PTIXW / Protagenic Therapeutics, Inc. - Equity Warrant - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Protagenic Therapeutics, Inc. - Equity Warrant

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LEI 549300KPBYAVJLPDKB70
CIK 1022899
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Protagenic Therapeutics, Inc. - Equity Warrant
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 28, 2025 EX-99.1

PHYTANIX BIO, INC. AND SUBSIDIARIES CONSOLIDATED FINANCIAL STATEMENTS (IN US$) March 31, 2025 and 2024

Exhibit 99.1 PHYTANIX BIO, INC. AND SUBSIDIARIES CONSOLIDATED FINANCIAL STATEMENTS (IN US$) March 31, 2025 and 2024 CONTENTS Report of Independent Registered Public Accounting Firm (PCAOB ID: 6580) F-2 Consolidated Financial Statements: Consolidated Balance Sheets as of March 31, 2025 and 2024 F-3 Consolidated Statements of Operations and Comprehensive Loss - For the Years Ended March 31, 2025 and

August 28, 2025 EX-99.2

PROTAGENIC THERAPEUTICS, INC. PRO FORMA COMBINED BALANCE SHEETS March 31, 2025

Exhibit 99.2 PROTAGENIC THERAPEUTICS, INC. PRO FORMA COMBINED BALANCE SHEETS March 31, 2025 PHYTANIX BIO, INC. AND SUBSIDIARIES PROTAGENIC THERAPEUTICS, INC. AND SUBSIDIARY Adjustments Pro Forma Combined March 31, 2025 March 31, 2025 March 31, 2025 ASSETS Current assets: Cash in bank 14,531 872,960 314,924 1,202,415 Prepaid expenses and other current assets - 55,216 55,216 VAT receivable 73,524 -

August 28, 2025 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 15, 2025 Protagenic Therapeutics, Inc.\new PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisd

August 22, 2025 EX-99.2

Protagenic Therapeutics Provides Update on Form 10-Q Filing Timeline and Nasdaq Compliance

Exhibit 99.2 FOR IMMEDIATE RELEASE Protagenic Therapeutics Provides Update on Form 10-Q Filing Timeline and Nasdaq Compliance New York, NY – August 22, 2025 – Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (the “Company”) today announced that it expects to file its Quarterly Report on Form 10-Q for the period ended June 30, 2025 in the near future, following a delay attributable to the completion of

August 22, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 7, 2025 Protagenic Therapeutics, Inc.\new PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisd

August 22, 2025 EX-16.1

EX-16.1

Exhibit 16.1

August 22, 2025 EX-99.1

EX-99.1

Exhibit 99.1

August 14, 2025 NT 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ☐ Form 10-K ☐ Form 20-F ☐ Form 11-K ☒ Form 10-Q ☐ Form 10-D  ☐Form N-SAR  ☐ Form N-CSR For Period Ended: June 30, 2025 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q ☐ Transition Report on F

August 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 7, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisd

July 30, 2025 EX-99.1

Protagenic Therapeutics Announces Grant of new patent in Japan for its Modified Stilbenoid Program Drug Candidates

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics Announces Grant of new patent in Japan for its Modified Stilbenoid Program Drug Candidates NEW YORK, NY and SANTA BARBARA, CA, July 30, 2025 Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (the “Company”) today announces that on July 18, 2025, the Japanese Patent Office granted Patent JP 7714571B, a patent which runs until March 31, 2041. Thi

July 30, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 18, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdi

July 24, 2025 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 18, 2025 Protagenic Therapeutics, Inc.\new PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdi

June 27, 2025 8-K

Material Modification to Rights of Security Holders, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 24, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdi

May 21, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 15, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdic

May 21, 2025 EX-99.1

Protagenic Therapeutics Receives $3.1 Million from Recent Warrant Activity

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics Receives $3.1 Million from Recent Warrant Activity NEW YORK, NY, May 21, 2025 — Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (the “Company”) announced today that warrant exchanges and exercises over the last four trading days have generated $3.1 million in cash for the Company. The proceeds will fund working-capital needs and advance the C

May 20, 2025 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 20, 2025 PROTAGENIC THERAPEUTICS, INC.Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdict

May 20, 2025 EX-10.1

FORM OF WARRANT EXCHANGE AGREEMENT

Exhibit 10.1 FORM OF WARRANT EXCHANGE AGREEMENT This Warrant Exchange Agreement (this “Agreement”) is made and entered into as of May 20, 2025 (the “Effective Date”), by and among Protagenic Therapeutics Inc., a Delaware corporation (the “Company”), and (the “Holder” and, together with the Company, the “parties”). RECITALS WHEREAS, the Holder currently owns, or will own, warrants (collectively, th

May 19, 2025 EX-3.1

PROTAGENIC therapeutics, inc.

Exhibit 3.1 PROTAGENIC therapeutics, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C NON-VOTING CONVERTIBLE PREFERRED STOCK Pursuant to Section 151 of the General Corporation Law of the State of Delaware THE UNDERSIGNED DOES HEREBY CERTIFY, on behalf of Protagenic Therapeutics, Inc., a Delaware corporation (the “Corporation”), that the following resolution was du

May 19, 2025 EX-4.1

[FORM OF WARRANT]

Exhibit 4.1 [FORM OF WARRANT] NEITHER THE ISSUANCE AND SALE OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATI

May 19, 2025 EX-10.2

FORM OF PURCHASER STOCKHOLDER SUPPORT AGREEMENT Protagenic Therapeutics, Inc. SUPPORT AGREEMENT

Exhibit 10.2 FORM OF PURCHASER STOCKHOLDER SUPPORT AGREEMENT Protagenic Therapeutics, Inc. SUPPORT AGREEMENT THIS SUPPORT AGREEMENT (this “Agreement”), dated as of May 15, 2025 (the “Effective Date”), is made by and between Protagenic Therapeutics, Inc., a Delaware corporation (“Purchaser”), and the undersigned holder (“Stockholder”) of shares of capital stock (the “Shares”) of Purchaser. WHEREAS,

May 19, 2025 EX-99.1

Protagenic Therapeutics and Phytanix Announce Business Combination to form Neuroactive Biopharmaceutical Company with Six Drug Candidates in Development including Treatments for Obesity and Metabolic Disorders

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics and Phytanix Announce Business Combination to form Neuroactive Biopharmaceutical Company with Six Drug Candidates in Development including Treatments for Obesity and Metabolic Disorders NEW YORK, NY and SANTA BARBARA, CA, May 19, 2025 — Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (the “Company”) and Phytanix Bio Inc. have entered into a d

May 19, 2025 EX-10.4

FORM OF REPURCHASE AGREEMENT

Exhibit 10.4 FORM OF REPURCHASE AGREEMENT This REPURCHASE AGREEMENT (this “Agreement”), dated as of May 15, 2025 (the “Effective Date”), is made and entered into by and among ALTEROLA BIOTECH INC., a Nevada corporation “Alterola”), EMC2 CAPITAL LLC, a Wyoming limited liability company (“EMC2” and, together with Alterola, “Optionees” and each, an “Optionee”) and PROTAGENIC THERAPEUTICS, INC., a Del

May 19, 2025 EX-10.3

LOCK-UP AGREEMENT

Exhibit 10.3 LOCK-UP AGREEMENT May 15, 2025 Protagenic Therapeutics, Inc. Re: Share Exchange Agreement, dated as of May 15, 2025 (the “Exchange Agreement”), by and between Protagenic Therapeutics, Inc. (the “Company”) and Alterola Biotech Inc., a Nevada corporation and EMC2 Capital LLC, a Wyoming limited liability company (“Sellers”) Ladies and Gentlemen: Defined terms not otherwise defined in thi

May 19, 2025 EX-3.2

PROTAGENIC therapeutics, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS SERIES C-1 NON-VOTING CONVERTIBLE PREFERRED STOCK Pursuant to Section 151 of the General Corporation Law of the State of Delaware

Exhibit 3.2 PROTAGENIC therapeutics, inc. CERTIFICATE OF DESIGNATION OF PREFERENCES, RIGHTS AND LIMITATIONS OF SERIES C-1 NON-VOTING CONVERTIBLE PREFERRED STOCK Pursuant to Section 151 of the General Corporation Law of the State of Delaware THE UNDERSIGNED DOES HEREBY CERTIFY, on behalf of Protagenic Therapeutics, Inc., a Delaware corporation (the “Corporation”), that the following resolution was

May 19, 2025 EX-10.1

REGISTRATION RIGHTS AGREEMENT

Exhibit 10.1 REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is dated as of May 15, 2025, by and between Protagenic Therapeutics, Inc., a Delaware corporation (the “Company”), Alterola Biotech Inc., a Nevada corporation (“Alterola”) and EMC2 Capital LLC (“EMC2”). This Agreement is made in connection with the Share Exchange Agreement, dated as of May 15, 2025 (th

May 19, 2025 EX-2.1

SHARE EXCHANGE AGREEMENT relating to PHYTANIX BIO, a Nevada corporation by and between Protagenic Therapeutics, INc., a Delaware corporation, Alterola biotech inc., a Nevada corporation, EMC2 CAPITAL LLC, a Wyoming limited liability company, the pref

Exhibit 2.1 SHARE EXCHANGE AGREEMENT relating to PHYTANIX BIO, a Nevada corporation by and between Protagenic Therapeutics, INc., a Delaware corporation, Alterola biotech inc., a Nevada corporation, EMC2 CAPITAL LLC, a Wyoming limited liability company, the preferred stockholders of Phytanix Bio set forth on Schedule A hereto, And Colin Stott, as Sellers’ Representative dated as of May 15, 2025 Ta

May 19, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 15, 2025 Protagenic Therapeutics, Inc.\new PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdic

May 19, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

May 19, 2025 EX-3.3

CERTIFICATE OF DESIGNATIONS OF RIGHTS AND PREFERENCES OF SERIES D CONVERTIBLE PREFERRED STOCK PROTAGENIC THERAPEUTICS, INC. Pursuant to Section 151 of the General Corporation Law of the State of Delaware

Exhibit 3.3 CERTIFICATE OF DESIGNATIONS OF RIGHTS AND PREFERENCES OF SERIES D CONVERTIBLE PREFERRED STOCK OF PROTAGENIC THERAPEUTICS, INC. Pursuant to Section 151 of the General Corporation Law of the State of Delaware THE UNDERSIGNED DOES HEREBY CERTIFY, on behalf of Protagenic Therapeutics, Inc., a Delaware corporation (the “Company”), a corporation organized and existing Section 151 of the Gene

May 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2025 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTAGENI

May 5, 2025 EX-3.1

Certificate of Amendment to Third Amended and Restated Certificate of Incorporation of Protagenic Therapeutics, Inc.

Exhibit 3.1 Amendment to Third Amended and Restated Certificate of Incorporation of the Company CERTIFICATE OF AMENDMENT OF THIRD AMENDED AND RESTATED RESTATED CERTIFICATE OF INCORPORATION OF PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Company”), does hereby certi

May 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 2, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdict

April 29, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 29, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisd

April 29, 2025 EX-99.1

Protagenic Therapeutics to Effect 1-for-14 Reverse Stock Split Measure taken to Comply with Nasdaq Rule 5550(a)(2) Regarding Minimum Bid Price

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics to Effect 1-for-14 Reverse Stock Split Measure taken to Comply with Nasdaq Rule 5550(a)(2) Regarding Minimum Bid Price April 29, 2025 — NEW YORK — Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (“Protagenic Therapeutics” or the “Company”), a leader in biopharmaceutical innovation, today announced that the Company’s Board of Directors has app

April 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 18, 2025 PROTAGENIC THERAPEUTICS, INC. Protagenic Therapeutics, Inc.\new (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisd

March 31, 2025 EX-19.1

Protagenic Therapeutics, Inc. Insider Trading Policy

Exhibit 19.1 MEMORANDUM TO: Protagenic Therapeutics, Inc. Directors, Officers and Employees FROM: Garo Armen, Ph.D., Executive Chairman DATE: May 26, 2021 RE: Insider Trading Policy Enclosed is a copy of the Insider Trading Policy (the “Policy”) for Protagenic Therapeutics, Inc. and its subsidiaries (collectively, the “Company”). As described in the Policy, violations of the insider trading laws c

March 31, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2024 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-12555 Protagenic Therapeutics, Inc. (Exact nam

March 10, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2t2)) ☒ Definitive Proxy Sta

February 27, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2t2)) ☐ Definitive Proxy Sta

February 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 21, 2025 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

February 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 21, 2025 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

January 29, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 22, 2025 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commis

January 16, 2025 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 15, 2025 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commis

January 10, 2025 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 9, 2025 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commiss

January 10, 2025 EX-1.1

Amendment No. 1 to At Market Issuance Sales Agreement, dated as of January 9, 2025, by and between Protagenic Therapeutics, Inc. and B. Riley Securities, Inc.

Exhibit 1.1 First Amendment to At Market Issuance Sales Agreement This First Amendment to the At Market Issuance Sales Agreement is entered into as of January 9, 2025 (the “Amendment”), by and between Protagenic Therapeutics, Inc. (the “Company”) and B. Riley Securities, Inc. (“BRS” or the “Agent” and, together with the Company, the “Parties”). The Company and the Agent are parties to that certain

January 10, 2025 424B5

Common Stock

Filed Pursuant to Rule 424(b)(5) Registration No. 333-280244 PROSPECTUS SUPPLEMENT (To Prospectus dated January 8, 2025) $1,200,000 Common Stock In accordance with the terms of the Common Stock Sales Agreement, dated as of July 2, 2021, as amended on January 9, 2025, or the sales agreement, that we entered into with B. Riley Securities, Inc. (the “Sales Agent”), we may offer and sell shares of our

January 7, 2025 CORRESP

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010 January 7, 2025 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-3 Originally filed June 14, 2024, as amended on January 7, 2025 File No. 333-280244 Ladies and Gentlemen: Pursuant to Ru

January 7, 2025 S-3/A

As filed with the Securities and Exchange Commission on January 7, 2025

As filed with the Securities and Exchange Commission on January 7, 2025 Registration No.

January 6, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.  ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defi

January 3, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

December 30, 2024 CORRESP

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010 December 30, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-3 Filed June 14, 2024 File No. 333-280244 Ladies and Gentlemen: Reference is made to our letter, filed as corresponden

December 27, 2024 424B3

PROTAGENIC THERAPEUTICS, INC. 5,844,885 Shares of Common Stock

Filed pursuant to Rule 424(b)(3) Registration Statement No. 333-283949 PROSPECTUS PROTAGENIC THERAPEUTICS, INC. 5,844,885 Shares of Common Stock The selling stockholders named in this prospectus may use this prospectus to offer and resell from time to time up to 5,844,885 shares of our common stock, par value $0.0001 per share, which are comprised of (i) 1,948,295 shares (the “Shares”) of our comm

December 23, 2024 CORRESP

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010 December 23, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-1 Filed December 20, 2024 File No. 333-283949 Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1

December 20, 2024 S-1

As filed with the Securities and Exchange Commission on December 19, 2024

As filed with the Securities and Exchange Commission on December 19, 2024 Registration Statement No.

December 20, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables FORM S-1 (Form Type) PROTAGENIC THERAPEUTICS, INC.

December 20, 2024 CORRESP

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010 December 20, 2024 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-3 Filed June 14, 2024 File No. 333-280244 Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933

December 19, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy State

December 3, 2024 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 29, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

November 22, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 19, 2024 PROTAGENIC THER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 19, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

November 14, 2024 SC 13G/A

PTIX / Protagenic Therapeutics, Inc. / ARMISTICE CAPITAL, LLC Passive Investment

SC 13G/A 1 armistice-ptix093024a3.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* PROTAGENIC THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 74365N202 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check

November 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2024 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTA

November 5, 2024 EX-99.1

Protagenic Therapeutics Announces Closing of Private Placement for Aggregate Gross Proceeds of $1.275 Million

Exhibit 99.1 Protagenic Therapeutics Announces Closing of Private Placement for Aggregate Gross Proceeds of $1.275 Million NEW YORK, Nov. 5, 2024 – Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (“Protagenic Therapeutics” or the “Company”), a leader in biopharmaceutical innovation, announced today that on November 4, 2024 it closed its previously announced private placement pursuant to a purchase ag

November 5, 2024 8-K

Regulation FD Disclosure, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 4, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commis

October 30, 2024 EX-99.1

Protagenic Therapeutics Announces Pricing of Private Placement for Aggregate Gross Proceeds of $1.275 Million

Exhibit 99.1 Protagenic Therapeutics Announces Pricing of Private Placement for Aggregate Gross Proceeds of $1.275 Million NEW YORK, Oct. 29, 2024 – Protagenic Therapeutics, Inc. (Nasdaq: PTIX) (“Protagenic Therapeutics” or the “Company”), a leader in biopharmaceutical innovation, announced today it has entered into a purchase agreement (the “Purchase Agreement”) for the purchase and sale of an ag

October 30, 2024 EX-4.1

Form of Series A Common Stock Purchase Warrant

Exhibit 4.1 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

October 30, 2024 EX-10.2

Form of Registration Rights Agreement

Exhibit 10.2 EXHIBIT B REGISTRATION RIGHTS AGREEMENT This Registration Rights Agreement (this “Agreement”) is made and entered into as of October 29, 2024, by and between Protagenic Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the several purchasers signatory hereto (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”). This Agreement is made pursuant

October 30, 2024 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 29, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commis

October 30, 2024 EX-10.1

Form of Securities Purchase Agreement

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of October 29, 2024, between Protagenic Therapeutics, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”). WHEREAS, subject to the terms and co

October 30, 2024 EX-4.2

Form of Series B Common Stock Purchase Warrant

Exhibit 4.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

October 30, 2024 EX-4.3

Form of Placement Agent Warrant

Exhibit 4.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTR

September 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 17, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Comm

August 14, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2024 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTAGENIC

July 26, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 24, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commissio

June 14, 2024 EX-4.5

Form of Indenture with respect to subordinated debt securities, between the registrant and one or more trustees to be named.

Exhibit 4.5 PROTAGENIC THERAPEUTICS, INC. Company AND [TRUSTEE] Trustee INDENTURE Dated as of [●], 20[●] Subordinated Debt Securities TABLE OF CONTENTS ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms. 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities. 5 Section 2.02 Form of Securities and Trustee’s

June 14, 2024 S-3

As filed with the Securities and Exchange Commission on June 14, 2024

As filed with the Securities and Exchange Commission on June 14, 2024 Registration No.

June 14, 2024 EX-4.4

Form of Indenture with respect to senior debt securities, between the registrant and one or more trustees to be named.

EXHIBIT 4.4 PROTAGENIC THERAPEUTICS, INC. Issuer AND [TRUSTEE] Trustee INDENTURE Dated as of [●], 20[●] Senior Debt Securities TABLE OF CONTENTS ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms. 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities. 5 Section 2.02 Form of Securities and Trustee’s Certif

June 14, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-3 (Form Type) Protagenic Therapeutics, Inc.

May 24, 2024 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 22, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commission

May 22, 2024 EX-99.1

Protagenic Therapeutics’ Stress-Regulating Peptide Demonstrates Exceptional Safety in Single Dose Portion of Phase I Trial, Paving the Way for Next Steps Toward Potential Breakthrough Treatments in Stress Related Neuropsychiatric Disorders

Exhibit 99.1 Protagenic Therapeutics’ Stress-Regulating Peptide Demonstrates Exceptional Safety in Single Dose Portion of Phase I Trial, Paving the Way for Next Steps Toward Potential Breakthrough Treatments in Stress Related Neuropsychiatric Disorders No Clinically-Relevant Adverse Events Reported in Single Dose Portion, Multiple Dose Portion to Commence Investor Call Scheduled for today, Wednesd

May 22, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 22, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commission

May 15, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2024 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTAGENI

May 14, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A ☒ ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2023 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-12555 Protagenic Therapeutics, Inc. (Exact n

April 24, 2024 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A ☒ ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2023 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-12555 Protagenic Therapeutics, Inc. (Exact n

April 1, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2023 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-12555 Protagenic Therapeutics, Inc. (Exact nam

April 1, 2024 EX-97.1

Protagenic Therapeutics, Inc. Policy on Recovery of Erroneously Awarded Compensation (Incorporated by reference to Exhibit 97 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 1, 2024)

Exhibit 97 PROTAGENIC THERAPEUTICS, INC. POLICY FOR RECOVERY OF ERRONEOUSLY AWARDED INCENTIVE COMPENSATION (Adopted April 1, 2024) 1. INTRODUCTION Protagenic Therapeutics, Inc. (the “Company”) is adopting this policy (this “Policy”) to provide for the Company’s recovery of certain Incentive Compensation (as defined below) erroneously awarded to Affected Officers (as defined below) under certain ci

April 1, 2024 EX-99.2

Compensation Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017 (Incorporated by reference to Exhibit 99.2 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 1, 2024).

Exhibit 99.2 Charter of the Compensation Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the “Company”) Purpose The principal purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) is to approve, administer and interpret the Company’s executive and key employee compensation and benefit policies, including the Company’s equity incentive

April 1, 2024 EX-99.3

Governance and Nominating Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017 (Incorporated by reference to Exhibit 99.3 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 1, 2024).

Exhibit 99.3 Charter of the Corporate Governance and Nominating Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the “Company”) Function The Corporate Governance and Nominating Committee (the “Committee”) shall, among other things, review and recommend policies to the Board of Directors of the Company (the “Board”) regarding Board procedures, Board leadership, the process for

April 1, 2024 EX-21.1

Subsidiaries (Incorporated by reference to Exhibit 21.1 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 1, 2024)

Exhibit 21.1 SUBSIDIARIES OF PROTAGENIC THERAPEUTICS, INC. Subsidiary Jurisdiction of Organization/Incorporation Protagenic Therapuetics Canada (2006) Inc. Canada

April 1, 2024 EX-4.1

Description of Securities (Incorporated by reference to Exhibit 4.1 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 1, 2024)

Exhibit 4.1 DESCRIPTION OF SECURITIES pursuant to section 12 of the securities exchange act of 11934 The following description is intended as a summary of our third amended and restated certificate of incorporation (which we refer to as our “charter”) and our bylaws, and to the applicable provisions of the Delaware General Corporation Law. Because the following is only a summary, it does not conta

April 1, 2024 EX-99.1

Audit Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017 (Incorporated by reference to Exhibit 99.1 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 1, 2024).

Exhibit 99.1 Charter of the Audit Committee of the Board of Directors of Protagenic Therapeutics, Inc. Purpose The principal purpose of the Audit and Finance Committee (the “Committee”) is to assist the Board of Directors (the “Board”) of Protagenic Therapeutics, Inc. (the “Company”) in fulfilling its responsibility to oversee the Company’s accounting and financial reporting processes and audits o

March 21, 2024 EX-99.1

Protagenic Therapeutics Announces Resolution of Nasdaq Deficiency Notice

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics Announces Resolution of Nasdaq Deficiency Notice NEW YORK, March 21, 2024 — Protagenic Therapeutics, Inc. (Nasdaq: PTIX), a biopharmaceutical innovator, regained compliance with Nasdaq Listing Rule 5550(a)(2) as the closing bid price of shares of PTIX has remained above $1.00 per share for ten consecutive trading days. This resolves the is

March 21, 2024 8-K

Regulation FD Disclosure, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 19, 2024 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commissi

February 14, 2024 SC 13G/A

US74365N2027 / PROTAGENIC THERA / ARMISTICE CAPITAL, LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

December 15, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 13, 2023 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

November 29, 2023 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 21, 2023 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

November 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2023 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTA

November 2, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2023 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTAGENIC

May 15, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2023 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTAGENI

April 17, 2023 10-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K/A Amendment No. 1 ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-51353 Protage

March 31, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2022 OR ☐ TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-51353 Protagenic Therapeutics, Inc. (Exact nam

March 31, 2023 EX-99.2

Compensation Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017*.

Exhibit 99.2 Charter of the Compensation Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the “Company”) Purpose The principal purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) is to approve, administer and interpret the Company’s executive and key employee compensation and benefit policies, including the Company’s equity incentive

March 31, 2023 EX-21.1

Subsidiaries *

Exhibit 21.1 SUBSIDIARIES OF PROTAGENIC THERAPEUTICS, INC. Subsidiary Jurisdiction of Organization/Incorporation Protagenic Therapuetics Canada (2006) Inc. Canada

March 31, 2023 EX-99.3

Governance and Nominating Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017*.

Exhibit 99.3 Charter of the Corporate Governance and Nominating Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the “Company”) Function The Corporate Governance and Nominating Committee (the “Committee”) shall, among other things, review and recommend policies to the Board of Directors of the Company (the “Board”) regarding Board procedures, Board leadership, the process for

March 31, 2023 EX-99.1

Audit Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017*.

Exhibit 99.1 Charter of the Audit Committee of the Board of Directors of Protagenic Therapeutics, Inc. Purpose The principal purpose of the Audit and Finance Committee (the “Committee”) is to assist the Board of Directors (the “Board”) of Protagenic Therapeutics, Inc. (the “Company”) in fulfilling its responsibility to oversee the Company’s accounting and financial reporting processes and audits o

March 31, 2023 EX-4.1

Description of Securities*

Exhibit 4.1 DESCRIPTION OF SECURITIES pursuant to section 12 of the securities exchange act of 11934 The following description is intended as a summary of our third amended and restated certificate of incorporation (which we refer to as our “charter”) and our bylaws, and to the applicable provisions of the Delaware General Corporation Law. Because the following is only a summary, it does not conta

March 22, 2023 EX-3.1

Certificate of Amendment to Third Amended and Restated Certificate of Incorporation of Protagenic Therapeutics, Inc.

Exhibit 3.1 CERTIFICATE OF AMENDMENT OF THIRD AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PROTAGENIC THERAPEUTICS, INC. (Pursuant to Section 242 of the General Corporation Law of the State of Delaware) Protagenic Therapeutics, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the “General Corporation L

March 22, 2023 EX-99.1

Protagenic Therapeutics to Effect 1-for-4 Reverse Stock Split Measure taken to Comply with Nasdaq Rule 5550(a)(2) Regarding Minimum Bid Price

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics to Effect 1-for-4 Reverse Stock Split Measure taken to Comply with Nasdaq Rule 5550(a)(2) Regarding Minimum Bid Price March 22, 2023 — NEW YORK — Protagenic Therapeutics, Inc. (Nasdaq: PTIX, the “Company”) a biopharmaceutical company focused on developing therapies to treat stress-related neurologic disorders, today announced that the Comp

March 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 21, 2023 PROTAGENIC THERAPE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 21, 2023 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commissi

February 14, 2023 SC 13G/A

PTIX / Protagenic Therapeutics Inc / ARMISTICE CAPITAL, LLC Passive Investment

SC 13G/A 1 armistice-ptix123122a1.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* PROTAGENIC THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 74365N103 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check t

November 29, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 23, 2022

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 23, 2022 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commi

November 14, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2022 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 001-12555 PROTA

October 12, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

September 2, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 30, 2022 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commiss

August 11, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2022 or ? Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTAGENIC

June 29, 2022 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 29, 2022 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 001-12555 06-1390025 (State or other jurisdiction of incorporation) (Commissio

May 13, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2022 or ? Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTAGENI

April 7, 2022 EX-99.2

Compensation Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017*.

Exhibit 99.2 Charter of the Compensation Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the ?Company?) Purpose The principal purpose of the Compensation Committee (the ?Committee?) of the Board of Directors (the ?Board?) is to approve, administer and interpret the Company?s executive and key employee compensation and benefit policies, including the Company?s equity incentive

April 7, 2022 EX-99.1

Audit Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017*.

Exhibit 99.1 Charter of the Audit Committee of the Board of Directors of Protagenic Therapeutics, Inc. Purpose The principal purpose of the Audit and Finance Committee (the ?Committee?) is to assist the Board of Directors (the ?Board?) of Protagenic Therapeutics, Inc. (the ?Company?) in fulfilling its responsibility to oversee the Company?s accounting and financial reporting processes and audits o

April 7, 2022 EX-99.3

Governance and Nominating Committee Charter adopted by Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017*.

Exhibit 99.3 Charter of the Corporate Governance and Nominating Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the ?Company?) Function The Corporate Governance and Nominating Committee (the ?Committee?) shall, among other things, review and recommend policies to the Board of Directors of the Company (the ?Board?) regarding Board procedures, Board leadership, the process for

April 7, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K ? ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2021 OR ? TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-51353 Protagenic Therapeutics, Inc. (Exact nam

April 7, 2022 EX-4.1

Description of Securities*

Exhibit 4.1 DESCRIPTION OF SECURITIES pursuant to section 12 of the securities exchange act of 11934 The following description is intended as a summary of our third amended and restated certificate of incorporation (which we refer to as our ?charter?) and our bylaws, and to the applicable provisions of the Delaware General Corporation Law. Because the following is only a summary, it does not conta

April 7, 2022 EX-21.1

Subsidiaries *

Exhibit 21.1 SUBSIDIARIES OF PROTAGENIC THERAPEUTICS, INC. Subsidiary Jurisdiction of Organization/Incorporation Protagenic Therapuetics Canada (2006) Inc. Canada

March 31, 2022 NT 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Check one): ??Form 10-K ??Form 20-F ??Form 11-K ??Form 10-Q ??Form 10-D ??Form N-SAR? ? Form N-CSR For Period Ended: December 31, 2021 ? Transition Report on Form 10-K ? Transition Report on Form 20-F ? Transition Report on Form 11-K ? Transition Report on Form 10-Q ? Transition Report

March 8, 2022 EX-FILING FEES

Filing Fee Table

Exh. 107.1 Calculation of Filing Fee Tables Form S-8 (Form Type) Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Title of Securities to be Registered Fee Calculation Rule Amount to be Registered (1) Proposed Maximum Offering Price Per Share Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Eq

March 8, 2022 S-8

As filed with the Securities and Exchange Commission on March 8, 2022

S-8 1 forms-8.htm As filed with the Securities and Exchange Commission on March 8, 2022 Registration No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PROTAGENIC THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 06-1390025 (State or other jurisdiction of Incorporation or orga

February 15, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13G (including additional amendments thereto) with respect to the shares of Common Stock, par value $0.0001, of Protagenic Therapeutics, Inc. This Joint Filing Agreement

February 15, 2022 SC 13G

PTIX / Protagenic Therapeutics Inc / ARMISTICE CAPITAL, LLC - SC 13G Passive Investment

SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

February 4, 2022 SC 13G/A

PTIX / Protagenic Therapeutics Inc / Hudson Bay Capital Management LP - PTIX 13G/A Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 6)* Protagenic Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 74365N103 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

November 15, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2021 or ☐ Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTA

October 5, 2021 8-K

Notice of Delisting or Failure to Satisfy a Continued Listing Rule or Standard; Transfer of Listing

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 1, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commiss

October 1, 2021 8-K

Submission of Matters to a Vote of Security Holders, Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 29, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Comm

October 1, 2021 EX-3.1

Amended and Restated Certificate of Incorporation

EX-3.1 2 ex3-1.htm Exhibit 3.1 CERTIFICATE OF AMENDMENT OF THIRD AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF PROTAGENIC THERAPEUTICS, INC. The corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware does hereby certify: FIRST: That at a meeting of the Board of Directors of Protagenic Therapeutics, Inc. resolutions were duly adopted se

September 14, 2021 CORRESP

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010 September 14, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-3/A Filed September 10, 2021 File No. 333-258825 Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act

September 10, 2021 S-3/A

As filed with the Securities and Exchange Commission on September 10, 2021

S-3/A 1 forms-3a.htm As filed with the Securities and Exchange Commission on September 10, 2021 Registration No. 333-258825 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Pre-Effective Amendment No. 1 to FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 06-1390025 (

September 8, 2021 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy State

August 19, 2021 8-K

Regulation FD Disclosure, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 17, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commiss

August 19, 2021 EX-99.1

Protagenic Therapeutics Announces Second Quarter 2021 Results and Provides Business Update

Exhibit 99.1 FOR IMMEDIATE RELEASE Protagenic Therapeutics Announces Second Quarter 2021 Results and Provides Business Update August 17, 2021 ? NEW YORK ? Protagenic Therapeutics, Inc. (Nasdaq: PTIX) a biopharmaceutical company focused on developing therapies to treat stress-related neurologic disorders, today announced results for the second quarter ended June 30, 2021. Recent Highlights ? Receiv

August 16, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ? Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2021 or ? Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTAGENIC

August 13, 2021 S-3

Powers of Attorney

S-3 1 forms-3.htm As filed with the Securities and Exchange Commission on August 13, 2021 Registration No. - UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in Its Charter) Delaware 06-1390025 (State or Other Jurisdiction of Incorporation or

July 26, 2021 8-K

Regulation FD Disclosure, Other Events, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 23, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissi

July 26, 2021 EX-99.1

Protagenic Therapeutics Updates Timeline for Commencement of Patient Enrollment for PT00114 Clinical Trial

Exhibit 99.1 Protagenic Therapeutics Updates Timeline for Commencement of Patient Enrollment for PT00114 Clinical Trial July 23, 2021 ? NEW YORK ? Protagenic Therapeutics, Inc. (Nasdaq: PTIX) a biopharmaceutical company focused on developing therapies to treat stress-related neurologic disorders, today announced that upon reviewing its investigational new drug (IND) application filed on June 29th,

July 2, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (date of earliest event reported): July 2, 2021 Protagenic Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commiss

July 2, 2021 EX-1.1

You’ve Exceeded the SEC’s Traffic Limit

U.S. Securities and Exchange Commission You’ve Exceeded the SEC’s Traffic Limit Your request rate has exceeded the SEC’s maximum allowable requests per second. Your access to SEC.gov will be limited for 10 minutes. Current guidelines limit each user to a total of no more than 10 requests per second, regardless of the number of machines used to submit requests. To ensure that SEC.gov remains

July 2, 2021 424B5

Common Stock

Filed Pursuant to Rule 424(b)(5) Registration No. 333-256790 PROSPECTUS SUPPLEMENT (To Prospectus dated June 23, 2021) $10,000,000 Common Stock In accordance with the terms of the Common Stock Sales Agreement, dated as of July 2, 2021, or the sales agreement, that we entered into with B. Riley Securities, Inc. (?B. Riley Securities?) and EF Hutton, division of Benchmark Investments, LLC (?EF Hutto

June 21, 2021 S-3/A

As filed with the Securities and Exchange Commission on June 21, 2021

S-3/A 1 forms-3a.htm As filed with the Securities and Exchange Commission on June 21, 2021 Registration No. 333-256790 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 to FORM S-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 149 Fifth Avenue New York, New

June 21, 2021 CORRESP

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010

Protagenic Therapeutics, Inc. 149 Fifth Avenue New York, NY 10010 June 21, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-3 Filed June 21, 2021 File No. 333-256790 Ladies and Gentlemen: Pursuant to Rule 461 under the Securities Act of 1933 and

June 4, 2021 EX-4.4

Form of Indenture with respect to senior debt securities, between the registrant and one or more trustees to be named.

EX-4.4 2 ex4-4.htm EXHIBIT 4.4 PROTAGENIC THERAPEUTICS, INC. Issuer AND [TRUSTEE] Trustee INDENTURE Dated as of [●], 20[●] Senior Debt Securities TABLE OF CONTENTS ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms. 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities. 5 Section 2.02 Form of Securities a

June 4, 2021 EX-4.5

Form of Indenture with respect to subordinated debt securities, between the registrant and one or more trustees to be named.

Exhibit 4.5 PROTAGENIC THERAPEUTICS, INC. Company AND [TRUSTEE] Trustee INDENTURE Dated as of [?], 20[?] Subordinated Debt Securities TABLE OF CONTENTS ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms. 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities. 5 Section 2.02 Form of Securities and Trustee?s

June 4, 2021 S-3

Powers of Attorney

As filed with the Securities and Exchange Commission on June 4, 2021 Registration No.

May 17, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2021 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTA

May 17, 2021 EX-10.1

5.00% Promissory Note

Exhibit 10.1 PROMISSORY NOTE $100,000.00 March 1, 2021 For value received, PROTAGENIC THERAPEUTICS, INC., a Delaware corporation (the ?Borrower?), promises to pay to PATRICE MCNICOLL, an individual, or his assigns (the ?Holder?), the principal sum of $100,000.00 (U.S. Dollars), together with all accrued and unpaid interest thereon as set forth below. Except as otherwise set forth herein, the princ

April 30, 2021 EX-1.1

Underwriting Agreement dated April 26, 2021, by and among the Company and Kingswood Capital Markets, division of Benchmark Investments, Inc,as representative of the underwriters.

EX-1.1 2 ex1-1.htm Exhibit 1.1 UNDERWRITING AGREEMENT between PROTAGENIC THERAPEUTICS, INC. and KINGSWOOD CAPITAL MARKETS, division of Benchmark Investments, Inc., as Representative of the Several Underwriters PROTAGENIC THERAPEUTICS, INC. UNDERWRITING AGREEMENT New York, New York April 26, 2021 Kingswood Capital Markets, division of Benchmark Investments, Inc. as Representative of the several Und

April 30, 2021 EX-99.2

Protagenic Therapeutics, Inc. Announces Closing of $13.2 Million Public Offering and Uplisting to Nasdaq

Exhibit 99.2 Protagenic Therapeutics, Inc. Announces Closing of $13.2 Million Public Offering and Uplisting to Nasdaq New York?April 29, 2021? Protagenic Therapeutics, Inc. (NASDAQ:PTIX) (?PTIX? or ?Company?) today announced the closing of an underwritten public offering of 3,180,000 units at a public offering price of $4.15 per unit. Each unit is comprised of one share of common stock and one war

April 30, 2021 EX-99.1

Protagenic Therapeutics, Inc. Announces Nasdaq Uplisting and Pricing of $13.2 Million Public Offering

Exhibit 99.1 Protagenic Therapeutics, Inc. Announces Nasdaq Uplisting and Pricing of $13.2 Million Public Offering New York?April 26, 2021? Protagenic Therapeutics, Inc. (NASDAQ:PTIX) (?PTIX? or ?Company?) today announced the pricing of an underwritten public offering of 3,180,000 units at a public offering price of $4.15 per unit for aggregate gross proceeds of approximately $13.2 million prior t

April 30, 2021 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 26, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissi

April 28, 2021 424B4

3,180,000 Units Each unit of consisting of one share of Common Stock and one Warrant to Purchase one share of Common Stock

Filed Pursuant to Rule 424(b)(4) Registration No. 333-253006 and 333-255525 PROSPECTUS 3,180,000 Units Each unit of consisting of one share of Common Stock and one Warrant to Purchase one share of Common Stock This is a firm commitment public offering of 3,180,000 units, each unit consisting of one share of our common stock and one warrant, for a total of 3,180,000 shares of our common stock and 3

April 28, 2021 424B4

3,180,000 Units Each unit of consisting of one share of Common Stock and one Warrant to Purchase one share of Common Stock

Filed Pursuant to Rule 424(b)(4) Registration No. 333-253006 and 333-255525 PROSPECTUS 3,180,000 Units Each unit of consisting of one share of Common Stock and one Warrant to Purchase one share of Common Stock This is a firm commitment public offering of 3,180,000 units, each unit consisting of one share of our common stock and one warrant, for a total of 3,180,000 shares of our common stock and 3

April 26, 2021 8-A12B

Form 8-A12B

8-A12B 1 form8-a12b.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 PROTAGENIC THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 06-1390025 (State or other jurisdiction of incorporation or organization) (I.R.

April 26, 2021 S-1MEF

-

S-1MEF 1 forms-1mef.htm As filed with the Securities and Exchange Commission on April 26, 2021 Registration No. 333-253006 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 7389 06-1390025 (State or other jurisdiction o

April 26, 2021 EX-10.15

Form of Warrant (included in Exhibit 10.15)

Exhibit 10.15 FORM OF WARRANT AGENT AGREEMENT THIS WARRANT AGENT AGREEMENT (this ?Agreement?) is dated April [ ], 2021, between PROTAGENIC THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, acting as warrant agent (the ?Warrant Agent?). WHEREAS, the Company proposes to issue common stock purchase warrants (the ?Warrants?) to acquire one sh

April 26, 2021 S-1/A

-

As filed with the U.S. Securities and Exchange Commission on April 26, 2021 Registration No. 333-253006 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT No. 5 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 7389 06-1390025 (State or other jurisdiction o

April 26, 2021 S-1/A

-

As filed with the U.S. Securities and Exchange Commission on April 23, 2021 Registration No. 333-253006 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 4 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 7389 06-1390025 (State or other jurisdiction o

April 23, 2021 S-1/A

-

As filed with the U.S. Securities and Exchange Commission on April 23, 2021 Registration No. 333-253006 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 3 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 7389 06-1390025 (State or other jurisdiction o

April 23, 2021 EX-10.15

Form of Warrant (included in Exhibit 10.15)

Exhibit 10.15 FORM OF WARRANT AGENT AGREEMENT THIS WARRANT AGENT AGREEMENT (this ?Agreement?) is dated April [ ], 2021, between PROTAGENIC THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, acting as warrant agent (the ?Warrant Agent?). WHEREAS, the Company proposes to issue common stock purchase warrants (the ?Warrants?) to acquire one sh

April 23, 2021 CORRESP

KINGSWOOD CAPITAL MARKETS Division of Benchmark Investments, Inc. 17 Battery Place, Suite 625 New York, New York 10004

KINGSWOOD CAPITAL MARKETS Division of Benchmark Investments, Inc. 17 Battery Place, Suite 625 New York, New York 10004 April 23, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.C. 20549 Attention: Nick Lamparski, Esq. Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-l File No. 333-253006 Ladies and Gen

April 23, 2021 CORRESP

PROTAGENIC THERAPEUTICS, INC. 149 Fifth Avenue New York, NY 10010 April 23, 2021

PROTAGENIC THERAPEUTICS, INC. 149 Fifth Avenue New York, NY 10010 April 23, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Nick Lamparski, Esq. Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-l File No. 333-253006 Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securitie

April 22, 2021 CORRESP

KINGSWOOD CAPITAL MARKETS Division of Benchmark Investments, Inc. 17 Battery Place, Suite 625 New York, New York 10004

CORRESP 1 filename1.htm KINGSWOOD CAPITAL MARKETS Division of Benchmark Investments, Inc. 17 Battery Place, Suite 625 New York, New York 10004 April 22, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.C. 20549 Attention: Nick Lamparski, Esq. Re: Withdrawal of Request for Acceleration of Effective Date Protagenic Therape

April 22, 2021 CORRESP

PROTAGENIC THERAPEUTICS, INC. 149 Fifth Avenue New York, New York 10010

PROTAGENIC THERAPEUTICS, INC. 149 Fifth Avenue New York, New York 10010 April 22, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 Re: Protagenic Therapeutics, Inc. Withdrawal of Request for Acceleration of Effectiveness of Registration Statement Registration Statement on Form S-1 (SEC File No. 333-253006) Ladie

April 21, 2021 CORRESP

KINGSWOOD CAPITAL MARKETS Division of Benchmark Investments, Inc. 17 Battery Place, Suite 625 New York, New York 10004

KINGSWOOD CAPITAL MARKETS Division of Benchmark Investments, Inc. 17 Battery Place, Suite 625 New York, New York 10004 April 21, 2021 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, D.C. 20549 Attention: Nick Lamparski, Esq. Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-l File No. 333-253006 Ladies and Gen

April 21, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 21, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissi

April 21, 2021 EX-99.1

Corporate Presentation

Exhibit 99.1

April 21, 2021 CORRESP

PROTAGENIC THERAPEUTICS, INC. 149 Fifth Avenue New York, NY 10010 April 21, 2021

PROTAGENIC THERAPEUTICS, INC. 149 Fifth Avenue New York, NY 10010 April 21, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attention: Nick Lamparski, Esq. Re: Protagenic Therapeutics, Inc. Registration Statement on Form S-l File No. 333-253006 Ladies and Gentlemen: Pursuant to Rule 461 promulgated under the Securitie

April 9, 2021 S-1/A

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As filed with the U.S. Securities and Exchange Commission on April 9, 2021 Registration No. 333-253006 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 2 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 7389 06-1390025 (State or other jurisdiction of

April 9, 2021 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 UNDERWRITING AGREEMENT between PROTAGENIC THERAPEUTICS, INC. and KINGSWOOD CAPITAL MARKETS, division of Benchmark Investments, Inc., as Representative of the Several Underwriters PROTAGENIC THERAPEUTICS, INC. UNDERWRITING AGREEMENT New York, New York [], 2021 Kingswood Capital Markets, division of Benchmark Investments, Inc. as Representative of the several Underwriters named on Schedu

April 9, 2021 EX-10.15

Form of Warrant (included in Exhibit 10.15)

Exhibit 10.15 FORM OF WARRANT AGENT AGREEMENT THIS WARRANT AGENT AGREEMENT (this ?Agreement?) is dated April [ ], 2021, between PROTAGENIC THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and AMERICAN STOCK TRANSFER & TRUST COMPANY, LLC, acting as warrant agent (the ?Warrant Agent?). WHEREAS, the Company proposes to issue common stock purchase warrants (the ?Warrants?) to acquire up to

April 9, 2021 EX-99.5

Clinical & Regulatory Committee Charter adopted by the Board of Directors of Protagenic Therapeutics, Inc.

Exhibit 99.5 Charter of the Clinical and Regulatory Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the ?Company?) Purpose The purpose of the Clinical and Regulatory Committee (the ?Committee?) shall be to provide advice, understanding and guidance both to management of the Company and to the Board of Directors on matters involving (i) the Company?s clinical testing plans and

April 8, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): April 7, 2021 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissio

April 8, 2021 EX-99.1

Corporate Presentation (April 2021)

EX-99.1 2 ex99-1.htm Exhibit 99.1

April 7, 2021 S-1/A

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As filed with the U.S. Securities and Exchange Commission on April 7, 2021 Registration No. 333-253006 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 7389 06-1390025 (State or other jurisdiction of

March 25, 2021 10-K

Annual Report -

10-K 1 form10-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K [X] ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2020 OR [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-51353 Protagenic Thera

March 25, 2021 EX-10.4

Amended and Restated Consulting Agreement, effective December 18, 2020, between Protagenic Therapeutics Inc. and Dr. Robert B. Stein. (Incorporated by reference to Exhibit 10.4 to Company’s Annual Report on Form 10-K, as filed with the SEC on March 25, 2021.)* **

EX-10.4 3 ex10-4.htm Exhibit 10.4

March 25, 2021 EX-10.2

Consulting Agreement, effective December 18, 2020, between Protagenic Therapeutics Inc. and Dr. Andrew Slee. (Incorporated by reference to Exhibit 10.2 to Company’s Annual Report on Form 10-K, as filed with the SEC on March 25, 2021.)* **

Exhibit 10.2

March 25, 2021 EX-21.1

Subsidiaries (Incorporated by reference to Exhibit 10.2 to Company’s Annual Report on Form 10-K, as filed with the SEC on March 24, 2021)

Exhibit 21.1 SUBSIDIARIES OF PROTAGENIC THERAPEUTICS, INC. Subsidiary Jurisdiction of Organization/Incorporation Protagenic Therapuetics Canada (2006) Inc. Canada

March 25, 2021 EX-99.1

Audit Committee Charter adopted by the Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017. (Incorporated by reference to Exhibit 99.1 to Company’s Annual Report on Form 10-K, as filed with the SEC on March 24, 2021.)

Exhibit 99.1 Charter of the Audit Committee of the Board of Directors of Protagenic Therapeutics, Inc. Purpose The principal purpose of the Audit and Finance Committee (the ?Committee?) is to assist the Board of Directors (the ?Board?) of Protagenic Therapeutics, Inc. (the ?Company?) in fulfilling its responsibility to oversee the Company?s accounting and financial reporting processes and audits o

March 25, 2021 EX-99.3

Governance and Nominating Committee Charter adopted by the Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017. (Incorporated by reference to Exhibit 99.3 to Company’s Annual Report on Form 10-K, as filed with the SEC on March 24, 2021.)

Exhibit 99.3 Charter of the Corporate Governance and Nominating Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the ?Company?) Function The Corporate Governance and Nominating Committee (the ?Committee?) shall, among other things, review and recommend policies to the Board of Directors of the Company (the ?Board?) regarding Board procedures, Board leadership, the process for

March 25, 2021 EX-99.2

Compensation Committee Charter adopted by the Board of Directors of Protagenic Therapeutics, Inc. on March 7, 2017. (Incorporated by reference to Exhibit 99.2 to Company’s Annual Report on Form 10-K, as filed with the SEC on March 24, 2021.)

EX-99.2 10 ex99-2.htm Exhibit 99.2 Charter of the Compensation Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the “Company”) Purpose The principal purpose of the Compensation Committee (the “Committee”) of the Board of Directors (the “Board”) is to approve, administer and interpret the Company’s executive and key employee compensation and benefit policies, including the Comp

March 11, 2021 S-8

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S-8 1 forms-8.htm As filed with the Securities and Exchange Commission on March 10, 2021 Registration No. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 PROTAGENIC THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 06-1390025 (State or other jurisdiction of Incorporation or org

February 11, 2021 S-1

Registration Statement -

S-1 1 forms-1.htm As filed with the U.S. Securities and Exchange Commission on February 11, 2021 Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Protagenic Therapeutics, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware 7389 06-1390025 (State or other jurisdiction of in

February 10, 2021 SC 13G/A

Protagenic Therapeutics, Inc.

SC 13G/A 1 ptix13ga.htm PTIX 13GA SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* Protagenic Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 74365N103 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the app

November 16, 2020 10-Q

Quarterly Report -

10-Q 1 form10-q.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2020 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File

October 7, 2020 8-K

Submission of Matters to a Vote of Security Holders -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): October 6, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commiss

September 3, 2020 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): August 28, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commiss

August 28, 2020 DEF 14A

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DEF 14A 1 formdef-14a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, For Use of the Commission Only (as permitted by Rule 14a

August 14, 2020 10-Q

Quarterly Report -

10-Q 1 form10q.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2020 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Numbe

July 21, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 18, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissio

July 9, 2020 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 8, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commission

June 18, 2020 10-Q

Quarterly Report -

10-Q 1 form10-q.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2020 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Num

May 14, 2020 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 14, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commission

May 8, 2020 8-K

Other Events -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 8, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commission

April 29, 2020 10-K

Annual Report -

10-K 1 form10-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K [X] ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2019 OR [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-51353 Protagenic Thera

April 29, 2020 EX-4.6

Description of Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934*

Exhibit 4.6 DESCRIPTION OF THE REGISTRANT’S SECURITIES REGISTERED PURSUANT TO SECTION 12 OF THE SECURITIES EXCHANGE ACT OF 1934 The following summary describes the common stock, $0.0001 par value per share, of Protagenic Therapeutics, Inc. (the “Company”, “our”, “us”, or “we”), which are the only securities of the Company registered under Section 12 of the Securities Exchange Act of 1934, as amend

April 29, 2020 EX-99.1

Science Committee Charter adopted by the Board of Directors of Protagenic Therapeutics, Inc. (Incorporated by reference to Exhibit 99.1 to the Company’s Annual Report on Form 10-K, as filed with the SEC on April 29, 2020)

Exhibit 99.1 Charter of the Science Committee of the Board of Directors of Protagenic Therapeutics, Inc. (the “Company”) Purpose The purpose of the Science Committee (the “Committee”) shall be to provide advice, understanding and guidance both to management of the Company and to the Board of Directors on matters involving (i) the Company’s development programs and projects, (ii) acquisitions of ne

March 31, 2020 8-K

Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 30, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorp

March 31, 2020 EX-99.1

Letter from Independent Auditors regarding Reasons for the Inability to Timely Issue the Audit Report

Exhibit 99.1

March 11, 2020 S-8

ATRN / Atrinsic, Inc. S-8 - -

As filed with the Securities and Exchange Commission on March 11, 2020 Registration No.

March 3, 2020 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): March 2, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissio

February 28, 2020 SC 13D/A

PTIX / Protagenic Therapeutics, Inc. / ARMEN GARO H Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(a) Under the Securities Exchange Act of 1934 (Amendment No. 2)* PROTAGENIC THERAPEUTICS, INC. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Sec

January 29, 2020 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): January 27, 2020 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commis

January 22, 2020 CORRESP

ATRN / Atrinsic, Inc. CORRESP - -

149 Fifth Ave, Suite 500 New York, NY 10010 January 22, 2020 VIA EDGAR TRANSMISSION Anthony Watson Division of Corporation Finance Office of Trade & Services U.

December 23, 2019 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 20, 2019 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of inc

December 23, 2019 CORRESP

ATRN / Atrinsic, Inc. CORRESP - -

149 Fifth Ave, Suite 500 New York, NY 10010 December 23, 2019 VIA EDGAR TRANSMISSION Anthony Watson Division of Corporation Finance Office of Trade & Services U.

December 4, 2019 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): December 3, 2019 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commis

November 25, 2019 CORRESP

ATRN / Atrinsic, Inc. CORRESP - -

149 Fifth Ave, Suite 500 New York, NY 10010 November 25, 2019 VIA EDGAR TRANSMISSION Anthony Watson Division of Corporation Finance Office of Trade & Services U.

November 21, 2019 EX-10.1

Form of Convertible Note Purchase Agreement (Incorporated by reference to Exhibit 10.1 to the Company’s Current Report on Form 8-K, as filed with the SEC on November 21, 2019)

CONVERTIBLE NOTE PURCHASE AGREEMENT This Convertible Note Purchase Agreement (the “Agreement”) is made as of , 2019 by and among Protagenic Therapeutics, Inc.

November 21, 2019 8-K

Entry into a Material Definitive Agreement, Material Modification to Rights of Security Holders, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): November 5, 2019 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commis

November 21, 2019 EX-10.2

Form of Convertible Promissory Note (Incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, as filed with the SEC on November 21, 2019)

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND, ACCORDINGLY, MAY NOT BE TRANSFERRED UNLESS (I) SUCH SECURITIES HAVE BEEN REGISTERED FOR SALE PURSUANT TO THE SECURITIES ACT OF 1933, AS AMENDED, (II) SUCH SECURITIES MAY BE SOLD PURSUANT TO RULE 144, OR (III) THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO IT THAT SUCH TRANSFER MAY LAWFULLY BE MADE WITHOUT REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED.

November 21, 2019 EX-10.3

Form of Guaranty (Incorporated by reference to Exhibit 10.2 to the Company’s Current Report on Form 8-K, as filed with the SEC on November 21, 2019)

Form of Guaranty THIS GUARANTY (“Guaranty”) is made as of this [] day of [], 2019, by Protagenic Therapeutics Canada (2006) Inc.

November 14, 2019 10-Q

ATRN / Atrinsic, Inc. 10-Q - Quarterly Report -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2019 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 P

September 24, 2019 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): September 23, 2019 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Comm

August 26, 2019 DEFA14A

ATRN / Atrinsic, Inc. DEFA14A - -

DEFA14A 1 formdefa14a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, For Use of the Commission Only (as perm

August 14, 2019 10-Q

ATRN / Atrinsic, Inc. 10-Q - Quarterly Report -

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2019 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTAG

August 12, 2019 DEF 14A

ATRN / Atrinsic, Inc. DEF 14A - -

DEF 14A 1 def14a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, For Use of the Commission Only (as permitted

July 3, 2019 S-8

ATRN / Atrinsic, Inc. S-8 - -

As filed with the Securities and Exchange Commission on July 3, 2019 Registration No.

July 3, 2019 10-K/A

ATRN / Atrinsic, Inc. 10-K/A - Annual Report -

10-K/A 1 form10-ka.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A Amendment No. 1 [X] ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2018 OR [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-5

June 14, 2019 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 14, 2019 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissio

May 16, 2019 10-Q/A

ATRN / Atrinsic, Inc. 10-Q/A Quarterly Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q/A Amendment No. 1 (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2019 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Numbe

May 15, 2019 10-Q

ATRN / Atrinsic, Inc. 10-Q Quarterly Report

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2019 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTA

March 29, 2019 EX-99.1

Charter of the Science Committee of the Board of Directors of the Company.

Charter of the Science Committee of the Board of Directors of Protagenic Therapeutics, Inc.

March 29, 2019 10-K

ATRN / Atrinsic, Inc. (Annual Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K [X] ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2018 OR [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 000-51353 Protagenic Therapeutics, Inc. (Exact

February 19, 2019 EX-99.1

Slide deck used to describe the Company to interested parties.

February 19, 2019 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 18, 2019 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commi

February 5, 2019 SC 13G/A

PTIX / Protagenic Therapeutics, Inc. / Hudson Bay Capital Management LP - PTIX 13GA Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Protagenic Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 74365N103 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule

November 8, 2018 10-Q

ATRN / Atrinsic, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended September 30, 2018 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 P

August 14, 2018 10-Q

ATRN / Atrinsic, Inc. 10-Q (Quarterly Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended June 30, 2018 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Number: 000-51353 PROTAG

July 25, 2018 8-K

Submission of Matters to a Vote of Security Holders

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): July 23, 2018 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorpo

July 2, 2018 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

8-K 1 form8-k.htm United States SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 29, 2018 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorpo

July 2, 2018 EX-99.1

Slide deck used to describe the Company to prospective corporate partners used during May and June 2018.

June 13, 2018 DEFA14A

ATRN / Atrinsic, Inc. DEFA14A

DEFA14A 1 defa14a.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, For Use of the Commission Only (as permitte

June 13, 2018 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): June 13, 2018 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (Commissio

June 13, 2018 EX-99.1

The Face of an Epidemic

The Face of an Epidemic Source: Publicly Available Government Records Deaths from prescription Opiates and Heroin is the fastest-growing major cause of death in the U.

June 13, 2018 DEF 14A

ATRN / Atrinsic, Inc. DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant [X] Filed by a Party other than the Registrant [ ] Check the appropriate box: [ ] Preliminary Proxy Statement [ ] Confidential, For Use of the Commission Only (as permitted by Rule 14a-6(e)(2))

June 11, 2018 8-K

Other Events, Financial Statements and Exhibits

8-K 1 form8-k.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 11, 2018 Protagenic Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 000-51353 06-1390025 (State or other Jurisdiction of Inco

June 11, 2018 EX-99.1

Three High Profile Publications Support the Potential of Protagenic Therapeutics’s Synthetic TCAP to Treat Stress-Related Psychological Disorders Ancient, central role of brain peptide TCAP in maintenance of brain health elucidated in publications in

Three High Profile Publications Support the Potential of Protagenic Therapeutics’s Synthetic TCAP to Treat Stress-Related Psychological Disorders Ancient, central role of brain peptide TCAP in maintenance of brain health elucidated in publications in Cell, Nature Communications, and the Journal of Neuro-endocrinology June 11, 2018 — NEW YORK — Protagenic Therapeutics, Inc.

June 1, 2018 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): May 31, 2018 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction (Commission (I.R.S. Employer

June 1, 2018 EX-3.1

Second Amended and Restated Bylaws Protagenic Therapeutics, Inc., (Incorporated by reference to Exhibit 3.1 to Company’s Current Report on Form 8-K, as filed with the SEC on June 1, 2018).

SECOND AMENDED AND RESTATED BYLAWS OF PROTAGENIC THERAPEUTICS, INC. (the “Corporation”) ARTICLE I Stockholders SECTION 1. (a) Annual Meeting. The annual meeting of stockholders (any such meeting being referred to in these Bylaws as an “Annual Meeting”) shall be held at the hour, date and place, if any, within or without the United States which is fixed by the Board of Directors of the Corporation

May 15, 2018 10-Q

ATRN / Atrinsic, Inc. 10-Q (Quarterly Report)

10-Q 1 form10-q.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) [X] Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the quarterly period ended March 31, 2018 or [ ] Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 For the transition period from to Commission File Num

April 5, 2018 10-K/A

ATRN / Atrinsic, Inc. 10-K/A (Annual Report)

10-K/A 1 form10-ka.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K/A Amendment No. 1 [X] ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2017 OR [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: Prota

April 2, 2018 10-K

ATRN / Atrinsic, Inc. 10-K (Annual Report)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 10-K [X] ANNUAL REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For fiscal year ended: December 31, 2017 OR [ ] TRANSITION REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: Protagenic Therapeutics, Inc. (Exact name of r

February 23, 2018 8-K

Current Report

atrn201802238k.htm SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of Earliest Event Reported): February 20, 2018 PROTAGENIC THERAPEUTICS, INC. (Exact name of Company as specified in its charter) Delaware 000-51353 06-1390025 (State or other jurisdiction of incorporation) (

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