November 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 14, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

November 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443

September 14, 2023 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 14, 2023 (September 13, 2023) Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdicti

August 14, 2023 SC 13G/A

OMIC / Singular Genomics Systems Inc / Flynn James E Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No.

August 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Com

August 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO S

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 Sing

August 9, 2023 EX-99.1

Singular Genomics Reports Recent Highlights and Second Quarter 2023 Financial Results

EX-99.1 Singular Genomics Reports Recent Highlights and Second Quarter 2023 Financial Results San Diego, CA, August 9, 2023 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for the second quart

August 8, 2023 EX-99

Singular Genomics Appoints Genomics Veteran Marcia Eisenberg, Ph.D., to Board of Directors

EX-99.1 Singular Genomics Appoints Genomics Veteran Marcia Eisenberg, Ph.D., to Board of Directors San Diego, CA, August 8, 2023 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today announced the appointment of Marcia Eisenberg, Ph.D., to the Company’s Board of Director

August 8, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 8, 2023 (August 4, 2023) Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of in

July 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

May 26, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 25, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commi

May 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 Sin

May 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 9, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commis

May 9, 2023 EX-99

Singular Genomics Reports Recent Highlights and First Quarter 2023 Financial Results

EX-99.1 Singular Genomics Reports Recent Highlights and First Quarter 2023 Financial Results San Diego, CA, May 9, 2023 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for the first quarter en

April 13, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☐ Defin

April 13, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a‑6(e)(2)) ☒ Defin

March 2, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022. ☐ TRANSITION REPORT PURSUANT TO SECT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022. ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number 001-40443 Singular Genomics Systems,

March 2, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

March 2, 2023 S-8

As filed with the Securities and Exchange Commission on March 2, 2023

As filed with the Securities and Exchange Commission on March 2, 2023 Registration No.

March 2, 2023 EX-10

Separation and Release Agreement, dated as of February 28, 2023, by and between the Registrant and Daralyn Durie.

Singular Genomics Systems, Inc. February 28, 2023 VIA ELECTRONIC MAIL Daralyn Durie [email protected] Re: Terms of Separation Dear Daralyn: This letter confirms the agreement (“Agreement”) between you and Singular Genomics Systems, Inc. (the “Company”) concerning the terms of your separation from employment and offers you certain benefits to which you would not otherwise be entitled, conditioned upo

March 2, 2023 EX-FILING FEES

Calculation of Filing Fee Tables

Calculation of Filing Fee Table Form S-8 (Form Type) Singular Genomics Systems, Inc.

March 2, 2023 EX-99

Singular Genomics Reports Recent Highlights and Fourth Quarter and Full Year 2022 Financial Results

EX-99.1 Singular Genomics Reports Recent Highlights and Fourth Quarter and Full Year 2022 Financial Results San Diego, CA, March 2, 2023 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for the

February 14, 2023 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Spaventa Andrew - SC 13G/A Passive Investment

SC 13G/A 1 d441685dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 Under the Securities Exchange Act of 1934 (Amendment No. 1)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value of $0.0001 per share (Title of Class of Securities) 82933R100 (CUSIP Number) December 31, 2022 (Date o

February 14, 2023 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Glezer Eli N. - SC 13G/A Passive Investment

SC 13G/A 1 d442494dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, par value of $0.0001 per share (Title of Class of Securities) 82933R100 (CUSIP Number) December 31, 2022 (Date o

February 14, 2023 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Revelation Alpine, LLC - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 82933R100 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate bo

February 10, 2023 SC 13G/A

OMIC / Singular Genomics Systems, Inc. / Flynn James E Passive Investment

SC 13G/A 1 e618268sc13ga-sgs.htm SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. 1)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 82933R100 (CUSIP Number) Decem

January 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date Earliest Event Reported): January 9, 2023 Singular Genomics Sy

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date Earliest Event Reported): January 9, 2023 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or Other Jurisdiction of Incorporation) (Commi

January 9, 2023 EX-99.1

Singular Genomics Reports Instrument Shipments and Preliminary Unaudited Fourth Quarter 2022 Revenue

EX-99.1 2 d388770dex991.htm EX-99.1 Exhibit 99.1 Singular Genomics Reports Instrument Shipments and Preliminary Unaudited Fourth Quarter 2022 Revenue San Diego, CA, January 9, 2023 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today announced instrument shipments and p

November 7, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 ☐ TRANSITION REPORT PURSUANT

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443

November 7, 2022 EX-99.1

Singular Genomics Reports Recent Highlights and Third Quarter 2022 Financial Results

Singular Genomics Reports Recent Highlights and Third Quarter 2022 Financial Results San Diego, CA, November 7, 2022 ? Singular Genomics Systems, Inc.

November 7, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 7, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

November 7, 2022 EX-10.1

First Amendment to Amended and Restated Loan and Security Agreement, dated September 30, 2022, by and between the Company and Silicon Valley Bank (filed as Exhibit 10.1 of the Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed with the SEC on November 7, 2022 and incorporated herein by reference (File No. 001-40443).

Exhibit 10.1 CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND is the type of information that the registrant treats as private and Confidential, AND HAS BEEN MARKED WITH ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE. FIRST AMENDMENT TO AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT This First Amendment to Amended and Restated Loan and Se

October 4, 2022 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date Earliest Event Reported): September 30, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or Other Jurisdiction of Incorporation) (Co

August 22, 2022 SC TO-I/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO/A (Amendment No. 1) (Rule 13e-4) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SINGULAR GENOMICS SYSTEMS, INC. (Nam

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO/A (Amendment No. 1) (Rule 13e-4) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SINGULAR GENOMICS SYSTEMS, INC. (Name of Subject Company (Issuer) and Filing Person (Offeror)) Options to Purchase Common Stock, Par Value $0.0001 Per Share (Title of Class of Securities

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 ☐ TRANSITION REPORT PURSUANT TO S

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 Sing

August 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Com

August 9, 2022 424B5

$100,000,000 Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-266221 PROSPECTUS SUPPLEMENT (To Prospectus dated July 27, 2022) $100,000,000 Common Stock We have entered into a sales agreement, or the Sales Agreement, with Cowen and Company, LLC, or Cowen, relating to the sale of shares of our common stock, par value $0.0001 per share, offered by this prospectus supplement and the accompa

August 9, 2022 EX-99.1

Singular Genomics Reports Recent Highlights and Second Quarter 2022 Financial Results

Singular Genomics Reports Recent Highlights and Second Quarter 2022 Financial Results San Diego, CA, August 9, 2022 ? Singular Genomics Systems, Inc.

July 25, 2022 EX-99.(D)(1)

Singular Genomics Systems, Inc. 2021 Equity Incentive Plan, as amended, and form agreements thereunder.

Exhibit (d)(1) SINGULAR GENOMICS SYSTEMS, INC. 2021 EQUITY INCENTIVE PLAN (AS AMENDED AND RESTATED ON JULY 22, 2022) SINGULAR GENOMICS SYSTEMS, INC. 2021 EQUITY INCENTIVE PLAN (AS AMENDED AND RESTATED ON JULY 22, 2022) ARTICLE 1. INTRODUCTION. The Board adopted the Plan to become effective immediately upon its approval on May 19, 2021, although no Awards were granted under the Plan prior to the IP

July 25, 2022 EX-99.(A)(1)(D)

Notice of Withdrawal of Election Form.

Exhibit (a)(1)(D) INSTRUCTIONS TO NOTICE OF WITHDRAWAL OF ELECTION FORM If you previously elected to accept the offer by Singular Genomics Systems, Inc.

July 25, 2022 EX-99.(A)(1)(C)

Election Form.

Exhibit (a)(1)(C) SINGULAR GENOMICS SYSTEMS, INC. 3010 Science Park Road San Diego, CA 92121 OPTION EXCHANGE - ELECTION FORM THIS OFFER AND YOUR WITHDRAWAL RIGHTS WILL EXPIRE AT 6:00 P.M., PACIFIC TIME, ON FRIDAY, AUGUST 19, 2022, UNLESS EXTENDED Before completing and signing this Election Form, we encourage you to read the documents that make up this tender offer, including (1) the Offer to Excha

July 25, 2022 EX-99.(A)(1)(A)

Offer to Exchange Eligible Option(s) for New Option(s), dated July 25, 2022.

Exhibit (a)(1)(A) SINGULAR GENOMICS SYSTEMS, INC. 3010 SCIENCE PARK ROAD SAN DIEGO, CALIFORNIA 92121 OFFER TO EXCHANGE ELIGIBLE OPTION(S) FOR NEW OPTION(S) JULY 25, 2022 SINGULAR GENOMICS SYSTEMS, INC. SUMMARY TERM SHEET - OVERVIEW OFFER TO EXCHANGE ELIGIBLE OPTION(S) FOR NEW OPTION(S) This offer and withdrawal rights will expire at 6:00 P.M., Pacific Time, on Friday, August 19, 2022, unless exten

July 25, 2022 EX-10.1

2021 Equity Incentive Plan as amended and restated, and forms of agreements thereunder.

EXHIBIT 10.1 SINGULAR GENOMICS SYSTEMS, INC. 2021 EQUITY INCENTIVE PLAN (AS AMENDED AND RESTATED ON JULY 22, 2022) SINGULAR GENOMICS SYSTEMS, INC. 2021 EQUITY INCENTIVE PLAN (AS AMENDED AND RESTATED ON JULY 22, 2022) ARTICLE 1. INTRODUCTION. The Board adopted the Plan to become effective immediately upon its approval on May 19, 2021, although no Awards were granted under the Plan prior to the IPO

July 25, 2022 EX-99.(A)(1)(I)

Form of Email Notice Regarding Rejection of Options for Exchange.

Exhibit (a)(1)(I) FORM OF EMAIL NOTICE REGARDING REJECTION OF OPTIONS FOR EXCHANGE From: SINGULAR GENOMICS SYSTEMS, INC.

July 25, 2022 EX-99.(A)(1)(B)

Form of Announcement Email to Eligible Holders.

Exhibit (a)(1)(B) FORM OF ANNOUNCEMENT EMAIL TO ELIGIBLE HOLDERS Subject: Singular Genomics Systems, Inc.

July 25, 2022 CORRESP

July 25, 2022

July 25, 2022 VIA EDGAR Division of Corporation Finance United States Securities and Exchange Commission 100 F Street, N.

July 25, 2022 SC TO-I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 13e-4) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SINGULAR GENOMICS SYSTEMS, INC. (Name of Subject Company

SC TO-I 1 d363074dsctoi.htm SC TO-I UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO (Rule 13e-4) Tender Offer Statement Under Section 14(d)(1) or 13(e)(1) of the Securities Exchange Act of 1934 SINGULAR GENOMICS SYSTEMS, INC. (Name of Subject Company (Issuer) and Filing Person (Offeror)) Options to Purchase Common Stock, Par Value $0.0001 Per Share (Title of Cla

July 25, 2022 EX-FILING FEES

Filing Fee Table.

EXHIBIT 107 Calculation of Filing Fee Tables Schedule TO (Form Type) Singular Genomics Systems, Inc.

July 25, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date Earliest Event Reported): July 22, 2022 Singular Genomics Syst

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date Earliest Event Reported): July 22, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or Other Jurisdiction of Incorporation) (Commiss

July 25, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date Earliest Event Reported): July 22, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or Other Jurisdiction of Incorporation) (Commiss

July 25, 2022 EX-99.(A)(1)(G)

Form of Reminder Email to Eligible Holders Regarding the Expiration of the Exchange Offer.

Exhibit (a)(1)(G) FORM OF REMINDER EMAIL TO ELIGIBLE HOLDERS REGARDING THE EXPIRATION OF THE EXCHANGE OFFER From: SINGULAR GENOMICS SYSTEMS, INC.

July 25, 2022 EX-99.(A)(1)(H)

Form of Email to Eligible Holders Confirming Acceptance of Eligible Option(s).

Exhibit (a)(1)(H) FORM OF EMAIL TO ELIGIBLE HOLDERS CONFIRMING ACCEPTANCE OF ELIGIBLE OPTION(S) From: SINGULAR GENOMICS SYSTEMS, INC.

July 25, 2022 EX-99.(A)(1)(F)

Form of Email Confirming Receipt of Notice of Withdrawal of Election Form.

Exhibit (a)(1)(F) FORM OF EMAIL CONFIRMING RECEIPT OF NOTICE OF WITHDRAWAL OF ELECTION FORM From: SINGULAR GENOMICS SYSTEMS, INC.

July 25, 2022 EX-99.(A)(1)(K)

Investor Presentation.

Stock Option Exchange Singular Genomics July 2022 Exhibit (a)(1)(K) Stock options are a critical component of our compensation philosophy, the focal point of which is to encourage our employees and consultants to build long-term stockholder value.

July 25, 2022 EX-99.(A)(1)(E)

Form of Email Confirming Receipt of Election Form.

Exhibit (a)(1)(E) FORM OF EMAIL CONFIRMING RECEIPT OF ELECTION FORM From: SINGULAR GENOMICS SYSTEMS, INC.

July 25, 2022 EX-99.(A)(1)(J)

Form of Expiration Notice Email.

Exhibit (a)(1)(J) FORM OF EXPIRATION NOTICE EMAIL From: SINGULAR GENOMICS SYSTEMS, INC.

July 19, 2022 EX-1.2

Sales Agreement dated as of July 19, 2022, by and between the Registrant and Cowen and Company, LLC.

Exhibit 1.2 Execution Version SINGULAR GENOMICS SYSTEMS, INC. $100,000,000 COMMON STOCK SALES AGREEMENT July 19, 2022 Cowen and Company, LLC 599 Lexington Avenue New York, NY 10022 Ladies and Gentlemen: Singular Genomics Systems, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cowen and Company, LLC (“Cowen”), as follows: 1. Issuance and Sale of Shares.

July 19, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Singular Genomics Systems, Inc.

July 19, 2022 EX-4.5

Form of Indenture with respect to the Securities.

Exhibit 4.5 INDENTURE between SINGULAR GENOMICS SYSTEMS, INC. as Issuer and [TRUSTEE] as Trustee Dated as of , 20 Providing for the Issuance of Debt Securities in Series SINGULAR GENOMICS SYSTEMS, INC. Reconciliation and tie between the Trust Indenture Act of 1939 and the Indenture Trust Indenture Act Section Indenture Section Sec. 310(a)(1) 607 (a)(2) 607 (b) 608 Sec. 312(c) 701 Sec. 314(a) 703 (

July 19, 2022 S-3

As filed with the Securities and Exchange Commission on July 19, 2022

Table of Contents As filed with the Securities and Exchange Commission on July 19, 2022 Registration No.

July 19, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 19, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

June 3, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 26, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commi

May 10, 2022 EX-99.1

Singular Genomics Systems, Inc. Reports Recent Highlights and First Quarter 2022 Financial Results

Singular Genomics Systems, Inc. Reports Recent Highlights and First Quarter 2022 Financial Results La Jolla, CA, May 10, 2022 ? Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for the quarter en

May 10, 2022 EX-10.1

Lease Agreement dated, as of January 19, 2022 by and between Singular Genomics Systems, Inc. and ARE-10933 North Torrey Pines, LLC.

DocuSign Envelope ID: FC2CC128-9822-4855-A001-C19E6B8CA968 LEASE AGREEMENT THIS LEASE AGREEMENT (this ?Lease?) is made this 19 day of January, 2022, between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (?Landlord?), and SINGULAR GENOMICS SYSTEMS, INC.

May 10, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 ☐ TRANSITION REPORT PURSUANT TO

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 SIN

May 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commi

April 26, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Com

April 14, 2022 DEF 14A

definitive proxy statement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a?6(e)(2)) ? Defin

April 14, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a?6(e)(2)) ? Defin

March 14, 2022 S-8

As filed with the Securities and Exchange Commission on March 14, 2022

As filed with the Securities and Exchange Commission on March 14, 2022 Registration No.

March 14, 2022 EX-FILING FEES

Calculation of Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Singular Genomics Systems Inc.

March 14, 2022 EX-4.2

Description of the Registrant’s Securities registered pursuant to Section 12 of the Securities Exchange Act of 1934.

Exhibit 4.2 DESCRIPTION OF SINGULAR GENOMICS SYSTEMS, INC.?S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 The following description of the common stock, par value $0.0001 per share, of Singular Genomics Systems, Inc. (?us,? ?our,? ?we,? or the ?Company?), which is the only security of the Company registered under Section 12 of the Securities Exchange Act of 1

March 14, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ☐ TRANSITION REPORT PURSUA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40443 SINGULAR GENOMI

March 2, 2022 EX-99.1

SINGULAR GENOMICS SYSTEMS, INC. Statements of Operations (in thousands, except share and per share amounts)

Singular Genomics Systems, Inc. Reports Recent Highlights, Fourth Quarter and Full Year 2021 Financial Results La Jolla, CA, March 2, 2022 ? Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today highlighted recent corporate achievements and reported financial results for t

March 2, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 2, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Comm

February 14, 2022 EX-99.1

Joint Filing Agreement

EXHIBIT 99.1 Joint Filing Agreement The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be

February 14, 2022 SC 13G

OMIC / Singular Genomics Systems, Inc. / Revelation Alpine, LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 82933R100 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to desig

February 14, 2022 SC 13G

OMIC / Singular Genomics Systems, Inc. / Glezer Eli N. - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Singular Genomics Systems, Inc.

February 14, 2022 SC 13G

OMIC / Singular Genomics Systems, Inc. / Spaventa Andrew - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G INFORMATION STATEMENT PURSUANT TO RULES 13d-1 AND 13d-2 UNDER THE SECURITIES EXCHANGE ACT OF 1934 Singular Genomics Systems, Inc.

February 4, 2022 SC 13G

OMIC / Singular Genomics Systems, Inc. / ARCH Venture Fund IX, L.P. - ARCH VENTURE FUND IX, L.P. - SINGULAR GENOMICS SYSTEMS -- SCH 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. ???)* Singular Genomics Systems, Inc. (Name of Issuer) Common Stock par value $0.0001 per share (Title of Class of Securities) 82933R100 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to des

January 26, 2022 EX-3.1

Certificate of Designation of Preferences, Rights and Limitations of the Series A Preferred Stock, par value $0.0001 per share, of the Registrant.

EX-3.1 2 omic-ex31.htm EX-3.1 SINGULAR GENOMICS SYSTEMS, INC. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES A COMMON STOCK EQUIVALENT CONVERTIBLE PREFERRED STOCK PURSUANT TO SECTION 151(g) OF THE DELAWARE GENERAL CORPORATION LAW Singular Genomics Systems, Inc., a Delaware corporation (the “Company”), in accordance with the provisions of Section 103 of the Delaware Gen

January 26, 2022 EX-10.1

Exchange Agreement, dated as of January 26, 2022, by and among the Company, Deerfield Private Design Fund IV, L.P. and Deerfield Partners, L.P

EXCHANGE AGREEMENT This EXCHANGE AGREEMENT (including the schedules, annexes and exhibits hereto, this ?Agreement?), dated as of January 26, 2022, is entered into by and among Singular Genomics Systems, Inc.

January 26, 2022 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 26, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

January 20, 2022 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 19, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

January 10, 2022 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 10, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

January 6, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2022 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Co

January 6, 2022 EX-99.1

Singular Genomics Appoints Genomics Research Pioneer Elaine R. Mardis, Ph.D., to Board of Directors

EX-99.1 2 d253895dex991.htm EX-99.1 Exhibit 99.1 Singular Genomics Appoints Genomics Research Pioneer Elaine R. Mardis, Ph.D., to Board of Directors La Jolla, CA, January 6, 2022 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and multiomics technologies to empower researchers and clinicians, today announced the addition of Elaine R. Ma

January 4, 2022 SC 13G

OMIC / Singular Genomics Systems, Inc. / Domain Partners IX, L.P. - SCHEDULE 13G Passive Investment

SC 13G 1 s13g123121-singular.htm SCHEDULE 13G SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b),(c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )1 Singular Genomics Systems, Inc. (Name of Issuer) Common Stock, $0.0001 par value (Title of Class of Securitie

December 16, 2021 EX-99.1

Singular Genomics Launches the G4 Sequencing Platform – Next-generation sequencing platform will provide up to three times more data output per hour than other benchtop instruments, while offering flexible run capacity –

EX-99.1 2 omic-ex991.htm EX-99.1 Singular Genomics Launches the G4 Sequencing Platform – Next-generation sequencing platform will provide up to three times more data output per hour than other benchtop instruments, while offering flexible run capacity – La Jolla, CA, December 16, 2021 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company leveraging novel next-generation sequencing (NGS) and

December 16, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 16, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

November 16, 2021 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 15, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (

November 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443

November 9, 2021 EX-99.1

Singular Genomics Systems, Inc. Reports Recent Highlights and Third Quarter Financial Results

EX-99.1 2 omic-ex991.htm EX-99.1 Singular Genomics Systems, Inc. Reports Recent Highlights and Third Quarter Financial Results La Jolla, CA, November 9, 2021 – Singular Genomics Systems, Inc. (Nasdaq: OMIC), a company focused on delivering genomic technologies for the advancement of science and medicine, today highlighted recent corporate achievements and reported financial results for the third q

November 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (C

November 9, 2021 EX-10.1

Amended and Restated Loan and Security Agreement, dated September 30, 2021, by and between the Registrant and Silicon Valley Bank (filed as Exhibit 10.1 to the Quarterly Report on Form 10-Q for the quarter ended September 30, 2021, filed with the SEC on November 9, 2021 and incorporated herein by reference (File No. 001-40443)).

EX-10.1 2 omic-ex101.htm EX-10.1 AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as of the Effective Date between SILICON VALLEY BANK, a California corporation (“Bank”), and the borrower listed on Schedule I hereto (“Borrower”). The parties agree as follows: Recitals A. Bank and Borrower have entered into that certa

October 4, 2021 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 30, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation)

September 10, 2021 8-K/A

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 31, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction o

August 31, 2021 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 31, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Co

August 25, 2021 S-8

As filed with the Securities and Exchange Commission on August 25, 2021

Table of Contents As filed with the Securities and Exchange Commission on August 25, 2021 Registration No.

August 11, 2021 8-K

Regulation FD Disclosure

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Co

August 3, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Com

August 3, 2021 EX-99.1

Singular Genomics Systems, Inc. Announces Second Quarter Financial Results and Operations Update

Exhibit 99.1 Singular Genomics Systems, Inc. Announces Second Quarter Financial Results and Operations Update La Jolla, CA, August 3, 2021 ? Singular Genomics Systems, Inc., a company focused on delivering genomic technologies for the advancement of science and medicine, today reported its second quarter 2021 financial results and highlighted recent operating and corporate achievements. Investors

August 3, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to . Commission File Number: 001-40443 SING

June 3, 2021 SC 13G

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No. )* Singula

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b) (Amendment No.

June 1, 2021 EX-3.2

Amended and Restated Bylaws of Registrant.

EX-3.2 3 d171098dex32.htm EX-3.2 Exhibit 3.2 Singular Genomics Systems, Inc. Amended and Restated Bylaws (amended and restated on May 19, 2021 and effective as of the closing of this corporation’s initial public offering) Table of Contents Page Article I Stockholders 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meetings 1 1.4 Notice of Meetings 1 1.5 Voting List 2 1.6 Quorum 2 1.7 Ad

June 1, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 1, 2021 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40443 81-2948451 (State or other jurisdiction of incorporation) (Commi

June 1, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of Registrant

EX-3.1 2 d171098dex31.htm EX-3.1 Exhibit 3.1 Singular Genomics Systems, Inc. Amended and Restated Certificate of Incorporation Singular Genomics Systems, Inc., a corporation organized and existing under the laws of the State of Delaware, hereby certifies as follows: 1. The name of the corporation is Singular Genomics Systems, Inc., which was the name under which the corporation was originally inco

June 1, 2021 EX-99.1

Singular Genomics Systems, Inc. Announces Closing of Initial Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares

Exhibit 99.1 Singular Genomics Systems, Inc. Announces Closing of Initial Public Offering and Full Exercise of Underwriters? Option to Purchase Additional Shares La Jolla, CA, June 1, 2021 ? Singular Genomics Systems, Inc. (?Singular Genomics?), a company focused on delivering genomic technologies for the advancement of science and medicine, today announced the closing of its initial public offeri

May 28, 2021 424B4

10,200,000 Shares Common Stock

Table of Contents Filed pursuant to Rule 424(b)(4) Registration No. 333-255912 Registration No. 333-256522 P R O S P E C T U S 10,200,000 Shares Common Stock This is the initial public offering of shares of common stock of Singular Genomics Systems, Inc. We are offering 10,200,000 shares of our common stock. Prior to this offering, there has been no public market for our common stock. The initial

May 27, 2021 S-8

Form S-8

As filed with the Securities and Exchange Commission on May 27, 2021 Registration No.

May 26, 2021 S-1MEF

Form S-1

As filed with the Securities and Exchange Commission on May 26, 2021. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 SINGULAR GENOMICS SYSTEMS, INC. (Exact name of Registrant as specified in its charter) Delaware 3826 81-2948451 (State or other jurisdiction of incorporation or organizati

May 25, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Singular Genomics Systems, Inc. (Exact name of registrant as specified in its charter) Delaware 81-2948451 (State of incorporation or organization) (I.R.S. Employer Identification No.) 10931 N. Tor

May 24, 2021 S-1/A

Form S-1

Table of Contents As filed with the Securities and Exchange Commission on May 24, 2021.

May 24, 2021 CORRESP

[signature page follows]

May 24, 2021 United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

May 24, 2021 EX-10.13

Management Cash Incentive Plan.

EX-10.13 10 d240097dex1013.htm EX-10.13 Exhibit 10.13 SINGULAR GENOMICS SYSTEMS, INC. MANAGEMENT CASH INCENTIVE PLAN ARTICLE 1. BACKGROUND AND PURPOSE 1.1 Effective Date. This Plan became effective upon its adoption by the Committee and is not subject to approval by the Company’s stockholders. 1.2 Purpose of the Plan. The Plan is intended to provide Participants with the possibility of earning inc

May 24, 2021 EX-4.1

Specimen common stock certificate of the Registrant.

EX-4.1 Exhibit 4.1 SEE REVERSE FOR IMPORTANT NOTICE REGARDING OWNERSHIP AND TRANSFER RESTRICTIONS AND CERTAIN OTHER INFORMATION INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE CUSIP 82933R 10 0 COMMON STOCK SEE REVERSE FOR CERTAIN DEFINITIONS SPECIMEN FULLY PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK $0.0001 PAR VALUE, OF SINGULAR GENOMICS SYSTEMS, INC. transferable on the books of the

May 24, 2021 EX-3.4

Amended and Restated Bylaws of Registrant.

EXHIBIT 3.4 Singular Genomics Systems, Inc. Amended and Restated Bylaws (amended and restated on May 19, 2021 and effective as of the closing of this corporation’s initial public offering) Table of Contents Page Article I Stockholders 1 1.1 Place of Meetings 1 1.2 Annual Meeting 1 1.3 Special Meetings 1 1.4 Notice of Meetings 1 1.5 Voting List 2 1.6 Quorum 2 1.7 Adjournments 3 1.8 Voting and Proxi

May 24, 2021 EX-10.3

2021 Equity Incentive Plan and forms of agreements thereunder.

EX-10.3 EXHIBIT 10.3 SINGULAR GENOMICS SYSTEMS, INC. 2021 EQUITY INCENTIVE PLAN (AS ADOPTED ON MAY 19, 2021) SINGULAR GENOMICS SYSTEMS, INC. 2021 EQUITY INCENTIVE PLAN ARTICLE 1. INTRODUCTION. The Board adopted the Plan to become effective immediately, although no Awards may be granted under the Plan prior to the IPO Date. The purpose of the Plan is to promote the long-term success of the Company

May 24, 2021 CORRESP

May 24, 2021

May 24, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Alan Campbell Jeffrey Gabor Ibolya Ignat Lynn Dicker Re: Singular Genomics Systems, Inc. Registration Statement on Form S-1 File No. 333-255912 Request for Acceleration of Effective Date Requested Date: Wednesday, May 26, 2021 Requested Time: 4:00 P.M.

May 24, 2021 EX-10.1

Form of Indemnification Agreement between the Registrant and each of its directors and executive officers.

EXHIBIT 10.1 [AMENDED AND RESTATED]1 INDEMNITY AGREEMENT THIS [AMENDED AND RESTATED] INDEMNITY AGREEMENT (this “Agreement”) dated as of , is made by and between Singular Genomics Systems, Inc., a Delaware corporation (the “Company”), and (“Indemnitee”). RECITALS: A. The Company desires to attract and retain the services of highly qualified individuals as directors, officers, employees and agents.

May 24, 2021 EX-3.2

Amended and Restated Certificate of Incorporation of Registrant.

EXHIBIT 3.2 Singular Genomics Systems, Inc. Amended and Restated Certificate of Incorporation Singular Genomics Systems, Inc., a corporation organized and existing under the laws of the State of Delaware, hereby certifies as follows: 1. The name of the corporation is Singular Genomics Systems, Inc., which was the name under which the corporation was originally incorporated. The date of the filing

May 24, 2021 EX-10.14

Executive Severance Plan.

EX-10.14 11 d240097dex1014.htm EX-10.14 Exhibit 10.14 SINGULAR GENOMICS SYSTEMS, INC. EXECUTIVE SEVERANCE PLAN 1. Purpose of the Plan The purpose of the Plan is to provide for the payment of severance benefits to certain eligible employees of the Company in the event such employees are subject to certain qualifying employment terminations. This Plan shall supersede any and all prior separation, se

May 24, 2021 EX-10.4

2021 Employee Stock Purchase Plan.

EXHIBIT 10.4 SINGULAR GENOMICS SYSTEMS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN (AS ADOPTED ON MAY 19, 2021) SINGULAR GENOMICS SYSTEMS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN SECTION 1. PURPOSE OF THE PLAN. The Board adopted the Plan effective as of the IPO Date. The purpose of the Plan is to provide Eligible Employees with an opportunity to increase their interest in the success of the Company by

May 24, 2021 EX-1.1

Form of Underwriting Agreement.

EX-1.1 2 d240097dex11.htm EX-1.1 Exhibit 1.1 Singular Genomics Systems, Inc. [•] Shares of Common Stock, par value $0.0001 per share Form of Underwriting Agreement [•], 2021 J.P. Morgan Securities LLC Goldman Sachs & Co. LLC BofA Securities, Inc. Cowen and Company, LLC As Representatives of the several Underwriters listed in Schedule 1 hereto c/o J.P. Morgan Securities LLC 383 Madison Avenue New Y

May 12, 2021 S-1/A

As filed with the Securities and Exchange Commission on May 12, 2021.

Table of Contents As filed with the Securities and Exchange Commission on May 12, 2021.

May 12, 2021 CORRESP

May 12, 2021

May 12, 2021 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-3720 Attention: Alan Campbell Jeffrey Gabor Re: Singular Genomics Systems, Inc. CIK No. 0001850906 Amendment No. 1 to Draft Registration Statement on Form S-1 Submitted April 26, 2021 Registration Statement on Form S-1 Filed May 7, 2021 Registration Statement No:

May 7, 2021 EX-10.8

Amended and Restated Offer Letter, dated January 7, 2020, by and between the Registrant and Andrew Spaventa (filed as Exhibit 10.8 to the Registration Statement on Form S-1, filed with the SEC on May 7, 2021 and incorporated herein by reference (File No. 333-255912)).

EX-10.8 10 d240097dex108.htm EX-10.8 Exhibit 10.8 SINGULAR GENOMICS SYSTEMS, INC. December 17, 2019 Andrew Spaventa Dear Drew: SINGULAR GENOMICS SYSTEMS, INC. (the “Company”) is pleased to confirm the amended terms of your employment with the Company, as follows: 1. Position. Your title will continue to be Chief Executive Officer, President and Chairman of the Board. This is a full-time position.

May 7, 2021 EX-3.3

Bylaws of Registrant, as currently in effect

EX-3.3 3 d240097dex33.htm EX-3.3 Exhibit 3.3 BYLAWS OF SINGULAR GENOMICS SYSTEMS, INC. (A DELAWARE CORPORATION) TABLE OF CONTENTS Page ARTICLE I OFFICES 1 1.1 Registered Office 1 1.2 Offices 1 ARTICLE II MEETINGS OF STOCKHOLDERS 1 2.1 Location 1 2.2 Timing 1 2.3 Notice of Meeting 1 2.4 Stockholders’ Records 1 2.5 Special Meetings 2 2.6 Notice of Meeting 2 2.7 Business Transacted at Special Meeting

May 7, 2021 EX-10.6

Lease Agreement, dated November 1, 2017, by and between ARE-10933 North Torrey Pines, LLC and the Registrant (filed as Exhibit 10.5 to the Registration Statement on Form S-1, filed with the SEC on May 7, 2021 and incorporated herein by reference (File No. 333-255912)).

EX-10.6 8 d240097dex106.htm EX-10.6 Exhibit 10.6 LEASE AGREEMENT THIS LEASE AGREEMENT (this “Lease”) is made this 26th day of June, 2020, between ARE-SD REGION NO. 27, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”). Building: 3010 Science Park Road, San Diego, California Premises: The entire Building, containing approx

May 7, 2021 EX-10.10

Offer Letter, dated September 25, 2019, by and between the Registrant and Dalen Meeter.

Exhibit 10.10 September 25, 2019 Dalen Meeter Dear Dalen: SINGULAR GENOMICS SYSTEMS, INC. (the “Company”) is pleased to offer you employment on the following terms: 1. Position. Your initial title will be Vice President, Finance. This is a full-time position. While you render services to the Company, you will not engage in any other employment, consulting or other business activity (whether full-t

May 7, 2021 EX-10.9

Amended and Restated Offer Letter, dated January 11, 2020, by and between the Registrant and Eli Glezer.

Exhibit 10.9 SINGULAR GENOMICS SYSTEMS, INC. December 17, 2019 Dr. Eli Glezer Dear Eli: SINGULAR GENOMICS SYSTEMS, INC. (the “Company”) is pleased to confirm the amended terms of your employment with the Company, as follows: 1. Position. You will continue to serve as the Company’s Chief Scientific Officer. This is a full-time position. In this position, you will be responsible for leading the Comp

May 7, 2021 S-1

Power of Attorney (included on signature page).

Table of Contents As filed with the Securities and Exchange Commission on May 7, 2021.

May 7, 2021 EX-10.7

Sublease, dated June 15, 2020, by and between the Registrant and Gossamer Bio, Inc.

Exhibit 10.7 SUBLEASE 1. PARTIES. This Sublease, dated June 15, 2020 (“Effective Date”) is made between GOSSAMER BIO, INC., a Delaware corporation (“Sublessor”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Sublessee”). 2. MASTER LEASE. Sublessor is the lessee under that certain Lease Agreement dated November 19, 2019, (the “Master Lease”) attached as Exhibit ‘B’, wherein ARE-SD R

May 7, 2021 EX-10.5

Lease Agreement, dated November 1, 2017, by and between ARE-10933 North Torrey Pines, LLC and the Registrant.

Exhibit 10.5 LEASE AGREEMENT THIS LEASE AGREEMENT (this “Lease”) is made this 1st day of November, 2017, between ARE-10933 NORTH TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Tenant”). Building: 10931 N. Torrey Pines Road, San Diego, California Premises: That portion of the Project, initially containing approxima

May 7, 2021 EX-4.3

Series B Preferred Stock Warrant, as amended.

EX-4.3 5 d240097dex43.htm EX-4.3 Exhibit 4.3 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTAN

May 7, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, dated June 27, 2019, as amended, by and among the Registrant and the other parties thereto (filed as Exhibit 4.2 to the Registration Statement on Form S-1, filed with the SEC on May 7, 2021 and incorporated herein by reference (File No. 333-255912)).

EX-4.2 4 d240097dex42.htm EX-4.2 Exhibit 4.2 SINGULAR GENOMICS SYSTEMS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT June 27, 2019 1 TABLE OF CONTENTS Page 1.  Definitions 1 2.  Registration Rights 3 2.1   Request for Registration 3 2.2   Company Registration 5 2.3   Form S-3 Registration 6 2.4   Obligations of the Company 8 2.5   Information from Holder 9 2.6   Expenses of Registration 9

May 7, 2021 EX-10.11

Loan Agreement, dated November 19, 2019, by and between the Registrant and Silicon Valley Bank.

Exhibit 10.11 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) dated as of November 19, 2019 (the “Effective Date”) between SILICON VALLEY BANK, a California corporation (“Bank”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Borrower”), provides the terms on which Bank shall lend to Borrower and Borrower shall repay Bank. The parties agree as follows

May 7, 2021 EX-10.12

Exclusive License Agreement, date August 12, 2016, as amended, by and between the Registrant and The Trustees of Columbia University in the City of New York.

Exhibit 10.12 CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED ?[***]? TO INDICATE WHERE OMISSIONS HAVE BEEN MADE. EXCLUSIVE LICENSE AGREEMENT AGREEMENT, dated August 12, 2016 (the ?Effective Date?), between THE TRUSTEES OF COLUMBIA UNIVERSITY IN TH

May 7, 2021 EX-10.2

2016 Stock Plan and forms of agreements thereunder.

EX-10.2 6 d240097dex102.htm EX-10.2 Exhibit 10.2 SINGULAR GENOMICS SYSTEMS, INC. 2016 STOCK PLAN ADOPTED ON SEPTEMBER 19, 2016 TABLE OF CONTENTS Page SECTION 1. ESTABLISHMENT AND PURPOSE 1 SECTION 2. ADMINISTRATION 1 (a) Committees of the Board of Directors 1 (b) Authority of the Board of Directors 1 SECTION 3. ELIGIBILITY 1 (a) General Rule 1 (b) Ten-Percent Stockholders 1 SECTION 4. STOCK SUBJEC

May 7, 2021 EX-3.1

Amended and Restated Certificate of Incorporation of Registrant, as currently in effect

EX-3.1 2 d240097dex31.htm EX-3.1 Exhibit 3.1 RESTATED CERTIFICATE OF INCORPORATION OF SINGULAR GENOMICS SYSTEMS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Singular Genomics Systems, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation L

April 26, 2021 EX-10.9

SINGULAR GENOMICS SYSTEMS, INC. December 17, 2019

EX-10.9 5 filename5.htm Exhibit 10.9 SINGULAR GENOMICS SYSTEMS, INC. December 17, 2019 Dr. Eli Glezer Dear Eli: SINGULAR GENOMICS SYSTEMS, INC. (the “Company”) is pleased to confirm the amended terms of your employment with the Company, as follows: 1. Position. You will continue to serve as the Company’s Chief Scientific Officer. This is a full-time position. In this position, you will be responsi

April 26, 2021 EX-10.10

September 25, 2019

EX-10.10 6 filename6.htm Exhibit 10.10 September 25, 2019 Dalen Meeter Dear Dalen: SINGULAR GENOMICS SYSTEMS, INC. (the “Company”) is pleased to offer you employment on the following terms: 1. Position. Your initial title will be Vice President, Finance. This is a full-time position. While you render services to the Company, you will not engage in any other employment, consulting or other business

April 26, 2021 EX-10.8

SINGULAR GENOMICS SYSTEMS, INC. December 17, 2019

EX-10.8 4 filename4.htm Exhibit 10.8 SINGULAR GENOMICS SYSTEMS, INC. December 17, 2019 Andrew Spaventa Dear Drew: SINGULAR GENOMICS SYSTEMS, INC. (the “Company”) is pleased to confirm the amended terms of your employment with the Company, as follows: 1. Position. Your title will continue to be Chief Executive Officer, President and Chairman of the Board. This is a full-time position. In this posit

April 26, 2021 EX-4.2

SINGULAR GENOMICS SYSTEMS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT June 27, 2019

EX-4.2 2 filename2.htm Exhibit 4.2 SINGULAR GENOMICS SYSTEMS, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT June 27, 2019 1 TABLE OF CONTENTS Page 1.  Definitions 1 2.  Registration Rights 3 2.1   Request for Registration 3 2.2   Company Registration 5 2.3   Form S-3 Registration 6 2.4   Obligations of the Company 8 2.5   Information from Holder 9 2.6   Expenses of Registration 9 2.7   Del

April 26, 2021 EX-4.3

WARRANT TO PURCHASE STOCK

EX-4.3 3 filename3.htm Exhibit 4.3 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFA

April 26, 2021 DRS/A

-

Table of Contents As confidentially submitted to the Securities and Exchange Commission on April 26, 2021 as Amendment No.

April 26, 2021 EX-10.12

CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED “[***]” TO INDICATE WHERE OMISSIONS HAVE BEEN MADE

EX-10.12 8 filename8.htm Exhibit 10.12 CERTAIN IDENTIFIED INFORMATION HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED, AND HAS BEEN MARKED “[***]” TO INDICATE WHERE OMISSIONS HAVE BEEN MADE. EXCLUSIVE LICENSE AGREEMENT AGREEMENT, dated August 12, 2016 (the “Effective Date”), between THE TRUSTEES OF

April 26, 2021 EX-10.11

LOAN AND SECURITY AGREEMENT

EX-10.11 7 filename7.htm Exhibit 10.11 LOAN AND SECURITY AGREEMENT THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) dated as of November 19, 2019 (the “Effective Date”) between SILICON VALLEY BANK, a California corporation (“Bank”), and SINGULAR GENOMICS SYSTEMS, INC., a Delaware corporation (“Borrower”), provides the terms on which Bank shall lend to Borrower and Borrower shall repay Bank. The

April 26, 2021 DRSLTR

April 26, 2021

DRSLTR 1 filename1.htm SILICON VALLEY ANN ARBOR BEIJING BOSTON LOS ANGELES NEW YORK SAN DIEGO SAN FRANCISCO SINGAPORE April 26, 2021 Via EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-3720 Attention: Alan Campbell Jeffrey Gabor Re: Singular Genomics Systems, Inc. Draft Registration Statement on Form S-1 Submitted March 22, 20

March 22, 2021 EX-10.2

SINGULAR GENOMICS SYSTEMS, INC. 2016 STOCK PLAN ADOPTED ON SEPTEMBER 19, 2016

EX-10.2 4 filename4.htm Exhibit 10.2 SINGULAR GENOMICS SYSTEMS, INC. 2016 STOCK PLAN ADOPTED ON SEPTEMBER 19, 2016 TABLE OF CONTENTS Page SECTION 1. ESTABLISHMENT AND PURPOSE 1 SECTION 2. ADMINISTRATION 1 (a) Committees of the Board of Directors 1 (b) Authority of the Board of Directors 1 SECTION 3. ELIGIBILITY 1 (a) General Rule 1 (b) Ten-Percent Stockholders 1 SECTION 4. STOCK SUBJECT TO PLAN 2

March 22, 2021 EX-3.3

BYLAWS OF SINGULAR GENOMICS SYSTEMS, INC. (A DELAWARE CORPORATION)

EX-3.3 3 filename3.htm Exhibit 3.3 BYLAWS OF SINGULAR GENOMICS SYSTEMS, INC. (A DELAWARE CORPORATION) TABLE OF CONTENTS Page ARTICLE I OFFICES 1 1.1 Registered Office 1 1.2 Offices 1 ARTICLE II MEETINGS OF STOCKHOLDERS 1 2.1 Location 1 2.2 Timing 1 2.3 Notice of Meeting 1 2.4 Stockholders’ Records 1 2.5 Special Meetings 2 2.6 Notice of Meeting 2 2.7 Business Transacted at Special Meeting 2 2.8 Quo

March 22, 2021 DRS

As confidentially submitted to the Securities and Exchange Commission on March 19, 2021. This draft registration statement has not been publicly filed with the Securities and Exchange Commission and all information herein remains strictly confidentia

Table of Contents As confidentially submitted to the Securities and Exchange Commission on March 19, 2021.

March 22, 2021 EX-3.1

RESTATED CERTIFICATE OF INCORPORATION SINGULAR GENOMICS SYSTEMS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware)

Exhibit 3.1 RESTATED CERTIFICATE OF INCORPORATION OF SINGULAR GENOMICS SYSTEMS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Singular Genomics Systems, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the ?General Corporation Law?), DOES HEREBY CERTIFY: FIRST:

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