ONCT / Oncternal Therapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Oncternal Therapeutics, Inc.
HINDI NA ACTIVE ANG SIMBONG ITO

Mga Batayang Estadistika
LEI 549300QZ85LIXQ8O7P72
CIK 1260990
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Oncternal Therapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 POS AM

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-197911 Registration No. 333-201132 Registration No. 333-204932 Registration No. 333-221040 Registration No. 333-254985 Registration No. 333-277795 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: Form S-3 Registration Registration No. 333-197911 For

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 POS AM

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-197911 Registration No. 333-201132 Registration No. 333-204932 Registration No. 333-221040 Registration No. 333-254985 Registration No. 333-277795 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: Form S-3 Registration Registration No. 333-197911 For

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 POS AM

As filed with the Securities and Exchange Commission on March 27, 2025.

POS AM As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-197911 Registration No. 333-201132 Registration No. 333-204932 Registration No. 333-221040 Registration No. 333-254985 Registration No. 333-277795 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: Form S-3 Registration Registration No. 333-197

March 27, 2025 POS AM

As filed with the Securities and Exchange Commission on March 27, 2025.

POS AM As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-197911 Registration No. 333-201132 Registration No. 333-204932 Registration No. 333-221040 Registration No. 333-254985 Registration No. 333-277795 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: Form S-3 Registration Registration No. 333-197

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 POS AM

As filed with the Securities and Exchange Commission on March 27, 2025.

POS AM As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-197911 Registration No. 333-201132 Registration No. 333-204932 Registration No. 333-221040 Registration No. 333-254985 Registration No. 333-277795 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: Form S-3 Registration Registration No. 333-197

March 27, 2025 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

15-12G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant as s

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 27, 2025 POS AM

As filed with the Securities and Exchange Commission on March 27, 2025.

POS AM As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-197911 Registration No. 333-201132 Registration No. 333-204932 Registration No. 333-221040 Registration No. 333-254985 Registration No. 333-277795 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO: Form S-3 Registration Registration No. 333-197

March 27, 2025 S-8 POS

As filed with the Securities and Exchange Commission on March 27, 2025.

As filed with the Securities and Exchange Commission on March 27, 2025. Registration No. 333-112576 Registration No. 333-118882 Registration No. 333-136527 Registration No. 333-149661 Registration No. 333-165507 Registration No. 333-188377 Registration No. 333-208744 Registration No. 333-210220 Registration No. 333-223742 Registration No. 333-233288 Registration No. 333-254581 Registration No. 333

March 17, 2025 25

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 000-50549 Issuer: Oncternal Th

25 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 25 NOTIFICATION OF REMOVAL FROM LISTING AND/OR REGISTRATION UNDER SECTION 12(b) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number 000-50549 Issuer: Oncternal Therapeutics, Inc. Exchange: The Nasdaq Stock Market, LLC (Exact name of Issuer as specified in its charter, and name of Exchange where security is l

November 25, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 22, 2024 Oncternal Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 22, 2024 Oncternal Therapeutics, Inc.

November 14, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Costs Associated with Exit or Disposal Activities

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 13, 2024 Oncternal Therapeutics, Inc.

November 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2024 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registr

September 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) September 11, 2024 Oncternal Therape

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) September 11, 2024 Oncternal Therapeutics, Inc.

August 8, 2024 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Second Quarter 2024 Financial Results

EXHIBIT 99.1 Oncternal Therapeutics Provides Business Update and Announces Second Quarter 2024 Financial Results - No dose-limiting toxicities or concerning side effects in our Phase 1/2 study with ONCT-534, our dual-action androgen receptor inhibitor (DAARI), for patients with advanced prostate cancer who are resistant to approved androgen receptor pathway inhibitors; 1200 mg cohort for ONCT-534

August 8, 2024 EX-10.1

Amended and Restated License Agreement between Oncternal Oncology, Inc. and The Regents of the University of California dated August 6, 2024

Exhibit 10.1 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN ONCTERNAL ONCOLOGY, INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA FOR CASE NO. SD2005-212 CASE NO. SD201

August 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2024 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant a

August 8, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 8, 2024 Oncternal Therapeutics, Inc.

June 21, 2024 8-K

Submission of Matters to a Vote of Security Holders

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) June 20, 2024 Oncternal Therapeutics, Inc.

May 9, 2024 EX-10.1

Non-Employee Director Compensation Program

EXHIBIT 10.1 ONCTERNAL THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM Non-employee members of the board of directors (the “Board”) of Oncternal Therapeutics, Inc. (the “Company”) shall be eligible to receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”) effective from and after March 14, 2024 (the “Effective Date”). The

May 9, 2024 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces First Quarter 2024 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces First Quarter 2024 Financial Results - Fourth dosing cohort at 300 mg per day is fully enrolled for the Phase 1/2 study with ONCT-534, our dual-action androgen receptor inhibitor (DAARI), for patients with advanced prostate cancer who are resistant to approved androgen receptor pathway inhibitors; initial data readout expec

May 9, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 9, 2024 Oncternal Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 9, 2024 Oncternal Therapeutics, Inc.

May 9, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2024 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant

April 29, 2024 CORRESP

Oncternal Therapeutics, Inc. 12230 El Camino Real, Suite 230 San Diego, California 92130

Oncternal Therapeutics, Inc. 12230 El Camino Real, Suite 230 San Diego, California 92130 April 29, 2024 VIA EDGAR Tyler Howes Division of Corporation Finance Office of Life Sciences U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Oncternal Therapeutics, Inc. Registration Statement on Form S-3 File No. 333-277795 To the addressee set forth above: Pursuant to Ru

April 26, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

April 26, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defini

March 8, 2024 S-3

As filed with the Securities and Exchange Commission on March 8, 2024

Table of Contents As filed with the Securities and Exchange Commission on March 8, 2024 Registration No.

March 8, 2024 EX-4.9

Form of Indenture

Exhibit 4.9 ONCTERNAL THERAPEUTICS, INC. INDENTURE Dated as of , 20 [     ] Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 5 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 6 Section 2.1. Issuable in Series 6 Section 2.2.

March 8, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Oncternal Therapeutics, Inc.

March 7, 2024 EX-10.17

2021 Employment Inducement Incentive Award Plan of the Registrant, as amended (the “Inducement Plan”)

EXHIBIT 10.17 Oncternal Therapeutics, Inc. 2021 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN This plan document has been updated to reflect the Company’s one-for-twenty reverse stock split effected by the Company on January 8, 2024. ARTICLE I. Purpose The Plan’s purpose is to enhance the Company’s ability to attract, retain and motivate Eligible Persons who are expected to make important contributio

March 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 7, 2024 Oncternal Therapeutics, Inc.

March 7, 2024 EX-10.5B

Second Amendment to the UTRF License Agreement dated March 4, 2024

EXHIBIT 10.5B [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. SECOND AMENDMENT TO THE AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION AND ONCTERNAL THERAPEUTICS, INC. This

March 7, 2024 EX-4.8

Description of Securities of the Registrant

Exhibit 4.8 Description of the Registrant’s SECURITIES Registered Pursuant to Section 12 Of the Securities Exchange Act of 1934 Oncternal Therapeutics, Inc. (“we,” “us,” and “our”) has one class of securities registered pursuant to Section 12 of the Securities Exchange Act of 1934, as amended: common stock. Description of Common Stock General The following summary of the terms of our common stock

March 7, 2024 EX-3.1

Restated Certificate of Incorporation of the Registrant dated March 4, 2024

EXHIBIT 3.1 RESTATED CERTIFICATE OF INCORPORATION OF ONCTERNAL THERAPEUTICS, INC. (Pursuant to Section 245 of the General Corporation Law of the State of Delaware) Oncternal Therapeutics, Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify as follows: FIRST: The name of the Corporation is Oncternal Therapeut

March 7, 2024 EX-10.15

2015 Equity Incentive Plan of Private Oncternal, as amended (the “2015 Plan”)

EXHIBIT 10.15 Oncternal Therapeutics, Inc. 2015 EQUITY INCENTIVE PLAN This plan document has been updated to reflect the Company’s one-for-twenty reverse stock split effected by the Company on January 8, 2024 and the adjustments for the merger of the Company with GTx, Inc. in June 2019. 1. Purpose. The purpose of the Plan is to advance the interests of the Company’s stockholders by enhancing the C

March 7, 2024 EX-97.1

Policy for Recovery of Erroneously Awarded Compensation

EXHIBIT 97.1 Policy for Recovery of Erroneously Awarded Compensation Oncternal Therapeutics, Inc. (“Oncternal”) has adopted this Policy for Recovery of Erroneously Awarded Compensation (this “Policy”), effective as of October 2, 2023 (the “Effective Date”). Capitalized terms used in this Policy but not otherwise defined are defined under the heading “Definitions.” Persons Subject to Policy This Po

March 7, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Speci

March 7, 2024 EX-10.16

2019 Incentive Award Plan of the Registrant (the “2019 Plan”)

EXHIBIT 10.16 Oncternal Therapeutics, Inc. 2019 INCENTIVE AWARD PLAN This plan document has been updated to reflect the Company’s one-for-twenty reverse stock split effected by the Company on January 8, 2024. ARTICLE I. Purpose The Plan’s purpose is to enhance the Company’s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by

March 7, 2024 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2023 Financial Results

EXHIBIT 99.1 Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2023 Financial Results - Third dosing cohort fully enrolled for our Phase 1/2 study for ONCT-534, our dual-action androgen receptor inhibitor, for the treatment of patients with advanced prostate cancer who are resistant to approved androgen receptor pathway inhibitors; initial data readout expe

March 7, 2024 EX-10.14

Non-Employee Director Compensation Program of Registrant

EXHIBIT 10.14 ONCTERNAL THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM This program has been updated to reflect the Company’s one-for-twenty reverse stock split effected by the Company on January 8, 2024. Non-employee members of the board of directors (the “Board”) of Oncternal Therapeutics, Inc. (the “Company”) shall be eligible to receive cash and equity compensation as set forth

February 13, 2024 SC 13G/A

ONCT / Oncternal Therapeutics, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv01610-oncternaltherapeutic.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 1)* Name of issuer: Oncternal Therapeutics Inc Title of Class of Securities: Common Stock CUSIP Number: 68236P107 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box

January 23, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 22, 2024 Oncternal Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 22, 2024 Oncternal Therapeutics, Inc.

January 23, 2024 EX-10.1

Amendment #4 to the Amended and Restated License Agreement between Oncternal Therapeutics, Inc. and UC San Diego dated August 31, 2018

Exhibit 10.1 AMENDMENT NO. 4 TO THE AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN ONCTERNAL THERAPEUTICS, INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA FOR UC CASE NUMBERS SD2005-212, SD2020-036, SD2011-178, SD2012-143, SD2012-403, SD2015-027, SD2015-200, SD2018-253 AND SD2019-278 This Amendment No. 4 (this “Amendment”) is made as of the date of the last signature below by and between Onct

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 3, 2024 Oncternal Therapeuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 3, 2024 Oncternal Therapeutics, Inc.

January 5, 2024 EX-3.1

Certificate of Amendment to Restated Certificate of Incorporation of Oncternal Therapeutics, Inc

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATION OF ONCTERNAL THERAPEUTICS, INC. Oncternal Therapeutics, Inc. (the “Corporation”), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “DGCL”), does hereby certify: 1. The Corporation, which was originally known as GTx, Inc., originally filed its Certificat

November 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 9, 2023 Oncternal Therapeutics, Inc.

November 9, 2023 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Third Quarter 2023 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces Third Quarter 2023 Financial Results - The first patient was dosed in our Phase 1/2 study for ONCT-534, our dual-action androgen receptor inhibitor, for the treatment of patients with advanced prostate cancer who are resistant to approved androgen receptor pathway inhibitors - Additional patients were treated in our ongoing

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2023 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registr

October 6, 2023 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) October 3, 2023 Oncternal Therapeutics, Inc.

September 14, 2023 8-K/A

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K/A (Amendment No.

August 10, 2023 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Second Quarter 2023 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces Second Quarter 2023 Financial Results - Obtained U.S. FDA IND clearance for ONCT-534, our dual-action androgen receptor inhibitor, for the treatment of patients with advanced prostate cancer who are resistant to approved androgen receptor signaling inhibitors - Dosed the first patient in our Phase 1/2 study for ONCT-808, ou

August 10, 2023 EX-10.1

Advisory Services Agreement effective June 14, 2023 between the Registrant and Gunnar F. Kaufmann, Ph.D

Exhibit 10.1 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. ADVISORY SERVICES AGREEMENT This Advisory Services Agreement (this “Agreement”) is effective June 14, 2023 (the “Effective Date”) by and between Oncternal The

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 10, 2023 Oncternal Therapeuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 10, 2023 Oncternal Therapeutics, Inc.

August 10, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2023 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant a

June 29, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) June 28, 2023 Oncternal Therapeutics

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) June 28, 2023 Oncternal Therapeutics, Inc.

June 2, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 26, 2023 Oncternal Therapeutics, Inc.

May 16, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

May 16, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

May 5, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defini

May 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2023 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant

May 4, 2023 EX-10

Letter agreement with Salim Yazji, M.D. dated March 31, 2023

Exhibit 10.2 March 31, 2023 Salim Yazji, M.D. Oncternal Therapeutics, Inc. Dear Dr. Yazji: Oncternal Therapeutics, Inc. (the “Company”) is providing this letter agreement to set forth agreements between you and the Company related to your compensation. This letter agreement amends the Employment Agreement between you and the Company, dated May 17, 2021 (the “Employment Agreement”). 1. 2023 Annual

May 4, 2023 EX-10

Letter agreement with Richard G. Vincent dated March 31, 2023

Exhibit 10.4 March 31, 2023 Richard Vincent Oncternal Therapeutics, Inc. Dear Mr. Vincent: Oncternal Therapeutics, Inc. (the “Company”) is providing this letter agreement to set forth agreements between you and the Company related to your compensation. This letter agreement amends the Employment Agreement between you and the Company, dated September 12, 2019 (the “Employment Agreement”). 1. 2023 A

May 4, 2023 EX-10

Letter agreement with Chase C. Leavitt dated March 31, 2023

Exhibit 10.5 March 31, 2023 Chase C. Leavitt Oncternal Therapeutics, Inc. Dear Mr. Leavitt: Oncternal Therapeutics, Inc. (the “Company”) is providing this letter agreement to set forth agreements between you and the Company related to your compensation. This letter agreement amends the Employment Agreement between you and the Company, dated April 12, 2021 (the “Employment Agreement”). 1. 2023 Annu

May 4, 2023 EX-10

Letter agreement with Rajesh Krishnan, Ph.D. dated March 31, 2023

Exhibit 10.6 March 31, 2023 Rajesh Krishnan, Ph.D. Oncternal Therapeutics, Inc. Dear Dr. Krishnan: Oncternal Therapeutics, Inc. (the “Company”) is providing this letter agreement to set forth agreements between you and the Company related to your compensation. This letter agreement amends the Amended and Restated Employment Agreement between you and the Company, dated January 6, 2021 (the “Employm

May 4, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 4, 2023 Oncternal Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 4, 2023 Oncternal Therapeutics, Inc.

May 4, 2023 EX-10

Letter agreement with Gunnar Kaufmann, Ph.D. dated March 31, 2023

Exhibit 10.3 March 31, 2023 Gunnar Kaufmann, Ph.D. Oncternal Therapeutics, Inc. Dear Dr. Kaufmann: Oncternal Therapeutics, Inc. (the “Company”) is providing this letter agreement to set forth agreements between you and the Company related to your compensation. This letter agreement amends the Employment Agreement between you and the Company, dated September 5, 2019 (the “Employment Agreement”). 1.

May 4, 2023 EX-99

Oncternal Therapeutics Provides Business Update and Announces First Quarter 2023 Financial Results

Oncternal Therapeutics Provides Business Update and Announces First Quarter 2023 Financial Results - Phase 1/2 study initiated for ONCT-808, our autologous CAR-T targeting ROR1-expressing hematologic malignancies, with initial clinical data expected in late 2023 - Final IND-enabling studies completed for ONCT-534, our novel dual-action androgen receptor inhibitor (DAARI), with expected IND submission in mid-2023 - Cash runway extended into 2025, with $54.

May 4, 2023 EX-10

Letter agreement with James B. Breitmeyer, M.D. dated March 31, 2023

Exhibit 10.1 March 31, 2023 James Breitmeyer, M.D., Ph.D. Oncternal Therapeutics, Inc. Dear Dr. Breitmeyer: Oncternal Therapeutics, Inc. (the “Company”) is providing this letter agreement to set forth agreements between you and the Company related to your compensation. This letter agreement amends the Employment Agreement between you and the Company, dated September 12, 2019 (the “Employment Agree

April 28, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Spe

April 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) April 4, 2023 Oncternal Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) April 4, 2023 Oncternal Therapeutics, Inc.

April 3, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 31, 2023 Oncternal Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 31, 2023 Oncternal Therapeutics, Inc.

March 17, 2023 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 4, 2023

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K/A (Amendment No.

March 9, 2023 EX-99

Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2022 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2022 Financial Results - Encouraging and improving interim Phase 1/2 study results for zilovertamab plus ibrutinib in patients with MCL and CLL, including those with mutated TP53 and/or del(17p), presented at ASH in December 2022 - Zilovertamab global Phase 3 registrational Study ZILO-301 for th

March 9, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Speci

March 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 9, 2023 Oncternal Therapeutics, Inc.

March 9, 2023 EX-10

Annual Incentive Plan of the Registrant

Exhibit 10.12 ONCTERNAL THERAPEUTICS INC. ANNUAL INCENTIVE PLAN 1. PURPOSE This Oncternal Therapeutics, Inc. Annual Incentive Plan (the “Plan”) is intended to provide an incentive for eligible employees and certain consultants of Oncternal Therapeutics Inc. (the “Company”) to perform to the best of their abilities and achieve the Company’s corporate objectives, to further the growth, development a

January 17, 2023 8-K/A

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K/A (Amendment No.

January 6, 2023 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 6, 2023 Oncternal Therapeutics, Inc.

January 4, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 4, 2023 Oncternal Therapeutics, Inc.

December 23, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 23, 2022 Oncternal Therapeu

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 23, 2022 Oncternal Therapeutics, Inc.

December 12, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 12, 2022 Oncternal Therapeu

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 12, 2022 Oncternal Therapeutics, Inc.

November 3, 2022 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Third Quarter 2022 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces Third Quarter 2022 Financial Results - Initiated Phase 3 global registrational Study ZILO-301 of our zilovertamab product candidate targeting ROR1 in combination with ibrutinib for the treatment of patients with MCL - Received acceptance for an oral presentation at the 64th ASH Annual Meeting and Exposition for the update o

November 3, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 3, 2022 Oncternal Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 3, 2022 Oncternal Therapeutics, Inc.

November 3, 2022 EX-10.1

First Amendment to the UTRF License Agreement

Exhibit 10.1 [***] Certain information in this document has been excluded pursuant to Regulation S-K, Item 601(b)(10). Such excluded information is not material and would likely cause competitive harm to the registrant if publicly disclosed. FIRST AMENDMENT to THE AMENDED AND RESTATED License Agreement Between THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION and ONCTERNAL THERAPEUTICS, INC. This Fi

November 3, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2022 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registr

October 3, 2022 8-K

Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) October 3, 2022 Oncternal Therapeutics, Inc.

August 31, 2022 8-K

Other Events

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 30, 2022 Oncternal Therapeutics, Inc.

August 9, 2022 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Second Quarter 2022 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces Second Quarter 2022 Financial Results - Interim Phase 1/2 results for zilovertamab plus ibrutinib in MCL presented at ASCO 2022, with ORR of 85% and CR rate of 41%, compare favorably to historical single agent ibrutinib data and support moving into Phase 3 Study ZILO-301 - Interim data from p53-mutated CLL patients in the s

August 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 9, 2022 Oncternal Therapeutics, Inc.

August 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2022 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2022 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant a

June 17, 2022 8-K

Submission of Matters to a Vote of Security Holders

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) June 16, 2022 Oncternal Therapeutics, Inc.

May 26, 2022 8-K

Other Events

``` UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 26, 2022 Oncternal Therapeutics, Inc.

May 5, 2022 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces First Quarter 2022 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces First Quarter 2022 Financial Results - Global registrational Phase 3 study, ZILO-301, of zilovertamab in patients with MCL on track to be initiated in Q3 2022 - Presenting interim clinical data update from the ongoing Phase 1/2 clinical trial of zilovertamab in combination with ibrutinib for patients with MCL and CLL at the

May 5, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 5, 2022 Oncternal Therapeutics, Inc.

May 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2022 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant

April 29, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

DEFA14A 1 onctdefa14a2022.htm DEFA14A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as

April 29, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defini

April 13, 2022 8-K

Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) April 13, 2022 Oncternal Therapeutics, Inc.

March 18, 2022 S-8

As filed with the Securities and Exchange Commission on March 18, 2022

As filed with the Securities and Exchange Commission on March 18, 2022 Registration No.

March 18, 2022 EX-FILING FEES

Filing Fee Table

EXHIBIT 107 Calculation of Filing Fee Table Form S-8 (Form Type) Oncternal Therapeutics, Inc.

March 10, 2022 EX-4.11

Description of Securities of the Registrant

Exhibit 4.11 Description of the Registrant?s SECURITIES Registered Pursuant to Section 12 Of the Securities Exchange Act of 1934 Oncternal Therapeutics, Inc. (?we,? ?us,? and ?our?) has one class of securities registered pursuant to Section 12 of the Securities Exchange Act of 1934, as amended: common stock. Description of Common Stock General The following summary of the terms of our common stock

March 10, 2022 EX-10.19.1

Form of Stock Option under the Inducement Plan

Exhibit 10.19.1 Oncternal Therapeutics, Inc. 2021 EMPLOYMENT INDUCEMENT Incentive Award Plan Stock Option Grant Notice Capitalized terms not specifically defined in this Stock Option Grant Notice (the ?Grant Notice?) have the meanings given to them in the 2021 Employment Inducement Incentive Award Plan (as amended from time to time, the ?Plan?) of Oncternal Therapeutics, Inc. (the ?Company?). The

March 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 10, 2022 Oncternal Therapeutics, Inc.

March 10, 2022 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2021 Financial Results

Exhibit 99.1 Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2021 Financial Results - Reached consensus with the FDA on the design and major details of the global Phase 3 Study ZILO-301 to treat patients with relapsed or refractory MCL with zilovertamab plus ibrutinib, which is on track to be initiated in the second quarter of 2022 - Interim Phase 1/2 res

March 10, 2022 EX-10.18.2

Form of Restricted Stock Unit under the 2019 Plan

Exhibit 10.18.2 ONCTERNAL THERAPEUTICS, INC. 2019 INCENTIVE AWARD PLAN RESTRICTED STOCK Unit Grant Notice Capitalized terms not specifically defined in this Restricted Stock Unit Grant Notice (this ?Grant Notice?) have the meanings given to them in the 2019 Incentive Award Plan (as amended from time to time, the ?Plan?) of Oncternal Therapeutics, Inc. (the ?Company?). The Company hereby grants to

March 10, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Speci

March 10, 2022 EX-10.18.1

Form of Stock Option Agreement under the 2019 Plan

Exhibit 10.18.1 Oncternal Therapeutics, Inc. 2019 Incentive Award Plan Stock Option Grant Notice Capitalized terms not specifically defined in this Stock Option Grant Notice (the ?Grant Notice?) have the meanings given to them in the 2019 Incentive Award Plan (as amended from time to time, the ?Plan?) of Oncternal Therapeutics, Inc. (the ?Company?). The Company hereby grants to the participant lis

March 10, 2022 EX-10.5

Amended and Restated License Agreement between the University of Tennessee Research Foundation and the Registrant dated March 9, 2022 (the “UTRF License Agreement”)

Exhibit 10.5 AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION AND ONCTERNAL THERAPEUTICS, INC. This Amended and Restated License Agreement (?Amended Agreement?) is made and entered into this 9th day of March, 2022 (?Amended Effective Date?) by and between the UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION, having an office at 910 Madison Avenue, Suite 827

March 10, 2022 EX-23.10

Consent of Independent Registered Public Accounting Firm

Exhibit 23.1 Consent of Independent Registered Public Accounting Firm Oncternal Therapeutics, Inc. San Diego, California We hereby consent to the incorporation by reference in the Registration Statements on Form S-3 (Nos. 333-221040, 333-204932, 333-201132, 333-197911, and 333-254985) and Form S-8 (Nos. 333-233288, 333-223742, 333-210220, 333-208744, 333-188377, 333-165507, 333-149661, 333-136527,

March 10, 2022 EX-10.18

2019 Incentive Award Plan of the Registrant effective June 7, 2019 (the “2019 Plan”)

Exhibit 10.18 Oncternal Therapeutics, Inc. 2019 INCENTIVE AWARD PLAN This plan document has been updated to reflect the Company?s name change and the one-for-seven reverse stock split effected by the Company on June 7, 2019 ARTICLE I. Purpose The Plan?s purpose is to enhance the Company?s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to

March 10, 2022 EX-10.19.3

Amendment No. 2 to the Inducement Plan dated December 15, 2021

Exhibit 10.19.3 AMENDMENT NO. 2 TO ONCTERNAL THERAPEUTICS, INC. 2021 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN THIS AMENDMENT NO. 2 TO THE ONCTERNAL THERAPEUTICS, INC. 2021 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN (this ?Amendment?) is made and adopted by Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?). Capitalized terms used but not otherwise defined herein shall have the

January 25, 2022 8-K

Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 25, 2022 Oncternal Therapeutics, Inc.

December 17, 2021 EX-1.1

Open Market Sale Agreement

EX-1.1 2 d251277dex11.htm EX-1.1 Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM December 17, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Oncternal Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “

December 17, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 17, 2021 Oncternal Therapeutics, Inc.

December 17, 2021 424B5

Up to $50,000,000 Common Stock

424B5 1 d140886d424b5.htm 424B5 Table of Contents Filed Pursuant to 424(b)(5) Registration Statement No. 333-254985 PROSPECTUS SUPPLEMENT (To Prospectus dated April 15, 2021) Up to $50,000,000 Common Stock We have entered into an Open Market Sale AgreementSM, or the sales agreement, with Jefferies LLC, or Jefferies, dated December 17, 2021, relating to shares of our common stock, par value $0.001

December 13, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 13, 2021 Oncternal Therapeutics, Inc.

November 4, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 4, 2021 Oncternal Therapeutics, Inc.

November 4, 2021 EX-99.1

Oncternal Provides Business Update and Announces Third Quarter 2021 Financial Results

EXHIBIT 99.1 Oncternal Provides Business Update and Announces Third Quarter 2021 Financial Results - Progressed the development of zilovertamab (formerly cirmtuzumab) for the treatment of patients with mantle cell lymphoma, including ongoing interactions with the US FDA on potential registration pathways - Identified ONCT-808 as the lead candidate for our autologous CAR-T program targeting ROR1-ex

November 4, 2021 EX-10.1

First Amendment to CVR Agreement dated November 1, 2021, between the Registrant, Holders’ Representative, and Rights Agent

EXHIBIT 10.1 FIRST AMENDMENT TO CONTINGENT VALUE RIGHTS AGREEMENT This First Amendment to Contingent Value Rights Agreement (this ?Amendment?) dated as of November 1, 2021 (the ?Amendment Effective Date?), is entered into by and among Oncternal Therapeutics, Inc. (F/K/A GTx, Inc.), a Delaware corporation (?Parent?), Marc S. Hanover, as representative of Holders (?Holders? Representative?), and Com

November 4, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registr

August 5, 2021 EX-10.1

Amended and Restated Employment Agreement dated January 6, 2021 between the Registrant and Raj Krishnan, Ph.D.

Exhibit 10.1 AMENDED AND RESTATED EMPLOYMENT AGREEMENT THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this ?Agreement?) is entered into by and between Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?), and Raj Krishnan, Ph.D. (?Executive?), and shall be effective as of January 6, 2021 (the ?Effective Date?). WHEREAS, the Company and Executive are parties to that certain Employm

August 5, 2021 EX-10.2

Employment Agreement dated April 12, 2021 between the Registrant and Chase Leavitt

Exhibit 10.2 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this ?Agreement?) is entered into by and between Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?), and Chase Leavitt (?Executive?), and shall be effective as of April 12, 2021 (the ?Effective Date?). WHEREAS, the Company desires to employ Executive, and Executive desires to accept employment with the Company, on the t

August 5, 2021 EX-99.1

Oncternal Provides Business Update and Announces Second Quarter 2021 Financial Results

Exhibit 99.1 Oncternal Provides Business Update and Announces Second Quarter 2021 Financial Results - Presented encouraging interim clinical data for cirmtuzumab in combination with ibrutinib in patients with mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) in a poster session at ASCO 2021 - Expanded the ongoing Phase 1/2 study to evaluate cirmtuzumab plus ibrutinib in patients wi

August 5, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant a

August 5, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 5, 2021 Oncternal Therapeutics, Inc.

August 5, 2021 EX-10.3

Employment Agreement dated May 17, 2021 between the Registrant and Salim Yazji, M.D.

Exhibit 10.3 EMPLOYMENT AGREEMENT THIS EMPLOYMENT AGREEMENT (this ?Agreement?) is entered into by and between Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?), and Salim Yazji (?Executive?), and shall be effective as of May 17, 2021 (the ?Effective Date?). WHEREAS, the Company desires to employ Executive, and Executive desires to accept employment with the Company, on the terms

June 21, 2021 8-K

Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) June 18, 2021 Oncternal Therapeutics, Inc.

May 28, 2021 EX-1.1

Open Market Sale Agreement

Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM May 28, 2021 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the ?Agent?), shares of the Company?s commo

May 28, 2021 EX-3.1

Certificate of Amendment of Restated Certificate dated May 25, 2021

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATION OF ONCTERNAL THERAPEUTICS, INC. Oncternal Therapeutics, Inc. (the ?Corporation?), a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the ?DGCL?), does hereby certify: 1. The Corporation, which was originally known as GTx, Inc., originally filed its Certificat

May 28, 2021 424B5

Up to $50,000,000 Common Stock

Table of Contents Filed Pursuant to 424(b)(5) Registration Statement No. 333-254985 PROSPECTUS SUPPLEMENT (To Prospectus dated April 15, 2021) Up to $50,000,000 Common Stock We have entered into an Open Market Sale AgreementSM, or the sales agreement, with Jefferies LLC, or Jefferies, dated May 28, 2021, relating to shares of our common stock, par value $0.001 per share, offered by this prospectus

May 28, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 25, 2021 Oncternal Therapeutics, Inc.

May 28, 2021 EX-10.1

Amendment No. 1 to the Inducement Plan dated May 28, 2021

Exhibit 10.1 AMENDMENT NO. 1 TO ONCTERNAL THERAPEUTICS, INC. 2021 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN THIS AMENDMENT NO. 1 TO THE ONCTERNAL THERAPEUTICS, INC. 2021 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN (this ?Amendment?) is made and adopted by Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?). Capitalized terms used but not otherwise defined herein shall have the mea

May 20, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 19, 2021 Oncternal Therapeutics, Inc.

May 6, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant

May 6, 2021 EX-10.1

Office Lease between Cognac Del Mar Owner II LLC and Registrant dated March 17, 2021

EXHIBIT 10.1 OFFICE LEASE by and between COGNAC DEL MAR OWNER II LLC, a Delaware limited liability company (?Landlord?) and ONCTERNAL THERAPEUTICS, INC., a Delaware corporation (?Tenant?) Office lease THIS OFFICE LEASE (?Lease?) is made between COGNAC DEL MAR OWNER II LLC, a Delaware limited liability company (?Landlord?), and the Tenant described in Item 1 of the Basic Lease Provisions. LEASE OF

May 6, 2021 EX-10.2

Non-Employee Director Compensation Program of Registrant

EXHIBIT 10.2 ONCTERNAL THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM (Effective Date: March 18, 2021) Non-employee members of the board of directors (the ?Board?) of Oncternal Therapeutics, Inc. (the ?Company?) shall be eligible to receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this ?Program?) effective from and after March 18,

May 6, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 6, 2021 Oncternal Therapeutics, Inc.

May 6, 2021 EX-10.3

Employment Transition Agreement between Frank Hsu, M.D. and Registrant, dated February 24, 2021

EXHIBIT 10.3 EMPLOYMENT TRANSITION AGREEMENT This Employment Transition Agreement (the ?Agreement?) is entered into by and among Frank Hsu, M.D. (?Executive?), and Oncternal Therapeutics, Inc. (the ?Company?) effective as of February 25, 2021 (the ?Effective Date?). Recitals WHEREAS, Executive is a party to that certain Employment Agreement with the Company dated August 26, 2019 (the ?Employment A

May 6, 2021 EX-99.1

Oncternal Provides Business Update and Announces First Quarter 2021 Financial Results

Exhibit 99.1 Oncternal Provides Business Update and Announces First Quarter 2021 Financial Results - Interim results of a Phase 1b trial of cirmtuzumab and paclitaxel in locally advanced/unresectable or metastatic HER2-negative breast cancer compare favorably to historical single-agent paclitaxel data (57% ORR vs. ~30% ORR historical single-agent paclitaxel) - In a preclinical study of cirmtuzumab

April 15, 2021 424B3

Common Stock Preferred Stock Debt Securities

424B3 Table of Contents Filed Pursuant to 424(b)(3) Registration Statement No. 333-254985 PROSPECTUS $250,000,000 Common Stock Preferred Stock Debt Securities Warrants Units We may offer and sell up to $250,000,000 in the aggregate of the securities identified above from time to time in one or more offerings. This prospectus provides you with a general description of the securities. Each time we o

April 13, 2021 CORRESP

Oncternal Therapeutics, Inc. 12230 El Camino Real, Suite 300 San Diego, California 92130

Oncternal Therapeutics, Inc. 12230 El Camino Real, Suite 300 San Diego, California 92130 April 13, 2021 VIA EDGAR Mr. Jason Drory Office of Life Sciences Division of Corporation Finance U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Re: Oncternal Therapeutics, Inc. Registration Statement on Form S-3 Filed April 2, 2021 File No. 333-254985 Dear Mr. Drory: Pursuant

April 13, 2021 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defini

April 13, 2021 DEF 14A

Definitive Proxy Statement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Ru

April 2, 2021 EX-4.14

Form of Indenture

EX-4.14 2 d156749dex414.htm EX-4.14 Exhibit 4.14 ONCTERNAL THERAPEUTICS, INC. INDENTURE Dated as of , 20 [ ] Trustee TABLE OF CONTENTS Page ARTICLE I. DEFINITIONS AND INCORPORATION BY REFERENCE 1 Section 1.1. Definitions 1 Section 1.2. Other Definitions 4 Section 1.3. Incorporation by Reference of Trust Indenture Act 4 Section 1.4. Rules of Construction 5 ARTICLE II. THE SECURITIES 5 Section 2.1.

April 2, 2021 S-3

- S-3

Table of Contents As filed with the Securities and Exchange Commission on April 1, 2021 Registration No.

April 2, 2021 PRE 14A

- PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Ru

March 22, 2021 8-K

Entry into a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 17, 2021 Oncternal Therapeutics, Inc.

March 22, 2021 EX-10.4

Form of Stock Option Grant Notice and Stock Option Agreement under the Oncternal Therapeutics, Inc. 2021 Employment Inducement Incentive Award Plan

EX-10.4 3 onct-ex10489.htm EX-10.4 EXHIBIT 10.4 Oncternal Therapeutics, Inc. 2021 EMPLOYMENT INDUCEMENT Incentive Award Plan Stock Option Grant Notice Capitalized terms not specifically defined in this Stock Option Grant Notice (the “Grant Notice”) have the meanings given to them in the 2021 Employment Inducement Incentive Award Plan (as amended from time to time, the “Plan”) of Oncternal Therapeu

March 22, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 22, 2021 Registration No.

March 12, 2021 EX-10.37

Engagement Letter between the Registrant and H.C. Wainwright & Co., LLC, dated as of December 9, 2020

EXHIBIT 10.37 Execution Version December 9, 2020 STRICTLY CONFIDENTIAL Oncternal Therapeutics, Inc. 12230 El Camino Real Suite 300 San Diego, California 92130 Attn: James B. Breitmeyer, M.D., Ph.D., President and Chief Executive Officer Dear Dr. Breitmeyer: This letter agreement (this ?Agreement?) constitutes the agreement between Oncternal Therapeutics, Inc. (the ?Company?) and H.C. Wainwright &

March 12, 2021 10-K/A

Annual Report - 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A (Amendment No. 1) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of

March 12, 2021 EX-10.14

Amendment #3 to Amended and Restated License Agreement between Oncternal Therapeutics, Inc. and the Regents of the University of California, dated February 5, 2021

EX-10.14 2 onct-ex101411.htm EX-10.14 EXHIBIT 10.14 AMENDMENT NO. 3 TO THE AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN ONCTERNAL THERAPEUTICS, INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA FOR UC CASE NUMBERS SD2005-212, SD2020-036, SD2011-178, SD2012-143, SD2012-403, SD2015-027, SD2015-200, SD2018-253 AND SD2019-278 This Amendment No. 3 (“Amendment No.3”) is made as of the Amendment No.

March 11, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Speci

March 11, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 11, 2021 Oncternal Therapeutics, Inc.

March 11, 2021 EX-10.14

Amendment #3 to the UCSD License Agreement dated February 5, 2021

EX-10.14 2 onct-ex1014496.htm EX-10.14 EXHIBIT 10.14 AMENDMENT NO. 3 TO THE AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN ONCTERNAL THERAPEUTICS, INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA FOR UC CASE NUMBERS SD2005-212, SD2020-036, SD2011-178, SD2012-143, SD2012-403, SD2015-027, SD2015-200, SD2018-253 AND SD2019-278 This Amendment No. 3 (“Amendment No.3”) is made as of the Amendment No

March 11, 2021 EX-99.1

Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2020 Financial Results

EX-99.1 2 onct-ex9916.htm EX-99.1 EXHIBIT 99.1 Oncternal Therapeutics Provides Business Update and Announces Fourth Quarter and Full Year 2020 Financial Results - Interim Phase 1/2 results for cirmtuzumab with ibrutinib in MCL presented at ASH in December 2020 compare favorably to historical single-agent ibrutinib data (47% CR vs. 20% CR historical single-agent ibrutinib) - Accelerating developmen

March 11, 2021 EX-10.37

Engagement Letter between the Registrant and H.C. Wainwright & Co., LLC, dated as of December 9, 2020

EXHIBIT 10.37 Execution Version December 9, 2020 STRICTLY CONFIDENTIAL Oncternal Therapeutics, Inc. 12230 El Camino Real Suite 300 San Diego, California 92130 Attn: James B. Breitmeyer, M.D., Ph.D., President and Chief Executive Officer Dear Dr. Breitmeyer: This letter agreement (this ?Agreement?) constitutes the agreement between Oncternal Therapeutics, Inc. (the ?Company?) and H.C. Wainwright &

March 1, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): February 24, 2021 Oncternal Therapeutics, Inc.

February 17, 2021 EX-10.1

2021 Employment Inducement Incentive Award Plan of the Registrant (the “Inducement Plan”)

EXHIBIT 10.1 Oncternal Therapeutics, Inc. 2021 EMPLOYMENT INDUCEMENT INCENTIVE AWARD PLAN ARTICLE I. Purpose The Plan?s purpose is to enhance the Company?s ability to attract, retain and motivate Eligible Persons who are expected to make important contributions to the Company by providing these individuals with equity ownership opportunities. Capitalized terms used in the Plan are defined in Artic

February 17, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) February 11, 2021 Oncternal Therapeutics, Inc.

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 16, 2021 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Onct

CUSIP No: 68236P107 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. 1)* Oncternal Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 68236P107 (CUSIP

January 28, 2021 EX-99.1

Oncternal Therapeutics Announces the Appointment of Dr. Rosemary Mazanet to the Board of Directors

EX-99.1 2 onct-ex99133.htm EX-99.1 Exhibit 99.1 Oncternal Therapeutics Announces the Appointment of Dr. Rosemary Mazanet to the Board of Directors SAN DIEGO, January 28, 2021 - Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced the appointment of Rosemary Mazanet, M.D., Ph.D., to its Board

January 28, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) January 28, 2021 Oncternal Therapeutics, Inc.

December 18, 2020 SC 13G

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. ____)* O

CUSIP No: 68236P107 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. )* Oncternal Therapeutics, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 68236P107 (CUSIP

December 18, 2020 SC 13D/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 12)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 12)* Oncternal Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 68236P 107 (CUSIP Number) Joseph R. Hyde, III 17 West Pontotoc Avenue, Suite 100 Memphis, Tennessee 38103 Phone: (901) 685-3412 (Name, Address an

December 11, 2020 EX-1.1

Form of Underwriter Warrant, issued by Registrant pursuant to the Amended and Restated Underwriting Agreement, dated December 9, 2020, between the Registrant and H.C. Wainwright & Co., LLC

EX-1.1 Exhibit 1.1 16,666,667 Shares ONCTERNAL THERAPEUTICS, INC. Common Stock AMENDED AND RESTATED UNDERWRITING AGREEMENT December 9, 2020 H.C. Wainwright & Co., LLC as Representative of the several Underwriters named in Schedule I hereto 430 Park Avenue, 4th Floor New York, NY 10022 Ladies and Gentlemen: Oncternal Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to t

December 11, 2020 EX-4.1

Form of Underwriter Warrant, issued by Registrant pursuant to the Amended and Restated Underwriting Agreement dated December 9, 2020, between the Registrant and H.C. Wainwright

EX-4.1 Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

December 11, 2020 EX-99.2

Oncternal Therapeutics Increases Previously Announced Bought Deal to $75.0 Million

EX-99.2 6 d67428dex992.htm EX-99.2 Exhibit 99.2 Oncternal Therapeutics Increases Previously Announced Bought Deal to $75.0 Million SAN DIEGO, December 9, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that due to demand, the underwriter has agreed to increase the size of the prev

December 11, 2020 8-K

Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): December 9, 2020 Oncternal Therapeutics, Inc.

December 11, 2020 EX-99.1

Oncternal Therapeutics Announces $40.0 Million Bought Deal Offering

EX-99.1 Exhibit 99.1 Oncternal Therapeutics Announces $40.0 Million Bought Deal Offering SAN DIEGO, December 9, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that it has entered into an underwriting agreement with H.C. Wainwright & Co., LLC under which the underwriter has agreed

December 10, 2020 FWP

Oncternal Therapeutics Announces $40.0 Million Bought Deal Offering

Free Writing Prospectus dated December 9, 2020 Filed pursuant to Rule 433 Relating to the Preliminary Prospectus Supplement dated December 9, 2020 Registration Statement No.

December 10, 2020 424B5

SUBJECT TO COMPLETION, DATED DECEMBER 9, 2020

424B5 1 d34333d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus

December 10, 2020 424B5

16,666,667 Shares Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 PROSPECTUS SUPPLEMENT (To Prospectus dated January 5, 2018) 16,666,667 Shares Common Stock We are offering 16,666,667 shares of our common stock. Our common stock is listed on The Nasdaq Capital Market under the symbol ?ONCT.? On December 8, 2020, the last reported sale price of our common stock on The Nasdaq Capital Ma

December 10, 2020 FWP

Oncternal Therapeutics Increases Previously Announced Bought Deal to $75.0 Million

Free Writing Prospectus dated December 9, 2020 Filed pursuant to Rule 433 Relating to the Preliminary Prospectus Supplement dated December 9, 2020 Registration Statement No.

December 7, 2020 8-K

Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) December 7, 2020 Oncternal Therapeutics, Inc.

November 19, 2020 424B5

7,258,065 Shares Common Stock

424B5 1 d37294d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 PROSPECTUS SUPPLEMENT (To Prospectus dated January 5, 2018) 7,258,065 Shares Common Stock We are offering 7,258,065 shares of our common stock. Our common stock is listed on The Nasdaq Capital Market under the symbol “ONCT.” On November 16, 2020, the last reported sale price of our common

November 19, 2020 EX-99.2

Oncternal Therapeutics Increases Previously Announced Bought Deal to $22.5 Million

Exhibit 99.2 Oncternal Therapeutics Increases Previously Announced Bought Deal to $22.5 Million SAN DIEGO, November 17, 2020 ? Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that due to demand, the underwriter has agreed to increase the size of the previously announced offering and purc

November 19, 2020 EX-99.1

Oncternal Therapeutics Announces $20.0 Million Bought Deal Offering

Exhibit 99.1 Oncternal Therapeutics Announces $20.0 Million Bought Deal Offering SAN DIEGO, November 17, 2020 ? Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that it has entered into an underwriting agreement with H.C. Wainwright & Co., LLC under which the underwriter has agreed to pur

November 19, 2020 EX-4.1

Form of Underwriter Warrant, issued by Registrant pursuant to the Amended and Restated Underwriting Agreement dated November 17, 2020, between the Registrant and H.C. Wainwright

EX-4.1 3 d76696dex41.htm EX-4.1 Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT

November 19, 2020 8-K

Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): November 17, 2020 Oncternal Therapeutics, Inc.

November 19, 2020 EX-1.1

Form of Underwriter Warrant, issued by Registrant pursuant to the Amended and Restated Underwriting Agreement, dated November 17, 2020, between the Registrant and H.C. Wainwright & Co., LLC

Exhibit 1.1 7,258,065 Shares ONCTERNAL THERAPEUTICS, INC. Common Stock AMENDED AND RESTATED UNDERWRITING AGREEMENT November 17, 2020 H.C. Wainwright & Co., LLC as Representative of the several Underwriters named in Schedule I hereto 430 Park Avenue, 4th Floor New York, NY 10022 Ladies and Gentlemen: Oncternal Therapeutics, Inc., a Delaware corporation (the ?Company?), proposes, subject to the term

November 18, 2020 FWP

Oncternal Therapeutics Increases Previously Announced Bought Deal to $22.5 Million

FWP 1 d43922dfwp.htm FWP Free Writing Prospectus dated November 17, 2020 Filed pursuant to Rule 433 Relating to the Preliminary Prospectus Supplement dated November 17, 2020 Registration Statement No. 333-222268 Oncternal Therapeutics Increases Previously Announced Bought Deal to $22.5 Million SAN DIEGO, November 17, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceu

November 17, 2020 FWP

Oncternal Therapeutics Announces $20.0 Million Bought Deal Offering

Free Writing Prospectus dated November 17, 2020 Filed pursuant to Rule 433 Relating to the Preliminary Prospectus Supplement dated November 17, 2020 Registration Statement No.

November 17, 2020 424B5

SUBJECT TO COMPLETION, DATED NOVEMBER 17, 2020

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these

November 4, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registr

November 4, 2020 EX-99.1

Oncternal Announces Third Quarter 2020 Financial Results and Provides Business Update

Exhibit 99.1 Oncternal Announces Third Quarter 2020 Financial Results and Provides Business Update • Rare Pediatric Disease Designation received from FDA for TK216 for treatment of Ewing sarcoma • Interim Phase 1 data for TK216 in 15 evaluable patients with relapsed/refractory Ewing sarcoma demonstrated two complete responses, with no relapses after complete response • Strengthened the balance she

November 4, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) November 4, 2020 Oncternal Therapeutics, Inc.

August 31, 2020 EX-4.1

Form of Underwriter Warrant, issued by Registrant pursuant to the Amended and Restated Underwriting Agreement dated August 27, 2020, between the Registrant and H.C. Wainwright & Co., LLC (“H.C. Wainwright”)

EX-4.1 Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

August 31, 2020 EX-99.1

Oncternal Therapeutics Announces $3.5 Million Bought Deal Offering

EX-99.1 Exhibit 99.1 Oncternal Therapeutics Announces $3.5 Million Bought Deal Offering SAN DIEGO, August 27, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that it has entered into an underwriting agreement with H.C. Wainwright & Co., LLC under which the underwriter has agreed t

August 31, 2020 EX-99.2

Oncternal Therapeutics Increases Previously Announced Bought Deal to $4.5 Million

EX-99.2 Exhibit 99.2 Oncternal Therapeutics Increases Previously Announced Bought Deal to $4.5 Million SAN DIEGO, August 27, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that due to demand, the underwriter has agreed to increase the size of the previously announced offering and

August 31, 2020 8-K

Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events - 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 27, 2020 Oncternal Therapeutics, Inc.

August 31, 2020 EX-1.1

Form of Underwriter Warrant, issued by Registrant pursuant to the Amended and Restated Underwriting Agreement, dated August 27, 2020, between the Registrant and H.C. Wainwright & Co., LLC

EX-1.1 Exhibit 1.1 2,142,858 Shares ONCTERNAL THERAPEUTICS, INC. Common Stock AMENDED AND RESTATED UNDERWRITING AGREEMENT August 27, 2020 H.C. Wainwright & Co., LLC as Representative of the several Underwriters named in Schedule I hereto 430 Park Avenue, 4th Floor New York, NY 10022 Ladies and Gentlemen: Oncternal Therapeutics, Inc., a Delaware corporation (the “Company”), proposes, subject to the

August 28, 2020 424B5

2,142,858 Shares Common Stock

424B5 1 d41795d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 PROSPECTUS SUPPLEMENT (To Prospectus dated January 5, 2018) 2,142,858 Shares Common Stock We are offering 2,142,858 shares of our common stock. Our common stock is listed on The Nasdaq Capital Market under the symbol “ONCT.” On August 26 2020, the last reported sale price of our common sto

August 28, 2020 FWP

Free Writing Prospectus dated August 27, 2020

FWP 1 d51293dfwp.htm FWP Free Writing Prospectus dated August 27, 2020 Filed pursuant to Rule 433 Relating to the Preliminary Prospectus Supplement dated August 27, 2020 Registration Statement No. 333-222268 Oncternal Therapeutics Increases Previously Announced Bought Deal to $4.5 Million SAN DIEGO, August 27, 2020 - Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical c

August 27, 2020 FWP

Oncternal Therapeutics Announces $3.5 Million Bought Deal Offering

FWP 1 d33092dfwp.htm FWP Free Writing Prospectus dated August 27, 2020 Filed pursuant to Rule 433 Relating to the Preliminary Prospectus Supplement dated August 27, 2020 Registration Statement No. 333-222268 Oncternal Therapeutics Announces $3.5 Million Bought Deal Offering SAN DIEGO, August 27, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused

August 27, 2020 424B5

SUBJECT TO COMPLETION, DATED AUGUST 27, 2020

424B5 1 d41795d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been declared effective by the Securities and Exchange Commission. This preliminary prospectus supplement and the accompanying prospectus

August 27, 2020 8-K

Termination of a Material Definitive Agreement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): August 27, 2020 Oncternal Therapeutics, Inc.

August 6, 2020 8-K

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) August 6, 2020 Oncternal Therapeutics, Inc.

August 6, 2020 EX-10.4

Amendment #4 to Collaboration Agreement between Oncternal Therapeutics, Inc. and The University of Texas M.D. Anderson Cancer Center, dated February 19, 2020

Exhibit 10.4 Amendment 4 to Collaboration Agreement This Amendment 4 to the Collaboration Agreement (the “Amendment 4”) is effective as of December 15, 2019 (the “Amendment 4 Effective Date”) and amends that certain Collaboration Agreement between The University of Texas M.D. Anderson Cancer Center (“MD Anderson”) and Oncternal Therapeutics, Inc., formerly Tokalas, Inc. (“Oncternal”) effective as

August 6, 2020 EX-99.1

Oncternal Provides Business Update and Announces Second Quarter 2020 Financial Results

Exhibit 99.1 Oncternal Provides Business Update and Announces Second Quarter 2020 Financial Results - 58% complete response rate reported in patients with relapsed/refractory mantle cell lymphoma (MCL) in ongoing Phase 1/2 clinical trial of cirmtuzumab with ibrutinib, and the regimen was well tolerated. Meeting requested with FDA to discuss registration pathway for cirmtuzumab for patients with MC

August 6, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant a

July 31, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 28, 2020 Oncternal Therapeutics, Inc.

July 23, 2020 EX-99.5

JOINT FILING AGREEMENT

EX-99.5 Exhibit 5 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that they are jointly filing this statement on Schedule 13D. Each of them is responsible for the timely filing of such statement and any amendments thereto, and for the completeness and accuracy of the information concerning su

July 23, 2020 SC 13D/A

ONCT / Oncternal Therapeutics, Inc. / Shanghai Pharmaceuticals (HK) Investment Ltd - SC 13D/A Activist Investment

SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1)* Oncternal Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.001 (Title of Class of Securities) 68236P 107 (CUSIP Number) Shen Bo 3545 John Hopkins Ct., Ste. 160 San Diego, CA 92121 858-925-4046 (Name, Address and Telephone Number of

July 21, 2020 424B5

2,581,867 Shares of Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 PROSPECTUS SUPPLEMENT (To the Prospectus Dated January 5, 2018) 2,581,867 Shares of Common Stock Pursuant to this prospectus supplement and the accompanying prospectus, we are offering to certain institutional and accredited investors 2,581,867 shares of our common stock at a purchase price of $2.3825 per share, f

July 21, 2020 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): July 17, 2020 Oncternal Therapeutics, Inc.

July 21, 2020 EX-10.1

Form of Securities Purchase Agreement, dated July 17, 2020, between the Registrant and the purchasers signatory thereto

EX-10.1 EXHIBIT 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of July 17, 2020, between Oncternal Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms an

July 21, 2020 EX-4.1

Form of Common Stock Warrant, issued by Registrant pursuant to the Securities Purchase Agreement dated July 17, 2020, between the Registrant and the purchasers signatory thereto (the “July 2020 Purchase Agreement”)

EX-4.1 EXHIBIT 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

July 21, 2020 EX-4.2

Form of Placement Agent Warrant, issued by Registrant pursuant to the July 2020 Purchase Agreement.

EX-4.2 EXHIBIT 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE

July 21, 2020 EX-99.1

Oncternal Therapeutics Announces $6.2 Million Registered Direct Offering Priced At-the-Market under Nasdaq Rules

EX-99.1 6 d68015dex991.htm EX-99.1 EXHIBIT 99.1 Oncternal Therapeutics Announces $6.2 Million Registered Direct Offering Priced At-the-Market under Nasdaq Rules SAN DIEGO, July 20, 2020 — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that it has entered into definitive agreements prima

June 30, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 30, 2020 Oncternal Therapeutics, Inc.

June 15, 2020 8-K

Current Report

8-K 1 onct-8k20200615.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): June 11, 2020 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 000-50549 62-1715807 (State or Other Jurisdiction of

May 29, 2020 SC 13G

ONCT / Oncternal Therapeutics, Inc. / ARMISTICE CAPITAL, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

May 21, 2020 EX-10.1

Form of Securities Purchase Agreement, dated May 19, 2020, between the Registrant and the purchasers signatory thereto

EXHIBIT 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of May 19, 2020, between Oncternal Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and conditi

May 21, 2020 EX-10.2

Engagement Letter between Oncternal Therapeutics, Inc. and H.C. Wainwright & Co., LLC, dated as of May 15, 2020

EXHIBIT 10.2 Execution Version May 15, 2020 STRICTLY CONFIDENTIAL Oncternal Therapeutics, Inc. 12230 El Camino Real Suite 300 San Diego, California 92130 Attn: James B. Breitmeyer, M.D., Ph.D., President and Chief Executive Officer Dear Dr. Breitmeyer: This letter agreement (this “Agreement”) constitutes the agreement between Oncternal Therapeutics, Inc. (the “Company”) and H.C. Wainwright & Co.,

May 21, 2020 EX-4.1

Form of Common Stock Warrant, issued by Registrant pursuant to the Securities Purchase Agreement dated May 19, 2020, between the Registrant and the purchasers signatory thereto (“May 2020 Purchase Agreement”)

EXHIBIT 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

May 21, 2020 EX-4.2

Form of Placement Agent Warrant, issued by Registrant pursuant to the May 2020 Purchase Agreement

EXHIBIT 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

May 21, 2020 424B5

1,943,636 Shares of Common Stock

424B5 1 d879759d424b5.htm 424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-222268 PROSPECTUS SUPPLEMENT (To the Prospectus Dated January 5, 2018) 1,943,636 Shares of Common Stock Pursuant to this prospectus supplement and the accompanying prospectus, we are offering to certain institutional and accredited investors 1,943,636 shares of our common stock at a purchase pri

May 21, 2020 EX-99.1

Oncternal Therapeutics Announces $5.0 Million Registered Direct Offering Priced At-the-Market under Nasdaq Rules

EX-99.1 7 onct-ex99111.htm EX-99.1 EXHIBIT 99.1 Oncternal Therapeutics Announces $5.0 Million Registered Direct Offering Priced At-the-Market under Nasdaq Rules SAN DIEGO, May 20, 2020 - Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that it has entered into definitive agreements with s

May 21, 2020 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Other Events

8-K 1 onct-8k20200519.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 19, 2020 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 000-50549 62-1715807 (State or Other Jurisdiction of

May 19, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): May 19, 2020 Oncternal Therapeutics, Inc.

May 7, 2020 8-K

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) May 7, 2020 Oncternal Therapeutics, Inc.

May 7, 2020 EX-99.1

Oncternal Provides Business Update and Announces First Quarter 2020 Financial Results

EX-99.1 2 onct-ex9917.htm EX-99.1 Exhibit 99.1 Oncternal Provides Business Update and Announces First Quarter 2020 Financial Results - Deep clinical responses reported for two of seven patients with relapsed/refractory Ewing sarcoma treated with the recommended Phase 2 dose of TK216 in ongoing Phase 1 clinical trial - 50% complete response rate reported in patients with relapsed/refractory MCL in

May 7, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 2020 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact name of registrant

April 29, 2020 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A (Rule 14a-101) SCHEDULE 14A INFORMATION PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Ru

April 29, 2020 DEFA14A

- DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 2, 2020 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported): April 2, 2020 Oncternal Therapeutics, Inc.

March 18, 2020 8-K

Current Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 18, 2020 Oncternal Therapeutics, Inc.

March 16, 2020 8-K

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of report (Date of earliest event reported) March 16, 2020 Oncternal Therapeutics, Inc.

March 16, 2020 EX-4.5

Description of Securities of Oncternal Therapeutics, Inc.

Exhibit 4.5 Description of the Registrant’s SECURITIES Registered Pursuant to Section 12 of the Securities Exchange Act of 1934 Oncternal Therapeutics, Inc. (“Oncternal,” “we,” “our” and “us”) has one class of securities registered pursuant to Section 12 of the Securities Exchange Act of 1934, as amended: our common stock Description of Common Stock General The following summary of the terms of ou

March 16, 2020 EX-10.13

Amendment #2 to Amended and Restated License Agreement between Oncternal Therapeutics, Inc. and the Regents of the University of California, dated May 15, 2019

Exhibit 10.13 *** CERTAIN MATERIAL (INDICATED BY THREE ASTERISKS IN BRACKETS) HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH (1) NOT MATERIAL AND (2) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. Amendment No. 2 TO AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN ONCTERNAL THERAPEUTICS, INC. AND THE REGENTS OF THE UNIVERSITY OF CALIFORNIA FOR UC CASE NOS. SD2005-212, SD2010-306, SD20

March 16, 2020 EX-10.32

Consulting Agreement dated September 20, 2019 between Robert J. Wills. Ph.D. and Oncternal Therapeutics, Inc.

EX-10.32 6 onct-ex1032768.htm EX-10.32 Exhibit 10.32 September 20, 2019 Robert J. Wills, Ph.D. Dear Dr. Wills: Oncternal Therapeutics, Inc., a Delaware corporation (“Oncternal” or the “Company”), invites you to consult with and advise Oncternal with respect to its efforts to out-license or sell the Company’s SARD and SARM assets in accordance with the following terms and conditions: 1. Services. A

March 16, 2020 10-K

Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 000-50549 Oncternal Therapeutics, Inc. (Exact Name of Registrant as Speci

March 16, 2020 EX-10.31

Form of Indemnification Agreement

EX-10.31 5 onct-ex1031767.htm EX-10.31 Exhibit 10.31 INDEMNIFICATION AGREEMENT This Indemnification Agreement (“Agreement”) is made as of , 20 by and between Oncternal Therapeutics, Inc., a Delaware corporation (the “Company”), and , [a member of the Board of Directors/ an officer] of the Company (“Indemnitee”). This Agreement supersedes and replaces any and all previous Agreements between the Com

March 16, 2020 EX-10.2

Amendment No. 1 to Commercial License Agreement between Selexis SA and Oncternal Therapeutics, Inc., dated February 7, 2020

EX-10.2 3 onct-ex102765.htm EX-10.2 Exhibit 10.2 *** CERTAIN MATERIAL (INDICATED BY THREE ASTERISKS IN BRACKETS) HAS BEEN OMITTED FROM THIS DOCUMENT BECAUSE IT IS BOTH (1) NOT MATERIAL AND (2) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. AMENDMENT NO. 1 TO COMMERCIAL LICENSE AGREEMENT This Amendment No. 1 to Commercial License Agreement (the “Amendment”), effective as of February 5, 2020

March 16, 2020 EX-99.1

Oncternal Provides Business Update and Announces Fourth Quarter and Full Year 2019 Financial Results

Exhibit 99.1 Oncternal Provides Business Update and Announces Fourth Quarter and Full Year 2019 Financial Results - Steady progress of clinical programs in four indications: MCL, Ewing sarcoma, breast cancer, and CLL - Cirmtuzumab in combination with ibrutinib demonstrated a 50% CR rate and 83% best ORR in patients with relapsed/refractory MCL in an interim analysis from an ongoing Phase 1/2 clini

March 16, 2020 EX-21.1

State of Incorporation

EX-21.1 7 onct-ex211764.htm EX-21.1 Exhibit 21.1 Subsidiaries State of Incorporation Oncternal Oncology, Inc. Delaware Oncternal, Inc. Delaware US-DOCS\114514280.1

February 14, 2020 EX-99.1

AGREEMENT

EX-99.1 EXHIBIT 1 AGREEMENT The persons below hereby agree that the Schedule 13G to which this agreement is attached as an exhibit, as well as all future amendments to such Schedule 13G, shall be filed on behalf of each of them. This agreement is intended to satisfy the requirements of Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934. Date: February 14, 2020 PERCEPTIVE ADVISORS LLC

February 14, 2020 SC 13G/A

ONCT / Oncternal Therapeutics, Inc. / PERCEPTIVE ADVISORS LLC - SC 13G/A Passive Investment

SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Oncternal Therapeutics, Inc. (Name of Issuer) Common stock, par value $0.001 per share (Title of Class of Securities) 68236P107 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box

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