SMLR / Semler Scientific, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Semler Scientific, Inc.
US ˙ NasdaqCM ˙ US81684M1045

Mga Batayang Estadistika
LEI 549300ZHL16S29QTW485
CIK 1554859
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Semler Scientific, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
September 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2025 SEMLER SCIENTIF

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): September 5, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

August 27, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.      )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.      ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a

August 25, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

August 19, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

August 19, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

August 4, 2025 EX-99.1

Semler Scientific® Reports Second Quarter 2025 Financial Results, BTC Holdings of 5,021 and BTC Yield of 31.3% YTD through July 31, 2025

Exhibit 99.1 Semler Scientific® Reports Second Quarter 2025 Financial Results, BTC Holdings of 5,021 and BTC Yield of 31.3% YTD through July 31, 2025 Campbell, CA – August 4, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a publicly traded company that has adopted Bitcoin as its primary treasury reserve asset and is one of the leading corporate holders of Bitcoin, today reported financial results

August 4, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

August 4, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36305 SEM

August 4, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2025 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 4, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

July 24, 2025 8-K

Regulation FD Disclosure, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 24, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

July 17, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2025 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 17, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

July 17, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(

July 17, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant x Filed by a Party other than the Registrant ¨ Check the appropriate box: ¨ Preliminary Proxy Statement ¨ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)

July 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 7, 2025 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 7, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

July 7, 2025 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(

June 24, 2025 8-K

Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 24, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

June 23, 2025 EX-3.1

Fifth Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 of our Form 8-K filed with the Securities and Exchange Commission on June 23, 2025).

Exhibit 3.1 fIFth AMENDED AND RESTATED BYLAWS OF SEMLER SCIENTIFIC, INC. (A DELAWARE CORPORATION) ARTICLE I Offices Section 1. Registered Office. The registered office of the corporation in the State of Delaware and the name of its registered agent at such address shall be as set forth in the Amended and Restated Certificate of Incorporation of the corporation (as the same may be amended and/or re

June 23, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 22, 2025 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 22, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

June 20, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2025 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 20, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

June 4, 2025 8-K

Regulation FD Disclosure, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

June 4, 2025 EX-3.1

Fourth Amended and Restated Bylaws of Semler Scientific, Inc.

Exhibit 3.1 fourth AMENDED AND RESTATED BYLAWS OF SEMLER SCIENTIFIC, INC. (A DELAWARE CORPORATION) ARTICLE I Offices Section 1. Registered Office. The registered office of the corporation in the State of Delaware and the name of its registered agent at such address shall be as set forth in the Amended and Restated Certificate of Incorporation of the corporation (as the same may be amended and/or r

June 4, 2025 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 4, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 23, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2025 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 23, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 19, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 15, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 13, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36305 SE

May 13, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 13, 2025 EX-99.1

Semler Scientific® Reports First Quarter 2025 Financial Results, BTC Yield of 22.2% YTD; Now holds 3,808 BTC

Exhibit 99.1 Semler Scientific® Reports First Quarter 2025 Financial Results, BTC Yield of 22.2% YTD; Now holds 3,808 BTC Campbell, CA – May 13, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a publicly traded company that has adopted bitcoin as its primary treasury reserve asset and is one of the leading corporate holders of bitcoin, today reported financial results for the first quarter ended Ma

May 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2025 SEMLER SCIENTIFIC, IN

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fil

April 30, 2025 EX-99.1

Semler Scientific® Announces Updated BTC & ATM Activity; Purchased Additional 165 BTC; Now Holds 3,467 BTC; YTD BTC Yield of 23.8%; Earnings Release Date and Conference Call for First Quarter 2025 Financial Results

Exhibit 99.1 Semler Scientific® Announces Updated BTC & ATM Activity; Purchased Additional 165 BTC; Now Holds 3,467 BTC; YTD BTC Yield of 23.8%; Earnings Release Date and Conference Call for First Quarter 2025 Financial Results Santa Clara, CA – April 30, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a publicly traded company that has adopted bitcoin as its primary treasury reserve asset and is o

April 30, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2025 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

April 25, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

April 25, 2025 EX-99.1

Semler Scientific® Announces Updated BTC & ATM Activity; Purchased Additional 111 BTC; Now Holds 3,303 BTC; YTD BTC Yield of 23.5%

Exhibit 99.1 Semler Scientific® Announces Updated BTC & ATM Activity; Purchased Additional 111 BTC; Now Holds 3,303 BTC; YTD BTC Yield of 23.5% Santa Clara, CA – April 25, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to assist its customers in evaluating and treating chronic diseases, today announced updates regarding its bit

April 21, 2025 CORRESP

April 21, 2025

April 21, 2025 VIA EDGAR Office of Life Sciences Division of Corporation Finance U.

April 15, 2025 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Semler Scientific, Inc.

April 15, 2025 EX-4.2

Form of Subordinated Indenture

Exhibit 4.2 SEMLER SCIENTIFIC, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [●], 202[●] Subordinated Debt Securities TABLE OF CONTENTS1 ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.0 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certi

April 15, 2025 EX-1.2

Controlled Equity Offering℠ Sales Agreement, dated as of April 15, 2025, by and among Barclays Capital Inc., Cantor Fitzgerald & Co., Canaccord Genuity LLC, Needham & Company, LLC, Craig-Hallum Capital Group LLC and Lake Street Capital Markets, LLC. (incorporated by reference to Exhibit 1.2 to our registration statement on Form S-3 filed with the Securities and Exchange Commission on April 15, 2025 (SEC File No. 333-286559).

Exhibit 1.2 Semler Scientific, Inc. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement April 15, 2025 Cantor Fitzgerald & Co. 110 East 59th Street New York, NY 10022 Barclays Capital Inc. 745 Seventh Avenue New York, NY 10019 Canaccord Genuity LLC One Post Office Square Suite 3000 Boston, MA 02109 Needham & Company, LLC 250 Park Avenue 10th Floor New Y

April 15, 2025 S-3

As filed with the Securities and Exchange Commission on April 15, 2025

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on April 15, 2025 Registration No.

April 15, 2025 EX-4.1

Form of Senior Indenture

Exhibit 4.1 SEMLER SCIENTIFIC, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [·], 202[·] Senior Debt Securities TABLE OF CONTENTS1 ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certificat

April 15, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2025 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 15, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

February 28, 2025 EX-4.2

Exhibit 4.2

Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from, and qualified in its entirety by reference to, our amended and restated certificate of incorporation and our second amended and restated bylaws, both of which h

February 28, 2025 EX-19.1

Semler Scientific, Inc. Insider Trading Policy.

EXHIBIT 19.1 SEMLER SCIENTIFIC, INC INSIDER TRADING POLICY This memorandum sets forth the policy of Semler Scientific, Inc. (the “Company”) regarding trading in the Company’s securities as described below and the disclosure of information concerning the Company. This Insider Trading Policy (the “Insider Trading Policy”) is designed to prevent insider trading or the appearance of impropriety, to sa

February 28, 2025 S-8

As filed with the Securities and Exchange Commission on February 28, 2025

As filed with the Securities and Exchange Commission on February 28, 2025 Registration No.

February 28, 2025 EX-FILING FEES

Calculation of Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Semler Scientific, Inc.

February 28, 2025 EX-10.7

SEMLER SCIENTIFIC, INC. AT-WILL EMPLOYMENT, CONFIDENTIAL INFORMATION, INVENTION ASSIGNMENT, AND ARBITRATION AGREEMENT

Exhibit 10.7 SEMLER SCIENTIFIC, INC. AT-WILL EMPLOYMENT, CONFIDENTIAL INFORMATION, INVENTION ASSIGNMENT, AND ARBITRATION AGREEMENT As a condition of my employment with Semler Scientific, Inc., its subsidiaries, affiliates, successors or assigns (together the “Company”), and in consideration of my employment with the Company and my receipt of the compensation now and hereafter paid to me by Company

February 28, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from: to Commission file number: 001-36305 SEMLE

February 18, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

February 18, 2025 EX-99.1

Semler Scientific® Reports Fourth Quarter and Full Year 2024 Financial Results with a BTC Yield of 107% since July 1, 2024; Now holds 3,192 BTC

Exhibit 99.1 Semler Scientific® Reports Fourth Quarter and Full Year 2024 Financial Results with a BTC Yield of 107% since July 1, 2024; Now holds 3,192 BTC Santa Clara, CA – February 18, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today reported financial results for the f

February 4, 2025 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 4, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

February 4, 2025 EX-99.1

Semler Scientific® Announces Updated BTC Activity; Monetizes Minority Investment to Purchase BTC; Purchased Additional 871 BTC; Now Holds 3,192 BTC; YTD BTC Yield of 152.2% Since July 1, 2024

Exhibit 99.1 Semler Scientific® Announces Updated BTC Activity; Monetizes Minority Investment to Purchase BTC; Purchased Additional 871 BTC; Now Holds 3,192 BTC; YTD BTC Yield of 152.2% Since July 1, 2024 Santa Clara, CA – February 4, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to assist its customers in evaluating and treat

February 3, 2025 EX-24

EX-24

EX-24 2 PowerOfAttorney.txt POWER OF ATTORNEY The undersigned, BlackRock, Inc., a corporation duly organized under the laws of the State of Delaware, United States (the "Company"), does hereby make, constitute and appoint each of Eric Andruczyk, Richard Cundiff, R. Andrew Dickson, III, Spencer Fleming, Laura Hildner, David Maryles, Christopher Meade, Charles Park, James Raby, Daniel Riemer, David

January 28, 2025 8-K

Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

January 28, 2025 EX-4.1

Form of Global Note, representing Semler Scientific, Inc.’s 4.25% Convertible Senior Notes due 2030 (included as Exhibit A to the Indenture filed as Exhibit 4.1).

  Exhibit 4.1         SEMLER SCIENTIFIC, INC.   AND   U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION,   as Trustee   INDENTURE   Dated as of January 28, 2025   4.25% Convertible Senior Notes due 2030               TABLE OF CONTENTS         Page ARTICLE 1 Definitions Section 1.01 . Definitions 1 Section 1.02 . References to Interest 15   ARTICLE 2 Issue, Description, Execution, Registration and Exch

January 28, 2025 EX-10.1

Form of Confirmation for Capped Call Transactions.

Exhibit 10.1 [Dealer name and address] To: Semler Scientific, Inc. 2340-2348 Walsh Avenue, Suite 2344 Santa Clara, CA 95051 From: [Dealer] Re: [Base][Additional] Capped Call Transaction Date: January [  ], 2025 Dear Ladies and Gentlemen: The purpose of this communication (this “Confirmation”) is to set forth the terms and conditions of the above-referenced transaction entered into on the Trade Dat

January 24, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2025 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

January 24, 2025 EX-99.1

Semler Scientific® Announces Proposed Private Offering of $75.0 Million of Convertible Senior Notes

EX-99.1 2 tm254336d1ex99-1.htm EXHIBIT 99.1 Exhibit 99.1 Semler Scientific® Announces Proposed Private Offering of $75.0 Million of Convertible Senior Notes SANTA CLARA, CA – January 23, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR) today announced that it intends to offer, subject to market conditions and other factors, $75.0 million aggregate principal amount of convertible senior notes due 2030

January 24, 2025 EX-99.2

Semler Scientific® Announces Pricing of Upsized Offering of $85.0 Million Convertible Senior Notes

Exhibit 99.2 Semler Scientific® Announces Pricing of Upsized Offering of $85.0 Million Convertible Senior Notes SANTA CLARA, CA – January 24, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR) today announced the pricing of its offering of $85.0 million aggregate principal amount of 4.25% convertible senior notes due 2030 (the “notes”) in a private offering (the “offering”) to persons reasonably believ

January 23, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 23, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

January 23, 2025 EX-99.1

Semler Scientific® Announces Select Preliminary Unaudited Fourth Quarter 2024 Financial Results and Significant Unrealized Gain from Change in Fair Value of Bitcoin Holdings

Exhibit 99.1 Semler Scientific® Announces Select Preliminary Unaudited Fourth Quarter 2024 Financial Results and Significant Unrealized Gain from Change in Fair Value of Bitcoin Holdings Santa Clara, CA – January 23, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announc

January 13, 2025 EX-99.1

Semler Scientific® Announces Updated BTC and ATM Activity; Purchased Additional 237 BTC; Now Holds 2,321 BTC; BTC Yield of 99.3%

Exhibit 99.1 Semler Scientific® Announces Updated BTC and ATM Activity; Purchased Additional 237 BTC; Now Holds 2,321 BTC; BTC Yield of 99.3% Santa Clara, CA – January 13, 2025 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announced updates regarding its bitcoin (BTC) activi

January 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

December 16, 2024 EX-99.1

Semler Scientific® Announces Updated BTC and ATM Activity; Purchased Additional 211 BTC; Now Holds 2,084 BTC; BTC Yield of 92.8%

Exhibit 99.1 Semler Scientific® Announces Updated BTC and ATM Activity; Purchased Additional 211 BTC; Now Holds 2,084 BTC; BTC Yield of 92.8% Santa Clara, CA – December 16, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announced updates regarding its bitcoin (BTC) activ

December 16, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 16, 2024 SEMLER SCIENTIF

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 16, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

December 16, 2024 424B5

Up to $50,000,000 Common Stock

TABLE OF CONTENTS  Filed pursuant to Rule 424(b)(5)  Registration No. 333-280013 PROSPECTUS SUPPLEMENT (To Prospectus dated August 13, 2024) Up to $50,000,000 Common Stock We previously entered into a Controlled Equity OfferingSM Sales Agreement, or sales agreement, on June 6, 2024 with Cantor Fitzgerald & Co., or Cantor, relating to the sale of shares of our common stock offered by this prospectu

December 12, 2024 SC 13D/A

SMLR / Semler Scientific, Inc. / Murphy-Chutorian Douglas - SC 13D/A Activist Investment

SC 13D/A 1 tm2430859d1sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 8) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Marianne C. Sarrazin, Esq. Goodwin Procter LLP 3 Embarcadero Center San Fr

December 5, 2024 EX-99.1

Semler Scientific® Announces Updated BTC and ATM Activity; Purchased Additional 303 BTC; Now Holds 1,873 BTC; BTC Yield of 78.7%

Exhibit 99.1 Semler Scientific® Announces Updated BTC and ATM Activity; Purchased Additional 303 BTC; Now Holds 1,873 BTC; BTC Yield of 78.7% Santa Clara, CA – December 5, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announced updates regarding its bitcoin (BTC) activi

December 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 5, 2024 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 5, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

November 26, 2024 EX-99.II

Joint Filing Agreement

CUSIP No: 81684M104 Exhibit II JOINT FILING AGREEMENT This will confirm the agreement by and among the undersigned that the Schedule 13G filed with the Securities and Exchange Commission on or about the date hereof with respect to the beneficial ownership by the undersigned of the shares of Common Stock of Semler Scientific, Inc.

November 26, 2024 EX-99.I

Limited Power of Attorney executed by Capital Ventures International in favor of Susquehanna Advisors Group, Inc., dated as of December 4, 2012

CUSIP No: 81684M104 EXHIBIT I LIMITED POWER OF ATTORNEY THIS LIMITED POWER OF ATTORNEY given on the 4th day of December, 2012 by Capital Ventures International (hereinafter called “the Company”), whose Registered Office is situated at Windward 1, Regatta Office Park, West Bay Road, Grand Cayman KY1-1103, Cayman Islands, WHEREAS, by agreement dated December 4, 2012, by and between the Company and Susquehanna Advisors Group, Inc.

November 26, 2024 SC 13G

SMLR / Semler Scientific, Inc. / CAPITAL VENTURES INTERNATIONAL - SC 13G Passive Investment

CUSIP No: 81684M104 SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2. (Amendment No. )* Semler Scientific, Inc. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 81684M104 (CUSIP Numbe

November 25, 2024 EX-99.1

Semler Scientific® Announces Updated BTC and ATM Activity Purchased Additional 297 BTC; Now Holds 1,570 BTC; BTC Yield of 58.4% Launches Additional $50.0 million ATM

Exhibit 99.1 Semler Scientific® Announces Updated BTC and ATM Activity Purchased Additional 297 BTC; Now Holds 1,570 BTC; BTC Yield of 58.4% Launches Additional $50.0 million ATM Santa Clara, CA – November 25, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announced upda

November 25, 2024 424B5

Up to $50,000,000 Common Stock

TABLE OF CONTENTS  Filed pursuant to Rule 424(b)(5)  Registration No. 333-280013 PROSPECTUS SUPPLEMENT (To Prospectus dated August 13, 2024) Up to $50,000,000 Common Stock We previously entered into a Controlled Equity OfferingSM Sales Agreement, or sales agreement, on June 6, 2024 with Cantor Fitzgerald & Co., or Cantor, relating to the sale of shares of our common stock offered by this prospectu

November 25, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 25, 2024 SEMLER SCIENTIF

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 25, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

November 18, 2024 EX-99.1

Semler Scientific® Announces BTC and ATM Activity Raised $21.5 million; Purchased Additional 215 BTC; Now Holds 1,273 BTC with BTC Yield of 37.3%

Exhibit 99.1 Semler Scientific® Announces BTC and ATM Activity Raised $21.5 million; Purchased Additional 215 BTC; Now Holds 1,273 BTC with BTC Yield of 37.3% Santa Clara, CA – November 18, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announced updates regarding its bi

November 18, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 18, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

November 12, 2024 SC 13D/A

SMLR / Semler Scientific, Inc. / Murphy-Chutorian Douglas - SC 13D/A Activist Investment

SC 13D/A 1 tm2428098d1sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 7) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Marianne C. Sarrazin, Esq. Goodwin Procter LLP 3 Embarcadero Center San Fr

November 5, 2024 EX-FILING FEES

Calculation of Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Semler Scientific, Inc.

November 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-3630

November 5, 2024 S-8

As filed with the Securities and Exchange Commission on November 5, 2024

As filed with the Securities and Exchange Commission on November 5, 2024 Registration No.

November 4, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2024 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 4, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

November 4, 2024 EX-99.1

Semler Scientific® Reports Third Quarter 2024 Financial Results and Additional Bitcoin Purchases

Exhibit 99.1 Semler Scientific® Reports Third Quarter 2024 Financial Results and Additional Bitcoin Purchases Santa Clara, CA – November 4, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today reported financial results for the third quarter ended September 30, 2024. In additi

October 8, 2024 EX-10.4

Form of Non-Qualified Stock Option Agreement for Non-Employee Directors under the 2024 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.4 of the registrant’s Form 8-K filed with the Securities and Exchange Commission on October 8, 2024).

Exhibit 10.4 NON-QUALIFIED STOCK OPTION AGREEMENT FOR NON-EMPLOYEE DIRECTORS UNDER SEMLER SCIENTIFIC, INC. 2024 STOCK OPTION AND INCENTIVE PLAN Name of Optionee: No. of Option Shares: Option Exercise Price per Share:$ [FMV on Grant Date] Grant Date: Expiration Date: [No more than 10 years] Pursuant to the Semler Scientific, Inc. 2024 Stock Option and Incentive Plan as amended through the date here

October 8, 2024 EX-10.5

Form of Restricted Stock Unit Award Agreement for Company Employees and Consultants under the 2024 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.5 of the registrant’s Form 8-K filed with the Securities and Exchange Commission on October 8, 2024).

Exhibit 10.5 RESTRICTED STOCK UNIT AWARD AGREEMENT FOR COMPANY EMPLOYEES AND CONSULTANTS UNDER THE SEMLER SCIENTIFIC, INC. 2024 STOCK OPTION AND INCENTIVE PLAN Name of Grantee: No. of Restricted Stock Units: Grant Date: Pursuant to the Semler Scientific, Inc. 2024 Stock Option and Incentive Plan as amended through the date hereof (the “Plan”), Semler Scientific, Inc. (the “Company”) hereby grants

October 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 4, 2024 SEMLER SCIENTIFIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 4, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

October 8, 2024 EX-10.2

Form of Incentive Stock Option Agreement under the 2024 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.2 of the registrant’s Form 8-K filed with the Securities and Exchange Commission on October 8, 2024).

Exhibit 10.2 INCENTIVE STOCK OPTION AGREEMENT UNDER THE SEMLER SCIENTIFIC, INC. 2024 STOCK OPTION AND INCENTIVE PLAN Name of Optionee: No. of Option Shares: Option Exercise Price per Share:$ [FMV on Grant Date (110% of FMV if a 10% owner)] Grant Date: Expiration Date: [up to 10 years (5 if a 10% owner)] Pursuant to the Semler Scientific, Inc. 2024 Stock Option and Incentive Plan as amended through

October 8, 2024 EX-10.1

Semler Scientific, Inc. 2024 Stock Option and Incentive Plan.

Exhibit 10.1 SEMLER SCIENTIFIC, INC. 2024 STOCK OPTION AND INCENTIVE PLAN SECTION 1. GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the Semler Scientific, Inc. 2024 Stock Option and Incentive Plan (the “Plan”). The purpose of the Plan is to encourage and enable the officers, employees, Non-Employee Directors and Consultants of Semler Scientific, Inc. (the “Company”) and its Affil

October 8, 2024 EX-10.6

Form of Restricted Stock Unit Award Agreement for Non-Employee Directors under the 2024 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.6 of the registrant’s Form 8-K filed with the Securities and Exchange Commission on October 8, 2024).

Exhibit 10.6 RESTRICTED STOCK UNIT AWARD AGREEMENT FOR NON-EMPLOYEE DIRECTORS UNDER THE SEMLER SCIENTIFIC, INC. 2024 STOCK OPTION AND INCENTIVE PLAN Name of Grantee: No. of Restricted Stock Units: Grant Date: Pursuant to the Semler Scientific, Inc. 2024 Stock Option and Incentive Plan as amended through the date hereof (the “Plan”), Semler Scientific, Inc. (the “Company”) hereby grants an award of

October 8, 2024 EX-10.3

Form of Non-Qualified Stock Option Agreement for Company Employees and Consultants under the 2024 Stock Option and Incentive Plan (incorporated by reference to Exhibit 10.3 of the registrant’s Form 8-K filed with the Securities and Exchange Commission on October 8, 2024).

Exhibit 10.3 NON-QUALIFIED STOCK OPTION AGREEMENT FOR COMPANY EMPLOYEES AND CONSULTANTS UNDER THE SEMLER SCIENTIFIC, INC. 2024 STOCK OPTION AND Incentive PLAN Name of Optionee: No. of Option Shares: Option Exercise Price per Share:$ [FMV on Grant Date] Grant Date: Expiration Date: Pursuant to the Semler Scientific, Inc. 2024 Stock Option and Incentive Plan as amended through the date hereof (the “

August 26, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2024 SEMLER SCIENTIFIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 26, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

August 26, 2024 EX-99.1

Semler Scientific Announces Additional Bitcoin Purchases

Exhibit 99.1 Semler Scientific Announces Additional Bitcoin Purchases Santa Clara, Calif. – August 26, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today announced that it has purchased an additional 83 bitcoins for $5.0 million in cash, inclusive of fees and expenses. As of

August 23, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6

August 12, 2024 CORRESP

August 12, 2024

August 12, 2024 VIA EDGAR Office of Life Sciences Division of Corporation Finance U.

August 9, 2024 S-3/A

As filed with the Securities and Exchange Commission on August 9, 2024

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on August 9, 2024 Registration No.

August 6, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36305 SEM

August 5, 2024 EX-99.1

Semler Scientific® Reports Second Quarter 2024 Financial Results and Additional Bitcoin Purchases

Exhibit 99.1 Semler Scientific® Reports Second Quarter 2024 Financial Results and Additional Bitcoin Purchases Santa Clara, CA – August 5, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, today reported financial results for the second quarter ended June 30, 2024. In addition, t

August 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2024 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 5, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

July 31, 2024 EX-99.2

NYDIG Digital Asset Custodial Agreement

Exhibit 99.2 CERTAIN INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL Digital Asset Custodial Term Sheet Effective Date May 23, 2024 Custodian NYDIG Trust Company LLC, a duly chartered New York limited liability trust company Client [Legal name of customer], a [st

July 31, 2024 S-3/A

As filed with the Securities and Exchange Commission on July 31, 2024

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on July 31, 2024 Registration No.

July 31, 2024 CORRESP

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Goodwin Procter LLP Three Embarcadero Center, 28th Floor San Francisco, CA 94111 goodwinlaw.

July 31, 2024 8-K/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2024

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorpor

July 31, 2024 EX-99.1

Bitcoin Strategy Related Supplemental Disclosures

Exhibit 99.1 Bitcoin Strategy Related Supplemental Disclosures Bitcoin Treasury Strategy WE ARE NOT REGISTERED AS AN INVESTMENT COMPANY UNDER THE INVESTMENT COMPANY ACT OF 1940 AND STOCKHOLDERS DO NOT HAVE THE PROTECTIONS ASSOCIATED WITH OWNERSHIP OF SHARES IN A REGISTERED INVESTMENT COMPANY NOR THE PROTECTIONS AFFORDED BY THE COMMODITIES EXCHANGE ACT. Summary This section summarizes our current a

July 31, 2024 EX-99.3

Coinbase Prime Broker Agreement

Exhibit 99.3 CERTAIN INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL COINBASE PRIME BROKER AGREEMENT General Terms and Conditions 1. Introduction 1.1 This agreement dated as of (the “Effective Date”) (including, the Coinbase Custody Services Agreement attached he

July 11, 2024 S-3/A

As filed with the Securities and Exchange Commission on July 11, 2024

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on July 11, 2024 Registration No.

July 11, 2024 EX-99.1

Bitcoin Strategy Related Supplemental Disclosures

Exhibit 99.1 Bitcoin Strategy Related Supplemental Disclosures Bitcoin Treasury Strategy WE ARE NOT REGISTERED AS AN INVESTMENT COMPANY UNDER THE INVESTMENT COMPANY ACT OF 1940 AND STOCKHOLDERS DO NOT HAVE THE PROTECTIONS ASSOCIATED WITH OWNERSHIP OF SHARES IN A REGISTERED INVESTMENT COMPANY NOR THE PROTECTIONS AFFORDED BY THE COMMODITIES EXCHANGE ACT. Summary This section summarizes our current a

July 11, 2024 CORRESP

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Goodwin Procter LLP Three Embarcadero Center, 28th Floor San Francisco, CA 94111 goodwinlaw.

July 11, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 11, 2024 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 11, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

June 6, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2024 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 6, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

June 6, 2024 EX-4.1

Form of Senior Indenture

Exhibit 4.1 SEMLER SCIENTIFIC, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [·], 202[·] Senior Debt Securities TABLE OF CONTENTS1 ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certificat

June 6, 2024 EX-4.2

Form of Subordinated Indenture

Exhibit 4.2 SEMLER SCIENTIFIC, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [●], 202[●] Subordinated Debt Securities TABLE OF CONTENTS1 ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.0 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certi

June 6, 2024 EX-1.2

Sales Agreement, dated June 6, 2024, by and between the registrant and Cantor Fitzgerald & Co.

Exhibit 1.2 Semler Scientific, Inc. Shares of Common Stock (par value $0.001 per share) Controlled Equity OfferingSM Sales Agreement June 6, 2024 Cantor Fitzgerald & Co. 110 East 59th Street New York, NY 10022 Ladies and Gentlemen: Semler Scientific, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Cantor Fitzgerald & Co. (the “Agent”), as follows: 1. Is

June 6, 2024 S-3

As filed with the Securities and Exchange Commission on June 6, 2024

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on June 6, 2024 Registration No.

June 6, 2024 EX-99.1

Bitcoin Strategy Related Supplemental Disclosures

Exhibit 99.1 Bitcoin Strategy Related Supplemental Disclosures Bitcoin Treasury Strategy Summary This section summarizes our current acquisition strategy for bitcoin, including our historical purchases, trading execution, custody, storage, and accounting considerations. We reserve the right to update and alter our acquisition strategy from time to time. We view bitcoin as a reliable store of value

June 6, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Semler Scientific, Inc.

May 28, 2024 EX-99.1

Semler Scientific® Announces Bitcoin Treasury Strategy

Exhibit 99.1 Semler Scientific® Announces Bitcoin Treasury Strategy Santa Clara, CA – May 28, 2024 – Semler Scientific, Inc. (Nasdaq: SMLR), a pioneer in developing and marketing technology products and services to healthcare providers to combat chronic diseases, announced today that its board of directors has adopted bitcoin as its primary treasury reserve asset. In addition, Semler Scientific an

May 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2024 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36305 SE

May 7, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2024 SEMLER SCIENTIFIC, IN

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fil

May 7, 2024 EX-99.1

Semler Scientific® Reports First Quarter 2024 Financial Results

Exhibit 99.1 Semler Scientific® Reports First Quarter 2024 Financial Results 2024 Q1 highlights compared to the corresponding period of 2023: ●First quarter revenues were $15.9 million, a decrease of 13% ●First quarter net income was $6.1 million, an increase of 22% ●Cash, cash equivalents and restricted cash balance increased to $62.9 million Santa Clara, CA – May 7, 2024 – Semler Scientific, Inc

March 7, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from: to Commission file number: 001-36305 SEMLE

March 7, 2024 EX-4.2

DESCRIPTION OF CAPITAL STOCK

Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from, and qualified in its entirety by reference to, our amended and restated certificate of incorporation and our second amended and restated bylaws, both of which h

March 7, 2024 EX-10.7

Employment agreement dated May 2, 2022 by and among Semler Scientific, Inc. and Renae Cormier.

Exhibit 10.7 SEMLER SCIENTIFIC, INC. AT-WILL EMPLOYMENT, CONFIDENTIAL INFORMATION, INVENTION ASSIGNMENT, AND ARBITRATION AGREEMENT As a condition of my employment with Semler Scientific, Inc., its subsidiaries, affiliates, successors or assigns (together the “Company”), and in consideration of my employment with the Company and my receipt of the compensation now and hereafter paid to me by Company

March 7, 2024 EX-97.1

Compensation Recovery Policy

Exhibit 97.1 SEMLER SCIENTIFIC, INC COMPENSATION RECOVERY POLICY Adopted as of October 19, 2023 Semler Scientific, Inc., a Delaware corporation (the “Company”), has adopted a Compensation Recovery Policy (this “Policy”) as described below. 1.Overview The Policy sets forth the circumstances and procedures under which the Company shall recover Erroneously Awarded Compensation from Covered Persons (a

March 5, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 5, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

March 5, 2024 EX-99.1

Semler Scientific Reports Fourth Quarter and Full Year 2023 Financial Results

Exhibit 99.1 Semler Scientific Reports Fourth Quarter and Full Year 2023 Financial Results 2023 Q4 and full year highlights compared to the corresponding period of 2022: ●Fourth quarter revenues were $15.1 million, an increase of 9% ●Fourth quarter net income was $4.2 million, an increase of 31% ●Full year revenues were $68.2 million, an increase of 20% ●Full year net income was $20.6 million, an

February 12, 2024 SC 13G/A

SMLR / Semler Scientific, Inc. / Topline Capital Management, LLC - SC 13G/A Passive Investment

SC 13G/A 1 d775482dsc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1) Semler Scientific, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 81684M104 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of Statement) Check the appropriate box to desi

February 12, 2024 EX-99.A

JOINT FILING UNDERTAKING

EX-99.A 2 d775482dex99a.htm EX-99.A EXHIBIT A JOINT FILING UNDERTAKING The undersigned, being authorized thereunto, hereby execute this agreement as an exhibit to this Schedule 13G to evidence the agreement of the below-named parties, in accordance with rules promulgated pursuant to the Securities Exchange Act of 1934, to file this Schedule, as it may be amended, jointly on behalf of each of such

January 22, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 22, 2024 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 22, 2024 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-3630

November 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

November 9, 2023 EX-99.1

Semler Scientific Reports Third Quarter and Year-to-Date 2023 Financial Results

Exhibit 99.1 Semler Scientific Reports Third Quarter and Year-to-Date 2023 Financial Results 2023 Q3 highlights: ●Revenue of $16.3 million, an increase of 16% compared to the corresponding period of 2022 ●Net income of $5.5 million, an increase of 50% compared to the corresponding period of 2022 ●Quarter-ending cash, cash equivalents and short-term investments of $56.0 million Santa Clara, CA – No

October 23, 2023 EX-3.1

Certificate of Amendment to the Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 of our Form 8-K filed with the Securities and Exchange Commission on October 23, 2023).

Exhibit 3.1 Page 1 Delaware The First State I, JEFFREY W. BULLOCK, SECRETARY OF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS A TRUE AND CORRECT COPY OF THE CERTIFICATE OF AMENDMENT OF “SEMLER SCIENTIFIC, INC.”, FILED IN THIS OFFICE ON THE NINETEENTH DAY OF OCTOBER, A.D. 2023, AT 2:19 O`CLOCK P.M. 5404039 8100Authentication: 204414749 SR# 20233771415Date: 10-19-23 You may verif

October 23, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 19, 2023 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 19, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

September 14, 2023 SC 13D/A

SMLR / Semler Scientific Inc / SEMLER ERIC - AMENDMENT NO. 2 TO THE SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 2)1 Semler Scientific, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M104 (CUSIP Number) ERIC SEMLER c

September 14, 2023 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ex991to13da210608006091423.htm JOINT FILING AGREEMENT, DATED SEPTEMBER 14, 2023 Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1)(iii) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a Statement on Schedule 13D (including additional amendments thereto) with respect to the common st

September 8, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6

August 29, 2023 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☒ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6

August 14, 2023 EX-10.3

Separation Agreement and Release, dated April 1, 2023 by and among Semler Scientific, Inc. and Douglas Murphy-Chutorian (incorporated by reference to Exhibit 10.3 of our Form 10-Q filed with the Securities and Exchange Commission on August 14, 2023).

Exhibit 10.3 SEPARATION AGREEMENT AND RELEASE This Separation Agreement and Release (“Agreement”) is made by and between Doug Murphy-Chutorian (“Employee”) and Semler Scientific, Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). RECITALS WHEREAS, Employee was employed by the Company; WHEREAS, Employee began serving as the Company’s Chief Exe

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-36305 SEM

August 14, 2023 EX-10.4

Employment agreement dated May 25, 2023 by and among Semler Scientific, Inc. and Douglas Murphy-Chutorian

Exhibit 10.4 INTERIM EMPLOYMENT AGREEMENT This Interim Employment Agreement (“Agreement”) is made by and between Doug Murphy-Chutorian (“Employee”) and Semler Scientific, Inc. (the “Company”) (collectively referred to as the “Parties” or individually referred to as a “Party”). RECITALS WHEREAS, Employee is currently employed by the Company; WHEREAS, Employee entered into an At-Will Employment, Con

August 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2023 SEMLER SCIENTIFIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 10, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

August 10, 2023 EX-99.1

Semler Scientific Reports Second Quarter and First Half of 2023 Financial Results

Exhibit 99.1 Semler Scientific Reports Second Quarter and First Half of 2023 Financial Results 2023 Q2 highlights: ●Revenue was $18.6 million, an increase of 25% compared to the corresponding period of 2022 ●Net income was $5.9 million, an increase of 44% compared to the corresponding period of 2022 ●Cash, cash equivalents and short-term investments of $51.8 million Santa Clara, CA – August 10, 20

July 25, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 25, 2023 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 25, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

July 11, 2023 EX-99.1

Semler Scientific Announces Appointment of Chief Financial Officer, Record Quarterly Revenues and Strategic Streamlining

Exhibit 99.1 Semler Scientific Announces Appointment of Chief Financial Officer, Record Quarterly Revenues and Strategic Streamlining Santa Clara, CA – July 11, 2023 – Semler Scientific, Inc. (Nasdaq: SMLR), a company that develops, manufactures and markets innovative medical products and services that assist in evaluating and treating chronic diseases, today announced the appointment of a chief f

July 11, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 7, 2023 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 7, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 17, 2023 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 16, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 17, 2023 SC 13D/A

SMLR / Semler Scientific Inc / Murphy-Chutorian Douglas - SC 13D/A Activist Investment

SC 13D/A 1 tm2316043d3sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 6) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Marianne C. Sarrazin, Esq. Goodwin Procter LLP 3 Embarcadero Center San Fr

May 17, 2023 EX-10.1

Warrant Repurchase Agreement between Semler Scientific, Inc. and the Murphy-Chutorian Family Trust U/D/T dated January 13, 1997, dated May 16, 2023 (incorporated by reference to Exhibit 10.1 of our Form 8-K filed with the Securities and Exchange Commission on May 17, 2023).

Exhibit 10.1 WARRANT REPURCHASE AGREEMENT This Warrant Repurchase Agreement (this “Agreement”) is made as of May 16, 2023, by and between Semler Scientific, Inc., a Delaware corporation (the “Company”), and the undersigned holder of warrants to purchase shares of the Company’s capital stock (the “Warrantholder,” and together with the Company, the “Parties”). WHEREAS, the Warrantholder had purchase

May 12, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36305 SEM

May 12, 2023 EX-10.1

Employment Agreement with Wayne T. Pan dated March 29, 2023

Exhibit 10.1 EXECUTIVE EMPLOYMENT AGREEMENT In consideration of the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, this Employment Agreement (“Agreement”) is made between Semler Scientific, Inc. (the “Company”) and Wayne T. Pan (“Executive”). The Company and Executive are referred to collectiv

May 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2023 SEMLER SCIENTIFIC, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fi

May 10, 2023 EX-99.1

Semler Scientific Reports First Quarter 2023 Financial Results

Exhibit 99.1 Semler Scientific Reports First Quarter 2023 Financial Results 2023 Q1 highlights: ●Revenue was $18.2 million, an increase of 30% compared to the corresponding period of 2022 ●Net income was $5.0 million, an increase of 48% compared to the corresponding period of 2022 ●Cash, cash equivalents and short-term investments of $43.0 million Santa Clara, CA – May 10, 2023 – Semler Scientific

May 2, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 1, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fil

April 28, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2023 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

April 20, 2023 SC 13D/A

SMLR / Semler Scientific Inc / William H.c. Chang & Diana Shon Chang Ttee Chang Family Trust U/a Dtd 10/23/2006 - SC 13D/A Activist Investment

  UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549   SCHEDULE 13D (Amendment No. 11)   Under the Securities Exchange Act of 1934   SEMLER SCIENTIFIC, INC. (Name of Issuer)   Common Stock, par value $0.001 per share (Title of Class of Securities)   81684M 104 (CUSIP Number)   Marianne C. Sarrazin, Esq. Goodwin Procter LLP 3 Embarcadero Center San Francisco, CA 94111 Telephone

April 20, 2023 SC 13D/A

SMLR / Semler Scientific Inc / SEMLER ERIC - AMENDMENT NO. 1 TO THE SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Rule 13d-101) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2(a) (Amendment No. 1)1 Semler Scientific, Inc. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M104 (CUSIP Number) Eric Semler c

April 19, 2023 EX-3.1

Third Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 of our Form 8-K filed with the Securities and Exchange Commission on April 19, 2023)

Exhibit 3.1 Third AMENDED AND RESTATED BYLAWS OF SEMLER SCIENTIFIC, INC. (A DELAWARE CORPORATION) ARTICLE I Offices Section 1. Registered Office. The registered office of the corporation in the State of Delaware and the name of its registered agent at such address shall be as set forth in the Amended and Restated Certificate of Incorporation of the corporation (as the same may be amended and/or re

April 19, 2023 EX-10.1

Cooperation Agreement, dated April 19, 2023, by and among Semler Scientific, Inc. and the Investors

Exhibit 10.1 AGREEMENT This Agreement (this “Agreement”) is made and entered into as of April 19, 2023 by and among Semler Scientific, Inc., a Delaware corporation (the “Company”) and Eric Semler and William H.C. Chang (each, an “Investor” and collectively, the “Investors”). The Company and each of the Investors are collectively herein referred to as the “Parties” and individually as a “Party.” RE

April 19, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 18, 2023 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 18, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

April 17, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2023 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 17, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

April 17, 2023 EX-99.1

Forward-Looking Statements This presentation includes statements that are, or may be deemed, “forward-looking statements.” In some cases, these forward-looking statements can be identified by the use of forward-looking terminology, including the term

Exhibit 99.1 NASDAQ:SMLR Needham Virtual Healthcare Conference April 2023 Forward-Looking Statements This presentation includes statements that are, or may be deemed, “forward-looking statements.” In some cases, these forward-looking statements can be identified by the use of forward-looking terminology, including the terms “believe,” “estimate,” “anticipate,” “expect,” “plan,” “intend,” “may,” “c

April 6, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

March 31, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2023 SEMLER SCIENTIFIC,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 29, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

March 23, 2023 EX-4.2

DESCRIPTION OF CAPITAL STOCK

Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from, and qualified in its entirety by reference to, our amended and restated certificate of incorporation and our second amended and restated bylaws, both of which h

March 23, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2022 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from: to Commission file number: 001-36305 SEMLE

March 21, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 19, 2023 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

March 21, 2023 EX-99.1

Semler Scientific Reports Fourth Quarter and Full Year 2022 Financial Results

Exhibit 99.1 Semler Scientific Reports Fourth Quarter and Full Year 2022 Financial Results 2022 Q4 and Full Year highlights compared to the corresponding period of 2021: ●Fourth quarter revenue was $13.8 million, an increase of 20% ●Fourth quarter net income was $3.2 million, an increase of 113% ●Full year revenue was $56.7 million, an increase of 7% ●Full year net income was $14.3 million, a decr

February 15, 2023 SC 13G

SMLR / Semler Scientific Inc / Topline Capital Management, LLC - SC 13G Passive Investment

SC 13G SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.) Semler Scientific, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 81684M104 (CUSIP Number) February 10, 2023 (Date of Event Which Requires Filing of Statement) Check the appropriate box to designate the rule pursuant to which t

February 15, 2023 EX-99.A

JOINT FILING UNDERTAKING

EX-99.A EXHIBIT A JOINT FILING UNDERTAKING The undersigned, being authorized thereunto, hereby execute this agreement as an exhibit to this Schedule 13G to evidence the agreement of the below-named parties, in accordance with rules promulgated pursuant to the Securities Exchange Act of 1934, to file this Schedule, as it may be amended, jointly on behalf of each of such parties. Dated: February 15,

February 14, 2023 SC 13G/A

SMLR / Semler Scientific Inc / Park West Asset Management LLC Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 5)* SEMLER SCIENTIFIC, INC. (Name of Issuer) COMMON STOCK, PAR VALUE $0.001 PER SHARE (Title of Class of Securities) 81684M104 (CUSIP Number) DECEMBER 31, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

January 5, 2023 SC 13D/A

SMLR / Semler Scientific Inc / William H.c. Chang & Diana Shon Chang Ttee Chang Family Trust U/a Dtd 10/23/2006 - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 10) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Marianne C. Sarrazin, Esq. Goodwin Procter LLP 3 Embarcadero Center San Francisco, CA 94111 Telephone: (415) 733-60

November 4, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36305

November 1, 2022 EX-99.1

Semler Reports Third Quarter and Year-to-Date 2022 Financial Results

Exhibit 99.1 Semler Reports Third Quarter and Year-to-Date 2022 Financial Results 2022 Q3 quarterly HIGHLIGHTS compared to the corresponding period of 2021: ? ?Revenue was $14.0 million, same as the prior year period ?Net income was $3.7 million, or $0.55 per basic share and $0.46 per diluted share, compared to $4.2 million, or $0.61 per basic share and $0.51 per diluted share ?Cash and cash equiv

November 1, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 ? Date of Report (Date of earliest event reported): November 1, 2022 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (C

October 25, 2022 SC 13D/A

SMLR / Semler Scientific Inc / William H.c. Chang & Diana Shon Chang Ttee Chang Family Trust U/a Dtd 10/23/2006 - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 9) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Marianne C. Sarrazin, Esq. Goodwin Procter LLP 3 Embarcadero Center San Francisco, CA 94111 Telephone: (415) 733-600

October 24, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 20, 2022 SEMLER SCIENTIFI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 20, 2022 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

September 9, 2022 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.    )

? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 ? SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ???) ? Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? ? Confidential, for Use of the Commission Only (as permitted by Ru

August 5, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 2, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 2, 2022 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

August 2, 2022 EX-99.1

Semler Reports Second Quarter and First Half of 2022 Financial Results

Exhibit 99.1 Semler Reports Second Quarter and First Half of 2022 Financial Results 2022 Q2 quarterly HIGHLIGHTS compared to the corresponding period of 2021: ●Revenues were $14.8 million, an increase of 4%, compared to $14.3 million ●Net income was $4.1 million, or $0.60 per basic share and $0.51 per diluted share, compared to $6.7 million, or $1.00 per basic share and $0.83 per diluted share ●Ca

May 6, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 2, 2022 EX-99.1

Semler Reports First Quarter 2022 Financial Results

Exhibit 99.1 Semler Reports First Quarter 2022 Financial Results 2022 Q1 HIGHLIGHTS compared to the corresponding period of 2021: ? ?Revenues were $14.0 million, an increase of $0.8 million, or 6%, compared to $13.2 million ?Net income was $3.4 million, or $0.50 per basic share and $0.41 per diluted share, compared to $4.9 million, or $0.73 per basic share and $0.60 per diluted share ?Cash at Marc

May 2, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 2, 2022 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

March 17, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2022 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

March 17, 2022 EX-99.1

Semler Scientific’s Board of Directors authorizes an up to $20.0 million stock repurchase program

Exhibit 99.1 Semler Scientific?s Board of Directors authorizes an up to $20.0 million stock repurchase program SANTA CLARA, Calif., March 14, 2022 - Semler Scientific, Inc. (Nasdaq: SMLR), a company that provides technology solutions to improve the clinical effectiveness and efficiency of healthcare providers, today announced that its board of directors has authorized a $20.0 million stock repurch

March 7, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Registration Fee Form S-8 (Form Type) Semler Scientific, Inc.

March 7, 2022 S-8

As filed with the Securities and Exchange Commission on March 7, 2022

As filed with the Securities and Exchange Commission on March 7, 2022 Registration No.

March 4, 2022 EX-4.2

Exhibit 4.2

? Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from, and qualified in its entirety by reference to, our amended and restated certificate of incorporation and our second amended and restated bylaws, both of which

March 4, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

February 28, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 28, 2022 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Co

February 28, 2022 EX-99.1

Semler Reports Fourth Quarter and Year-to-Date 2021 Financial Results

Exhibit 99.1 Semler Reports Fourth Quarter and Year-to-Date 2021 Financial Results 2021 HIGHLIGHTS compared to 2020: ?Annual revenues increased by 37% ?Net income increased by 23% ?Cash at December 31, 2021 increased to $37.3 million from $22.1 million ? Santa Clara, CA ? February 28, 2022 ? Semler Scientific, Inc. (Nasdaq: SMLR), a company that provides technology solutions to improve the clinica

February 14, 2022 SC 13G/A

SMLR / Semler Scientific Inc / Park West Asset Management LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 4)* SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, PAR VALUE $0.001 per share (Title of Class of Securities) 81684M104 (CUSIP Number) DECEMBER 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

February 14, 2022 SC 13G/A

SMLR / Semler Scientific Inc / Nantahala Capital Management, LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M104 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the

November 5, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

November 1, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 1, 2021 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Com

November 1, 2021 EX-99.1

Semler Reports Third Quarter and Year-to-Date 2021 Financial Results

? Exhibit 99.1 Semler Reports Third Quarter and Year-to-Date 2021 Financial Results HIGHLIGHTS - Year-to-Date 2021 compared to the corresponding period of 2020: ? ? Revenues were $41.5 million, an increase of 56% compared to $26.5 million ? Pre-tax net income of $17.7 million, an increase of $7.7 million, or 77% compared to $10.0 million ? Net income was $15.7 million, an increase of $7.1 million,

October 26, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 21, 2021 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

October 26, 2021 EX-3.1

Second Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 of our Form 8-K filed with the Securities and Exchange Commission on October 26, 2021).

Exhibit 3.1 Second AMENDED AND RESTATED BYLAWS OF SEMLER SCIENTIFIC, INC. (A DELAWARE CORPORATION) ARTICLE I Offices Section 1. Registered Office. The registered office of the corporation in the State of Delaware and the name of its registered agent at such address shall be as set forth in the Amended and Restated Certificate of Incorporation of the corporation (as the same may be amended and/or r

September 27, 2021 8-A12B

Form 8-A filed on September 27, 2021

8-A12B 1 tm2128264d18a12b.htm 8-A12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Semler Scientific, Inc. (Exact name of registrant as specified in its charter) Delaware 26-1367393 (State or other jurisdiction of incorporation or organization

September 10, 2021 DEF 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.__)

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

August 6, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

August 2, 2021 EX-99.1

Semler Reports Second Quarter and First Half of 2021 Financial Results

? Exhibit 99.1 Semler Reports Second Quarter and First Half of 2021 Financial Results 2021 Q2 HIGHLIGHTS compared to the corresponding period of 2020: ? ? Revenues were $14.3 million, an increase of 125% compared to $6.4 million ? Pre-tax net income of $6.5 million, an increase of $5.5 million, or 554%, compared to $1.0 million ? Net income was $6.7 million, or $1.00 per basic share and $0.83 per

August 2, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 2, 2021 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commi

May 7, 2021 10-Q

Quarterly Report - 10-Q

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

May 3, 2021 EX-99.1

Semler Reports First Quarter 2021 Financial Results

Exhibit 99.1 Semler Reports First Quarter 2021 Financial Results 2021 Q1 HIGHLIGHTS compared to the corresponding period of 2020: ? Revenues were $13.2 million, an increase of 40% ? Pre-tax net income of $6.0 million, an increase of $2.5 million, or 74%, compared to $3.5 million ? Net income was $4.9 million, or $0.73 per basic share and $0.60 per diluted share, compared to $2.7 million, or $0.41

May 3, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 3, 2021 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) ? Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

March 9, 2021 10-K

Annual Report - FORM 10-K

Table of Contents ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

March 1, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 1, 2021 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

March 1, 2021 EX-99.1

Semler Reports Record Fourth Quarter and Year End 2020 Financial Results

Exhibit 99.1 Semler Reports Record Fourth Quarter and Year End 2020 Financial Results 2020 HIGHLIGHTS compared to 2019: · Annual revenues increased by 18% · Pre-tax net income of $16.5 million, an increase of $5.8 million, or 54%, compared to $10.7 million · Net income of $14.0 million, a decrease of $1.1 million, or 7%, compared to $15.1 million (which included a $4.4 million income tax benefit)

February 16, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)*

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, PAR VALUE $0.001 per share (Title of Class of Securities) 81684M104 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

February 16, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) (C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 81684M104 (CUSIP Number) December 31, 2020 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursu

February 12, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1) SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock (Title of Class of Securities) (CUSIP Number) Dec

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1) SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 81684M104 (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which thi

November 12, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissi

November 6, 2020 10-Q

Quarterly Report - FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36305

November 5, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

November 5, 2020 EX-99.1

Semler Reports Record Third Quarter and Year-to-Date 2020 Financial Results

Exhibit 99.1 Semler Reports Record Third Quarter and Year-to-Date 2020 Financial Results 2020 Q3 HIGHLIGHTS compared to Q2 2020: · Revenues were $10,727,000, an increase of $4,354,000, or 68%, compared to $6,373,000 · Pre-tax net income of $5,595,000, an increase of $4,605,000, or 465%, compared to $990,000 · Net income was $4,866,000, or $0.74 per basic share and $0.61 per diluted share, compared

October 23, 2020 8-K

Submission of Matters to a Vote of Security Holders - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 22, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

September 11, 2020 DEF 14A

- DEF 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

August 17, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers - FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 13, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

August 6, 2020 10-Q

Quarterly Report - FORM 10-Q

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36305 SEML

August 3, 2020 EX-99.1

Semler Reports Second Quarter and First Half 2020 Financial Results

Exhibit 99.1 Semler Reports Second Quarter and First Half 2020 Financial Results 2020 Q2 HIGHLIGHTS compared to the corresponding period of 2019: · Revenues were $6,373,000, a decrease of 20% · Pre-tax net income was $990,000, a decrease of $1,706,000 · Net income was $0.16 per basic share and $0.13 per diluted share, compared to $0.41 per basic share and $0.32 per diluted share · Cash at June 30,

August 3, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

May 7, 2020 10-Q

Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2020 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to Commission File Number 001-36305 SEMLER SCIENTIFIC, IN

May 4, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fil

May 4, 2020 EX-99.1

Semler Reports First Quarter 2020 Financial Results

Exhibit 99.1 Semler Reports First Quarter 2020 Financial Results 2020 Q1 HIGHLIGHTS compared to the corresponding period of 2019: · Revenues were $9,430,000, which is an increase of 39% · Pre-tax net income of $3,450,000, an increase of $1,596,000, or 86%, compared to $1,854,000 · Net income grew to $0.41 per basic share and $0.33 per diluted share, compared to $0.29 per basic share and $0.23 per

March 30, 2020 SC 13G

SMLR / Semler Scientific, Inc. / Opaleye Management Inc. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock (Title of Class of Securities) 81684M104 (CUSIP Number) March 23, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [

March 9, 2020 EX-4.2

Description of Capital Stock.

Exhibit 4.2 DESCRIPTION OF CAPITAL STOCK The following description of our capital stock is not complete and may not contain all the information you should consider before investing in our capital stock. This description is summarized from, and qualified in its entirety by reference to, our certificate of incorporation and bylaws, both of which have been publicly filed with the Securities and Excha

March 9, 2020 10-K

SMLR / Semler Scientific, Inc. 10-K - Annual Report - 10-K

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2019 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from:                   to                   SEM

March 3, 2020 EX-99.1

Semler Reports Record Fourth Quarter and Year End 2019 Financial Results

Exhibit 99.1 Semler Reports Record Fourth Quarter and Year End 2019 Financial Results 2019 HIGHLIGHTS compared to 2018: · Annual revenues increased by 52% · Pre-tax income of $10,701,000, an increase of $5,661,000, or 112%, compared to $5,040,000 · Net income after tax grew to $2.34 per basic share and $1.88 per diluted share, compared to $0.82 per basic share and $0.66 per diluted share · Income

March 3, 2020 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 3, 2020 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

February 14, 2020 SC 13G/A

SMLR / Semler Scientific, Inc. / Park West Asset Management LLC - SC 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, $0.001 par value per share (Title of Class of Securities) 81684M104 (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

November 14, 2019 SC 13D/A

SMLR / Semler Scientific, Inc. / William H.c. Chang & Diana Shon Chang Ttee Chang Family Trust U/a Dtd 10/23/2006 - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 8) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Yvan-Claude Pierre, Esq. Marianne C. Sarrazin, Esq. Cooley LLP 55 Hudson Yards New York, New York 10001-2157 Telepho

November 8, 2019 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 6, 2019 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

November 8, 2019 EX-10.1

Warrant Repurchase Agreement between Semler Scientific, Inc. and Murphy-Chutorian Family Trust U/D/T dated January 13, 1997, dated November 6, 2019.

Exhibit 10.1 WARRANT REPURCHASE AGREEMENT This Warrant Repurchase Agreement (this “Agreement”) is made as of November 6, 2019, by and between Semler Scientific, Inc., a Delaware corporation (the “Company”), and the undersigned holder of warrants to purchase shares of the Company’s capital stock (the “Warrantholder,” and together with the Company, the “Parties”). WHEREAS, the Company has granted to

November 8, 2019 SC 13D/A

SMLR / Semler Scientific, Inc. / Murphy-Chutorian Douglas - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 5) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Yvan-Claude Pierre, Esq. Marianne C. Sarrazin, Esq. Cooley LLP 55 Hudson Yards New York, New York 10001-2157 Telepho

November 6, 2019 10-Q

SMLR / Semler Scientific, Inc. 10-Q - Quarterly Report - FROM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36305 SEMLER SCIENTIFIC

October 30, 2019 EX-99.1

Semler Reports Record Third Quarter and Year-to-Date 2019 Financial Results

Exhibit 99.1 Semler Reports Record Third Quarter and Year-to-Date 2019 Financial Results 2019 Q3 HIGHLIGHTS compared to the corresponding period of 2018: · Revenues were $8,902,000, an increase of 60% · Pre-tax income of $3,108,000, an increase of $1,640,000, or 112%, compared to $1,468,000 · Net income grew to $1.20 per basic share and $0.96 per diluted share, compared to $0.24 per basic share an

October 30, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 30, 2019 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commissio

October 3, 2019 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 2, 2019 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

August 30, 2019 DEF 14A

SMLR / Semler Scientific, Inc. DEF 14A - - DEF 14A

SCHEDULE 14A INFORMATION Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.

August 2, 2019 10-Q

SMLR / Semler Scientific, Inc. 10-Q - Quarterly Report - FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-36305 SEMLER SCIENTIFIC, INC

July 26, 2019 EX-99.1

Semler Reports Record Second Quarter and First Half 2019 Financial Results

Exhibit 99.1 Semler Reports Record Second Quarter and First Half 2019 Financial Results 2019 Q2 HIGHLIGHTS compared to the corresponding period of 2018: · Revenues were $7,953,000, an increase of 45% · Net income grew to $0.41 per basic share and $0.32 per diluted share, compared to $0.24 per basic share and $0.19 per diluted share · Cash at June 30, 2019 increased to $4,182,000 from $2,009,000 Sa

July 26, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2019 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission F

May 7, 2019 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 3, 2019 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission Fil

May 7, 2019 EX-10.1

Warrant Repurchase Agreement between Semler Scientific, Inc. and Murphy-Chutorian Family Trust U/D/T dated January 13, 1997, dated May 3, 2019.

Exhibit 10.1 WARRANT REPURCHASE AGREEMENT This WARRANT REPURCHASE AGREEMENT (this “Agreement”) is made as May 3, 2019, by and between Semler Scientific, Inc., a Delaware corporation (the “Company”), and the undersigned holder of warrants to purchase shares of the Company’s capital stock (the “Warrantholder,” and together with the Company, the “Parties”). WHEREAS, the Company has granted to the War

May 7, 2019 SC 13D/A

SMLR / Semler Scientific, Inc. / William H.c. Chang & Diana Shon Chang Ttee Chang Family Trust U/a Dtd 10/23/2006 - SCHEDULE 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 7) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Yvan-Claude Pierre, Esq. Marianne C. Sarrazin, Esq. Cooley LLP 55 Hudson Yards New York, New York 10001-2157 Telepho

May 7, 2019 SC 13D/A

SMLR / Semler Scientific, Inc. / Murphy-Chutorian Douglas - AMENDMENT NO. 4 TO SCHEDULE 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D (Amendment No. 4) Under the Securities Exchange Act of 1934 SEMLER SCIENTIFIC, INC. (Name of Issuer) Common Stock, par value $0.001 per share (Title of Class of Securities) 81684M 104 (CUSIP Number) Yvan-Claude Pierre, Esq. Marianne C. Sarrazin, Esq. Cooley LLP 55 Hudson Yards New York, New York 10001-2157 Telepho

May 7, 2019 10-Q/A

SMLR / Semler Scientific, Inc. 10-Q/A Quarterly Report 10-Q/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q/A Amendment No. 1 x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to Commission File Number 001-36305 SEM

May 3, 2019 10-Q

SMLR / Semler Scientific, Inc. 10-Q Quarterly Report FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Quarterly Period Ended March 31, 2019 OR ¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period from to Commission File Number 001-36305 SEMLER SCIENTIFIC, IN

April 29, 2019 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 29, 2019 SEMLER SCIENTIFIC, INC. (Exact name of registrant as specified in its charter) Delaware 001-36305 26-1367393 (State or other jurisdiction of incorporation) (Commission

April 29, 2019 EX-99.1

Semler Reports First Quarter 2019 Financial Results

Exhibit 99.1 Semler Reports First Quarter 2019 Financial Results 2019 Q1 HIGHLIGHTS compared to the corresponding period of 2018: · Revenue was $6,761,000, which is an increase of 51% · Net income grew to $0.29 per basic share and $0.23 per diluted share, compared to $0.12 per basic and 0.10 per diluted share · Cash at March 31, 2019 increased to $4,544,000 from $419,000 one year ago San Jose, Cal

March 7, 2019 10-K

SMLR / Semler Scientific, Inc. FORM 10-K (Annual Report)

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended: December 31, 2018 Or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from:                   to                   SEM

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