DSGN / Design Therapeutics, Inc. - Pengajuan SECLaporan Tahunan, Pernyataan Proksi

Design Therapeutics, Inc.
US ˙ NasdaqGS ˙ US25056L1035

Mga Batayang Estadistika
CIK 1807120
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Design Therapeutics, Inc.
SEC Filings (Chronological Order)
Halaman ini menyediakan daftar lengkap dan kronologis dari Pengajuan SEC, tidak termasuk pengajuan kepemilikan yang kami sediakan di tempat lain.
August 7, 2025 EX-99.2

Company Presentation

Exhibit 99.2

August 7, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

August 7, 2025 8-K

FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 07, 2025 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissi

August 7, 2025 EX-99.1

Design Therapeutics Highlights Progress Across Lead GeneTAC® Programs and Reports Second Quarter 2025 Financial Results Early Human Pharmacokinetics Data for DT-216P2 Demonstrates Favorable Translation from non-human primates (NHPs) to Humans and Imp

Exhibit 99.1 Design Therapeutics Highlights Progress Across Lead GeneTAC® Programs and Reports Second Quarter 2025 Financial Results Early Human Pharmacokinetics Data for DT-216P2 Demonstrates Favorable Translation from non-human primates (NHPs) to Humans and Improved DT-216 Product Profile for Friedreich Ataxia (FA) Program RESTORE-FA Phase 1/2 Multiple-Ascending Dose Trial of DT-216P2 in FA Pati

June 12, 2025 8-K

FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 10, 2025 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

May 14, 2025 CORRESP

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, California 92011

CORRESP DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, California 92011 May 14, 2025 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jessica Dickerson Re: Design Therapeutics, Inc. Registration Statement on Form S-3 (File No. 333-287043) Filed: May 7, 2025 Request for Acceleration of Effective

May 7, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Design Therapeutics, Inc.

May 7, 2025 EX-4.8

Form of Common Stock Warrant Agreement and Warrant Certificate.

EX-4.8 Exhibit 4.8 DESIGN THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF DESIGN THERAPEUTICS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between DESIGN THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] organized an

May 7, 2025 EX-4.9

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

EX-4.9 Exhibit 4.9 DESIGN THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF DESIGN THERAPEUTICS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of [•], between DESIGN THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] org

May 7, 2025 S-3

As filed with the Securities and Exchange Commission on May 7, 2025

Table of Contents As filed with the Securities and Exchange Commission on May 7, 2025 Registration No.

May 7, 2025 EX-99.1

Design Therapeutics Highlights Momentum Across Lead GeneTAC® Programs and Reports First Quarter 2025 Financial Results Phase 1 Single Ascending Dose Trial of DT-216P2 for Friedreich Ataxia (FA) Program Ongoing Reported Favorable Phase 1 Data for DT-1

Exhibit 99.1 Design Therapeutics Highlights Momentum Across Lead GeneTAC® Programs and Reports First Quarter 2025 Financial Results Phase 1 Single Ascending Dose Trial of DT-216P2 for Friedreich Ataxia (FA) Program Ongoing Reported Favorable Phase 1 Data for DT-168 for Fuchs Endothelial Corneal Dystrophy (FECD) Program Well-Capitalized with Cash and Securities of $229.7 Million to Fund Operations

May 7, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

May 7, 2025 EX-4.6

Form of Indenture, between the registrant and one or more trustees to be named.

Exhibit 4.6 DESIGN THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20[•] Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1  DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2  ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee’s Certificat

May 7, 2025 EX-4.10

Form of Debt Securities Warrant Agreement and Warrant Certificate.

EX-4.10 Exhibit 4.10 DESIGN THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF DESIGN THERAPEUTICS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of [•], between DESIGN THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [•], a [corporation] [national banking association] o

May 7, 2025 8-K

FORM 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 07, 2025 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

April 30, 2025 DEFR14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 24, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 24, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

March 10, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40288 Design Therapeu

March 10, 2025 EX-99.1

Design Therapeutics Highlights Progress Across Lead GeneTAC® Programs and Reports Fourth Quarter and Full Year 2024 Financial Results Initiated Phase 1 Single Ascending Dose Trial of DT-216P2 in Healthy Volunteers; Friedreich Ataxia (FA) Patient Dosi

Exhibit 99.1 Design Therapeutics Highlights Progress Across Lead GeneTAC® Programs and Reports Fourth Quarter and Full Year 2024 Financial Results Initiated Phase 1 Single Ascending Dose Trial of DT-216P2 in Healthy Volunteers; Friedreich Ataxia (FA) Patient Dosing to Begin in mid-2025 Dosing Complete in DT-168 Phase 1 Healthy Volunteer Trial, with Data on Track for the First Half of 2025; Enrollm

March 10, 2025 S-8

As filed with the Securities and Exchange Commission on March 10, 2025

As filed with the Securities and Exchange Commission on March 10, 2025 Registration No.

March 10, 2025 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Design Therapeutics, Inc.

March 10, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2025 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissio

March 10, 2025 EX-19.1

Insider Trading Policy of the Registrant.

Exhibit 19.1 DESIGN THERAPEUTICS, INC. INSIDER TRADING POLICY Persons Covered This Insider Trading Policy of Design Therapeutics, Inc. (the “Company”) applies to all directors, officers, other employees and consultants of the Company and any subsidiaries. It also applies to their family members who reside with them, anyone else who lives in their households and any family members who do not live i

January 13, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commiss

January 13, 2025 EX-99.1

Company Presentation

Exhibit 99.1

November 7, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 07, 2024 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commis

November 7, 2024 EX-99.1

Design Therapeutics Announces Third Quarter 2024 Financial Results and Reviews Near-term Milestones for GeneTACTM Portfolio Fuchs Endothelial Corneal Dystrophy (FECD) Phase 1 Trial Initiated with Data Expected in the First Half of 2025 Friedreich Ata

Exhibit 99.1 Design Therapeutics Announces Third Quarter 2024 Financial Results and Reviews Near-term Milestones for GeneTACTM Portfolio Fuchs Endothelial Corneal Dystrophy (FECD) Phase 1 Trial Initiated with Data Expected in the First Half of 2025 Friedreich Ataxia (FA) Program on Track to Initiate Phase 1 Single Ascending Dose, Healthy Volunteer Study in the First Half of 2025 Active Research Pi

November 7, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

August 13, 2024 SC 13D/A

DSGN / Design Therapeutics, Inc. / Logos Global Management LP Activist Investment

SC 13D/A 1 dsgn13d.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1) Design Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 25056L103 (CUSIP Number) Derek Gould Logos Global Management LP One Letterman Drive, Building C, Suite C3-350 San Fr

August 5, 2024 EX-99.1

Design Therapeutics Announces Second Quarter 2024 Financial Results and Reviews Near-term Milestones for GeneTACTM Portfolio Friedreich Ataxia (FA) and Fuchs Endothelial Corneal Dystrophy (FECD) Programs on Track and Advancing Toward Clinical Trials

Exhibit 99.1 Design Therapeutics Announces Second Quarter 2024 Financial Results and Reviews Near-term Milestones for GeneTACTM Portfolio Friedreich Ataxia (FA) and Fuchs Endothelial Corneal Dystrophy (FECD) Programs on Track and Advancing Toward Clinical Trials Active Research Pipeline with Programs Progressing in Myotonic Dystrophy Type-1 (DM1) and Huntington’s Disease (HD) Cash and Securities o

August 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 05, 2024 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissi

August 5, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

June 17, 2024 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

May 8, 2024 EX-99.1

Design Therapeutics Announces First Quarter 2024 Financial Results and Highlights Upcoming Program Milestones Advancing DT-216P2, New Drug Product for Friedreich Ataxia (FA), Toward Clinical Trials Starting Phase 1 Development for Fuchs Endothelial C

Exhibit 99.1 Design Therapeutics Announces First Quarter 2024 Financial Results and Highlights Upcoming Program Milestones Advancing DT-216P2, New Drug Product for Friedreich Ataxia (FA), Toward Clinical Trials Starting Phase 1 Development for Fuchs Endothelial Corneal Dystrophy (FECD) in 2024; Observational Study Currently Enrolling Patients Progressing GeneTACTM Pipeline Programs in Huntington’s

May 8, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 08, 2024 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

May 8, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

April 25, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 25, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

March 19, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40288 Design Therapeu

March 19, 2024 EX-99.1

Design Therapeutics Outlines Progress Across GeneTAC™ Platform and Announces Fourth Quarter and Full Year 2023 Financial Results New Drug Product for Friedreich Ataxia (FA) DT-216P2 with Favorable Nonclinical Pharmacokinetic and Injection Site Safety

Exhibit 99.1 Design Therapeutics Outlines Progress Across GeneTAC™ Platform and Announces Fourth Quarter and Full Year 2023 Financial Results New Drug Product for Friedreich Ataxia (FA) DT-216P2 with Favorable Nonclinical Pharmacokinetic and Injection Site Safety Profile; Complete GLP Studies by Year-end 2024 to Start Patient Trials in 2025 IND Cleared for DT-168 for Treatment of Fuchs Endothelial

March 19, 2024 EX-10.13

Third Amendment to Consulting Agreement, by and between the Registrant and Aseem Z. Ansari, Ph.D., dated November 9, 2023

Exhibit 10.13 DESIGN THERAPEUTICS, INC. THIRD AMENDMENT TO CONSULTING AGREEMENT THIS THIRD AMENDMENT TO CONSULTING AGREEMENT (“Amendment”) is made this 9th day of November 2023, by DESIGN THERAPEUTICS, INC. and ASEEM Z. ANSARI, PhD, parties to that certain Consulting Agreement dated December 27, 2017 (“Agreement”). 1. Section 2.2 of Exhibit A to the Agreement is amended and restated in its entiret

March 19, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 19, 2024 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissio

March 19, 2024 EX-10.7

Non-Employee Director Compensation Policy

Exhibit 10.7 DESIGN THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY Each member of the Board of Directors (the “Board”) who is not also serving as an employee of or consultant to Design Therapeutics, Inc. (the “Company”) or any of its subsidiaries (each such member, an “Eligible Director”) will receive the compensation described in this Non-Employee Director Compensation Policy for hi

March 19, 2024 EX-4.3

Exhibit 4.3

Exhibit 4.3 DESCRIPTION OF COMMON STOCK The following summary description of the common stock of Design Therapeutics, Inc. (we, our or us) is based on the provisions of our amended and restated certificate of incorporation, as well as our amended and restated bylaws, and the applicable provisions of the Delaware General Corporation Law. This information is qualified entirely by reference to the ap

March 19, 2024 EX-10.14

Consulting Agreement by and between the Registrant and Rodney Lappe, Ph.D., dated November 22, 2023.

Exhibit 10.14 DESIGN THERAPEUTICS, INC. CONSULTING AGREEMENT This Consulting Agreement (the “Agreement”) is entered into as of November 22, 2023, (the “Effective Date”) by and between Design Therapeutics, Inc., a Delaware corporation (the “Client”), and Rodney Lappe, Ph.D. (“Consultant”). Whereas, the Client desires to retain Consultant as an independent contractor to perform consulting services f

March 19, 2024 S-8

As filed with the Securities and Exchange Commission on March 19, 2024

As filed with the Securities and Exchange Commission on March 19, 2024 Registration No.

March 19, 2024 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Design Therapeutics, Inc.

March 19, 2024 EX-97.1

Design Therapeutics, Inc. Incentive Compensation Recoupment Policy

Exhibit 97.1 DESIGN THERAPEUTICS, INC. Incentive Compensation Recoupment Policy 1. Introduction The Board of Directors (the “Board”) of Design Therapeutics, Inc., a Delaware corporation (the “Company”), has determined that it is in the best interests of the Company and its stockholders to adopt this Incentive Compensation Recoupment Policy (this “Policy”) providing for the Company’s recoupment of

February 14, 2024 SC 13G/A

DSGN / Design Therapeutics, Inc. / CITADEL ADVISORS LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm243953d3sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 2)* Design Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (the “Shares”

February 14, 2024 SC 13G/A

DSGN / Design Therapeutics, Inc. / Cormorant Asset Management, LP - AMENDMENT NO. 3 Passive Investment

SC 13G/A 1 schedule13ga.htm AMENDMENT NO. 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* Design Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 25056L103 (CUSIP Number) December 31, 2023 (Date of Event which Requires Filing of this Statement) Check the appropriate bo

November 14, 2023 SC 13G/A

DSGN / Design Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm2330558d1sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* DESIGN THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 25056L 10 3 (CUSIP Number) November 14, 2023 (Date of Event Which Requires Filing of this Statem

November 13, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

November 13, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commis

November 13, 2023 EX-10.1

Separation Agreement by and between the Company and João Siffert, M.D., dated August 25, 2023.

Exhibit 10.1 6005 Hidden Valley Road, Suite 110 Carlsbad, CA 92011 August 25, 2023 João Siffert, M.D. Re: Separation Agreement Dear João: This letter sets forth the substance of the separation agreement (the “Agreement”) that Design Therapeutics, Inc. (the “Company”) is offering to you to aid in your employment transition. 1. Separation. In connection with a mutual separation, you hereby submit, a

November 13, 2023 EX-99.1

Design Therapeutics Reports Third Quarter 2023 Financial Results and Plans for a Comprehensive Portfolio Update in Early 2024 Seasoned Biotech Executive Pratik Shah Appointed as Chief Executive Officer to Lead Company Turnaround Current Cash and Secu

Exhibit 99.1 Design Therapeutics Reports Third Quarter 2023 Financial Results and Plans for a Comprehensive Portfolio Update in Early 2024 Seasoned Biotech Executive Pratik Shah Appointed as Chief Executive Officer to Lead Company Turnaround Current Cash and Securities of ~$290M Support Extended Five-Year Operating Runway Through 2028 Revised Corporate Strategy with Realignment Towards Long-Term G

August 25, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 25, 2023 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or other jurisdiction of incorporation) (Commissi

August 14, 2023 EX-99.1

Phase 1 MAD Study FXN mRNA Skeletal Muscle Response Chart

Exhibit 99.1 Phase 1 MAD Study Clinical Activity Significant and prolonged FXN mRNA increase in skeletal muscle Muscle FXN mRNA response correlated with dose and muscle DT-216 exposure, p < 0.05* Cohorts: 200mg and 300mg Muscle FXN mRNA (mean % change from baseline) p < 0.05** NS** 75th% FA † 40 20 0 -20 -40 2 Days 7 Days Days After 3rd Weekly Dose Pooled Placebo (n=6) DT-216 200mg (n=7) DT-216 30

August 14, 2023 EX-99.1

Design Therapeutics Provides Pipeline Update and Reports Second Quarter 2023 Financial Results Initial Data from Phase 1 Multiple-Ascending Dose Trial of DT-216 for Friedreich Ataxia Showed Significant Increase in FXN mRNA Levels in Skeletal Muscle C

Exhibit 99.1 Design Therapeutics Provides Pipeline Update and Reports Second Quarter 2023 Financial Results Initial Data from Phase 1 Multiple-Ascending Dose Trial of DT-216 for Friedreich Ataxia Showed Significant Increase in FXN mRNA Levels in Skeletal Muscle Company Expects to Resume a Multiple Dose Phase 1 Clinical Study with DT-216 with an Improved Formulation in the Second Half of 2024 and R

August 14, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 14, 2023 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissi

August 14, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

June 1, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 31, 2023 Design Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 31, 2023 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or other jurisdiction of incorporation) (Commission

May 9, 2023 EX-99

Design Therapeutics Provides Pipeline Updates and Reports First Quarter 2023 Financial Results Initial Data from Phase 1 Multiple-Ascending Dose Trial of DT-216 for Friedreich Ataxia Expected in the Third Quarter of 2023 Progress Across GeneTAC™ Smal

Exhibit 99.1 Design Therapeutics Provides Pipeline Updates and Reports First Quarter 2023 Financial Results Initial Data from Phase 1 Multiple-Ascending Dose Trial of DT-216 for Friedreich Ataxia Expected in the Third Quarter of 2023 Progress Across GeneTAC™ Small Molecule Pipeline with IND Submissions for FECD and DM1 Programs On-track for the Second Half of 2023 and 2024, Respectively $315.4 Mil

May 9, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 09, 2023 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

May 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

April 13, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Defin

April 13, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defin

April 3, 2023 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Shares of Design Therapeutics, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each of the under

April 3, 2023 SC 13G

DSGN / Design Therapeutics Inc / CITADEL ADVISORS LLC - DESIGN THERAPEUTICS, INC. Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. )* Design Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (the “Shares”) (Title of Class of Securities) 25056L103

March 14, 2023 S-8

As filed with the Securities and Exchange Commission on March 14, 2023

As filed with the Securities and Exchange Commission on March 14, 2023 Registration No.

March 14, 2023 EX-99

Design Therapeutics Highlights Pipeline Progress and Reports Fourth Quarter and Full Year 2022 Financial Results Phase 1 Multiple-Ascending Dose Trial of DT-216 for Friedreich Ataxia Ongoing with Data Expected Mid-Year Continued Progress Across Pipel

Exhibit 99.1 Design Therapeutics Highlights Pipeline Progress and Reports Fourth Quarter and Full Year 2022 Financial Results Phase 1 Multiple-Ascending Dose Trial of DT-216 for Friedreich Ataxia Ongoing with Data Expected Mid-Year Continued Progress Across Pipeline of GeneTACTM Small Molecules with Three Programs Expected to be in Clinical Development in the Next Two Years Strong Financial Positi

March 14, 2023 10-K

Form 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40288 Design Therapeu

March 14, 2023 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Design Therapeutics, Inc.

March 14, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 14, 2023 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissio

February 14, 2023 SC 13G/A

DSGN / Design Therapeutics Inc / CITADEL ADVISORS LLC - SC 13G/A Passive Investment

SC 13G/A 1 tm233474-27sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO § 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO § 240.13d-2 (Amendment No. 1)* Design Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (the “Shares

February 14, 2023 SC 13G/A

DSGN / Design Therapeutics Inc / Cormorant Asset Management, LP Passive Investment

SC 13G/A 1 schedule13g.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* Design Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 25056L103 (CUSIP Number) December 31, 2022 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate th

December 22, 2022 EX-99.2

SCHEDULE 13D JOINT FILING AGREEMENT

Exhibit 2 SCHEDULE 13D JOINT FILING AGREEMENT In accordance with the requirements of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, and subject to the limitations set forth therein, the parties set forth below agree to jointly file the Schedule 13D to which this joint filing agreement is attached, and any subsequent amendments thereto, and have duly executed this joint filing agreement as of the date set forth below.

December 22, 2022 EX-99.3

LIMITED POWER OF ATTORNEY

Exhibit 3 LIMITED POWER OF ATTORNEY Know all by these presents, that the undersigned hereby makes, constitutes and appoints Sasha Keough, Karen Narolewski-Engel, James Macadam, and Alexander M.

December 22, 2022 SC 13D/A

DSGN / Design Therapeutics Inc / SR One Capital Fund I Aggregator LP - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Design Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 25056L 10 3 (CUSIP Number) Sasha Keough c/o SR One Capital Management, LP 985 Old Eagle School Road, Suite 511 Wayne, PA 19087 410-800-7503 (Name,

December 22, 2022 SC 13G

DSGN / Design Therapeutics Inc / CITADEL ADVISORS LLC - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G* (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO ? 240.13d-1(b), (c), AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO ? 240.13d-2 (Amendment No. )* Design Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (the ?Shares?) (Title of Class of Securities) 25056L103

December 22, 2022 EX-99.1

JOINT FILING AGREEMENT

EXHIBIT 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Shares of Design Therapeutics, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(c) under the Securities Exchange Act of 1934, as amended, on behalf of each of the under

December 22, 2022 EX-99.1

Trade Date

Exhibit 1 Trade Date Number of Shares Average Price Per Share* Low Price High Price Where/How Effected 12/16/2022 500,000 $ 8.

November 3, 2022 EX-99.1

Design Therapeutics Highlights Pipeline Progress and Upcoming Milestones and Reports Third Quarter 2022 Financial Results Initial Data from Single-Ascending Dose Phase 1 Trial of DT-216 for Friedreich Ataxia Expected to be Reported in December 2022 D

Exhibit 99.1 Design Therapeutics Highlights Pipeline Progress and Upcoming Milestones and Reports Third Quarter 2022 Financial Results Initial Data from Single-Ascending Dose Phase 1 Trial of DT-216 for Friedreich Ataxia Expected to be Reported in December 2022 Dosing Initiated in the Multiple-Ascending Dose Phase 1 Trial of DT-216; Trial Completion Anticipated in Mid-2023 Strong Financial Positio

November 3, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

November 3, 2022 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 03, 2022 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commis

October 13, 2022 SC 13G

DSGN / Design Therapeutics Inc / RA CAPITAL MANAGEMENT, L.P. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* DESIGN THERAPEUTICS, INC. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 25056L 10 3 (CUSIP Number) October 3, 2022 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate t

August 8, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

August 8, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 08, 2022 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissi

August 8, 2022 EX-99.1

Design Therapeutics Highlights Upcoming Milestones and Reports Second Quarter 2022 Financial Results Initial Data from Friedreich Ataxia Phase 1 Trial of DT-216 Expected in the Fourth Quarter of 2022 Strong Financial Position with $359.4 Million in C

Exhibit 99.1 Design Therapeutics Highlights Upcoming Milestones and Reports Second Quarter 2022 Financial Results Initial Data from Friedreich Ataxia Phase 1 Trial of DT-216 Expected in the Fourth Quarter of 2022 Strong Financial Position with $359.4 Million in Cash and Securities to Support Multi-Year Operating Runway Carlsbad, Calif., Aug. 8, 2022 ? Design Therapeutics, Inc. (Nasdaq: DSGN), a cl

June 16, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2022 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

May 9, 2022 EX-99.1

Design Therapeutics Highlights Clinical and Research Progress and Reports First Quarter 2022 Financial Results Clinical Execution of Lead GeneTACTM Molecule, DT-216, with Initiation of Phase 1 Trial for the Treatment of Friedreich Ataxia Robust Resea

Exhibit 99.1 Design Therapeutics Highlights Clinical and Research Progress and Reports First Quarter 2022 Financial Results Clinical Execution of Lead GeneTACTM Molecule, DT-216, with Initiation of Phase 1 Trial for the Treatment of Friedreich Ataxia Robust Research Pipeline of GeneTACTM Candidates, with Promising New Data for Fuchs Endothelial Corneal Dystrophy Strong Cash Position with $371.2 Mi

May 9, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 09, 2022 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commission

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

May 5, 2022 CORRESP

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, California 92011

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, California 92011 May 5, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Dorrie Yale Re: Design Registration Statement on Form S-3 (File No. 333-264521) Filed: April 27, 2022 Request for Acceleration of Effective Date Ladies and Gentlemen: Des

May 2, 2022 CORRESP

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, California 92011

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, California 92011 May 2, 2022 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Dorrie Yale Re: Design Therapeutics, Inc. Registration Statement on Form S-3 (File No. 333-264521) Filed: April 27, 2022 Request for Acceleration of Effective Date Ladies

April 27, 2022 EX-1.2

Open Market Sale AgreementSM, dated April 27, 2022, by and between the Registrant and Jefferies LLC.

Exhibit 1.2 OPEN MARKET SALE AGREEMENTSM April 27, 2022 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Design Therapeutics, Inc., a Delaware corporation (the ?Company?), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the ?Agent?), shares of the Company?s common

April 27, 2022 EX-4.8

Form of Common Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.8 DESIGN THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF DESIGN THERAPEUTICS, INC. FORM OF COMMON STOCK WARRANT AGREEMENT THIS COMMON STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between DESIGN THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized and exist

April 27, 2022 DEF 14A

Schedule 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

April 27, 2022 EX-4.9

Form of Preferred Stock Warrant Agreement and Warrant Certificate.

Exhibit 4.9 DESIGN THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF DESIGN THERAPEUTICS, INC. FORM OF PREFERRED STOCK WARRANT AGREEMENT THIS PREFERRED STOCK WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between DESIGN THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized

April 27, 2022 EX-FILING FEES

Filing Fee Table.

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Design Therapeutics, Inc.

April 27, 2022 S-3

As filed with the Securities and Exchange Commission on April 27, 2022

As filed with the Securities and Exchange Commission on April 27, 2022 Registration No.

April 27, 2022 EX-4.6

Form of Indenture, between the registrant and one or more trustees to be named.

Exhibit 4.6 DESIGN THERAPEUTICS, INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20[?] Debt Securities TABLE OF CONTENTS PAGE ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 5 Section 2.01 Designation and Terms of Securities 5 Section 2.02 Form of Securities and Trustee?s Certificate

April 27, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ? Filed by a Party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Defin

April 27, 2022 EX-4.10

Form of Debt Securities Warrant Agreement and Warrant Certificate.

Exhibit 4.10 DESIGN THERAPEUTICS, INC. AND , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF DESIGN THERAPEUTICS, INC. FORM OF DEBT SECURITIES WARRANT AGREEMENT THIS DEBT SECURITIES WARRANT AGREEMENT (this ?Agreement?), dated as of [?], between DESIGN THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and [?], a [corporation] [national banking association] organized

March 31, 2022 SC 13D

DSGN / Design Therapeutics Inc / Logos Global Management LP Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. ) Design Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 25056L103 (CUSIP Number) Virginia Yee Logos Global Management LP One Letterman Drive, Building C, Suite C3-350 San Francisco, CA 94129 Telep

March 22, 2022 EX-10.1

First Amendment to Lease Agreement, by and between the Registrant and Crossing Holdings, LLC, dated March 18, 2022 (incorporated by reference to Exhibit 10.1 to the Registrant's Current Report on Form 8-K, filed March 22, 2022).

Exhibit 10.1 FIRST AMENDMENT TO LEASE This First Amendment to Lease (?First Amendment?) is entered into and effective as of March 18, 2022 (?Effective Date?) by and between CROSSING HOLDINGS, LLC, a California limited liability company (?Landlord?) and DESIGN THERAPEUTICS, INC, a Delaware corporation (?Tenant?), with reference to the recitals set forth below: RECITALS A. Landlord and Tenant entere

March 22, 2022 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2022 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissio

March 10, 2022 EX-FILING FEES

Filing Fee Table.

EX-FILING FEES 4 d320439dexfilingfees.htm EX-FILING FEES Exhibit 107 Calculation of Filing Fee Tables Form S-8 (Form Type) Design Therapeutics, Inc. (Exact name of Registrant as Specified in its Charter) Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Share(2) Maximum Aggregate Offering Price(2) Fee Rate Amount of Registration Fee Fe

March 10, 2022 EX-4.3

Description of the Registrant’s Common Stock.

Exhibit 4.3 DESCRIPTION OF COMMON STOCK The following summary description of the common stock of Design Therapeutics, Inc. (we, our or us) is based on the provisions of our amended and restated certificate of incorporation, as well as our amended and restated bylaws, and the applicable provisions of the Delaware General Corporation Law. This information is qualified entirely by reference to the ap

March 10, 2022 EX-10.3

Design Therapeutics, Inc. 2021 Equity Incentive Plan, and Forms of Option Grant Notice, Option Agreement and Notice of Exercise thereunder (incorporated by reference to Exhibit 10.3 to the Registrant's Annual Report on Form 10-K for the year ended December 31, 2021, filed with the SEC on March 10, 2022).

Exhibit 10.3 Design Therapeutics, Inc. 2021 Equity Incentive Plan Adopted by the Board of Directors: March 18, 2021 Approved by the Stockholders: March 19, 2021 Table of Contents Page 1. General. 1 2. Shares Subject to the Plan. 1 3. Eligibility and Limitations. 2 4. Options and Stock Appreciation Rights. 3 5. Awards Other Than Options and Stock Appreciation Rights. 7 6. Adjustments upon Changes i

March 10, 2022 EX-99.1

Design Therapeutics Reports Pipeline and Business Progress and Fourth Quarter and Full Year 2021 Financial Results Phase 1 Trial of DT-216, a Novel FA GeneTACTM Molecule, in Patients with Friedreich Ataxia On Track to Begin Soon Preclinical Data Supp

Exhibit 99.1 Design Therapeutics Reports Pipeline and Business Progress and Fourth Quarter and Full Year 2021 Financial Results Phase 1 Trial of DT-216, a Novel FA GeneTACTM Molecule, in Patients with Friedreich Ataxia On Track to Begin Soon Preclinical Data Supporting Development of Novel GeneTACTM Small Molecules for the Treatment of Fuchs Endothelial Corneal Dystrophy (FECD) to be Presented at

March 10, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-40288 Design Therapeu

March 10, 2022 S-8

As filed with the Securities and Exchange Commission on March 10, 2022

As filed with the Securities and Exchange Commission on March 10, 2022 Registration No.

March 10, 2022 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2022 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commissio

February 14, 2022 SC 13G/A

DSGN / Design Therapeutics Inc / Cormorant Asset Management, LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Design Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 25056L103 (CUSIP Number) December 31, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which th

February 9, 2022 SC 13G

DSGN / Design Therapeutics Inc / Ansari Aseem Z. - SC 13G Passive Investment

SC 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 Design Therapeutics, Inc.

February 9, 2022 SC 13G

DSGN / Design Therapeutics Inc / Light Irrevocable Trust #1 dated April 22, 2019 - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 Design Therapeutics, Inc.

February 9, 2022 EX-99.A

Joint Filing Agreement

CUSIP No. 25056L 103 13G EXHIBIT A Joint Filing Agreement In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, each of the persons named below agrees to the joint filing of a Statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Design Therapeutics, Inc. a Delaware corporation. Dated: February 8, 2022 Star Irrevocable Trust

February 9, 2022 EX-99.A

13G CUSIP No. 25056L 103

13G CUSIP No. 25056L 103 EXHIBIT A Joint Filing Agreement In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, each of the persons named below agrees to the joint filing of a Statement on Schedule 13G (including amendments thereto) with respect to the Common Stock of Design Therapeutics Inc., a Delaware corporation. Dated: February 8, 2022 Light Irrevocable Trust

February 9, 2022 SC 13G

DSGN / Design Therapeutics Inc / Star Irrevocable Trust #1 dated April 22, 2019 - SC 13G Passive Investment

SC 13G SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 Design Therapeutics, Inc.

November 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

November 9, 2021 EX-99.1

Design Therapeutics Reports Pipeline Progress and Third Quarter 2021 Results Clinical Initiation of Lead GeneTACTM Program for Friedreich Ataxia On-track for the First Half of 2022

Exhibit 99.1 Design Therapeutics Reports Pipeline Progress and Third Quarter 2021 Results Clinical Initiation of Lead GeneTACTM Program for Friedreich Ataxia On-track for the First Half of 2022 Carlsbad, CA, Nov. 9, 2021 ? Design Therapeutics, Inc. (Nasdaq: DSGN), a biotechnology company developing treatments for degenerative genetic disorders, today reported recent pipeline progress and third qua

November 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 09, 2021 Design Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 001-40288 82-3929248 (State or Other Jurisdiction of Incorporation) (Commis

August 20, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 18, 2021 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or other jurisdiction of incorporation) (Commissi

August 9, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

August 9, 2021 EX-99.1

Design Therapeutics Reports GeneTAC™ Portfolio Progress and Second Quarter 2021 Results Preclinical Data Support Initiation of Clinical Development of Lead GeneTAC Program for Friedreich Ataxia in the First Half of 2022 Leadership Team Strengthened w

Exhibit 99.1 Design Therapeutics Reports GeneTAC? Portfolio Progress and Second Quarter 2021 Results Preclinical Data Support Initiation of Clinical Development of Lead GeneTAC Program for Friedreich Ataxia in the First Half of 2022 Leadership Team Strengthened with Appointment of Elizabeth Gordon, Ph.D., as Senior Vice President of Regulatory Affairs Carlsbad, CA, Aug. 9, 2021 ? Design Therapeuti

August 9, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 9, 2021 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 001-40288 (Commission File Numb

August 6, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 2, 2021 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or other jurisdiction of incorporation) (Commissio

June 7, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8?K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 3, 2021 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 001-40288 (Commission File Number

May 10, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8?K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 10, 2021 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware (State or other jurisdiction of incorporation) 001-40288 (Commission File Number

May 10, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-40288 Design Therapeutics, Inc.

May 10, 2021 EX-99.1

Design Therapeutics Announces Business Highlights and Reports First Quarter 2021 Financial Results Successful $276 Million IPO Completed to Advance GeneTACTM Programs for Friedreich Ataxia and Myotonic Dystrophy Type-1 Toward Clinical Development Com

Exhibit 99.1 Design Therapeutics Announces Business Highlights and Reports First Quarter 2021 Financial Results Successful $276 Million IPO Completed to Advance GeneTACTM Programs for Friedreich Ataxia and Myotonic Dystrophy Type-1 Toward Clinical Development Company On-track to Initiate Phase 1 Clinical Trial for the Treatment of Friedreich Ataxia in the First Half of 2022 Carlsbad, CA, May 10, 2

April 9, 2021 SC 13D

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Design Therapeutics, Inc. (Name of Issuer) Common Stock, Par Value $0.0001 (Title of Class of Securities)

SC 13D UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. )* Design Therapeutics, Inc. (Name of Issuer) Common Stock, Par Value $0.0001 (Title of Class of Securities) 25056L 10 3 (CUSIP Number) Karen Narolewski Engel c/o SR One Capital Management, LP 985 Old Eagle School Road, Suite 511 Wayne, PA 19087 610-7

April 9, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT This Joint Filing Agreement, dated as of April 9, 2021, is by and among Cormorant Global Healthcare Master Fund, LP, Cormorant Global Healthcare GP, LLC, Cormorant Private Healthcare Fund II, LP, Cormorant Private Healthcare GP II, LLC, Cormorant Private Healthcare Fund III, LP, Cormorant Private Healthcare GP III, LLC, Cormorant Asset Management, LP and Bihua C

April 9, 2021 SC 13G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Design Therapeutics, Inc. (Name of Issuer) Common Stock (Title of Class of Securities) 25056L103 (CUSIP Number) March 30, 2021 (Date of Event which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this S

March 30, 2021 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Other Events

8-K 1 d108026d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 30, 2021 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-40288 82-3929248 (State or other jurisdiction of

March 30, 2021 EX-99.1

Design Therapeutics Announces Closing of Initial Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares

Exhibit 99.1 Design Therapeutics Announces Closing of Initial Public Offering and Full Exercise of Underwriters? Option to Purchase Additional Shares Carlsbad, CA, March 30, 2021 ? Design Therapeutics, Inc. (Nasdaq: DSGN) (?Design?), a biotechnology company developing a platform of gene targeted chimera (GeneTAC?) small molecules for the treatment of serious degenerative disorders caused by inheri

March 30, 2021 EX-3.2

Amended and Restated Bylaws (incorporated by reference to Exhibit 3.2 to the Registrant’s Current Report on Form 8-K, filed March 30, 2021).

Exhibit 3.2 AMENDED AND RESTATED BYLAWS OF DESIGN THERAPEUTICS, INC. ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be in the City of Wilmington, County of New Castle. Section 2. Other Offices. The corporation shall also have and maintain an office or principal place of business at such place as may be fixed by the corporatio

March 30, 2021 EX-3.1

Amended and Restated Certificate of Incorporation (incorporated by reference to Exhibit 3.1 to the Registrant’s Current Report on Form 8-K, filed March 30, 2021).

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DESIGN THERAPEUTICS, INC. Jo?o Siffert, M.D., hereby certifies that: ONE: He is the duly elected Chief Executive Officer of Design Therapeutics, Inc., a Delaware corporation. TWO: The date of filing the original Certificate of Incorporation of the Company with the Secretary of State of the State of Delaware was December 18, 2017. THR

March 26, 2021 S-8

- S-8

As filed with the Securities and Exchange Commission on March 26, 2021 Registration No.

March 26, 2021 424B4

12,000,000 Shares

Table of Contents Filed Pursuant to Rule 424(b)(4) Registration No. 333-253954 12,000,000 Shares Common Stock This is the initial public offering of shares of common stock of Design Therapeutics, Inc. We are offering 12,000,000 shares of our common stock. Prior to this offering, there has been no public market for our common stock. The initial public offering price is $20.00 per share of our commo

March 23, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Design Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 82-3929248 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification N

March 23, 2021 CORRESP

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, CA 92011

DESIGN THERAPEUTICS, INC. 6005 Hidden Valley Road, Suite 110 Carlsbad, CA 92011 March 23, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jeanne Bennett Vanessa Robertson Kasey Robinson Jeffrey Gabor Re: Design Therapeutics, Inc. Registration Statement on Form S-1, as amended (File No. 333-253954) Request for Ac

March 23, 2021 CORRESP

March 23, 2021

March 23, 2021 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jeanne Bennett Vanessa Robertson Kasey Robinson Jeffrey Gabor Re: Design Therapeutics, Inc. Registration Statement on Form S-1, as amended (File No. 333-253954) Request for Acceleration of Effective Date Ladies and Gentlemen: Pursuant to Rule 461 under th

March 22, 2021 EX-10.8

Non-Employee Director Compensation Policy (incorporated by reference to Exhibit 10.8 to the Registrant’s Registration Statement on Form S-1, as amended, filed March 22, 2021).

Exhibit 10.8 DESIGN THERAPEUTICS, INC. NON-EMPLOYEE DIRECTOR COMPENSATION POLICY Each member of the Board of Directors (the ?Board?) who is not also serving as an employee of or consultant to Design Therapeutics, Inc. (the ?Company?) or any of its subsidiaries (each such member, an ?Eligible Director?) will receive the compensation described in this Non-Employee Director Compensation Policy for hi

March 22, 2021 EX-10.12

Consulting Agreement, by and between the Registrant and Aseem Z. Ansari, Ph.D., dated December 27, 2017, as amended (incorporated by reference to Exhibit 10.12 to the Registrant’s Registration Statement on Form S-1, as amended, filed March 22, 2021).

Exhibit 10.12 DESIGN THERAPEUTICS, INC. CONSULTING AGREEMENT THIS CONSULTING AGREEMENT (?Agreement?) is entered into as of December 27, 2017, by and between DESIGN THERAPEUTICS, INC., a Delaware corporation having its principal place of business located at 991C Lomas Santa Fe #436, Solana Beach, CA 92075 (collectively with its affiliates, ?Company?), and ASEEM Z. ANSARI, PhD (?Consultant?). The Co

March 22, 2021 EX-4.1

Form of Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registrant’s Registration Statement on Form S-1, as amended, filed March 22, 2021).

Exhibit 4.1 DESIGN THERAPEUTICS NUMBER DT SHARES INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE CUSIP 25056L 10 3 SEE REVERSE FOR CERTAIN DEFINITIONS AND LEGENDS This certifies that is the record holder of FULLY PAID AND NONASSESSABLE SHARES OF COMMON STOCK, $0.0001 PAR VALUE PER SHARE, OF Design Therapeutics, Inc. transferable on the books of the Corporation in person or by duly authorized

March 22, 2021 EX-10.10

DESIGN THERAPEUTICS CONSULTING AGREEMENT EFFECTIVE DATE: March 1, 2020

Exhibit 10.10 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. DESIGN THERAPEUTICS CONSULTING AGREEMENT EFFECTIVE DATE: March 1, 2020 THIS CONSULTING AGREEMENT (the ?Agreement?) is made as of the Effective Date set forth above by and between Design Therap

March 22, 2021 EX-10.4

Design Therapeutics, Inc. 2021 Employee Stock Purchase Plan (incorporated by reference to Exhibit 10.4 to the Registrant’s Registration Statement on Form S-1, as amended, filed March 22, 2021).

Exhibit 10.4 DESIGN THERAPEUTICS, INC. 2021 EMPLOYEE STOCK PURCHASE PLAN ADOPTED BY THE BOARD OF DIRECTORS: MARCH 18, 2021 APPROVED BY THE STOCKHOLDERS: MARCH 19, 2021 1. GENERAL; PURPOSE. (a) The Plan provides a means by which Eligible Employees of the Company and certain designated Related Corporations may be given an opportunity to purchase shares of Common Stock. The Plan permits the Company t

March 22, 2021 EX-3.1

Amended and Restated Certificate of Incorporation, as currently in effect.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DESIGN THERAPEUTICS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Design Therapeutics, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the ?General Corporation Law?), DOES HEREBY CERTIFY: 1. Tha

March 22, 2021 CORRESP

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Kenneth J. Rollins +1 858 550 6136 [email protected] March 22, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jeanne Bennett, Vanessa Robertson, Kasey Robinson and Jeffrey Gabor Re: Design Therapeutics, Inc. Registration Statement on Form S-1 Filed March 5, 2021 File No. 333-253954 Ladies and Gentlemen: On behalf of De

March 22, 2021 S-1/A

- S-1/A

Table of Contents As filed with the Securities and Exchange Commission on March 22, 2021.

March 22, 2021 EX-10.3

Design Therapeutics, Inc. 2021 Equity Incentive Plan, and Forms of Option Grant Notice, Option Agreement and Notice of Exercise thereunder (incorporated by reference to Exhibit 10.3 to the Registrant’s Registration Statement on Form S-1, as amended (File No. 333-253954), filed with the SEC on March 22, 2021).

Exhibit 10.3 DESIGN THERAPEUTICS, INC. 2021 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: MARCH 18, 2021 APPROVED BY THE STOCKHOLDERS: March 19, 2021 TABLE OF CONTENTS Page 1. GENERAL. 1 2. SHARES SUBJECT TO THE PLAN. 1 3. ELIGIBILITY AND LIMITATIONS. 2 4. OPTIONS AND STOCK APPRECIATION RIGHTS. 3 5. AWARDS OTHER THAN OPTIONS AND STOCK APPRECIATION RIGHTS. 7 6. ADJUSTMENTS UPON CHANGES I

March 16, 2021 CORRESP

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETED ASTERISKS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE COMMISSION PURSUANT TO 17 CFR §200.83.

*FOIA Confidential Treatment Request* Confidential Treatment Requested by Design Therapeutics, Inc.

March 5, 2021 CORRESP

Cooley LLP 4401 Eastgate Mall San Diego, CA 92121-1909 t: (858) 550-6000 f: (858) 550-6420 cooley.com

Kenneth J. Rollins +1 858 550 6136 [email protected] March 5, 2021 U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Jeanne Bennett, Vanessa Robertson, Kasey Robinson and Jeffrey Gabor Re: Design Therapeutics, Inc. Draft Registration Statement on Form S-1 Submitted January 26, 2021 CIK No. 0001807120 Ladies and Gentlemen: On b

March 5, 2021 EX-10.5

Employment Agreement, by and between the Registrant and Pratik Shah, Ph.D., dated March 1, 2020 (incorporated by reference to Exhibit 10.5 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.5 DESIGN THERAPEUTICS, INC. March 1, 2020 Pratik Shah, Ph.D. Re: Offer of Employment Dear Pratik: Design Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of Executive Chairperson on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin on the l

March 5, 2021 EX-10.7

Employment Agreement, by and between the Registrant and Sean Jeffries, dated May 21, 2019 (incorporated by reference to Exhibit 10.7 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.7 DESIGN THERAPEUTICS, INC. May 21, 2019 Sean Jeffries Re: Employment Terms Dear Sean: Design Therapeutics, Inc. (the ?Company?) is pleased to offer you the position of Principal scientist/Chief Business Officer on the terms set forth below. This offer is subject to the following conditions: ? As required by law, the Company receipt of satisfactory proof of your right to work in the Uni

March 5, 2021 S-1

Form S-1

Table of Contents As filed with the Securities and Exchange Commission on March 5, 2021.

March 5, 2021 EX-1.1

Form of Underwriting Agreement.

Exhibit 1.1 Design Therapeutics, Inc. Common Stock Underwriting Agreement [?], 2021 Goldman Sachs & Co. LLC SVB Leerink LLC Piper Sandler & Co. As representatives (the ?Representatives?) of the several Underwriters named in Schedule I hereto, c/o Goldman Sachs & Co. LLC 200 West Street, New York, New York 10282-2198 c/o SVB Leerink LLC One Federal Street, 37th Floor Boston, Massachusetts 02110 c/o

March 5, 2021 EX-10.9

Human Therapeutics Exclusive License Agreement, by and between the Registrant and Wisconsin Alumni Research Foundation, dated February 20, 2019 (incorporated by reference to Exhibit 10.9 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.9 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. Agreement No. [***] HUMAN THERAPEUTICS EXCLUSIVE LICENSE AGREEMENT This Human Therapeutics Exclusive License Agreement (?Agreement?) is made effective the 20th day of February, 2019 (?Effective

March 5, 2021 EX-10.10

Consulting Agreement, by and between the Registrant and Marlinspike Group, LLC, dated March 1, 2020 (incorporated by reference to Exhibit 10.10 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.10 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. DESIGN THERAPEUTICS CONSULTING AGREEMENT EFFECTIVE DATE: March 1, 2020 THIS CONSULTING AGREEMENT (the ?Agreement?) is made as of the Effective Date set forth above by and between Design Therap

March 5, 2021 EX-10.6

Employment Agreement, by and between the Registrant and João Siffert, M.D., dated September 21, 2020 (incorporated by reference to Exhibit 10.6 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.6 DESIGN THERAPEUTICS, INC. September 21, 2020 Joao Siffert Re: Offer of Employment Dear Joao: Design Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of Chief Executive Officer (?CEO?) on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin o

March 5, 2021 EX-3.2

Form of Amended and Restated Certificate of Incorporation to become effective immediately prior to the closing of this offering.

Exhibit 3.2 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DESIGN THERAPEUTICS, INC. Jo?o Siffert, M.D., hereby certifies that: ONE: He is the duly elected Chief Executive Officer of Design Therapeutics, Inc., a Delaware corporation. TWO: The date of filing the original Certificate of Incorporation of the Company with the Secretary of State of the State of Delaware was December 18, 2017. THR

March 5, 2021 EX-3.3

Bylaws, as currently in effect.

Exhibit 3.3 BYLAWS OF DESIGN THERAPEUTICS, INC. (A DELAWARE CORPORATION) ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be 251 Little Falls Drive, City of Wilmington, County of New Castle, 19808 or in such other location as the Board of Directors of the corporation (the ?Board of Directors?) may from time to time determine or

March 5, 2021 EX-4.2

Amended and Restated Investors’ Rights Agreement, by and between the Registrant and certain of its stockholders, dated January 25, 2021 (incorporated by reference to Exhibit 4.2 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 4.2 AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT (this ?Agreement?), is made as of January 25, 2021, by and among Design Therapeutics, Inc., a Delaware corporation (the ?Company?), each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an ?Investor?. RECITALS: A. The Company and certain

March 5, 2021 EX-10.11

Lease, by and between the Registrant and Crossing Holdings, LLC, dated February 2, 2021 (incorporated by reference to Exhibit 10.11 to the Registrant’s Registration Statement on Form S-1, as amended, filed March 5, 2021).

Exhibit 10.11 LEASE This Lease (?Lease?) is made and dated as of February 2, 2021 (?Effective Date?), by and between CROSSING HOLDINGS, LLC, a California limited liability company (?Landlord?) and DESIGN THERAPEUTICS, INC., a Delaware corporation (?Tenant?). NOW, THEREFORE, in consideration of the foregoing, and the mutual covenants and agreements contained in this Lease, and intending to be legal

March 5, 2021 EX-10.1

Form of Indemnity Agreement, by and between the Registrant and its directors and officers (incorporated by reference to Exhibit 10.1 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.1 INDEMNITY AGREEMENT THIS INDEMNITY AGREEMENT (this ?Agreement?) dated as of , 20 , is made by and between DESIGN THERAPEUTICS, INC., a Delaware corporation (the ?Company?), and (?Indemnitee?). RECITALS A. The Company desires to attract and retain the services of highly qualified individuals as directors, officers, employees and agents. B. The Company?s Amended and Restated Bylaws (the

March 5, 2021 EX-10.2

Design Therapeutics, Inc. 2018 Equity Incentive Plan, as amended, and Forms of Option Grant notice, Option Agreement, Notice of Exercise, Early Exercise Stock Purchase Agreement, Restricted Stock Grant Notice and Restricted Stock Award Agreement thereunder (incorporated by reference to Exhibit 10.2 to the Registrant’s Registration Statement on Form S-1, filed March 5, 2021).

Exhibit 10.2 DESIGN THERAPEUTICS, INC. 2018 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: June 18, 2018 APPROVED BY THE STOCKHOLDERS: June 18, 2018 AMENDEDMENT ADOPTED BY THE BOARD OF DIRECTORS: October 29, 2020 AMENDMENT APPROVED BY THE STOCKHOLDERS: November 17, 2020 TERMINATION DATE: June 17, 2028 1. GENERAL. (a) Eligible Stock Award Recipients. Employees, Directors and Consultants a

March 5, 2021 EX-3.1

Amended and Restated Certificate of Incorporation, as currently in effect.

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DESIGN THERAPEUTICS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Design Therapeutics, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the ?General Corporation Law?), DOES HEREBY CERTIFY: 1. Tha

March 5, 2021 EX-3.4

Form of Amended and Restated Bylaws to become effective upon the closing of this offering.

Exhibit 3.4 AMENDED AND RESTATED BYLAWS OF DESIGN THERAPEUTICS, INC. ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be in the City of Wilmington, County of New Castle. Section 2. Other Offices. The corporation shall also have and maintain an office or principal place of business at such place as may be fixed by the corporatio

January 26, 2021 EX-10.7

DESIGN THERAPEUTICS, INC.

Exhibit 10.7 DESIGN THERAPEUTICS, INC. May 21, 2019 Sean Jeffries Re: Employment Terms Dear Sean: Design Therapeutics, Inc. (the ?Company?) is pleased to offer you the position of Principal scientist/Chief Business Officer on the terms set forth below. This offer is subject to the following conditions: ? As required by law, the Company receipt of satisfactory proof of your right to work in the Uni

January 26, 2021 EX-3.1

AMENDED AND RESTATED CERTIFICATE OF INCORPORATION DESIGN THERAPEUTICS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware)

Exhibit 3.1 AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF DESIGN THERAPEUTICS, INC. (Pursuant to Sections 242 and 245 of the General Corporation Law of the State of Delaware) Design Therapeutics, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of Delaware (the ?General Corporation Law?), DOES HEREBY CERTIFY: 1. Tha

January 26, 2021 EX-10.11

DESIGN THERAPEUTICS CONSULTING AGREEMENT EFFECTIVE DATE: March 1, 2020

Exhibit 10.11 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. DESIGN THERAPEUTICS CONSULTING AGREEMENT EFFECTIVE DATE: March 1, 2020 THIS CONSULTING AGREEMENT (the ?Agreement?) is made as of the Effective Date set forth above by and between Design Therap

January 26, 2021 EX-10.5

DESIGN THERAPEUTICS, INC.

Exhibit 10.5 DESIGN THERAPEUTICS, INC. March 1, 2020 Pratik Shah, Ph.D. Re: Offer of Employment Dear Pratik: Design Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of Executive Chairperson on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin on the l

January 26, 2021 DRS

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Table of Contents As confidentially submitted to the Securities and Exchange Commission on January 26, 2021.

January 26, 2021 EX-10.10

HUMAN THERAPEUTICS EXCLUSIVE LICENSE AGREEMENT

Exhibit 10.10 CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED. Agreement No. [***] HUMAN THERAPEUTICS EXCLUSIVE LICENSE AGREEMENT This Human Therapeutics Exclusive License Agreement (?Agreement?) is made effective the 20th day of February, 2019 (?Effectiv

January 26, 2021 EX-4.2

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

Exhibit 4.2 AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT THIS AMENDED AND RESTATED INVESTORS? RIGHTS AGREEMENT (this ?Agreement?), is made as of January 25, 2021, by and among Design Therapeutics, Inc., a Delaware corporation (the ?Company?), each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an ?Investor?. RECITALS: A. The Company and certain

January 26, 2021 EX-10.6

DESIGN THERAPEUTICS, INC.

Exhibit 10.6 DESIGN THERAPEUTICS, INC. September 21, 2020 Joao Siffert Re: Offer of Employment Dear Joao: Design Therapeutics, Inc. (the ?Company?) is pleased to offer you at-will employment in the position of Chief Executive Officer (?CEO?) on the terms and conditions set forth in this letter agreement (the ?Agreement?). 1. Employment by the Company. Your employment with the Company shall begin o

January 26, 2021 EX-3.3

BYLAWS DESIGN THERAPEUTICS, INC. (A DELAWARE CORPORATION)

Exhibit 3.3 BYLAWS OF DESIGN THERAPEUTICS, INC. (A DELAWARE CORPORATION) ARTICLE I OFFICES Section 1. Registered Office. The registered office of the corporation in the State of Delaware shall be 251 Little Falls Drive, City of Wilmington, County of New Castle, 19808 or in such other location as the Board of Directors of the corporation (the ?Board of Directors?) may from time to time determine or

January 26, 2021 EX-10.2

DESIGN THERAPEUTICS, INC. 2018 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: June 18, 2018 APPROVED BY THE STOCKHOLDERS: June 18, 2018 AMENDEDMENT ADOPTED BY THE BOARD OF DIRECTORS: October 29, 2020 AMENDMENT APPROVED BY THE STOCKHOLDERS:

Exhibit 10.2 DESIGN THERAPEUTICS, INC. 2018 EQUITY INCENTIVE PLAN ADOPTED BY THE BOARD OF DIRECTORS: June 18, 2018 APPROVED BY THE STOCKHOLDERS: June 18, 2018 AMENDEDMENT ADOPTED BY THE BOARD OF DIRECTORS: October 29, 2020 AMENDMENT APPROVED BY THE STOCKHOLDERS: November 17, 2020 TERMINATION DATE: June 17, 2028 1. GENERAL. (a) Eligible Stock Award Recipients. Employees, Directors and Consultants a

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