SLP / Simulations Plus, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Simulations Plus, Inc.
US ˙ NasdaqGS ˙ US8292141053

Mga Batayang Estadistika
CIK 1023459
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Simulations Plus, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
July 15, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 9, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact na

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 9, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 15, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended May 31, 2025 OR o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

July 15, 2025 EX-16.1

Letter of Grant Thornton LLP dated July 14, 2025

GT.COM Grant Thornton LLP is a U.S. member firm of Grant Thornton International Ltd (GTIL). GTIL and each of its member firms are separate legal entities and are not a worldwide partnership. July 14, 2025 U.S. Securities and Exchange Commission Office of the Chief Accountant 100 F Street, NE Washington, DC 20549 Re: Simulations Plus File No. 001-32046 Dear Sir or Madam: We have read Item 4.01(a) o

July 14, 2025 EX-99.2

1 Earnings Call – Q3 - FY25 July 14, 2025 Except for historical information, the matters discussed in this presentation are forward-looking statements that involve risks and uncertainties. Words like “believe,” “will”, “can”, “believe”, “expect,” “an

1 Earnings Call – Q3 - FY25 July 14, 2025 Except for historical information, the matters discussed in this presentation are forward-looking statements that involve risks and uncertainties.

July 14, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 14, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 14, 2025 EX-99.1

Simulations Plus Reports Third Quarter Fiscal 2025 Financial Results Updated full-year revenue guidance of between $76 to $80 million and adjusted diluted EPS of $0.93 to $1.06

Exhibit 99.1 Simulations Plus Reports Third Quarter Fiscal 2025 Financial Results Updated full-year revenue guidance of between $76 to $80 million and adjusted diluted EPS of $0.93 to $1.06 RESEARCH TRIANGLE PARK, NC, July 14, 2025 – Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus” or the “Company”), a leading provider of cheminformatics, biosimulation, simulation-enabled performance and i

June 18, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 18, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

June 18, 2025 EX-99.1

Simulations Plus Announces Rescheduling of Third Quarter Fiscal 2025 Earnings Release and Conference Call To be released on July 14, 2025, with conference call at 5 p.m. ET

Simulations Plus Announces Rescheduling of Third Quarter Fiscal 2025 Earnings Release and Conference Call To be released on July 14, 2025, with conference call at 5 p.

June 12, 2025 EX-99.1

Simulations Plus Announces Preliminary Third Quarter Fiscal 2025 Revenue Updates fiscal 2025 revenue guidance range Third quarter fiscal 2025 full results to be released on July 2, 2025, with conference call at 5 p.m. ET

For Immediate Release: June 11, 2025 Simulations Plus Announces Preliminary Third Quarter Fiscal 2025 Revenue Updates fiscal 2025 revenue guidance range Third quarter fiscal 2025 full results to be released on July 2, 2025, with conference call at 5 p.

June 12, 2025 8-K/A

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 11, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

June 11, 2025 EX-99.1

Simulations Plus Announces Preliminary Third Quarter Fiscal 2025 Revenue Updates fiscal 2025 revenue guidance range Third quarter fiscal 2025 full results to be released on July 2, 2025, with conference call at 5 p.m. ET

For Immediate Release: June 11, 2025 Simulations Plus Announces Preliminary Third Quarter Fiscal 2025 Revenue Updates fiscal 2025 revenue guidance range Third quarter fiscal 2025 full results to be released on July 2, 2025, with conference call at 5 p.

June 11, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 11, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

June 2, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 May 30, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact na

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 May 30, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

April 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 15, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 15, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number

April 18, 2025 EX-16.1

Letter from Rose, Snyder & Jacobs LLC

April 16, 2025 Securi�es and Exchange Commission 100 F Street, N.E. Washington, DC 20549 Commissioners: We have read the statements made by Simula�ons Plus, Inc., which we understand will be filed with the Securi�es and Exchange Commission, pursuant to Item 4.01 of Form 8-K of Simula�ons Plus, Inc. dated April 15, 2025. We agree with the statements concerning our Firm contained therein. Yours trul

April 4, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended February 28, 2025 OR o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

April 3, 2025 EX-99.2

1 Earnings Call – Q2 - FY25 April 3, 2025 Except for historical information, the matters discussed in this presentation are forward-looking statements that involve risks and uncertainties. Words like “believe,” “will”, “can”, “expect,” “anticipate” a

1 Earnings Call – Q2 - FY25 April 3, 2025 Except for historical information, the matters discussed in this presentation are forward-looking statements that involve risks and uncertainties.

April 3, 2025 EX-99.1

Simulations Plus Reports Second Quarter Fiscal 2025 Financial Results Total revenue grew 23% year-over-year driven by strong growth in both software and services Maintains full-year revenue guidance of $90 to $93 million and adjusted diluted EPS of $

Exhibit 99.1 Simulations Plus Reports Second Quarter Fiscal 2025 Financial Results Total revenue grew 23% year-over-year driven by strong growth in both software and services Maintains full-year revenue guidance of $90 to $93 million and adjusted diluted EPS of $1.07 to $1.20 RESEARCH TRIANGLE PARK, NC, April 3, 2025 – Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus”), a leading provider o

April 3, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 3, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

February 18, 2025 8-K

Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 13, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

January 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended November 30, 2024 OR o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

January 7, 2025 EX-99.2

1 Earnings Call – Q1 - FY25 January 7, 2025 Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties. Words like “believe,” “expect,” and “anticipate” mean that

1 Earnings Call – Q1 - FY25 January 7, 2025 Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties.

January 7, 2025 EX-99.1

Simulations Plus Reports First Quarter Fiscal 2025 Financial Results Total revenue up 31% year-over-year primarily driven by strong software growth

Exhibit 99.1 Simulations Plus Reports First Quarter Fiscal 2025 Financial Results Total revenue up 31% year-over-year primarily driven by strong software growth RESEARCH TRIANGLE PARK, NC, January 7, 2025 – Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus”), a leading provider of cheminformatics, biosimulation, simulation-enabled performance and intelligence solutions, and medical communica

January 7, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 7, 2025 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

December 23, 2024 DEF 14A

______________________________________________________________________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a

December 23, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defini

October 30, 2024 EX-97.1

Simulations Plus, Inc. Compensation Recovery Policy

Simulations Plus, Inc. Executive Compensation Recovery Policy Adopted: October 19, 2023 1. INTRODUCTION Simulations Plus, Inc. (the “Company”) is committed to creating and maintaining strong corporate governance practices. As part of this commitment, and in order to comply with applicable rules and regulations, the Company’s Board of Directors (the “Board”) has adopted this Compensation Recovery P

October 30, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended August 31, 2024 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

October 30, 2024 EX-19.1

Simulations Plus, Inc. Insider Trading Policy

Insider Trading Policy March 2023 Introduction This policy applies to directors, executive officers, employees of Simulations Plus, Inc.

October 30, 2024 EX-21.1

List of Subsidiaries.

Exhibit 21.1 LIST OF SUBSIDIARIES Simulations Plus International, Inc., a Delaware corporation Simulations Plus France (f/k/a Lixoft), a French société par actions simplifiée Pro-ficiency, LLC , a Delaware limited liability company, and its subsidiaries; •Caravel Group Communications, LLC, a Delaware limited liability company •Eclipse Meeting Productions, LLC, a Delaware limited liability company

October 23, 2024 EX-99.1

Simulations Plus Reports Fourth Quarter and Fiscal 2024 Financial Results Fiscal 2024 revenue grew 18% year-over-year to $70 million, with diluted earnings per share (EPS) of $0.49 Provides fiscal 2025 revenue guidance of $90 to $93 million (+28% to

Exhibit 99.1 Simulations Plus Reports Fourth Quarter and Fiscal 2024 Financial Results Fiscal 2024 revenue grew 18% year-over-year to $70 million, with diluted earnings per share (EPS) of $0.49 Provides fiscal 2025 revenue guidance of $90 to $93 million (+28% to +33%) and adjusted diluted EPS guidance of $1.07 to $1.20 LANCASTER, CA, October 23, 2024 – Simulations Plus, Inc. (Nasdaq: SLP) (“Simula

October 23, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 23, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 23, 2024 EX-99.2

1 Earnings Call – Q4 - FY24 October 23, 2024 Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties. Words like “believe,” “expect,” and “anticipate” mean tha

1 Earnings Call – Q4 - FY24 October 23, 2024 Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties.

August 23, 2024 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 August 23, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

August 23, 2024 EX-99.1

Simulations Plus Optimizes Business Unit Structure to Support Future Growth Following Recent Strategic Acquisitions Announces leadership appointments for newly structured business units LANCASTER, CA, August 23, 2024 -- Simulations Plus, Inc. (Nasdaq

Simulations Plus Optimizes Business Unit Structure to Support Future Growth Following Recent Strategic Acquisitions Announces leadership appointments for newly structured business units LANCASTER, CA, August 23, 2024 - Simulations Plus, Inc.

August 8, 2024 SC 13G/A

SLP / Simulations Plus, Inc. / Neuberger Berman Group LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 5)* Simulations Plus, Inc. (Name of Issuer) Common (Title of Class of Securities) 829214105 (CUSIP Number) July 31, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

July 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended May 31, 2024 OR o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

July 2, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 2, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 2, 2024 EX-99.2

1 Earnings Call – Q3 - FY24 July 2, 2024 Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties. Words like “believe,” “expect,” and “anticipate” mean that th

1 Earnings Call – Q3 - FY24 July 2, 2024 Except for historical information, the matters discussed in this press release are forward-looking statements that involve risks and uncertainties.

July 2, 2024 EX-99.1

Simulations Plus Reports Third Quarter Fiscal 2024 Financial Results Total revenue of $18.5 million and diluted earnings per share (EPS) of $0.15 Maintains full-year revenue guidance of $69 to $72 million and updates EPS guidance

Exhibit 99.1 Simulations Plus Reports Third Quarter Fiscal 2024 Financial Results Total revenue of $18.5 million and diluted earnings per share (EPS) of $0.15 Maintains full-year revenue guidance of $69 to $72 million and updates EPS guidance LANCASTER, CA, July 2, 2024 – Simulations Plus, Inc. (NASDAQ: SLP) (“Simulations Plus”), a leading provider of biosimulation, simulation-enabled performance

June 12, 2024 EX-99.1

Simulations Plus Acquires Pro-ficiency, Creating One-of-a-Kind Platform Spanning the Drug Development Continuum Acquisition doubles the Company’s TAM to $8 billion Expected to be accretive to fiscal 2025 EPS Conference call at 5:00PM ET to discuss tr

Exhibit 99.1 For Immediate Release: June 12, 2024 Simulations Plus Acquires Pro-ficiency, Creating One-of-a-Kind Platform Spanning the Drug Development Continuum Acquisition doubles the Company’s TAM to $8 billion Expected to be accretive to fiscal 2025 EPS Conference call at 5:00PM ET to discuss transaction LANCASTER, CA, JUNE 12, 2024 – Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus”),

June 12, 2024 EX-10.1

Amended and Restated Employment Agreement between Simulations Plus, Inc. and Michael Raymer, dated June 11, 2024.

AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (this “Agreement”) is effective as of 11, 2024 (the “Effective Date”), by Simulations Plus, Inc.

June 12, 2024 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 11, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

June 12, 2024 EX-99.2

1 Pro-ficiency Acquisition June 12, 2024 ©2024, Simulations Plus, Inc. All Rights Reserved. With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and unc

1 Pro-ficiency Acquisition June 12, 2024 ©2024, Simulations Plus, Inc. All Rights Reserved. With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect” and “anticipate” mean that these are our best estimates as of this writing, but that there can be no assura

June 12, 2024 EX-2.1

Stock Purchase Agreement, by and among the Company, Pro-ficiency Holdings, Inc. (“Pro-ficiency”), each of the stockholders of Pro-ficiency (collectively, the “Sellers”) and WRYP Stockholders Services, LLC, solely in its capacity as the Sellers’ Representative, dated June 11, 2024, incorporated by reference to Exhibit 2.1 to the Company’s Form 8-K filed June 12, 2024.

Exhibit 2.1 CERTAIN IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS NOT MATERIAL AND IS THE TYPE OF INFORMATION THAT THE REGISTRANT CUSTOMARILY AND ACTUALLY TREATS AS PRIVATE AND CONFIDENTIAL. REDACTED INFORMATION IS INDICATED BY [***]. STOCK PURCHASE AGREEMENT by and among SIMULATIONS PLUS, INC., as “Purchaser” THE UNDERSIGNED STOCKHOLDERS OF PRO-FICIENCY HOLDINGS, INC.,

May 20, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 May 20, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

May 20, 2024 EX-99.1

Investor Presentation NASDAQ: SLP Q2 FY24 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect”

Investor Presentation NASDAQ: SLP Q2 FY24 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

April 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended February 29, 2024 OR o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

April 3, 2024 EX-99.2

1 Earnings Call – Q2 - FY24 April 3, 2024 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect” and “an

1 Earnings Call – Q2 - FY24 April 3, 2024 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

April 3, 2024 EX-99.1

Simulations Plus Reports Second Quarter Fiscal 2024 Financial Results Total revenue of $18.3 million and diluted earnings per share (EPS) of $0.20 Maintains full-year revenue guidance of $66 to $69 million (+10-15%) and EPS guidance of $0.66 to $0.68

Exhibit 99.1 Simulations Plus Reports Second Quarter Fiscal 2024 Financial Results Total revenue of $18.3 million and diluted earnings per share (EPS) of $0.20 Maintains full-year revenue guidance of $66 to $69 million (+10-15%) and EPS guidance of $0.66 to $0.68 LANCASTER, CA, April 3, 2024 – Simulations Plus, Inc. (NASDAQ: SLP) (“Simulations Plus”), a leading provider of modeling and simulation

April 3, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 3, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

March 6, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table Form S-8 (Form Type) Simulation Plus, Inc.

March 6, 2024 S-8

As filed with the Securities and Exchange Commission on March 6, 2024

As filed with the Securities and Exchange Commission on March 6, 2024 Registration No.

February 13, 2024 EX-99.1

Investor Presentation NASDAQ: SLP Q1 FY24 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect”

Investor Presentation NASDAQ: SLP Q1 FY24 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

February 13, 2024 SC 13G/A

SLP / Simulations Plus, Inc. / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv01927-simulationsplusinc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 2)* Name of issuer: Simulations Plus Inc Title of Class of Securities: Common Stock CUSIP Number: 829214105 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to desi

February 13, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 13, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

February 12, 2024 EX-10.1

Second Amendment to 2021 Equity Incentive Plan, of Simulations Plus, Inc., dated February 8, 2024.

SECOND AMENDMENT TO 2021 EQUITY INCENTIVE PLAN OF SIMULATIONS PLUS, INC. WHEREAS, the Board of Directors and stockholders of Simulations Plus, Inc. (the “Company”) have adopted the 2021 Equity Incentive Plan of Simulations Plus, Inc., dated April 9, 2021, as amended by that First Amendment to 2021 Equity Incentive Plan of the Company, dated as of February 9, 2023 (as amended, the “Plan”); WHEREAS,

February 12, 2024 SC 13G/A

SLP / Simulations Plus, Inc. / Neuberger Berman Group LLC Passive Investment

SC 13G/A 1 formsc13ga-02122024090200.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 4)* Simulations Plus, Inc. (Name of Issuer) Common (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to desig

February 12, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 8, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

January 5, 2024 SC 13G/A

SLP / Simulations Plus, Inc. / Conestoga Capital Advisors, LLC - CONESTOGA CAPITAL ADVISORS Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Simulations Plus (Name of Issuer) Common Stock, $0.01 Par Value (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

January 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended November 30, 2023 OR o Transition Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

January 3, 2024 EX-99.1

Simulations Plus Reports First Quarter Fiscal 2024 Financial Results Total revenue of $14.5 million and diluted earnings per share (EPS) of $0.10 Maintains full-year revenue guidance of $66 to $69 million (+10-15%) and EPS guidance of $0.66 to $0.68

Exhibit 99.1 Simulations Plus Reports First Quarter Fiscal 2024 Financial Results Total revenue of $14.5 million and diluted earnings per share (EPS) of $0.10 Maintains full-year revenue guidance of $66 to $69 million (+10-15%) and EPS guidance of $0.66 to $0.68 LANCASTER, CA, January 3, 2024 – Simulations Plus, Inc. (NASDAQ: SLP) (“Simulations Plus”), a leading provider of modeling and simulation

January 3, 2024 EX-99.3

1 Earnings Call – Q1 - FY24 January 3, 2024 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect” and “

slpearningscalldeck241 1 Earnings Call – Q1 - FY24 January 3, 2024 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

January 3, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 3, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 3, 2024 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

January 3, 2024 EX-99.2

Simulations Plus Announces Leadership Appointments Supporting Commitment to Clients and Driving Growth

Exhibit 99.2 Simulations Plus Announces Leadership Appointments Supporting Commitment to Clients and Driving Growth LANCASTER, CA, JANUARY 3, 2024 - Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus”), a leading provider of modeling and simulation software and services for pharmaceutical safety and efficacy, today announced the following leadership changes effective January 3, 2024. “We are

December 22, 2023 DEF 14A

______________________________________________________________________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use of the Commission Only (as permitted by Rule 14a

December 22, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defini

November 17, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 17, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

November 17, 2023 EX-99.1

Investor Presentation NASDAQ: SLP Q4 FY23 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect”

Investor Presentation NASDAQ: SLP Q4 FY23 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

November 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 14, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exa

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 14, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

November 14, 2023 EX-99.1

Putting Clients First Drives Growth And Fuels Innovation INVESTOR DAY NOVEMBER 14, 2023 NASDAQ: SLP Agenda + OPENING REMARKS | SHAWN O’CONNOR, CEO + CLINICAL PHARMACOLOGY & PHARMACOMETRICS | JILL FIEDLER-KELLY, M.S., FISoP, JONATHAN CHAUVIN, PH.D. +

slpinvestorday202311923v Putting Clients First Drives Growth And Fuels Innovation INVESTOR DAY NOVEMBER 14, 2023 NASDAQ: SLP Agenda + OPENING REMARKS | SHAWN O’CONNOR, CEO + CLINICAL PHARMACOLOGY & PHARMACOMETRICS | JILL FIEDLER-KELLY, M.

November 1, 2023 EX-10.5

Amended and Restated Employment Agreement between Simulations Plus, Inc. and Jill Fiedler-Kelly, dated June 16, 2023.

Exhibit 10.5 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is effective as of November 1, 2023 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”), and Jill Fiedler-Kelly an individual (the “Employee”) with reference to the following facts: A.The Company desires to secure the services of the Employ

November 1, 2023 EX-10.3

Amended and Restated Employment Agreement between Simulations Plus, Inc. and Brett Howell, dated June 16, 2023.

Exhibit 10.3 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is effective as of November 1, 2023 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”), and Brett Howell an individual (the “Employee”) with reference to the following facts: A.The Company desires to secure the services of the Employee as

November 1, 2023 EX-10.4

Amended and Restated Employment Agreement between Simulations Plus, Inc. and John DiBella, dated June 16, 2023.

Exhibit 10.4 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is effective as of November 1, 2023 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”), and John DiBella an individual (the “Employee”) with reference to the following facts: A.The Company desires to secure the services of the Employee as

November 1, 2023 EX-10.2

Amended and Restated Employment Agreement between Simulations Plus, Inc. and Will Frederick, dated November 1, 2023.

Exhibit 10.2 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is effective as of November 1, 2023 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”), and Will Frederick, an individual (the “Employee”) with reference to the following facts: A.The Company desires to secure the services of the Employee

November 1, 2023 EX-10.1

Amended and Restated Employment Agreement between Simulations Plus, Inc. and Shawn O’Connor, dated November 1, 2023.

Exhibit 10.1 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (the “Agreement”) is effective as of September 1, 2023 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”), and Shawn O’Connor, an individual (the “Employee”) with reference to the following facts: A.The Company desires to secure the services of the Employee

November 1, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 1, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 27, 2023 EX-21.1

List of Subsidiaries.

Exhibit 21.1 LIST OF SUBSIDIARIES Simulations Plus International, Inc. Lixoft, a French société par actions simplifiée

October 27, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended August 31, 2023 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

October 27, 2023 EX-4.3

Description of Securities.

Exhibit 4.3 DESCRIPTION OF SECURITIES The following is a summary of the material terms and provisions of the securities of Simulations Plus, Inc. (“us,” “our,” “we” or the “Company”) that are registered under Section 12 of the Securities Exchange Act of 1934, as amended, and certain provisions of our articles of incorporation (“Charter”) and amended and restated bylaws, as amended (“Bylaws”), that

October 25, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 25, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 25, 2023 EX-99.2

1 Earnings Call – Q4 - FY23 October 25, 2023 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect” and

1 Earnings Call – Q4 - FY23 October 25, 2023 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

October 25, 2023 EX-99.1

Simulations Plus Reports Fourth Quarter and Fiscal 2023 Financial Results Fiscal 2023 revenue increased 11% year-over-year to $59.6 million Provides Fiscal 2024 revenue guidance of $66 - $69 million (+10-15%) and EPS guidance of $0.66 - $0.68 Simulat

Exhibit 99.1 Simulations Plus Reports Fourth Quarter and Fiscal 2023 Financial Results Fiscal 2023 revenue increased 11% year-over-year to $59.6 million Provides Fiscal 2024 revenue guidance of $66 - $69 million (+10-15%) and EPS guidance of $0.66 - $0.68 Simulations Plus to host its Investor Day on November 14, 2023 LANCASTER, CA, October 25, 2023 – Simulations Plus, Inc. (Nasdaq: SLP), a leading

July 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended May 31, 2023 OR o Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

July 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 7, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact na

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 7, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 7, 2023 EX-99.1

Investor Presentation NASDAQ: SLP Q3 FY23 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect”

simulationsplusinvestorp Investor Presentation NASDAQ: SLP Q3 FY23 Update With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

July 6, 2023 EX-99.2

1 Earnings Call – Q3 - FY23 July 6, 2023 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. Words like “believe,” “expect” and “ant

slpearningscalldeck233-f 1 Earnings Call – Q3 - FY23 July 6, 2023 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

July 6, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 6, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact na

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 6, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 6, 2023 EX-99.1

Simulations Plus Reports Third Quarter Fiscal 2023 Financial Results Total revenue of $16.2 million and diluted earnings per share (EPS) of $0.20 Maintains full-year revenue guidance of $59.3 - $62.0 million (+10-15%) and EPS guidance of $0.63 - $0.6

Exhibit 99.1 Simulations Plus Reports Third Quarter Fiscal 2023 Financial Results Total revenue of $16.2 million and diluted earnings per share (EPS) of $0.20 Maintains full-year revenue guidance of $59.3 - $62.0 million (+10-15%) and EPS guidance of $0.63 - $0.67 LANCASTER, CA, July 6, 2023 – Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation software and services

June 20, 2023 EX-2.1

Agreement and Plan of Merger, dated June 16, 2023, by and among Simulations Plus, Inc., Insight Merger Sub, Inc., Immunetrics, Inc. and LaunchCyte LLC, incorporated by reference to an Exhibit 2.1 to the Company’s Form 8-K filed June 20, 2023.

ex21agreementandplanofme 315367143.12 Exhibit 2.1 AGREEMENT AND PLAN OF MERGER BY AND AMONG SIMULATIONS PLUS, INC., INSIGHT MERGER SUB, INC., IMMUNETRICS, INC. AND LAUNCHCYTE LLC AS STOCKHOLDER REPRESENTATIVE June 16, 2023 - i - TABLE OF CONTENTS Page ARTICLE I THE MERGERS ....................................................................................................................... 2 Sect

June 20, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 16, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact n

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 16, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

June 20, 2023 EX-10.2

Amended and Restated Employment Agreement between Simulations Plus, Inc. and Steven Chang, dated June 16, 2023.

ex102-stevechangemployme Exhibit 10.2 AMENDED AND RESTATED EMPLOYMENT AGREEMENT This Amended and Restated Employment Agreement (this “Agreement”) is entered into as of June 16, 2023 (the “Effective Date”), by Immunetrics, Inc., a Delaware corporation (the “Company”) and Steven Chang, an individual (the “Employee”) with reference to the following facts: A. The Employee entered into that certain Exe

June 20, 2023 EX-99.1

Exhibit 99.1 Simulations Plus Acquires Immunetrics to Expand its Immunology and Oncology Drug Development Capabilities Acquisition increases breadth and depth of QSP expertise and range of therapeutic applications LANCASTER, CA, JUNE 20, 2023 -- Simu

ex991-pressreleaseinsigh Exhibit 99.1 Simulations Plus Acquires Immunetrics to Expand its Immunology and Oncology Drug Development Capabilities Acquisition increases breadth and depth of QSP expertise and range of therapeutic applications LANCASTER, CA, JUNE 20, 2023 - Simulations Plus, Inc. (Nasdaq: SLP) (“Simulations Plus”), a leading provider of modeling and simulation software and services for

June 20, 2023 EX-10.1

Earnout Agreement by and among Simulations Plus, Inc., Insight Merger Sub, Inc., Immunetrics, Inc. and LaunchCyte LLC, dated June 16, 2023, incorporated by reference to Exhibit 10.1 to the Company’s Form 8-K filed June 20, 2023.

ex101-earnoutagreementu 315442075.6 Exhibit 10.1 EARNOUT AGREEMENT THIS EARNOUT AGREEMENT (this “Agreement”) is entered into as of June 16, 2023, by and among Simulations Plus, Inc., a California corporation (“Parent”), Insight Merger Sub, Inc., a Delaware corporation and a direct, wholly-owned subsidiary of Parent (“Merger Sub”), Immunetrics, Inc., a Delaware corporation (“Company”), and LaunchCy

April 7, 2023 EX-10.3

Fourth Amendment to Lease by and between the Company and Crest Development LLC, dated as of February 17, 2023, incorporated by reference to Exhibit 10.3 to the Company’s Form 10-Q filed April 7, 2023.

simulationsamendment4-ex

April 7, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended February 28, 2023 OR o Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

April 5, 2023 EX-99.2

1 | NASDAQ: SLP April 5, 2023 1 Earnings Call - Q2 - FY23 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties. Words

slpearningscalldeck232fi 1 | NASDAQ: SLP April 5, 2023 1 Earnings Call - Q2 - FY23 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties.

April 5, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 5, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact n

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 5, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

April 5, 2023 EX-99.1

Simulations Plus Reports Second Quarter Fiscal 2023 Financial Results Total revenue of $15.8 million; Diluted Earnings Per Share (EPS) of $0.20; Maintains full-year revenue guidance of $59.3 - $62.0 million (+10-15%) and EPS Guidance of $0.63 - $0.67

Exhibit 99.1 Simulations Plus Reports Second Quarter Fiscal 2023 Financial Results Total revenue of $15.8 million; Diluted Earnings Per Share (EPS) of $0.20; Maintains full-year revenue guidance of $59.3 - $62.0 million (+10-15%) and EPS Guidance of $0.63 - $0.67 LANCASTER, CA, April 5, 2023 – Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation software and services

March 7, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 March 7, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact n

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 March 7, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

March 7, 2023 EX-99.1

Investor Presentation NASDAQ: SLP Q1 FY23 Update NASDAQ: SLP2 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. The actual results

slpinvestorpresentation- Investor Presentation NASDAQ: SLP Q1 FY23 Update NASDAQ: SLP2 With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

February 13, 2023 EX-10.1

First Amendment to 2021 Equity Incentive Plan, of Simulations Plus, Inc., dated February 9, 2023.

February 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 9, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 9, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

February 10, 2023 SC 13G/A

SLP / Simulations Plus Inc / Neuberger Berman Group LLC - NONE Passive Investment

SC 13G/A 1 doc1.htm NONE UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Simulations Plus Inc (Name of Issuer) Common (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursua

February 9, 2023 SC 13G/A

SLP / Simulations Plus Inc / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv01897-simulationsplusinc.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 1)* Name of issuer: Simulations Plus Inc. Title of Class of Securities: Common Stock CUSIP Number: 829214105 Date of Event Which Requires Filing of this Statement: December 30, 2022 Check the appropriate box to des

January 19, 2023 SC 13G/A

SLP / Simulations Plus Inc / Conestoga Capital Advisors, LLC - CONESTOGA CAPITAL ADVISORS Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Simulations Plus (Name of Issuer) Common Stock, $0.01 Par Value (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

January 12, 2023 EX-10.1

Confirmation for Fixed Dollar Accelerated Share Repurchase Transaction, dated as of January 11, 2023, by and between Simulations Plus, Inc. and Morgan Stanley & Co. LLC.

MORGAN STANLEY & CO. LLC 1585 BROADWAY NEW YORK, NY 10036-8293 (212) 761-4000 January 11, 2023 Fixed Dollar Accelerated Share Repurchase Transaction Simulations Plus, Inc. 42505 10th Street West Lancaster, California 93534 Dear Sir/Madam: The purpose of this letter agreement (this “Confirmation”) is to confirm the terms and conditions of the transaction entered into between Morgan Stanley & Co. LL

January 12, 2023 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 11, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

January 12, 2023 EX-99.1

Simulations Plus Executes $20 Million Accelerated Share Repurchase Agreement Initiates first steps in updated capital allocation strategy

Exhibit 99.1 Simulations Plus Executes $20 Million Accelerated Share Repurchase Agreement Initiates first steps in updated capital allocation strategy LANCASTER, CA, January 11, 2023 – Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation software and services for pharmaceutical safety and efficacy, today announced it has entered into an accelerated share repurchase a

January 6, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended November 30, 2022 OR o Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

January 4, 2023 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 4, 2023 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

January 4, 2023 EX-99.1

Simulations Plus Reports First Quarter Fiscal 2023 Financial Results Total revenue of $12 million; Diluted Earnings Per Share (EPS) of $0.06; Both in line with fiscal 2023 guidance and Q1 expectations for revenue seasonality shift Provides capital al

Exhibit 99.1 Simulations Plus Reports First Quarter Fiscal 2023 Financial Results Total revenue of $12 million; Diluted Earnings Per Share (EPS) of $0.06; Both in line with fiscal 2023 guidance and Q1 expectations for revenue seasonality shift Provides capital allocation strategy update focusing on corporate development activities, $50 million share repurchase program, and internal investment LANC

January 4, 2023 EX-99.2

1 | NASDAQ: SLP January 4, 2023 1 Earnings Call - Q1 - FY23 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties. Wor

1 | NASDAQ: SLP January 4, 2023 1 Earnings Call - Q1 - FY23 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties.

December 23, 2022 DEF 14A

______________________________________________________________________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No

DEF 14A 1 simulationsplusinc-proxyfy.htm DEF 14A Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant x Filed by a party other than the Registrant o Check the appropriate box: o Preliminary Proxy Statement o Confidential, for Use

December 23, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defini

November 7, 2022 EX-99.1

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP Q4 FY22 Update 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of ri

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP Q4 FY22 Update 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties.

November 7, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 7, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 28, 2022 EX-10.14

Employment Agreement by and between the Company and Jill Fiedler-Kelly, dated January 1, 2022.

jillfiedler-kellyemploym

October 28, 2022 EX-10.12

Employment Agreement by and between the Company and John DiBella, dated January 1, 2022.

johndibellaemploymentagr

October 28, 2022 EX-10.13

Employment Agreement by and between the Company and Brett Howell, dated January 1, 2022.

bretthowellemploymentagr

October 28, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended August 31, 2022 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

October 28, 2022 EX-21.1

List of Subsidiaries.

Exhibit 21.1 LIST OF SUBSIDIARIES Lixoft, a French société par actions simplifiée

October 26, 2022 EX-99.1

Simulations Plus Reports Fourth Quarter and Full Fiscal Year 2022 Financial Results Fiscal 2022 revenue increased 16% year-over-year to $53.9 million Diluted earnings per share increased 28% year-over-year to $0.60 Provides Fiscal 2023 guidance for t

Exhibit 99.1 Simulations Plus Reports Fourth Quarter and Full Fiscal Year 2022 Financial Results Fiscal 2022 revenue increased 16% year-over-year to $53.9 million Diluted earnings per share increased 28% year-over-year to $0.60 Provides Fiscal 2023 guidance for total revenue of $59.3 million to $62.0 million (+10% to 15%) LANCASTER, CA, October 26, 2022 – Simulations Plus, Inc. (Nasdaq: SLP), a le

October 26, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 20, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 26, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 26, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exac

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 26, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 26, 2022 EX-99.2

1 | NASDAQ: SLP October 26, 2022 1 Earnings Call - Q4 - FY22 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties. Wo

slpearningscalldeckfy224 1 | NASDAQ: SLP October 26, 2022 1 Earnings Call - Q4 - FY22 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties.

October 20, 2022 EX-99.1

Simulations Plus Announces Cash Dividend Board of Directors announces quarterly dividend of $0.06 per share

For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Brian Siegel 661-723-7723 346-396-8696 [email protected] [email protected] For Immediate Release: October 20, 2022 Simulations Plus Announces Cash Dividend Board of Directors announces quarterly dividend of $0.0

October 20, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 20, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

September 14, 2022 EX-99.1

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP Q3 FY22 Update 1 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of

EX-99.1 2 slpinvestorpresentation-.htm EX-99.1 1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP Q3 FY22 Update 1 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward-looking statements that involve a number of risks and uncertainties. The actual results of the Company could differ significantly from those statem

September 14, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 September 14, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Nu

July 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q x Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended May 31, 2022 OR o Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

July 6, 2022 EX-99.2

1 | NASDAQ: SLP July 6, 2022 1 Earnings Call - Q3 - FY22 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties. Words

1 | NASDAQ: SLP July 6, 2022 1 Earnings Call - Q3 - FY22 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward- looking statements that involve a number of risks and uncertainties.

July 6, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 6, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 6, 2022 EX-99.1

Simulations Plus Reports Third Quarter Fiscal 2022 Financial Results Total revenue growth of 17%; Software revenue growth of 16%; Services revenue growth of 19%; Diluted Earnings Per Share (EPS) growth of 11%; Board of Directors announces quarterly d

EX-99.1 2 slp-20220706xexx991x223.htm EX-99.1 Exhibit 99.1 Simulations Plus Reports Third Quarter Fiscal 2022 Financial Results Total revenue growth of 17%; Software revenue growth of 16%; Services revenue growth of 19%; Diluted Earnings Per Share (EPS) growth of 11%; Board of Directors announces quarterly dividend of $0.06 per share LANCASTER, CA, July 6, 2022 – Simulations Plus, Inc. (Nasdaq: SL

April 26, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 26, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number

April 26, 2022 EX-99.1

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP Q2 FY22 Update 1 Safe Harbor Statement 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number o

Exhibit 99.1 1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP Q2 FY22 Update 1 Safe Harbor Statement 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause

April 8, 2022 10-Q

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ? Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended February 28, 2022 OR ? Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

April 6, 2022 EX-99.1

Simulations Plus Reports Second Quarter Fiscal 2022 Financial Results Total revenue growth of 13%; Software revenue growth of 25%; Diluted Earnings Per Share (EPS) growth of 40% Board of Directors announces quarterly dividend of $0.06 per share

EX-99.1 2 simulationsex9901.htm PRESS RELEASE ISSUED ON APRIL 6, 2022. Exhibit 99.1 Simulations Plus Reports Second Quarter Fiscal 2022 Financial Results Total revenue growth of 13%; Software revenue growth of 25%; Diluted Earnings Per Share (EPS) growth of 40% Board of Directors announces quarterly dividend of $0.06 per share LANCASTER, CA, April 6, 2022 – Simulations Plus, Inc. (Nasdaq: SLP), a

April 6, 2022 EX-99.2

1 | NASDAQ: SLP Earnings Call – Q2 FY22 April 6, 2022 1 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . Words

Exhibit 99.2 1 | NASDAQ: SLP Earnings Call ? Q2 FY22 April 6, 2022 1 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . Words like ?believe,? ?expect? and ?anticipate? mean that these are our best estimates as of this writing, but that there can be no assurances

April 6, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 6, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

February 15, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 15, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

February 15, 2022 EX-99.1

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP February 2022 1 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of

Exhibit 99.1 1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP February 2022 1 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause

February 14, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 11, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

February 11, 2022 SC 13G/A

SLP / Simulations Plus Inc / Neuberger Berman Group LLC - NONE Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Simulations Plus Inc (Name of Issuer) Common (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule

February 10, 2022 SC 13G

SLP / Simulations Plus Inc / VANGUARD GROUP INC - SCHEDULE 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 Name of issuer: Simulations Plus Inc. Title of Class of Securities: Common Stock CUSIP Number: 829214105 Date of Event Which Requires Filing of this Statement: December 31, 2021 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: ??Rule 13d-1(b) ??R

January 19, 2022 EX-99.1

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP January 2022 1

Exhibit 99.1 1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP January 2022 1 1 2 | NASDAQ: SLP Safe Harbor Statement With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause

January 19, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 19, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

January 10, 2022 SC 13G/A

SLP / Simulations Plus Inc / Conestoga Capital Advisors, LLC - CONESTOGA CAPITAL ADVISORS Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Simulations Plus (Name of Issuer) Common Stock, $0.01 Par Value (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

January 7, 2022 10-Q

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ? Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended November 30, 2021 OR ? Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

January 6, 2022 EX-99.2

1 | NASDAQ: SLP Earnings Call – Q1 FY22 January 6, 2022 1 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . Wor

Exhibit 99.2 1 | NASDAQ: SLP Earnings Call ? Q1 FY22 January 6, 2022 1 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . Words like ?believe,? ?expect? and ?anticipate? mean that these are our best estimates as of this writing, but that there can be no assuranc

January 6, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 6, 2022 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

January 6, 2022 EX-99.1

Simulations Plus Reports First Quarter Fiscal 2022 Financial Results Total revenue growth of 16%; Software revenue growth of 19%; Diluted Earnings Per Share (EPS) growth of 25% Board of Directors announces quarterly dividend of $0.06 per share

Exhibit 99.1 Simulations Plus Reports First Quarter Fiscal 2022 Financial Results Total revenue growth of 16%; Software revenue growth of 19%; Diluted Earnings Per Share (EPS) growth of 25% Board of Directors announces quarterly dividend of $0.06 per share LANCASTER, CA, January 6, 2022 ? Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation software and services for

December 17, 2021 DEF 14A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Table of Contents SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a party other than the Registrant [] Check the appropriate box: [] Preliminary Proxy Statement [] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) [X] Definitive

December 17, 2021 DEFA14A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy Statement ? Definit

November 19, 2021 EX-10.1

First Amendment to Employment Agreement, by and between Simulations Plus, Inc. and Shawn O’Connor, dated November 19, 2021

EX-10.1 2 simulationsex1001.htm Exhibit 10.1 FIRST AMENDMENT TO EMPLOYMENT AGREEMENT This Amendment to Employment Agreement (this “Amendment”) is made as of November 19, 2021 (the “Effective Date”), by and between Simulations Plus, Inc. (the “Company”) and Shawn O’Connor (“Employee”), and shall amend that certain Employment Agreement dated September 3, 2020 (the “Agreement”) between the Company an

November 19, 2021 EX-99.2

Simulations Plus Names Sharlene Evans to Board of Directors Experienced Human Resource, Development and Organizational Leader Bolsters Board

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Hayden IR Simulations Plus Investor Relations Mr. Brian Siegel Ms. Renee Bouche 346-396-8696 661-723-7723 [email protected] [email protected] For Immediate Release: November 19, 2021 Simulations Plus Names Sharlene Evans to Board of Directors Experienced Human Resource, D

November 19, 2021 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 15, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

October 27, 2021 EX-21.1

List of Subsidiaries.

Exhibit 21.1 LIST OF SUBSIDIARIES Lixoft, a French soci?t? par actions simplifi?e

October 27, 2021 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended August 31, 2021 or ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

October 25, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 25, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numb

October 25, 2021 EX-99.2

Simulations Plus Reports Fourth Quarter and Full Year Fiscal 2021 Results Fiscal 2021 revenue increased 12% year-over-year to $46.5 million Software revenue increased 28% year-over-year to $27.7 million Fiscal 2022 financial outlook for total revenue

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Hayden IR Simulations Plus Investor Relations Mr. Brian Siegel Ms. Renee Bouche 346-396-8696 661-723-7723 [email protected] [email protected] For Immediate Release: October 25, 2021 Simulations Plus Reports Fourth Quarter and Full Year Fiscal 2021 Results Fiscal 20

October 25, 2021 EX-99.1

1 | NASDAQ: SLP Earnings Call – Q4 FY21 October 25, 2021 1 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . Wo

EX-99.1 3 simulationsex9902.htm PRESS RELEASE Exhibit 99.2 1 | NASDAQ: SLP Earnings Call – Q4 FY21 October 25, 2021 1 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . Words like “believe,” “expect” and “anticipate” mean that these are our best estimates as of

October 13, 2021 EX-99.1

Simulations Plus Announces Cash Dividend Board of Directors announces quarterly dividend of $0.06 per share

EX-99.1 2 simulationsex9901.htm PRESS RELEASE Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Brian Siegel 661-723-7723 346-396-8696 [email protected] [email protected] For Immediate Release: October 13, 2021 Simulations Plus Announces Cash Dividend Boa

October 13, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 7, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

September 21, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 September 20, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Nu

September 21, 2021 EX-99.1

1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP September 2021 1

Exhibit 99.1 1 | NASDAQ: SLP Investor Presentation NASDAQ: SLP September 2021 1 Safe Harbor Statement 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause

August 11, 2021 S-8

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SIMULATIONS PLUS, INC. (Exact name of Registrant as specified in its charter)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SIMULATIONS PLUS, INC. (Exact name of Registrant as specified in its charter) California 95-4595609 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification Number) 42505 10th Street West Lancaster, California 93534-7059 (Add

July 14, 2021 10-Q

SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ? Quarterly Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the quarterly period ended May 31, 2021 OR ? Transmission Report Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

July 12, 2021 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 12, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of re

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 12, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S.

July 12, 2021 EX-99.2

1 | NASDAQ: SLP Earnings Call – Q3 FY21 July 12, 2021

Exhibit 99.2 1 | NASDAQ: SLP Earnings Call ? Q3 FY21 July 12, 2021 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause or contribute to such differences

July 12, 2021 EX-99.1

Simulations Plus Reports Third Quarter Fiscal 2021 Financial Results Third quarter total revenue increased 4% to $12.8 million, with software revenue up 21%; Board of Directors announces quarterly dividend of $0.06 per share

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Brian Siegel 661-723-7723 346-396-8696 [email protected] [email protected] For Immediate Release: July 12, 2021 Simulations Plus Reports Third Quarter Fiscal 2021 Financial Results Third quarter total reve

June 25, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 23, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S.

June 11, 2021 DEFA14A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy Statement ? Definit

June 11, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 11, 2021 Date of Report (Date of earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission F

June 10, 2021 DEFA14A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy Statement ? Definit

June 10, 2021 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 10, 2021 Date of Report (Date of earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission F

June 8, 2021 DEFA14A

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy Statement ? Definit

June 8, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 June 8, 2021 Date of Report (Date of earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission Fi

June 8, 2021 EX-10.1

Simulation Plus, Inc. 2021 Equity Incentive Plan, incorporated by reference to Exhibit 10.1 to the Company’s Form 8-K filed June 8, 2021.

Exhibit 10.1 Simulations Plus, Inc. 2021 EQUITY INCENTIVE PLAN Plan Adopted by the Board: April 9, 2021 Plan Approved by the Shareholders: , 2021 Termination Date: April 9, 2031 1. General. (a) Purposes. The purposes of the Plan are as follows: (i) To provide additional incentive for selected Employees, Directors and Consultants to further the growth, development and financial success of the Compa

May 20, 2021 EX-99.1

1 | NASDAQ: SLP 16 th Annual Needham Technology & Media Conference Shawn O’Connor, CEO May 20, 2021 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve

Ex 99.1 1 | NASDAQ: SLP 16 th Annual Needham Technology & Media Conference Shawn O?Connor, CEO May 20, 2021 2 | NASDAQ: SLP With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could

May 20, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 May 20, 2021 Date of Report (Date of earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission Fi

May 11, 2021 DEF 14A

- DEFINITIVE PROXY STATEMENT

Table of Contents SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy S

April 14, 2021 10-Q

Quarterly Report - FORM 10-Q

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ? Quarterly Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1934 for the quarterly period ended February 28, 2021 OR ? Transmission Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1937 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

April 14, 2021 EX-10.2

Separation Agreement, dated December 1, 2020, by and between the Company and John Kneisel

Exhibit 10.2 FIRST SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS THIS FIRST SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS (hereinafter "First Agreement") is entered into by and between John Kneisel (hereinafter "Mr. Kneisel") and Simulations Plus, Inc. (hereinafter "Employer") (Mr. Kneisel and Employer hereinafter collectively referred to as "the Parties"). RECITALS A. Employer is a corp

April 12, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 12, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S.

April 12, 2021 EX-99.1

Simulations Plus Reports Record Second Quarter Fiscal 2021 Financial Results Second quarter revenue of $13.1 million, reflecting 27% year-over-year growth Board of Directors announces quarterly dividend of $0.06 per share

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: April 12, 2021 Simulations Plus Reports Record Second Quarter Fiscal 2021 Financial Results Second quarter

April 12, 2021 EX-99.2

Earnings Call – Q2 FY21 Shawn O’Connor, CEO William Frederick, CFO April 12, 2021 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks

Exhibit 99.2 Earnings Call – Q2 FY21 Shawn O’Connor, CEO William Frederick, CFO April 12, 2021 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause or cont

March 1, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 25, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R

February 18, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 18, 2021 Date of Report (Date of earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commissi

February 18, 2021 EX-99.1

BTIG Virtual MedTech, Digital Health, Life Science and Diagnostic Tools Conference February 18, 2021 (NASDAQ:SLP)

Exhibit 99.1 BTIG Virtual MedTech, Digital Health, Life Science and Diagnostic Tools Conference February 18, 2021 (NASDAQ:SLP) With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that co

February 11, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Simulations Plus Inc (Name of Issuer) (Title of Class of Securities) (CUSIP Number) December 31, 2020 (D

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Simulations Plus Inc (Name of Issuer) Common (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which

January 15, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 14, 2021 Date of Report (Date of earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commissio

January 15, 2021 EX-99.1

Needham 23 rd Annual Virtual Growth Conference January 14, 2021 (NASDAQ:SLP) With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties .

Exhibit 99.1 Needham 23 rd Annual Virtual Growth Conference January 14, 2021 (NASDAQ:SLP) With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause or contribute to such diffe

January 11, 2021 10-Q

Quarterly Report - FORM 10-Q

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1934 for the quarterly period ended November 30, 2020 OR ☐ Transmission Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1937 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

January 11, 2021 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 11, 2021 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.

January 11, 2021 EX-99.2

Earnings Call – Q1 FY21 Shawn O’Connor, CEO William Frederick, CFO January 11, 2021 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risk

Exhibit 99.2 Earnings Call – Q1 FY21 Shawn O’Connor, CEO William Frederick, CFO January 11, 2021 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause or co

January 11, 2021 EX-99.1

Simulations Plus Reports Record First Quarter FY2021 Financial Results First quarter revenue of $10.7 million, reflecting 14% year-over-year growth Board of Directors announces quarterly dividend of $0.06 per share

EX-99.1 2 simulationsex9901.htm PRESS RELEASE Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: January 11, 2021 Simulations Plus Reports Record First Quart

January 11, 2021 EX-10.2

Employment Agreement by and between the Company and Will Frederick, dated December 1, 2020.

Exhibit 10.2 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is made as of this 1st day of December, 2020 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”) and Will Frederick, an individual (the “Employee”) with reference to the following facts: A. The Company desires to secure the services of the Employee as Chief Financial Officer (“CFO”

January 4, 2021 EX-10.1

Third Amendment to Lease by and between the Company and Crest Development LLC, dated as of December 28, 2020 incorporated by reference to Exhibit 10.1 to the Company’s Form 8-K filed January 4, 2021.

EX-10.1 2 simulationsex1001.htm THIRD AMENDMENT TO LEASE Exhibit 10.1 Third AMENDMENT TO LEASE THIS AMENDMENT TO LEASE is made and entered into as of December 28, 2020 ,by and between Crest Development Group LLC (“Lessor”) and Simulations Plus, Inc. (“Lessee”). WHEREAS, on or about 9/12/05 a Lease was entered into by and between Lessor and Lessee relating to certain real property commonly known as

January 4, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits - CURRENT REPORT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(D) OF THE SECURITIES EXCHANGE ACT OF 1934 Date of Report (Date of earliest event reported): December 28, 2020 Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commiss

December 29, 2020 DEF 14A

- DEFINITIVE PROXY STATEMENT

Table of Contents SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a party other than the Registrant [] Check the appropriate box: [] Preliminary Proxy Statement [] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) [X] Definitive

December 18, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 December 17, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R

December 18, 2020 EX-99.1

OPCO Fireside Chat December 17, 2020 Nasdaq: SLP 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the

Exhibit 99.1 OPCO Fireside Chat December 17, 2020 Nasdaq: SLP 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause or contribute to such differences include but are not

December 17, 2020 PRE 14A

- PRE 14A

Table of Contents SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a party other than the Registrant [] Check the appropriate box: [X] Preliminary Proxy Statement [] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) [] Definitive

December 1, 2020 EX-99.1

Simulations Plus Names Industry Veteran Will Frederick as Chief Financial Officer Brings 25 years of Financial Leadership, Significant Public Company Experience, and M&A Expertise to Company

EX-99.1 2 simulationsex9901.htm PRESS RELEASE Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 661.723.7723 www.simulations-plus.com CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: December 1, 2020 Simul

December 1, 2020 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 December 1, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.

November 17, 2020 EX-99.2

Q4 and Fiscal Year 2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO November 16, 2020 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that inv

Exhibit 99.2 Q4 and Fiscal Year 2020 Investor Conference Call Shawn O?Connor, CEO John Kneisel, CFO November 16, 2020 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors t

November 17, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 November 16, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

November 17, 2020 EX-99.1

Simulations Plus Reports FY2020 and Fourth Quarter FY2020 Financial Results Full-Year Revenue Increased 22.4% to $41.6 Million; Fourth Quarter Revenue Increased 18.9% to $9.5 Million; Fourth Quarter Diluted EPS of $0.11 and Full-Year Diluted EPS of $

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: November 16, 2020 Simulations Plus Reports FY2020 and Fourth Quarter FY2020 Financial Results Full-Year Re

November 16, 2020 EX-21.1

List of Subsidiaries.

Exhibit 21.1 LIST OF SUBSIDIARIES Cognigen Corporation, a Delaware corporation DILIsym Services, Inc., a Delaware corporation Lixoft, a French société par actions simplifiée

November 16, 2020 10-K

Annual Report - FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-K x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended August 31, 2020 or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

October 13, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 October 9, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S

October 13, 2020 EX-99.1

Simulations Plus Announces Quarterly Cash Dividend of $0.06 per Share

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: October 13, 2020 Simulations Plus Announces Quarterly Cash Dividend of $0.06 per Share LANCASTER, CA, Octo

September 9, 2020 EX-10.1

Employment Agreement by and between the Company and Shawn O’Connor, dated as of September 3, 2020.

EX-10.1 2 simulationsex1001.htm EMPLOYMENT AGREEMENT Exhibit 10.1 EMPLOYMENT AGREEMENT This Employment Agreement (the “Agreement”) is made as of this 3rd day of September, 2020 (the “Effective Date”), by Simulations Plus, Inc., a California corporation (the “Company”) and Shawn O’Connor, an individual (the “Employee”) with reference to the following facts: A. The Company desires to secure the serv

September 9, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 September 3, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Num

August 10, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 August 5, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number

August 10, 2020 EX-99.2

Simulations Plus Announces Proposed Underwritten Public Offering

Exhibit 99.2 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: August 4, 2020 Simulations Plus Announces Proposed Underwritten Public Offering LANCASTER, CA, August 4, 2

August 10, 2020 EX-1.1

Underwriting Agreement, by and between Simulations Plus, Inc. and Oppenheimer & Co. Inc., dated August 5, 2020.

EX-1.1 2 simulations8k-ex0101.htm UNDERWRITING AGREEMENT Exhibit 1.1 Execution Version 1,818,182 Shares SIMULATIONS PLUS, INC. Common Stock UNDERWRITING AGREEMENT August 5, 2020 Oppenheimer & Co. Inc. as Representative of the several Underwriters named in Schedule I hereto c/o Oppenheimer & Co. Inc. 85 Broad Street New York, New York 10004 Ladies and Gentlemen: Simulations Plus, Inc., a California

August 10, 2020 EX-99.1

Simulations Plus Announces Closing of Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renée Bouché Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: August 10, 2020 Simulations Plus Announces Closing of Public Offering and Full Exercise of Underwriters’ O

August 10, 2020 EX-99.3

Simulations Plus Announces Pricing of $100 Million Underwritten Offering of Common Stock

Exhibit 99.3 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: August 5, 2020 Simulations Plus Announces Pricing of $100 Million Underwritten Offering of Common Stock LA

August 6, 2020 424B5

Calculation of Registration Fee

Filed Pursuant to Rule 424(b)(5) File No. 333-239770 Calculation of Registration Fee Title of each class of securities to be registered Amount to be registered Amount of registration fee Common stock, par value $0.001 per share $114,999,995 $14,927.00 (1) Calculated pursuant to Rule 457(r) under the Securities Act of 1933, as amended (the “Securities Act”). The fee payable in connection with the o

August 4, 2020 424B5

Subject to completion, dated August 4, 2020

Filed Pursuant to Rule 424(b)(5) File No. 333-239770 The information in this preliminary prospectus supplement is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell these securities and are not soliciting an offer to buy these securities in any jurisdiction where the offer or sale is not permitted. Subject to completion,

July 24, 2020 10-Q/A

Quarterly Report - AMENDMENT NO. 1

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q/A (Amendment No.

July 13, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 July 7, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number)

July 13, 2020 EX-99.1

Simulations Plus Reports Third Quarter FY2020 Financial Results Third Quarter and 9MoFY20 Revenues Grow 24% Board of Directors Announces Quarterly Dividend of $0.06 Per Share Company Files Shelf Registration Statement

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renée Bouché Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: July 9, 2020 Simulations Plus Reports Third Quarter FY2020 Financial Results Third Quarter and 9MoFY20 Rev

July 13, 2020 EX-99.2

Q3FY2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO July 9, 2020 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of ris

EX-99.2 3 simulationsex9902.htm POWERPOINT PRESENTATION AT THE INVESTOR CONFERENCE CALL Exhibit 99.2 Q3FY2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO July 9, 2020 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the

July 9, 2020 10-Q

Quarterly Report - FORM 10-Q

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1934 for the quarterly period ended May 31, 2020 OR ☐ Transmission Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1937 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

July 9, 2020 S-3ASR

- FORM S-3 ASR

As filed with the Securities and Exchange Commission on July 9, 2020 Registration No.

June 16, 2020 EX-99.01

Active Balance Sheet

Exhibit 99.01 Table of Contents LIXOFT Limited Liability Company – Share capital 11.175 € 8, rue de la Renaissance – 92160 ANTONY REPORT ON THE FINANCIAL STATEMENTS Year ending December 31st, 2019 LIXOFT Limited Liability Company–Share capital 11.175 € 8, rue de la Renaissance– 92160 ANTONY REPORT ON THE FINANCIAL STATEMENTS Year ending December 31st ,2019 To the Shareholders, We have audited the

June 16, 2020 8-K/A

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 1, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Numbe

June 16, 2020 EX-99.2

Balance sheet

EX-99.2 4 simulationsex9902.htm UNAUDITED BALANCE SHEET OF LIXOFT AS OF MARCH 31, 2020 AND THE UNAUDITED STATEMENTS OF OPERATIONS FOR THE THREE MONTHS ENDED MARCH 31, 2020 AND 2019 Exhibit 99.2 Lixoft Balance sheet March 31, 2020 (Unaudited) in Euro ASSETS Current assets Cash and cash equivalents € 3,444,365.00 Accounts receivable, net 506,191 Prepaid expenses and other current assets 207,660 Tota

June 16, 2020 EX-99.3

UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL STATEMENTS

Exhibit 99.3 UNAUDITED PRO FORMA CONDENSED COMBINED FINANCIAL STATEMENTS The accompanying unaudited pro forma condensed combined financial statements present the pro forma combined balance sheets and results of operations of the combined company based upon the historical financial statements of Simulations Plus, Inc. (“SIMPLUS”) and Lixoft, a French société par actions simplifiée (“Lixoft”), after

April 10, 2020 EX-99.1

Simulations Plus Reports Record Second Quarter FY2020 Revenue Quarterly Revenues Up 22%; Board of Directors Announces Quarterly Dividend of $0.06 Per Share

EX-99.1 2 simulationsex9901.htm PRESS RELEASE Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renée Bouché Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: April 9, 2020 Simulations Plus Reports Record Second Quarter

April 10, 2020 EX-99.2

Q2FY2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO April 9, 2020 (NASDAQ:SLP) With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risk

Exhibit 99.2 Q2FY2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO April 9, 2020 (NASDAQ:SLP) With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause or co

April 10, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 April 7, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S.

April 9, 2020 10-Q

February 29, 2020

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1934 for the quarterly period ended February 29, 2020 OR ☐ Transmission Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1937 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

April 3, 2020 EX-4.2

Credit Agreement, dated as of March 31, 2020, by and between the Company, as borrower, and Wells Fargo Bank, National Association, as lender.

Exhibit 4.2 CREDIT AGREEMENT THIS CREDIT AGREEMENT (this "Agreement") dated March 31, 2020, is by and between SIMULATIONS PLUS, INC., a California corporation ("Borrower"), and WELLS FARGO BANK, NATIONAL ASSOCIATION ("Bank"). RECITALS Borrower has requested that Bank extend or continue credit to Borrower as described below, and Bank has agreed to provide such credit to Borrower on the terms and co

April 3, 2020 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 March 31, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S.

April 3, 2020 EX-4.1

Revolving Line of Credit Note, dated as of March 31, 2020, by and between the Company, as borrower, and Wells Fargo Bank, National Association, as lender.

EX-4.1 2 simulationsex0401.htm REVOLVING LINE OF CREDIT NOTE Exhibit 4.1 REVOLVING LINE OF CREDIT NOTE $3,500,000.00 Woodland Hills, California March 31, 2020 FOR VALUE RECEIVED, the undersigned SIMULATIONS PLUS, INC. ("Borrower") promises to pay to the order of WELLS FARGO BANK, NATIONAL ASSOCIATION ("Bank") at its office at MAC E2155-011, 21255 Burbank Blvd., Suite 110, Woodland Hills, Californi

April 2, 2020 EX-2.1

Share Purchase and Contribution Agreement, dated March 31, 2020

Exhibit 2.1 By and between Jérôme Kalifa Marc Lavielle Pablo Lavielle Oriana Lavielle Kaelig Chatel Jean-François Si Abdallah Jonathan Chauvin Géraldine Ayral as Transferors and Simulations Plus Inc. as Purchaser SHARE PURCHASE AND CONTRIBUTION AGREEMENT RELATING TO LIXOFT 31 March 2020 TABLE OF CONTENTS SECTION 1: PRELIMINARY PROVISIONS 21 Article 2. Provisional Consideration 21 2.1 Amount of the

April 2, 2020 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Completion of Acquisition or Disposition of Assets

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 March 31, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S.

April 2, 2020 EX-99.1

Simulations Plus Acquires Lixoft, Expanding Modeling Software Offerings and Broadening Presence in Europe Accretive acquisition adds Monolix Suite, a population PKPD modeling solution for pharmacometricians

EX-99.1 3 simulationsex9901.htm PRESS RELEASE ISSUED ON APRIL 2, 2020 Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renée Bouché Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: April 2, 2020 Simulations Plus Acqui

February 24, 2020 EX-99.1

(NASDAQ:SLP) Annual Shareholders’ Meeting February 21, 2020 • Chairman: Walt Woltosz • Welcome and Introductions • Chief Executive Officer: Shawn O’Connor • Company Update • Chief Financial Officer: John Kneisel • Discussion of Voting Issues • Financ

EX-99.1 2 simulations8k-ex9901.htm PRESENTATION Exhibit 99.1 (NASDAQ:SLP) Annual Shareholders’ Meeting February 21, 2020 • Chairman: Walt Woltosz • Welcome and Introductions • Chief Executive Officer: Shawn O’Connor • Company Update • Chief Financial Officer: John Kneisel • Discussion of Voting Issues • Financial Overview • Questions & Answers • Adjournment of Official Meeting Agenda 2 3 Safe Harb

February 24, 2020 8-K

Financial Statements and Exhibits, Other Events, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 February 21, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R

February 13, 2020 SC 13G

SLP / Simulations Plus, Inc. / Neuberger Berman Group LLC - NONE Passive Investment

Schedule 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. n/a )* Simulations Plus Inc (Name of Issuer) Common (Title of Class of Securities) 829214105 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to whi

January 10, 2020 EX-99.2

Q1FY2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO January 9, 2020 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of

Exhibit 99.2 Q1FY2020 Investor Conference Call Shawn O’Connor, CEO John Kneisel, CFO January 9, 2020 (NASDAQ:SLP) 2 With the exception of historical information, the matters discussed in this presentation are forward - looking statements that involve a number of risks and uncertainties . The actual results of the Company could differ significantly from those statements . Factors that could cause o

January 10, 2020 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 January 7, 2020 (Date of the earliest event reported) Simulations Plus, Inc. (Exact name of registrant as specified in its charter) California 001-32046 95-4595609 (State or other jurisdiction of incorporation) (Commission File Number) (I.R.S

January 10, 2020 EX-99.1

Simulations Plus Reports Record First Quarter FY2020 Financial Results First quarter net revenues of $9.4 million reflecting 24.8% year-over-year growth Board of Directors announces quarterly dividend of $0.06 per share

Exhibit 99.1 For Further Information: Simulations Plus, Inc. 42505 10th Street West Lancaster, CA 93534-7059 CONTACT: Simulations Plus Investor Relations Hayden IR Ms. Renee Bouche Mr. Cameron Donahue 661-723-7723 651-653-1854 [email protected] [email protected] For Immediate Release: January 9, 2020 Simulations Plus Reports Record First Quarter FY2020 Financial Results First quarter n

January 9, 2020 10-Q

November 30, 2019

Table of Contents SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 10-Q ☒ Quarterly Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1934 for the quarterly period ended November 30, 2019 OR ☐ Transmission Report Pursuant to Section 13 or 15(d) of the Security Exchange Act of 1937 for the transition period from to Commission file number: 001-32046 Simulations Plus, Inc.

December 30, 2019 DEF 14A

definitive proxy statement

Table of Contents SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant [X] Filed by a party other than the Registrant [] Check the appropriate box: [] Preliminary Proxy Statement [] Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) [X] Definitive

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