ACRS Insider Trading - Aclaris Therapeutics, Inc.

Jumlah Saham Beredar	108,332,218 shares
Saham Orang Dalam	30,414,323 shares
Kepemilikan oleh Orang Dalam	28.08 %
Orang Dalam Sejati	48

Skor Sentimen Orang Dalam

Skor Sentimen Orang Dalam mengidentifikasi perusahaan yang dibeli oleh orang dalam korporat.

Ini adalah hasil dari model kuantitatif multifaktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi internal tertinggi. Model penilaian ini menggunakan kombinasi dari jumlah bersih orang dalam yang membeli dalam 90 hari sebelumnya, total saham yang dibeli sebagai persentase dari jumlah saham yang beredar, dan total saham yang dimiliki oleh orang dalam. Angka tersebut berkisar dari 0 hingga 100, dengan angka yang lebih tinggi menunjukkan tingkat akumulasi yang lebih tinggi dibandingkan dengan perusahaan sejenis, dan 50 adalah rata-rata.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan akumulasi orang dalam tertinggi.

Lihat Saham dengan Peringkat Tertinggi

Skor Sentimen Petugas

Skor Sentimen Pejabat menemukan perusahaan yang dibeli oleh Pejabat Korporat.

Menurut definisi, Pejabat Korporasi adalah Orang Dalam Korporasi, tetapi tidak seperti beberapa Orang Dalam lainnya (Pemegang Saham 10% dan Anggota Dewan), Pejabat bekerja untuk perusahaan setiap hari, dan mereka menggunakan uang mereka sendiri saat bertransaksi . (Pemegang Saham 10% dan Anggota Dewan seringkali adalah manajer dana yang mengelola uang orang lain.) Dengan demikian, transaksi orang dalam yang dilakukan oleh Pejabat jauh lebih signifikan dan harus ditangani dengan tepat.

Seperti Skor Sentimen Internal, Skor Sentimen Pejabat adalah hasil dari model kuantitatif multi-faktor yang canggih yang mengidentifikasi perusahaan dengan tingkat akumulasi pejabat tertinggi.

Frekuensi Pembaruan: Setiap Hari

Lihat Pilihan Teratas dari Orang Dalam, yang menyediakan daftar perusahaan dengan sentimen orang dalam tertinggi.

Lihat Saham dengan Peringkat Tertinggi

Metrik Utama Orang Dalam

Kartu ini menunjukkan peringkat perusahaan berdasarkan berbagai metrik internal. Peringkat persentil menunjukkan bagaimana perusahaan ini dibandingkan dengan perusahaan lain di pasar AS. Peringkat yang lebih tinggi menunjukkan situasi yang lebih baik.

Sebagai contoh, secara umum diterima bahwa pembelian oleh orang dalam perusahaan adalah indikator positif, sehingga perusahaan dengan lebih banyak pembelian oleh orang dalam akan mendapat peringkat lebih tinggi daripada perusahaan dengan lebih sedikit pembelian oleh orang dalam (atau bahkan penjualan oleh orang dalam).

Jumlah Bersih Pembelian oleh Orang Dalam (Peringkat)

0 ( )

5407 out of 11323

Jumlah Bersih Pembelian oleh Orang Dalam adalah total jumlah orang dalam yang membeli dikurangi total jumlah orang dalam yang menjual dalam 90 hari terakhir. Peringkat persentil ditunjukkan di sini (kisaran dari 0 hingga 100%).

Persentase Saham yang Dibeli oleh Orang Dalam (Peringkat)

0.000 %( )

5370 out of 11244

Persentase Saham yang Dibeli oleh Orang Dalam adalah total jumlah saham yang dibeli oleh orang dalam dikurangi total jumlah saham yang dijual oleh orang dalam dalam 90 hari terakhir, dibagi dengan total jumlah saham yang beredar dan dikalikan dengan 100.

Grafik Perdagangan Orang Dalam

Grafik berikut menunjukkan Aclaris Therapeutics, Inc. transaksi orang dalam. Orang dalam adalah pejabat, direktur, atau investor signifikan dalam suatu perusahaan. Secara umum, melakukan transaksi di perusahaan mereka berdasarkan informasi material yang belum dipublikasikan adalah ilegal bagi orang dalam. Ini tidak berarti bahwa mereka dilarang melakukan transaksi apa pun di perusahaan mereka sendiri. Namun, mereka wajib melaporkan semua transaksi kepada SEC melalui Formulir 4.

Daftar Orang Dalam dan Metrik Profitabilitas

Tabel ini menampilkan daftar orang dalam yang diketahui, dan dibuat secara otomatis dari pengajuan yang diungkapkan kepada SEC. Selain nama, jabatan terbaru, dan sebutan direktur, pejabat, atau pemilik 10%, kami memberikan kepemilikan terbaru yang diungkapkan. Selain itu, jika memungkinkan, kami memberikan kinerja perdagangan historis untuk orang dalam tersebut. Kinerja perdagangan historis adalah rata-rata tertimbang dari kinerja transaksi pembelian pasar terbuka aktual yang dilakukan oleh orang dalam tersebut. Untuk informasi lebih lanjut tentang bagaimana ini dihitung, tonton webinar YouTube ini.

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Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Srinivas Akkaraju 10% Owner - [10%]	2,289,480	2,289,480
Kamil Ali-Jackson Chief Legal Officer - [O]	160,214	160,214
Kevin Balthaser Chief Financial Officer - [O]	92,608	92,608
Rick Bierly	8,000
Albert Cha Director - [D]	4,191,397	4,191,397
Gail Cawkwell Chief Medical Officer - [O]	9,593	9,593
Management Co Deerfield 10% Owner - [10%]	3,159,165	3,159,165
Deerfield Partners, L.p. 10% Owner - [10%]	3,159,165	3,159,165
Deerfield Mgmt L.P. 10% Owner - [10%]	3,159,165	3,159,165
Deerfield Special Situations Fund, L.P. 10% Owner - [10%]	3,159,165	3,159,165
FMR LLC / Fidelity Management & Research 10% Owner - [10%]	326,917	326,917
Brett Fair Chief Commercial Officer - [O]	10,582	10,582
James E Flynn 10% Owner - [10%]	3,159,165	3,159,165
Foresite Capital Fund III, L.P. 10% Owner - [10%]	8,276	8,276
Foresite Capital Fund IV, L.P. 10% Owner - [10%]	8,276	8,276
Foresite Capital Fund V, L.P. 10% Owner - [10%]	8,276	8,276

Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Foresite Capital Management III, LLC 10% Owner - [10%]	8,276	8,276
Foresite Capital Management IV, LLC 10% Owner - [10%]	8,276	8,276
Foresite Capital Management V, LLC 10% Owner - [10%]	8,276	8,276
Maxine Gowen Director - [D]	21,754	21,754
Gordon David N. Chief Medical Officer - [O]	147,447	147,447
James Healy 10% Owner - [10%]	2,289,480	2,289,480
Humphries William D. Director - [D]	33,525	33,525
Peter Kolchinsky 10% Owner - [10%]	2,102,169	2,102,169
Braden Michael Leonard 10% Owner - [10%]	14,250,000	14,250,000
James Loerop Chief Business Officer - [O]	103,306	103,306
Vincent Milano Director - [D]	17,316	17,316
Manion Douglas J. Pres and CEO, Director - [D] [O]	41,813	41,813
Anand Mehra Director - [D]	714,823	714,823
Molineaux Christopher P. Director - [D]	57,956	57,956
Joseph Monahan Chief Scientific Officer - [O]	265,855	265,855
Michael Powell 10% Owner - [10%]	2,289,480	2,289,480

Orang Dalam	Saham Dimiliki	Terbagi Disesuaikan
Christopher Powala Chief Reg & Develop Officer - [O]	141,729	141,729
Andrew Kenneth William Powell Director - [D]	33,523	33,523
Ra Capital Management, Llc 10% Owner - [10%]	2,102,169	2,102,169
RA Capital Healthcare Fund LP 10% Owner - [10%]	2,102,169	2,102,169
Reasons Bryan M. Director - [D]	28,732	28,732
Frank Ruffo Chief Financial Officer - [O]	201,883	201,883
Andrew N Schiff Director - [D]	13,960	13,960
Stuart Shanler Chief Scientific Officer - [O]	272,047	272,047
Sofinnova Management VIII, L.L.C. 10% Owner - [10%]	2,289,480	2,289,480
Sofinnova Venture Partners VIII, L.P. 10% Owner - [10%]	2,289,480	2,289,480
Tananbaum James B. 10% Owner - [10%]	8,276	8,276
Tullman Stephen A. Director - [D]	177,457	177,457
Vivo Ventures Vii, Llc 10% Owner - [10%]	60,972	60,972
Vivo Ventures Fund VII, L.P. 10% Owner - [10%]	60,972	60,972
Vivo Ventures VII Affiliates Fund, L.P. 10% Owner - [10%]	60,972	60,972
Neal Walker CEO, Director - [D] [O]	1,479,824	1,479,824

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Rekam Jejak Pembelian Orang Dalam - Analisis Keuntungan Jangka Pendek

Pada bagian ini, kami menganalisis profitabilitas setiap pembelian saham oleh orang dalam di pasar terbuka yang tidak direncanakan yang dilakukan di ACRS / Aclaris Therapeutics, Inc.. Analisis ini membantu memahami apakah orang dalam tersebut secara konsisten menghasilkan pengembalian abnormal, dan layak untuk diikuti. Analisis ini dilakukan selama satu tahun setelah setiap transaksi, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan pembelian pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Maksimal	Harga di Maksimal	Maksimal Keuntungan ($)	Maksimum Pengembalian (%)
2024-11-19	Mehra Anand	666,666	2.2500	666,666	2.2500	1,499,998	0	4.5900	1,559,999	104.00
2024-08-05	Leonard Braden Michael	206,025	1.2443	206,025	1.2443	256,357
2024-08-02	Leonard Braden Michael	167,544	1.2916	167,544	1.2916	216,400
2024-07-31	Leonard Braden Michael	100,000	1.3264	100,000	1.3264	132,640
2024-07-30	Leonard Braden Michael	173,730	1.3030	173,730	1.3030	226,370
2024-07-22	Leonard Braden Michael	17,716	1.3297	17,716	1.3297	23,557
2024-07-19	Leonard Braden Michael	6,689	1.3000	6,689	1.3000	8,696
2024-07-18	Leonard Braden Michael	130,317	1.3011	130,317	1.3011	169,555
2024-07-05	Leonard Braden Michael	123,017	1.1489	123,017	1.1489	141,334

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

ACRS / Aclaris Therapeutics, Inc. Insider Trades

Rekam Jejak Penjualan Orang Dalam - Analisis Kerugian Jangka Pendek

Dalam bagian ini, kami menganalisis penghindaran kerugian jangka pendek dari setiap penjualan dalam pasar terbuka yang tidak direncanakan oleh orang dalam yang dilakukan di ACRS / Aclaris Therapeutics, Inc.. Pola penghindaran kerugian yang konsisten dapat menunjukkan bahwa transaksi penjualan di masa mendatang dapat memprediksi penurunan harga. Analisis ini berlaku untuk satu tahun setelah setiap perdagangan, dan hasilnya bersifat teoretis .

Tabel berikut menunjukkan penjualan pasar terbuka terbaru yang bukan bagian dari rencana perdagangan otomatis.

Tanggal Perdagangan	Orang Dalam	Dilaporkan Saham	Dilaporkan Harga	Disesuaikan Saham	Disesuaikan Harga	Dasar Biaya	Hari-hari menuju Menit	Harga di Menit	Kerugian Maksimal Dihindari ($)	Kerugian Maksimal Dihindari (%)
2023-03-03	Monahan Joseph	16,037	12.6342	16,037	12.6342	202,615	255	0.6449	-192,272	-94.90
2023-03-03	Balthaser Kevin	894	12.6281	894	12.6281	11,290
2023-03-03	Walker Neal	30,240	12.6346	30,240	12.6346	382,070
2023-03-02	Monahan Joseph	14,800	12.3665	14,800	12.3665	183,024
2023-03-02	Balthaser Kevin	1,000	12.2890	1,000	12.2890	12,289
2023-03-02	Walker Neal	29,000	12.3651	29,000	12.3651	358,588
2023-02-08	Loerop James	4,267	13.8909	4,267	13.8909	59,272
2022-03-11	Walker Neal	56,303	15.9147	56,303	15.9147	896,045
2022-03-10	Ruffo Frank	12,823	15.5451	12,823	15.5451	199,335

Harga yang Disesuaikan adalah harga yang disesuaikan dengan pemisahan saham. Ang Adjusted Shares ay ang jumlah saham yang disesuaikan dengan pemisahan saham (stock split).

Riwayat Transaksi

Klik ikon tautan untuk melihat riwayat transaksi lengkap. Transaksi yang dilaporkan sebagai bagian dari rencana perdagangan otomatis 10b5-1 akan memiliki tanda X di kolom yang bertanda 10b-5.

Berkas Tanggal	Perdagangan Tanggal	Formulir	Orang Dalam	Ticker	Judul Keamanan	Kode	Langsung	Latihan Harga	Satuan Harga	Unit Diubah	Nilai Diubah (1 ribu)	Sisa Pilihan	Sisa Saham
2025-06-09	2025-06-06	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D			4,793			57,956
2025-06-09	2025-06-06	4	GOWEN MAXINE	ACRS	Common Stock	M - Exercise	D			4,793			21,754
2025-06-09	2025-06-06	4	Humphries William D.	ACRS	Common Stock	M - Exercise	D			4,793			33,525
2025-06-09	2025-06-06	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D			4,793			714,823
2025-06-09	2025-06-06	4	MILANO VINCENT	ACRS	Common Stock	M - Exercise	D			4,793			17,316
2025-06-09	2025-06-06	4	SCHIFF ANDREW N	ACRS	Common Stock	M - Exercise	D			4,793			13,960
2025-05-05	2025-05-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.3800	-2,975	-4		1,479,824
2025-05-05	2025-05-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,482,799
2025-04-03	2025-04-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.4800	-3,042	-5		1,473,332
2025-04-03	2025-04-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,476,374
2025-03-04	2025-03-01	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		1.9900	-27,258	-54		265,662
2025-03-04	2025-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			10,925			292,920
2025-03-04	2025-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			50,000			281,995
2025-03-04	2025-03-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.9900	-3,277	-7		1,466,907
2025-03-04	2025-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,466			1,470,184
2025-03-04	2025-03-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		1.9900	-727	-1		92,608
2025-03-04	2025-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			2,375			93,335
2025-03-04	2025-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,100			90,960
2025-02-04	2025-02-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		2.4800	-3,559	-9		1,460,718
2025-02-04	2025-02-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,464,277
2025-02-04	2025-02-01	4	Loerop James	ACRS	Common Stock	F - Taxes	D		2.4800	-15,447	-38		103,306
2025-02-04	2025-02-01	4	Loerop James	ACRS	Common Stock	M - Exercise	D			14,750			118,753
2025-02-04	2025-02-01	4	Loerop James	ACRS	Common Stock	M - Exercise	D			7,500			104,003
2025-02-04	2025-02-01	4	Loerop James	ACRS	Common Stock	M - Exercise	D			11,250			96,503
2025-02-04	2025-02-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		2.4800	-5,816	-14		89,860
2025-02-04	2025-02-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			14,750			95,676
2025-02-04	2025-02-01	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		2.4800	-11,317	-28		231,995
2025-02-04	2025-02-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			14,750			243,312
2025-02-04	2025-02-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			7,500			228,562
2025-01-03	2025-01-02	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		2.4800	-13,532	-34		1,454,810
2025-01-03	2025-01-02	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			29,149			1,468,342
2025-01-03	2025-01-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		2.4800	-3,904	-10		1,439,193
2025-01-03	2025-01-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,443,097
2025-01-03	2025-01-02	4	Loerop James	ACRS	Common Stock	F - Taxes	D		2.4800	-8,575	-21		85,253
2025-01-03	2025-01-02	4	Loerop James	ACRS	Common Stock	M - Exercise	D			18,150			93,828
2025-01-03	2024-12-31	4	Loerop James	ACRS	Common Stock	F - Taxes	D		2.4800	-32,089	-80		75,678
2025-01-03	2024-12-31	4	Loerop James	ACRS	Common Stock	M - Exercise	D			73,750			107,767
2025-01-03	2025-01-02	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		2.4800	-5,059	-13		80,926
2025-01-03	2025-01-02	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			13,200			85,985
2025-01-03	2025-01-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		2.4800	-2,430	-6		72,785
2025-01-03	2025-01-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			7,500			75,215
2025-01-03	2024-12-31	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		2.4800	-30,732	-76		67,715
2025-01-03	2024-12-31	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			73,750			98,447
2025-01-03	2025-01-02	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D			-8,914			221,062
2025-01-03	2025-01-02	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			17,380			229,976
2025-01-03	2024-12-31	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D			-32,937			212,596
2025-01-03	2024-12-31	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			73,750			245,533
2024-12-12	2024-12-10	4	Monahan Joseph	ACRS	Common Stock	G - Gift	D			-15,000			171,783
2024-12-06	2024-12-04	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		3.7600	-68,343	-257		1,433,630
2024-12-06	2024-12-04	4	Walker Neal	ACRS	Common Stock	M - Exercise	D		1.5200	118,840	181		1,501,973
2024-12-03	2024-12-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		4.0700	-2,721	-11		1,383,133
2024-12-03	2024-12-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,466			1,385,854
2024-11-20	2024-11-19	4	Mehra Anand	ACRS	Common Stock	P - Purchase	D		2.2500	666,666	1,500		710,030
2024-11-05	2024-11-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		2.0900	-2,721	-6		1,376,388
2024-11-05	2024-11-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,379,109
2024-10-03	2024-10-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.1800	-2,722	-3		1,369,642
2024-10-03	2024-10-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,372,364
2024-09-04	2024-09-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		1.1800	-286	-0		24,697
2024-09-04	2024-09-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,000			24,983
2024-09-04	2024-09-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.1800	-2,722	-3		1,362,897
2024-09-04	2024-09-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,466			1,365,619
2024-08-13	2024-08-09	4	Walker Neal	ACRS	Common Stock	M - Exercise	D		0.7200	43,548	31		1,356,153
2024-08-05	2024-08-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.3200	-2,722	-4		1,312,605
2024-08-05	2024-08-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,315,327
2024-08-05	2024-08-05	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.2443	206,025	256		14,250,000
2024-08-05	2024-08-02	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.2916	167,544	216		14,043,975
2024-07-31	2024-07-31	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.3264	100,000	133		13,876,421
2024-07-31	2024-07-30	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.3030	173,730	226		13,776,421
2024-07-22	2024-07-22	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.3297	17,716	24		13,602,691
2024-07-22	2024-07-19	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.3000	6,689	9		13,584,975
2024-07-22	2024-07-18	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.3011	130,317	170		13,578,286
2024-07-05	2024-07-05	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1489	123,017	141		13,447,969
2024-07-05	2024-07-03	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1590	143,288	166		13,324,952
2024-07-05	2024-07-02	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.1440	86,092	98		13,181,664
2024-07-03	2024-07-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.1500	-2,722	-3		1,305,860
2024-07-03	2024-07-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,308,582
2024-07-01	2024-07-01	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1373	107,434	122		13,095,572
2024-07-01	2024-06-28	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1300	400,000	452		12,988,134
2024-07-01	2024-06-28	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1193	801,000	897		12,588,134
2024-07-01	2024-06-27	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.1546	235,000	271		11,787,134
2024-06-18	2024-06-18	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1301	50,000	57		11,552,134
2024-06-18	2024-06-17	4	Leonard Braden Michael Holding of BML Investment Partners, L.P	ACRS	Common Stock	P - Purchase	I		1.1300	150,000	169		11,502,134
2024-06-18	2024-06-14	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.1658	345,000	402		11,352,134
2024-06-13	2024-06-13	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.1500	500,000	575		11,007,134
2024-06-13	2024-06-13	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.1445	28,621	33		10,507,134
2024-06-13	2024-06-12	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.1400	82,579	94		10,478,513
2024-06-13	2024-06-11	4	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock	P - Purchase	I		1.0800	1,000,000	1,080		10,395,934
2024-06-04	2024-06-01	4	SCHIFF ANDREW N	ACRS	Common Stock	M - Exercise	D			4,660			9,167
2024-06-04	2024-06-01	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D			4,660			43,364
2024-06-04	2024-06-01	4	Humphries William D.	ACRS	Common Stock	M - Exercise	D			4,660			28,732
2024-06-04	2024-06-01	4	GOWEN MAXINE	ACRS	Common Stock	M - Exercise	D			4,660			16,961
2024-06-04	2024-06-01	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D			4,660			53,163
2024-06-04	2024-06-01	4	Reasons Bryan M.	ACRS	Common Stock	M - Exercise	D			4,660			28,732
2024-06-04	2024-06-01	4	MILANO VINCENT	ACRS	Common Stock	M - Exercise	D			4,660			12,523
2024-06-04	2024-06-01	4	Powell Andrew Kenneth William	ACRS	Common Stock	M - Exercise	D			4,660			33,523
2024-06-04	2024-06-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.0300	-2,722	-3		1,299,115
2024-06-04	2024-06-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,466			1,301,837
2024-05-03	2024-05-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.2600	-2,784	-4		1,292,371
2024-05-03	2024-05-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,295,155
2024-04-03	2024-04-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.2600	-3,224	-4		1,285,688
2024-04-03	2024-04-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,467			1,288,912
2024-03-05	2024-03-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.2400	-3,223	-4		1,279,445
2024-03-05	2024-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			9,466			1,282,668
2024-03-05	2024-03-02	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		1.2400	-3,531	-4		186,783
2024-03-05	2024-03-02	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			12,500			190,314
2024-03-05	2024-03-01	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		1.2400	-3,183	-4		177,814
2024-03-05	2024-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			10,925			180,997
2024-03-05	2024-03-01	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		1.2400	-14,569	-18		170,072
2024-03-05	2024-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			50,000			184,641
2024-03-05	2024-03-02	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		1.2400	-427	-1		23,983
2024-03-05	2024-03-02	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,500			24,410
2024-03-05	2024-03-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		1.2400	-677	-1		22,910
2024-03-05	2024-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			2,375			23,587
2024-03-05	2024-03-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		1.2400	-313	-0		21,212
2024-03-05	2024-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,100			21,525
2024-03-05	2024-03-04	4	Powell Andrew Kenneth William	ACRS	Common Stock	P - Purchase	D		1.2500	6,000	8		28,863
2024-03-05	2024-03-01	4	Powell Andrew Kenneth William	ACRS	Common Stock	P - Purchase	D		1.2300	8,500	10		22,863
2024-02-08		3	Leonard Braden Michael Holding of BML Investment Partners, L.P.	ACRS	Common Stock		I						9,395,934
2024-02-05	2024-02-01	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		1.2000	-2,583	-3		134,641
2024-02-05	2024-02-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			7,500			137,224
2024-02-05	2024-02-01	4	Loerop James	ACRS	Common Stock	F - Taxes	D		1.2000	-2,568	-3		34,017
2024-02-05	2024-02-01	4	Loerop James	ACRS	Common Stock	M - Exercise	D			7,500			36,585
2024-02-05	2024-02-01	4	Loerop James	ACRS	Common Stock	F - Taxes	D		1.2000	-3,853	-5		29,085
2024-02-05	2024-02-01	4	Loerop James	ACRS	Common Stock	M - Exercise	D			11,250			32,938
2024-01-03	2024-01-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		1.0500	-2,536	-3		20,425
2024-01-03	2024-01-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			7,500			22,961
2024-01-03	2024-01-01	4	Manion Douglas J.	ACRS	Common Stock	F - Taxes	D		1.0500	-9,125	-10		41,813
2024-01-03	2024-01-01	4	Manion Douglas J.	ACRS	Common Stock	M - Exercise	D			27,000			50,938
2023-10-25	2023-10-23	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		5.0767	-6,000	-30		129,724
2023-09-07	2023-09-06	4	Balthaser Kevin	ACRS	Common Stock	P - Purchase	D		7.9000	9,490	75		15,461
2023-09-05	2023-09-01	4	Balthaser Kevin	ACRS	Common Stock	F - Taxes	D		7.9000	-285	-2		5,971
2023-09-05	2023-09-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,000			6,256
2023-08-28	2023-08-28	4	Loerop James	ACRS	Common Stock	P - Purchase	D		6.7976	14,705	100		21,688
2023-08-22	2023-08-21	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		7.3158	-6,000	-44		135,724
2023-08-03	2023-08-01	4	Manion Douglas J.	ACRS	Common Stock	F - Taxes	D		9.8100	-4,437	-44		23,938
2023-08-03	2023-08-01	4	Manion Douglas J.	ACRS	Common Stock	M - Exercise	D			15,575			28,375
2023-07-05	2023-07-01	4	Cawkwell Gail	ACRS	Common Stock	F - Taxes	D		10.3700	-5,407	-56		9,593
2023-07-05	2023-07-01	4	Cawkwell Gail	ACRS	Common Stock	M - Exercise	D			15,000			15,000
2023-06-22	2023-06-20	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		1.4100	16,500	23		48,503
2023-06-22	2023-06-20	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		10.2771	-6,000	-62		141,724
2023-06-20	2023-06-15	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		1.5200	198	0		32,003
2023-06-20	2023-06-15	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		0.7200	51	0		31,805
2023-06-05	2023-06-02	4	Humphries William D.	ACRS	Common Stock	M - Exercise	D			4,507			24,072
2023-06-05	2023-06-02	4	MILANO VINCENT	ACRS	Common Stock	M - Exercise	D			4,507			7,863
2023-06-05	2023-06-02	4	GOWEN MAXINE	ACRS	Common Stock	M - Exercise	D			4,507			12,301
2023-06-05	2023-06-02	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D			4,507			31,754
2023-06-05	2023-06-02	4	Reasons Bryan M.	ACRS	Common Stock	M - Exercise	D			4,507			24,072
2023-06-05	2023-06-02	4	SCHIFF ANDREW N	ACRS	Common Stock	M - Exercise	D			4,507			4,507
2023-06-05	2023-06-02	4	Powell Andrew Kenneth William	ACRS	Common Stock	M - Exercise	D			4,507			14,363
2023-06-05	2023-06-02	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D			4,507			38,704
2023-03-17	2023-03-17	4	Manion Douglas J.	ACRS	Common Stock	P - Purchase	D		7.8623	6,300	50		12,800
2023-03-09	2023-03-09	4	Manion Douglas J.	ACRS	Common Stock	P - Purchase	D		7.7350	6,500	50		6,500
2023-03-03	2023-03-03	4	Walker Neal	ACRS	Common Stock	S - Sale	D		12.6346	-30,240	-382		1,273,202
2023-03-03	2023-03-02	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			18,254			1,303,442
2023-03-03	2023-03-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		12.3651	-29,000	-359		1,285,188
2023-03-03	2023-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			24,000			1,314,188
2023-03-03	2023-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			18,275			1,290,188
2023-03-03	2023-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			96,150			1,271,913
2023-03-03	2023-03-03	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		12.6342	-16,037	-203		147,724
2023-03-03	2023-03-02	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			12,500			163,761
2023-03-03	2023-03-02	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		12.3665	-14,800	-183		151,261
2023-03-03	2023-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			10,925			166,061
2023-03-03	2023-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			50,000			155,136
2023-03-03	2023-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			13,750			105,136
2023-03-03	2023-03-03	4	Balthaser Kevin	ACRS	Common Stock	S - Sale	D		12.6281	-894	-11		5,256
2023-03-03	2023-03-02	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,500			6,150
2023-03-03	2023-03-02	4	Balthaser Kevin	ACRS	Common Stock	S - Sale	D		12.2890	-1,000	-12		4,650
2023-03-03	2023-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			2,375			5,650
2023-03-03	2023-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,100			3,275
2023-03-03	2023-03-01	4	Balthaser Kevin	ACRS	Common Stock	M - Exercise	D			1,475			2,175
2023-02-17	2023-02-15	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		13.0621	-5,000	-65		91,386
2023-02-10	2023-02-08	4	Loerop James	ACRS	Common Stock	S - Sale	D		13.8909	-4,267	-59		6,983
2023-02-03	2023-02-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		17.5350	-200	-4		1,175,763
2023-02-03	2023-02-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		16.8827	-3,121	-53		1,175,963
2023-02-03	2023-02-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		15.5533	-600	-9		1,179,084
2023-02-03	2023-02-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		14.5671	-1,079	-16		1,179,684
2023-02-03	2023-02-01	4	Walker Neal	ACRS	Common Stock	S - Sale	D		16.7470	-25,000	-419		1,180,763
2023-02-03	2023-02-01	4	Loerop James	ACRS	Common Stock	M - Exercise	D			11,250			11,250
2023-01-20	2022-11-08	4	Powell Andrew Kenneth William	ACRS	Common Stock	G - Gift	D			-4,000			9,856
2023-01-06		3	Balthaser Kevin	ACRS	Common Stock		D						700
2023-01-04	2023-01-04	4	Walker Neal	ACRS	Common Stock	S - Sale	D		14.8895	-15,000	-223		1,205,763
2023-01-04	2023-01-03	4	Walker Neal	ACRS	Common Stock	S - Sale	D		16.1594	-1,618	-26		1,220,763
2023-01-04	2023-01-03	4	Walker Neal	ACRS	Common Stock	S - Sale	D		15.1855	-23,382	-355		1,222,381
2022-12-16	2022-12-15	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		15.8823	-5,000	-79		96,386
2022-11-14	2022-11-14	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		17.0800	-1,371	-23		434,455
2022-11-14	2022-11-11	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		17.0597	-41,160	-702		435,826
2022-11-14	2022-11-10	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		17.0246	-11,395	-194		476,986
2022-10-26	2022-10-26	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		17.0050	-14,540	-247		488,381
2022-10-26	2022-10-25	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		17.0175	-12,018	-205		502,921
2022-10-26	2022-10-24	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		17.0078	-14,616	-249		514,939
2022-10-19	2022-10-18	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		16.8891	-32,093	-542		529,555
2022-10-19	2022-10-17	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		16.0493	-19,944	-320		561,648
2022-10-19	2022-10-17	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		15.9815	-5,000	-80		101,386
2022-10-11	2022-10-07	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		16.1591	-7,324	-118		581,592
2022-10-06	2022-10-06	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		16.5370	-37,839	-626		588,916
2022-10-06	2022-10-04	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	S - Sale	I		16.0076	-7,700	-123		626,755
2022-06-21	2022-06-17	4	SCHIFF ANDREW N	ACRS	Common Stock	S - Sale	D		15.1428	-19,565	-296		0
2022-06-06	2022-06-03	4	SCHIFF ANDREW N	ACRS	Common Stock	M - Exercise	D			3,356			19,565
2022-06-06	2022-06-03	4	Reasons Bryan M.	ACRS	Common Stock	M - Exercise	D			3,356			19,565
2022-06-06	2022-06-03	4	Powell Andrew Kenneth William	ACRS	Common Stock	M - Exercise	D			3,356			13,856
2022-06-06	2022-05-16	4	Powell Andrew Kenneth William	ACRS	Common Stock	G - Gift	D			-709			10,500
2022-06-06	2022-06-03	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D			3,356			27,247
2022-06-06	2022-06-03	4	MILANO VINCENT	ACRS	Common Stock	M - Exercise	D			3,356			3,356
2022-06-06	2022-06-03	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D			3,356			34,197
2022-06-06	2022-06-03	4	Humphries William D.	ACRS	Common Stock	M - Exercise	D			3,356			19,565
2022-06-06	2022-06-03	4	GOWEN MAXINE	ACRS	Common Stock	M - Exercise	D			3,356			7,794
2022-04-25	2022-04-25	4	Walker Neal	ACRS	Common Stock	S - Sale	D		15.1828	-20,000	-304		1,245,763
2022-04-25	2022-04-22	4	Walker Neal	ACRS	Common Stock	S - Sale	D		15.0439	-25,000	-376		1,265,763
2022-04-25	2022-04-21	4	Walker Neal	ACRS	Common Stock	S - Sale	D		15.2379	-25,000	-381		1,290,763
2022-04-20	2022-04-18	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		16.2766	-30,000	-488		106,386
2022-03-14	2022-03-11	4	Walker Neal	ACRS	Common Stock	S - Sale	D		15.9147	-56,303	-896		1,315,763
2022-03-14	2022-03-10	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		15.5451	-12,823	-199		201,883
2022-03-14	2022-03-10	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		15.7115	-27,165	-427		136,386
2022-03-03	2022-03-02	4	Monahan Joseph	ACRS	Restricted stock units	M - Exercise	D			-12,500		25,000
2022-03-03	2022-03-02	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			12,500			163,551
2022-03-03	2022-03-01	4	Monahan Joseph	ACRS	Restricted stock units	M - Exercise	D			-50,000		150,000
2022-03-03	2022-03-01	4	Monahan Joseph	ACRS	Restricted stock units	M - Exercise	D			-13,750		13,750
2022-03-03	2022-03-01	4	Monahan Joseph	ACRS	Restricted stock units	A - Award	D			43,700		43,700
2022-03-03	2022-03-01	4	Monahan Joseph	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	14.94		153,100		153,100
2022-03-03	2022-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			50,000			151,051
2022-03-03	2022-03-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			13,750			101,051
2022-03-03	2022-03-02	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-8,297		16,595
2022-03-03	2022-03-02	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			8,297			214,706
2022-03-03	2022-03-01	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-8,300		24,900
2022-03-03	2022-03-01	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-25,750		25,750
2022-03-03	2022-03-01	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			44,300		44,300
2022-03-03	2022-03-01	4	Ruffo Frank	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	14.94		155,200		155,200
2022-03-03	2022-03-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			8,300			206,409
2022-03-03	2022-03-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			25,750			198,109
2022-03-03	2022-03-02	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-18,254		36,508
2022-03-03	2022-03-02	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			18,254			1,372,066
2022-03-03	2022-03-01	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-18,275		54,825
2022-03-03	2022-03-01	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-96,150		96,150
2022-03-03	2022-03-01	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			96,000		96,000
2022-03-03	2022-03-01	4	Walker Neal	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	14.94		336,100		336,100
2022-03-03	2022-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			18,275			1,353,812
2022-03-03	2022-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			96,150			1,335,537
2022-02-11	2022-02-09	4	Walker Neal	ACRS	Common Stock	S - Sale	D		12.6602	-3,595	-46		1,239,387
2022-02-11	2022-02-09	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		12.6574	-1,388	-18		172,359
2022-02-11	2022-02-09	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		12.6818	-383	-5		87,301
2022-02-03	2022-02-01	4	Monahan Joseph	ACRS	Restricted Stock Units	M - Exercise	D			-1,050		0
2022-02-03	2022-02-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			1,050			87,684
2022-02-03	2022-02-01	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		0
2022-02-03	2022-02-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			3,875			173,747
2022-02-03	2022-02-01	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-10,800		0
2022-02-03	2022-02-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			10,800			1,242,982
2022-02-01	2022-02-01	4	Loerop James	ACRS	Restricted Stock Units	A - Award	D			45,000		45,000
2022-02-01	2022-02-01	4	Loerop James	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	11.58		155,000		155,000
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-7,100		0
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Restricted Stock Unit	M - Exercise	D			-6,638		0
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-27,905		0
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		0
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			7,100			160,214
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			6,638			153,114
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			27,905			146,476
2022-01-05	2022-01-03	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			3,875			118,571
2021-12-03	2021-11-23	4	Powell Andrew Kenneth William	ACRS	Common Stock	G - Gift	D			-5,500			11,209
2021-11-22	2021-03-11	4	Ali-Jackson Kamil	ACRS	Common Stock	G - Gift	D			-7,500			114,696
2021-11-03	2021-11-01	4	Foresite Capital Management III, LLC	ACRS	Common Stock	J - Other	I			8,276			8,276
2021-11-03	2021-11-01	4	Foresite Capital Management III, LLC	ACRS	Common Stock	J - Other	I			-1,954,904			0
2021-09-02	2021-09-01	4	Monahan Joseph	ACRS	Restricted Stock Units	M - Exercise	D			-2,333		0
2021-09-02	2021-09-01	4	Monahan Joseph	ACRS	Common Stock	F - Taxes	D		17.2200	-1,041	-18		86,634
2021-09-02	2021-09-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			2,333			87,675
2021-07-14	2021-07-13	4	Gordon David N.	ACRS	Common Stock	S - Sale	D		16.9801	-2,631	-45		147,447
2021-07-07	2021-07-02	4	Gordon David N.	ACRS	Restricted Stock Units	M - Exercise	D			-6,000		6,000
2021-07-07	2021-07-02	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			6,000			150,078
2021-06-04	2021-06-03	4	SCHIFF ANDREW N	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	SCHIFF ANDREW N	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	Reasons Bryan M.	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	Reasons Bryan M.	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	Powell Andrew Kenneth William	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	Powell Andrew Kenneth William	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	Molineaux Christopher P.	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	Molineaux Christopher P.	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	MILANO VINCENT	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	MILANO VINCENT	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	Mehra Anand	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	Mehra Anand	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	Humphries William D.	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	Humphries William D.	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	GOWEN MAXINE	ACRS	Restricted Stock Units	A - Award	D			3,356		3,356
2021-06-04	2021-06-03	4	GOWEN MAXINE	ACRS	Stock Option (Right to Buy)	A - Award	D	21.90		12,250		12,250
2021-06-04	2021-06-03	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		21.9575	-9,492	-208		122,196
2021-06-02	2021-06-02	4	Gordon David N.	ACRS	Common Stock	S - Sale	D		22.2649	-6,800	-151		144,078
2021-06-02	2021-06-02	4	Gordon David N.	ACRS	Common Stock	S - Sale	D		21.4954	-31,114	-669		150,878
2021-06-02	2021-06-01	4	Gordon David N.	ACRS	Restricted Stock Units	M - Exercise	D			-87,500		0
2021-06-02	2021-06-01	4	Gordon David N.	ACRS	Common Stock	S - Sale	D		23.5705	-4,885	-115		181,992
2021-06-02	2021-06-01	4	Gordon David N.	ACRS	Common Stock	S - Sale	D		22.7124	-9,115	-207		186,877
2021-06-02	2021-06-01	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			87,500			195,992
2021-06-02	2021-06-02	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		22.3112	-2,387	-53		131,688
2021-06-02	2021-06-02	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		21.5066	-12,732	-274		134,075
2021-06-02	2021-06-02	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		22.3175	-2,517	-56		146,807
2021-06-02	2021-06-02	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		21.5022	-12,483	-268		149,324
2021-06-02	2021-06-01	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-33,189		0
2021-06-02	2021-06-01	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.5728	-5,254	-124		161,807
2021-06-02	2021-06-01	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		22.7219	-9,746	-221		167,061
2021-06-02	2021-06-01	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			33,189			176,807
2021-06-02	2021-06-02	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		22.3114	-3,550	-79		85,342
2021-06-02	2021-06-02	4	Monahan Joseph	ACRS	Common Stock	S - Sale	D		21.5039	-18,240	-392		88,892
2021-06-02	2021-06-01	4	Monahan Joseph	ACRS	Restricted Stock Units	M - Exercise	D			-50,000		0
2021-06-02	2021-06-01	4	Monahan Joseph	ACRS	Common Stock	M - Exercise	D			50,000			107,132
2021-06-02	2021-06-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		22.3017	-5,517	-123		1,232,182
2021-06-02	2021-06-02	4	Walker Neal	ACRS	Common Stock	S - Sale	D		21.5080	-27,743	-597		1,237,699
2021-06-02	2021-06-01	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-73,015		0
2021-06-02	2021-06-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			73,015			1,265,442
2021-06-02	2021-06-02	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		22.3000	-2,450	-55		169,872
2021-06-02	2021-06-02	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		21.5101	-12,587	-271		172,322
2021-06-02	2021-06-01	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-33,189		0
2021-06-02	2021-06-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			33,189			184,909
2021-05-17		3	Monahan Joseph	ACRS	Common Stock		D						57,132
2021-05-17		3	Monahan Joseph By Spouse	ACRS	Common Stock		I						193
2021-05-07	2021-05-07	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	M - Exercise	D	10.66		-5,416		0
2021-05-07	2021-05-07	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.9886	-2,100	-50		143,618
2021-05-07	2021-05-07	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.2255	-3,316	-77		145,718
2021-05-07	2021-05-07	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		10.6600	5,416	58		149,034
2021-05-07	2021-05-06	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	M - Exercise	D	10.66		-15,000		5,416
2021-05-07	2021-05-06	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.8606	-3,102	-74		143,618
2021-05-07	2021-05-06	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.3180	-11,898	-277		146,720
2021-05-07	2021-05-06	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		10.6600	15,000	160		158,618
2021-05-05	2021-05-05	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	M - Exercise	D	10.66		-15,000		20,416
2021-05-05	2021-05-05	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		24.3559	-498	-12		143,618
2021-05-05	2021-05-05	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.9680	-14,502	-348		144,116
2021-05-05	2021-05-05	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		10.6600	15,000	160		158,618
2021-05-05	2021-05-04	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	M - Exercise	D	10.66		-15,000		35,416
2021-05-05	2021-05-04	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		24.4691	-1,279	-31		143,618
2021-05-05	2021-05-04	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		23.6055	-13,721	-324		144,897
2021-05-05	2021-05-04	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		10.6600	15,000	160		158,618
2021-05-05	2021-05-03	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	M - Exercise	D	10.66		-15,000		50,416
2021-05-05	2021-05-03	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		24.9075	-4,339	-108		143,618
2021-05-05	2021-05-03	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		24.4578	-10,661	-261		147,957
2021-05-05	2021-05-03	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		10.6600	15,000	160		158,618
2021-04-26	2021-04-26	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		26.4400	-100	-3		151,720
2021-04-26	2021-04-26	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		25.7933	-27,239	-703		151,820
2021-04-26	2021-04-23	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		27.3287	-800	-22		179,059
2021-04-26	2021-04-23	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		26.6369	-29,200	-778		179,859
2021-04-26	2021-04-22	4	Ruffo Frank	ACRS	Common Stock	S - Sale	D		26.8406	-30,000	-805		209,059
2021-04-26	2021-04-22	4	Walker Neal	ACRS	Common Stock	S - Sale	D		26.8413	-30,000	-805		1,192,427
2021-03-03	2021-03-02	4	Gordon David N.	ACRS	Restricted stock units	M - Exercise	D			-8,297		24,892
2021-03-03	2021-03-02	4	Gordon David N.	ACRS	Common Stock	F - Taxes	D		23.2500	-2,280	-53		108,492
2021-03-03	2021-03-02	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			8,297			110,772
2021-03-03	2021-03-01	4	Gordon David N.	ACRS	Restricted stock units	M - Exercise	D			-20,600		41,200
2021-03-03	2021-03-01	4	Gordon David N.	ACRS	Restricted stock units	A - Award	D			28,400		28,400
2021-03-03	2021-03-01	4	Gordon David N.	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	24.06		99,500		99,500
2021-03-03	2021-03-01	4	Gordon David N.	ACRS	Common Stock	F - Taxes	D		24.0600	-5,660	-136		102,475
2021-03-03	2021-03-01	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			20,600			108,135
2021-03-03	2021-03-02	4	Ali-Jackson Kamil	ACRS	Restricted stock units	M - Exercise	D			-6,637		19,914
2021-03-03	2021-03-02	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		23.2500	-1,906	-44		143,618
2021-03-03	2021-03-02	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			6,637			145,524
2021-03-03	2021-03-01	4	Ali-Jackson Kamil	ACRS	Restricted stock units	M - Exercise	D			-17,175		34,350
2021-03-03	2021-03-01	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			28,400		28,400
2021-03-03	2021-03-01	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	24.06		99,500		99,500
2021-03-03	2021-03-01	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		24.0600	-4,934	-119		138,887
2021-03-03	2021-03-01	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			17,175			143,821
2021-03-03	2021-03-02	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-8,297		24,892
2021-03-03	2021-03-02	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		23.2500	-2,844	-66		239,059
2021-03-03	2021-03-02	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			8,297			241,903
2021-03-03	2021-03-01	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-25,750		51,500
2021-03-03	2021-03-01	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			33,200		33,200
2021-03-03	2021-03-01	4	Ruffo Frank	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	24.06		116,000		116,000
2021-03-03	2021-03-01	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		24.0600	-7,333	-176		233,606
2021-03-03	2021-03-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			25,750			240,939
2021-03-03	2021-03-02	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-18,253		54,762
2021-03-03	2021-03-02	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		23.2500	-7,982	-186		1,222,427
2021-03-03	2021-03-02	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			18,253			1,230,409
2021-03-03	2021-03-01	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-96,150		192,300
2021-03-03	2021-03-01	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			73,100		73,100
2021-03-03	2021-03-01	4	Walker Neal	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	24.06		255,800		255,800
2021-03-03	2021-03-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		24.0600	-39,792	-957		1,212,156
2021-03-03	2021-03-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			96,150			1,251,948
2021-02-10		3	Tananbaum James B.	ACRS	Common Stock		I						3,399,034
2021-02-10		3	Tananbaum James B.	ACRS	Common Stock		I						1,258,243
2021-02-10		3	Tananbaum James B.	ACRS	Common Stock		I						1,954,904
2021-02-03	2021-02-02	4	Mehra Anand	ACRS	Option Grant (right to buy)	M - Exercise	D	18.32		-6,632		0
2021-02-03	2021-02-02	4	Mehra Anand	ACRS	Option Grant (right to buy)	M - Exercise	D	18.35		-8,000		0
2021-02-03	2021-02-02	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D		18.3200	6,632	121		30,841
2021-02-03	2021-02-02	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D		18.3500	8,000	147		24,209
2021-02-03	2021-02-01	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		3,875
2021-02-03	2021-02-01	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		21.3500	-1,308	-28		215,189
2021-02-03	2021-02-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			3,875			216,497
2021-02-03	2021-02-01	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		3,875
2021-02-03	2021-02-01	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		21.3500	-1,318	-28		126,646
2021-02-03	2021-02-01	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			3,875			127,964
2021-02-03	2021-02-01	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-10,800		10,800
2021-02-03	2021-02-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		21.3500	-3,316	-71		1,155,798
2021-02-03	2021-02-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			10,800			1,159,114
2020-12-17	2020-12-15	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-3,034		0
2020-12-17	2020-12-15	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		4.5900	-871	-4		1,148,314
2020-12-17	2020-12-15	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			3,034			1,149,185
2020-12-17	2020-12-15	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,734		0
2020-12-17	2020-12-15	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		4.5900	-498	-2		124,089
2020-12-17	2020-12-15	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,734			124,587
2020-12-17	2020-12-15	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		0
2020-12-17	2020-12-15	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		4.5900	-370	-2		212,622
2020-12-17	2020-12-15	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,300			212,992
2020-09-03	2020-09-01	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-83,092		0
2020-09-03	2020-09-01	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			83,092		83,092
2020-09-03	2020-09-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		2.3300	-23,872	-56		1,146,151
2020-09-03	2020-09-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			83,092			1,170,023
2020-07-07	2020-07-02	4	Gordon David N.	ACRS	Restricted stock units	M - Exercise	D			-6,000		12,000
2020-07-07	2020-07-02	4	Gordon David N.	ACRS	Common Stock	F - Taxes	D		1.5000	-1,360	-2		87,535
2020-07-07	2020-07-02	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			6,000			88,895
2020-06-08	2020-06-06	4	Mehra Anand	ACRS	Restricted Stock Units	M - Exercise	D			-7,333		0
2020-06-08	2020-06-06	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D			7,333			16,209
2020-06-08	2020-06-04	4	Mehra Anand	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-06	4	Molineaux Christopher P.	ACRS	Restricted Stock Units	M - Exercise	D			-7,333		0
2020-06-08	2020-06-06	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D			7,333			23,891
2020-06-08	2020-06-04	4	Molineaux Christopher P.	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-04	4	GOWEN MAXINE	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-06	4	Reasons Bryan M.	ACRS	Restricted Stock Units	M - Exercise	D			-7,333		0
2020-06-08	2020-06-06	4	Reasons Bryan M.	ACRS	Common Stock	M - Exercise	D			7,333			16,209
2020-06-08	2020-06-04	4	Reasons Bryan M.	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-04	4	MILANO VINCENT	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-06	4	SCHIFF ANDREW N	ACRS	Restricted Stock Units	M - Exercise	D			-7,333		0
2020-06-08	2020-06-06	4	SCHIFF ANDREW N	ACRS	Common Stock	M - Exercise	D			7,333			16,209
2020-06-08	2020-06-04	4	SCHIFF ANDREW N	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-06	4	Powell Andrew Kenneth William	ACRS	Restricted Stock Units	M - Exercise	D			-7,333		0
2020-06-08	2020-06-06	4	Powell Andrew Kenneth William	ACRS	Common Stock	M - Exercise	D			7,333			16,709
2020-06-08	2020-06-04	4	Powell Andrew Kenneth William	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-08	2020-06-06	4	Humphries William D.	ACRS	Restricted Stock Units	M - Exercise	D			-7,333		0
2020-06-08	2020-06-06	4	Humphries William D.	ACRS	Common Stock	M - Exercise	D			7,333			16,209
2020-06-08	2020-06-04	4	Humphries William D.	ACRS	Option Grant (right to buy)	A - Award	D	1.41		16,500		16,500
2020-06-03	2020-06-01	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-73,014		73,015
2020-06-03	2020-06-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.3200	-20,976	-28		1,086,931
2020-06-03	2020-06-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			73,014			1,107,907
2020-06-03	2020-06-01	4	Ali-Jackson Kamil	ACRS	Restricted stock units	M - Exercise	D			-33,188		33,189
2020-06-03	2020-06-01	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		1.3200	-9,534	-13		122,853
2020-06-03	2020-06-01	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			33,188			132,387
2020-06-03	2020-06-01	4	Gordon David N.	ACRS	Restricted stock units	M - Exercise	D			-87,500		87,500
2020-06-03	2020-06-01	4	Gordon David N.	ACRS	Common Stock	F - Taxes	D		1.3200	-24,045	-32		82,895
2020-06-03	2020-06-01	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			87,500			106,940
2020-06-03	2020-06-01	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-33,188		33,189
2020-06-03	2020-06-01	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		1.3200	-9,451	-12		211,692
2020-06-03	2020-06-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			33,188			221,143
2020-03-04	2020-03-02	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			33,189		33,189
2020-03-04	2020-03-02	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			66,377		66,377
2020-03-04	2020-03-02	4	Ruffo Frank	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	1.26		116,160		116,160
2020-03-04	2020-03-02	4	Ruffo Frank	ACRS	Restricted stock units	M - Exercise	D			-25,750		77,250
2020-03-04	2020-03-02	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		1.2600	-7,162	-9		187,955
2020-03-04	2020-03-02	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			25,750			195,117
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-52,564		0
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			52,564		52,564
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			73,015		73,015
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			146,029		146,029
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	1.26		255,552		255,552
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Restricted stock units	M - Exercise	D			-96,150		288,450
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.2600	-15,101	-19		1,034,893
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			52,564			1,049,994
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.2600	-27,623	-35		997,430
2020-03-04	2020-03-02	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			96,150			1,025,053
2020-03-04	2020-03-02	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			26,551		26,551
2020-03-04	2020-03-02	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			66,377		66,377
2020-03-04	2020-03-02	4	Ali-Jackson Kamil	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	1.26		92,928		92,928
2020-03-04	2020-03-02	4	Ali-Jackson Kamil	ACRS	Restricted stock units	M - Exercise	D			-17,175		51,525
2020-03-04	2020-03-02	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		1.2600	-4,779	-6		99,199
2020-03-04	2020-03-02	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			17,175			103,978
2020-03-04	2020-03-02	4	GOWEN MAXINE	ACRS	Restricted stock units	M - Exercise	D			-4,438		0
2020-03-04	2020-03-02	4	GOWEN MAXINE	ACRS	Restricted stock units	A - Award	D			4,438		4,438
2020-03-04	2020-03-02	4	GOWEN MAXINE	ACRS	Common Stock	M - Exercise	D			4,438			4,438
2020-03-04	2020-03-02	4	Humphries William D.	ACRS	Restricted stock units	M - Exercise	D			-8,876		0
2020-03-04	2020-03-02	4	Humphries William D.	ACRS	Restricted stock units	A - Award	D			8,876		8,876
2020-03-04	2020-03-02	4	Humphries William D.	ACRS	Common Stock	M - Exercise	D			8,876			8,876
2020-03-04	2020-03-02	4	Mehra Anand	ACRS	Restricted stock units	M - Exercise	D			-8,876		0
2020-03-04	2020-03-02	4	Mehra Anand	ACRS	Restricted stock units	A - Award	D			8,876		8,876
2020-03-04	2020-03-02	4	Mehra Anand	ACRS	Common Stock	M - Exercise	D			8,876			8,876
2020-03-04	2020-03-02	4	Molineaux Christopher P.	ACRS	Restricted stock units	M - Exercise	D			-8,876		0
2020-03-04	2020-03-02	4	Molineaux Christopher P.	ACRS	Restricted stock units	A - Award	D			8,876		8,876
2020-03-04	2020-03-02	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D			8,876			16,558
2020-03-04	2020-03-02	4	Powell Andrew Kenneth William	ACRS	Restricted stock units	M - Exercise	D			-8,876		0
2020-03-04	2020-03-02	4	Powell Andrew Kenneth William	ACRS	Restricted stock units	A - Award	D			8,876		8,876
2020-03-04	2020-03-02	4	Powell Andrew Kenneth William	ACRS	Common Stock	M - Exercise	D			8,876			9,376
2020-03-04	2020-03-02	4	Reasons Bryan M.	ACRS	Restricted stock units	M - Exercise	D			-8,876		0
2020-03-04	2020-03-02	4	Reasons Bryan M.	ACRS	Restricted stock units	A - Award	D			8,876		8,876
2020-03-04	2020-03-02	4	Reasons Bryan M.	ACRS	Common Stock	M - Exercise	D			8,876			8,876
2020-03-04	2020-03-02	4	SCHIFF ANDREW N	ACRS	Restricted stock units	M - Exercise	D			-8,876		0
2020-03-04	2020-03-02	4	SCHIFF ANDREW N	ACRS	Restricted stock units	A - Award	D			8,876		8,876
2020-03-04	2020-03-02	4	SCHIFF ANDREW N	ACRS	Common Stock	M - Exercise	D			8,876			8,876
2020-03-04	2020-03-02	4	Gordon David N.	ACRS	Restricted stock units	A - Award	D			33,189		33,189
2020-03-04	2020-03-02	4	Gordon David N.	ACRS	Employee Stock Option (Right to Buy)	A - Award	D	1.26		116,160		116,160
2020-03-04	2020-03-02	4	Gordon David N.	ACRS	Restricted stock units	M - Exercise	D			-20,600		61,800
2020-03-04	2020-03-02	4	Gordon David N.	ACRS	Common Stock	F - Taxes	D		1.2600	-5,512	-7		19,440
2020-03-04	2020-03-02	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			20,600			24,952
2020-02-04	2020-02-03	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		7,750
2020-02-04	2020-02-03	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		1.2800	-1,318	-2		86,803
2020-02-04	2020-02-03	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			3,875			88,121
2020-02-04	2020-02-03	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		7,750
2020-02-04	2020-02-03	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		1.2800	-1,308	-2		169,367
2020-02-04	2020-02-03	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			3,875			170,675
2020-02-04	2020-02-03	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-10,800		21,600
2020-02-04	2020-02-03	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.2800	-3,675	-5		928,903
2020-02-04	2020-02-03	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			10,800			932,578
2020-01-09	2020-01-07	4	MILANO VINCENT	ACRS	Stock Option (right to buy)	A - Award	D	1.85		22,000		22,000
2019-12-20	2019-12-18	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,075		0
2019-12-20	2019-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		1.8100	-277	-1		84,246
2019-12-20	2019-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,075			84,523
2019-12-20	2019-12-18	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,250		0
2019-12-20	2019-12-18	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		1.8100	-356	-1		166,800
2019-12-20	2019-12-18	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,250			167,156
2019-12-20	2019-12-18	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-2,925		0
2019-12-20	2019-12-18	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.8100	-743	-1		921,778
2019-12-20	2019-12-18	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			2,925			922,521
2019-12-18	2019-12-16	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,733		1,734
2019-12-18	2019-12-16	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		1.8000	-497	-1		83,448
2019-12-18	2019-12-16	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,733			83,945
2019-12-18	2019-12-16	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		1,300
2019-12-18	2019-12-16	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		1.8000	-370	-1		165,906
2019-12-18	2019-12-16	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,300			166,276
2019-12-18	2019-12-16	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-3,033		3,034
2019-12-18	2019-12-16	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		1.8000	-782	-1		919,596
2019-12-18	2019-12-16	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			3,033			920,378
2019-10-31	2019-10-30	4	Gordon David N.	ACRS	Restricted stock units	A - Award	D			175,000		175,000
2019-07-03	2019-07-02	4	Gordon David N.	ACRS	Restricted Stock Units	M - Exercise	D			-6,000		18,000
2019-07-03	2019-07-02	4	Gordon David N.	ACRS	Common Stock	F - Taxes	D		2.3400	-1,648	-4		4,352
2019-07-03	2019-07-02	4	Gordon David N.	ACRS	Common Stock	M - Exercise	D			6,000			6,000
2019-07-03	2019-07-02	4	GOWEN MAXINE	ACRS	Stock option (right to buy)	A - Award	D	2.34		16,000		16,000
2019-07-01	2019-06-27	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		2.6907	-590,801	-1,590		3,159,165
2019-07-01	2019-06-27	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		2.6907	-108,674	-292		964,101
2019-06-26	2019-06-26	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		4.5015	-1,352	-6		3,749,966
2019-06-26	2019-06-26	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		4.5015	-352	-2		1,072,775
2019-06-25	2019-06-25	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		4.5089	-40,850	-184		3,751,318
2019-06-25	2019-06-25	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		4.5089	-10,634	-48		1,073,127
2019-06-25	2019-06-24	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		4.5225	-50,177	-227		3,792,168
2019-06-25	2019-06-24	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		4.5225	-13,063	-59		1,083,761
2019-06-25	2019-06-21	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		4.6154	-269,402	-1,243		3,842,345
2019-06-25	2019-06-21	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		4.6154	-70,135	-324		1,096,824
2019-06-10	2019-06-06	4	Mehra Anand	ACRS	Restricted Stock Units	A - Award	D			7,333		7,333
2019-06-10	2019-06-06	4	SCHIFF ANDREW N	ACRS	Restricted Stock Units	A - Award	D			7,333		7,333
2019-06-10	2019-06-06	4	Reasons Bryan M.	ACRS	Restricted Stock Units	A - Award	D			7,333		7,333
2019-06-10	2019-06-06	4	Powell Andrew Kenneth William	ACRS	Restricted Stock Units	A - Award	D			7,333		7,333
2019-06-10	2019-06-06	4	Molineaux Christopher P.	ACRS	Restricted Stock Units	A - Award	D			7,333		7,333
2019-06-10	2019-06-06	4	Humphries William D.	ACRS	Restricted Stock Units	A - Award	D			7,333		7,333
2019-05-13	2019-05-10	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		6.0492	-71,869	-435		1,166,959
2019-05-13	2019-05-10	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		6.0492	-108,696	-658		4,111,747
2019-05-13	2019-05-09	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	ACRS	Common Stock	S - Sale	I		6.1575	-172,800	-1,064		1,238,828
2019-05-13	2019-05-09	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Common Stock	S - Sale	I		6.1575	-261,345	-1,609		4,220,443
2019-03-04	2019-03-01	4	Shanler Stuart	ACRS	Restricted stock units	A - Award	D			82,200		82,200
2019-03-04	2019-03-01	4	Gordon David N.	ACRS	Restricted stock units	A - Award	D			82,400		82,400
2019-03-04	2019-03-01	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			103,000		103,000
2019-03-04	2019-03-01	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			384,600		384,600
2019-03-04	2019-03-01	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			68,700		68,700
2019-02-05	2019-02-01	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		11,625
2019-02-05	2019-02-01	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		6.9600	-1,308	-9		82,212
2019-02-05	2019-02-01	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			3,875			83,520
2019-02-05	2019-02-01	4	Fair Brett	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		11,625
2019-02-05	2019-02-01	4	Fair Brett	ACRS	Common Stock	F - Taxes	D		6.9600	-1,308	-9		10,582
2019-02-05	2019-02-01	4	Fair Brett	ACRS	Common Stock	M - Exercise	D			3,875			11,890
2019-02-05	2019-02-01	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		11,625
2019-02-05	2019-02-01	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		6.9600	-1,308	-9		164,976
2019-02-05	2019-02-01	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			3,875			166,284
2019-02-05	2019-02-01	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-3,875		11,625
2019-02-05	2019-02-01	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		6.9600	-1,308	-9		272,047
2019-02-05	2019-02-01	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			3,875			273,355
2019-02-05	2019-02-01	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-3,400		10,200
2019-02-05	2019-02-01	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		6.9600	-1,114	-8		141,729
2019-02-05	2019-02-01	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			3,400			142,843
2019-02-05	2019-02-01	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-10,800		32,400
2019-02-05	2019-02-01	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		6.9600	-3,579	-25		917,345
2019-02-05	2019-02-01	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			10,800			920,924
2019-01-18	2019-01-15	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.93		1		1
2019-01-18	2019-01-14	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.97		1		1
2019-01-18	2019-01-11	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	7.00		1		1
2019-01-02	2018-12-28	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	7.00		1		1
2018-12-27	2018-12-27	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.89		1		1
2018-12-27	2018-12-26	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.86		1		1
2018-12-27	2018-12-24	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.92		1		1
2018-12-21	2018-12-21	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.94		1		1
2018-12-21	2018-12-20	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.84		1		1
2018-12-21	2018-12-19	4	Flynn James E Through Deerfield Partners, L.P.	ACRS	Cash-Settled Total Return Swap	J - Other	I	6.91		1		1
2018-12-21	2018-12-18	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-1,625		1,625
2018-12-21	2018-12-18	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		6.3000	-446	-3		139,443
2018-12-21	2018-12-18	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			1,625			139,889
2018-12-21	2018-12-18	4	Fair Brett	ACRS	Restricted Stock Units	M - Exercise	D			-1,750		1,750
2018-12-21	2018-12-18	4	Fair Brett	ACRS	Common Stock	F - Taxes	D		6.3000	-498	-3		8,015
2018-12-21	2018-12-18	4	Fair Brett	ACRS	Common Stock	M - Exercise	D			1,750			8,513
2018-12-21	2018-12-18	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-1,450		1,450
2018-12-21	2018-12-18	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		6.3000	-412	-3		269,480
2018-12-21	2018-12-18	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			1,450			269,892
2018-12-21	2018-12-18	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-2,925		2,925
2018-12-21	2018-12-18	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		6.3000	-833	-5		910,124
2018-12-21	2018-12-18	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			2,925			910,957
2018-12-21	2018-12-18	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,250		1,250
2018-12-21	2018-12-18	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		6.3000	-356	-2		162,409
2018-12-21	2018-12-18	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,250			162,765
2018-12-20	2018-12-18	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,075		1,075
2018-12-20	2018-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		6.3000	-306	-2		79,645
2018-12-20	2018-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,075			79,951
2018-12-18	2018-12-15	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		2,600
2018-12-18	2018-12-15	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		7.3100	-370	-3		161,515
2018-12-18	2018-12-15	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,300			161,885
2018-12-18	2018-12-15	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-3,033		6,067
2018-12-18	2018-12-15	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		7.3100	-863	-6		908,032
2018-12-18	2018-12-15	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			3,033			908,895
2018-12-18	2018-12-15	4	Fair Brett	ACRS	Restricted Stock Units	M - Exercise	D			-1,013		2,025
2018-12-18	2018-12-15	4	Fair Brett	ACRS	Common Stock	F - Taxes	D		7.3100	-288	-2		6,763
2018-12-18	2018-12-15	4	Fair Brett	ACRS	Common Stock	M - Exercise	D			1,013			7,051
2018-12-18	2018-12-15	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		2,600
2018-12-18	2018-12-15	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		7.3100	-357	-3		138,264
2018-12-18	2018-12-15	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			1,300			138,621
2018-12-18	2018-12-15	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,733		3,467
2018-12-18	2018-12-15	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		7.3100	-493	-4		78,876
2018-12-18	2018-12-15	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,733			79,369
2018-12-18	2018-12-15	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		2,600
2018-12-18	2018-12-15	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		7.3100	-370	-3		268,442
2018-12-18	2018-12-15	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			1,300			268,812
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Partners, L.P.	ACRS	Common stock		I						10,375,204
2018-10-24		3	Deerfield Special Situations Fund, L.P. Through Deerfield Special Situations Fund, L.P.	ACRS	Common stock		I						7,305,044
2018-10-23	2018-10-22	4	Mehra Anand	ACRS	Common Stock	P - Purchase	I		10.7500	372,093	4,000		1,911,573
2018-10-05	2018-10-04	4	Tullman Stephen A.	ACRS	Common Stock	P - Purchase	D		13.9958	7,100	99		177,457
2018-08-27	2018-08-23	4	Tullman Stephen A.	ACRS	Common Stock	P - Purchase	D		14.9977	6,600	99		170,357
2018-08-17	2018-08-15	4	Tullman Stephen A.	ACRS	Common Stock	P - Purchase	D		15.9700	6,250	100		163,757
2018-06-12	2018-06-12	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		20.0000	-4,900	-98		77,636
2018-06-12	2018-06-11	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		20.0000	-100	-2		82,536
2018-06-08	2018-06-07	4	Mehra Anand	ACRS	Stock Option (right to buy)	A - Award	D	18.35		8,000		8,000
2018-06-08	2018-06-07	4	Humphries William D.	ACRS	Stock Option (right to buy)	A - Award	D	18.35		8,000		8,000
2018-06-08	2018-06-07	4	Molineaux Christopher P.	ACRS	Stock Option (right to buy)	A - Award	D	18.35		8,000		8,000
2018-06-08	2018-06-07	4	Powell Andrew Kenneth William	ACRS	Stock Option (right to buy)	A - Award	D	18.35		8,000		8,000
2018-06-08	2018-06-07	4	SCHIFF ANDREW N	ACRS	Stock Option (right to buy)	A - Award	D	18.35		8,000		8,000
2018-05-21	2018-05-18	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		20.0000	-10,000	-200		82,636
2018-05-17	2018-05-16	4	Powell Andrew Kenneth William	ACRS	Common Stock	P - Purchase	D		19.1200	500	10		500
2018-05-09	2018-05-07	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-6,933		5,200
2018-05-09	2018-05-07	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		18.1000	-1,974	-36		92,636
2018-05-09	2018-05-07	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			6,933			94,610
2018-05-09	2018-05-07	4	Fair Brett	ACRS	Restricted Stock Units	M - Exercise	D			-4,050		3,038
2018-05-09	2018-05-07	4	Fair Brett	ACRS	Common Stock	F - Taxes	D		18.1000	-1,153	-21		6,038
2018-05-09	2018-05-07	4	Fair Brett	ACRS	Common Stock	M - Exercise	D			4,050			7,191
2018-05-09	2018-05-07	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-5,200		3,900
2018-05-09	2018-05-07	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		18.1000	-1,480	-27		137,321
2018-05-09	2018-05-07	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			5,200			138,801
2018-05-09	2018-05-07	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-5,200		3,900
2018-05-09	2018-05-07	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		18.1000	-1,480	-27		160,585
2018-05-09	2018-05-07	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			5,200			162,065
2018-05-09	2018-05-07	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-5,200		3,900
2018-05-09	2018-05-07	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		18.1000	-1,480	-27		267,512
2018-05-09	2018-05-07	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			5,200			268,992
2018-05-09	2018-05-07	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-12,133		9,100
2018-05-09	2018-05-07	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		18.1000	-3,455	-63		905,862
2018-05-09	2018-05-07	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			12,133			909,317
2018-05-07	2018-05-07	4	Ruffo Frank	ACRS	Common Stock	P - Purchase	D		18.2200	1,250	23		156,865
2018-04-23	2018-04-20	4	Reasons Bryan M.	ACRS	Stock Option (right to buy)	A - Award	D	17.73		16,000		16,000
2018-04-17		3	Fair Brett	ACRS	Common Stock		D						6,282
2018-04-17		3	Fair Brett	ACRS	Common Stock		D						6,282
2018-04-17		3	Fair Brett	ACRS	Common Stock		D						6,282
2018-04-09	2018-04-06	4	Molineaux Christopher P.	ACRS	Common Stock	S - Sale	D		16.5200	2,300	38		7,682
2018-04-09	2018-04-06	4	Tullman Stephen A.	ACRS	Common Stock	P - Purchase	D		16.5400	26,700	442		157,507
2018-04-09	2018-04-06	4	Ruffo Frank	ACRS	Common Stock	P - Purchase	D		16.5900	1,250	21		155,615
2018-04-09	2018-04-05	4	Walker Neal	ACRS	Common Stock	P - Purchase	D		16.7500	10,000	168		897,184
2018-03-22	2018-03-20	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	M - Exercise	D	1.52		-264		198
2018-03-22	2018-03-20	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	M - Exercise	D	0.72		-120		51
2018-03-22	2018-03-20	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	M - Exercise	D	0.41		-1,993		0
2018-03-22	2018-03-20	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		1.5200	264	0		9,982
2018-03-22	2018-03-20	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		0.7200	120	0		9,718
2018-03-22	2018-03-20	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		0.4100	1,993	1		9,598
2018-03-20	2018-03-16	4	Walker Neal	ACRS	Common Stock	J - Other	D			9,018			887,184
2018-03-20	2018-03-16	4	Ruffo Frank	ACRS	Common Stock	J - Other	D			9,018			154,365
2018-03-20	2018-03-16	4	Ali-Jackson Kamil	ACRS	Common Stock	J - Other	D			9,018			87,677
2018-03-20	2018-03-16	4	Tullman Stephen A.	ACRS	Common Stock	J - Other	D			9,018			130,807
2018-03-20	2018-03-16	4	Tullman Stephen A. By NST, LLC	ACRS	Common Stock	J - Other	I			-94,151			0
2018-02-05	2018-02-01	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			43,200		43,200
2018-02-05	2018-02-01	4	Walker Neal	ACRS	Stock option (right to buy)	A - Award	D	22.09		151,200		151,200
2018-02-05	2018-02-01	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			15,500		15,500
2018-02-05	2018-02-01	4	Ali-Jackson Kamil	ACRS	Stock option (right to buy)	A - Award	D	22.09		54,000		54,000
2018-02-05	2018-02-01	4	Shanler Stuart	ACRS	Restricted stock units	A - Award	D			15,500		15,500
2018-02-05	2018-02-01	4	Shanler Stuart	ACRS	Stock option (right to buy)	A - Award	D	22.09		54,000		54,000
2018-02-05	2018-02-01	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			15,500		15,500
2018-02-05	2018-02-01	4	Ruffo Frank	ACRS	Stock option (right to buy)	A - Award	D	22.09		54,000		54,000
2018-02-05	2018-02-01	4	Powala Christopher	ACRS	Restricted stock units	A - Award	D			13,600		13,600
2018-02-05	2018-02-01	4	Powala Christopher	ACRS	Stock option (right to buy)	A - Award	D	22.09		47,600		47,600
2017-12-21	2017-12-18	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-1,450		2,900
2017-12-21	2017-12-18	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		24.1200	-441	-11		263,792
2017-12-21	2017-12-18	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			1,450			264,233
2017-12-21	2017-12-15	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		9,100
2017-12-21	2017-12-15	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		24.2300	-395	-10		262,783
2017-12-21	2017-12-15	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			1,300			263,178
2017-12-21	2017-12-18	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,075		2,150
2017-12-21	2017-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		24.1200	-327	-8		78,659
2017-12-21	2017-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,075			78,986
2017-12-21	2017-12-15	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,733		12,133
2017-12-21	2017-12-15	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		24.2300	-527	-13		77,911
2017-12-21	2017-12-15	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,733			78,438
2017-12-21	2017-12-18	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-1,625		3,250
2017-12-21	2017-12-18	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		24.1200	-494	-12		133,601
2017-12-21	2017-12-18	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			1,625			134,095
2017-12-21	2017-12-15	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		9,100
2017-12-21	2017-12-15	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		24.2300	-395	-10		132,470
2017-12-21	2017-12-15	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			1,300			132,865
2017-12-21	2017-12-18	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,250		2,500
2017-12-21	2017-12-18	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		24.1200	-380	-9		145,347
2017-12-21	2017-12-18	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,250			145,727
2017-12-21	2017-12-15	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,300		9,100
2017-12-21	2017-12-15	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		24.2300	-395	-10		144,477
2017-12-21	2017-12-15	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,300			144,872
2017-12-21	2017-12-18	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-2,925		5,850
2017-12-21	2017-12-18	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		24.1200	-889	-21		878,166
2017-12-21	2017-12-18	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			2,925			879,055
2017-12-21	2017-12-15	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-3,033		21,233
2017-12-21	2017-12-15	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		24.2300	-922	-22		876,130
2017-12-21	2017-12-15	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			3,033			877,052
2017-08-18		3	FMR LLC / Fidelity Management & Research F-Prime Capital Partners Healthcare Fund III LP	ACRS	Common Stock		I						630,960
2017-08-18		3	FMR LLC / Fidelity Management & Research F-Prime Capital Partners Healthcare Advisors Fund III LP	ACRS	Common Stock		I						342,282
2017-08-18		3	FMR LLC / Fidelity Management & Research FIMM, LLC	ACRS	Common Stock		I						326,917
2017-08-18		3	FMR LLC / Fidelity Management & Research F-Prime Inc	ACRS	Common Stock		I						332,926
2017-08-18		3	FMR LLC / Fidelity Management & Research F-Prime Capital Partners Healthcare Advisors Fund III LP	ACRS	Common Stock		I						342,282
2017-08-18		3	FMR LLC / Fidelity Management & Research F-Prime Inc	ACRS	Common Stock		I						332,926
2017-08-18		3	FMR LLC / Fidelity Management & Research F-Prime Capital Partners Healthcare Fund III LP	ACRS	Common Stock		I						630,960
2017-08-18		3	FMR LLC / Fidelity Management & Research FIMM, LLC	ACRS	Common Stock		I						326,917
2017-08-16	2017-08-16	4	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock	P - Purchase	I		23.0200	108,601	2,500		634,455
2017-08-14		3	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock		I						1,051,708
2017-08-14		3	SCHIFF ANDREW N By Aisling Capital IV LP	ACRS	Common Stock		I						1,051,708
2017-08-14	2017-08-09	4	SCHIFF ANDREW N	ACRS	Stock Option (right to buy)	A - Award	D	26.97		16,000		16,000
2017-06-16	2017-06-15	4	Powell Andrew Kenneth William	ACRS	Stock Option (right to buy)	A - Award	D	24.58		8,000		8,000
2017-06-16	2017-06-15	4	Humphries William D.	ACRS	Stock Option (right to buy)	A - Award	D	24.58		8,000		8,000
2017-06-16	2017-06-15	4	Bierly Rick	ACRS	Stock Option (right to buy)	A - Award	D	24.58		8,000		8,000
2017-06-16	2017-06-15	4	Mehra Anand	ACRS	Stock Option (right to buy)	A - Award	D	24.58		8,000		8,000
2017-06-16	2017-06-15	4	Molineaux Christopher P.	ACRS	Stock Option (right to buy)	A - Award	D	24.58		8,000		8,000
2017-03-21	2017-03-17	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	M - Exercise	D	0.72		-311		171
2017-03-21	2017-03-17	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	M - Exercise	D	1.52		-592		462
2017-03-21	2017-03-17	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	M - Exercise	D	0.41		-6,702		1,993
2017-03-21	2017-03-17	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		0.7200	311	0		7,605
2017-03-21	2017-03-17	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		1.5200	592	1		7,294
2017-03-21	2017-03-17	4	Molineaux Christopher P.	ACRS	Common Stock	M - Exercise	D		0.4100	6,702	3		6,702
2017-03-02	2017-03-02	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	S - Sale	I		31.2000	-2,666	-83		60,972
2017-03-02	2017-03-02	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	S - Sale	I		31.2000	-122,334	-3,817		2,797,597
2017-03-02	2017-03-01	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	S - Sale	I		30.9800	-2,133	-66		63,638
2017-03-02	2017-03-01	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	S - Sale	I		30.9800	-97,867	-3,032		2,919,931
2017-03-02	2017-02-28	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	S - Sale	I		30.5000	-4,266	-130		65,771
2017-03-02	2017-02-28	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	S - Sale	I		30.5000	-195,734	-5,970		3,017,798
2017-01-26	2017-01-25	4	Powell Andrew Kenneth William	ACRS	Stock Option (right to buy)	A - Award	D	27.30		16,000		16,000
2017-01-12	2017-01-10	4	Mehra Anand By Funds	ACRS	Common Stock	S - Sale	I		28.2511	-750,000	-21,188		1,539,480
2016-12-21	2016-12-19	4	FMR LLC / Fidelity Management & Research	ACRS	Common Stock	J - Other	I			-639,627			1,931,727
2016-12-20	2016-12-18	4	Walker Neal	ACRS	Restricted Stock Units	M - Exercise	D			-2,925		8,775
2016-12-20	2016-12-18	4	Walker Neal	ACRS	Common Stock	F - Taxes	D		31.2500	-889	-28		874,019
2016-12-20	2016-12-18	4	Walker Neal	ACRS	Common Stock	M - Exercise	D			2,925			874,908
2016-12-20	2016-12-18	4	Powala Christopher	ACRS	Restricted Stock Units	M - Exercise	D			-1,625		4,875
2016-12-20	2016-12-18	4	Powala Christopher	ACRS	Common Stock	F - Taxes	D		31.2500	-494	-15		131,565
2016-12-20	2016-12-18	4	Powala Christopher	ACRS	Common Stock	M - Exercise	D			1,625			132,059
2016-12-20	2016-12-18	4	Shanler Stuart	ACRS	Restricted Stock Units	M - Exercise	D			-1,450		4,350
2016-12-20	2016-12-18	4	Shanler Stuart	ACRS	Common Stock	F - Taxes	D		31.2500	-441	-14		261,878
2016-12-20	2016-12-18	4	Shanler Stuart	ACRS	Common Stock	M - Exercise	D			1,450			262,319
2016-12-20	2016-12-18	4	Ali-Jackson Kamil	ACRS	Restricted Stock Units	M - Exercise	D			-1,075		3,225
2016-12-20	2016-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	F - Taxes	D		31.2500	-327	-10		76,705
2016-12-20	2016-12-18	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D			1,075			77,032
2016-12-20	2016-12-18	4	Ruffo Frank	ACRS	Restricted Stock Units	M - Exercise	D			-1,250		3,750
2016-12-20	2016-12-18	4	Ruffo Frank	ACRS	Common Stock	F - Taxes	D		31.2500	-380	-12		143,572
2016-12-20	2016-12-18	4	Ruffo Frank	ACRS	Common Stock	M - Exercise	D			1,250			143,952
2016-12-19	2016-12-15	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			24,266		24,266
2016-12-19	2016-12-15	4	Walker Neal	ACRS	Stock option (right to buy)	A - Award	D	28.92		145,600		145,600
2016-12-19	2016-12-15	4	Powala Christopher	ACRS	Restricted stock units	A - Award	D			10,400		10,400
2016-12-19	2016-12-15	4	Powala Christopher	ACRS	Stock option (right to buy)	A - Award	D	28.92		62,400		62,400
2016-12-19	2016-12-15	4	Shanler Stuart	ACRS	Restricted stock units	A - Award	D			10,400		10,400
2016-12-19	2016-12-15	4	Shanler Stuart	ACRS	Stock option (right to buy)	A - Award	D	28.92		62,400		62,400
2016-12-19	2016-12-15	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			13,866		13,866
2016-12-19	2016-12-15	4	Ali-Jackson Kamil	ACRS	Stock option (right to buy)	A - Award	D	28.92		83,200		83,200
2016-12-19	2016-12-15	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			10,400		10,400
2016-12-19	2016-12-15	4	Ruffo Frank	ACRS	Stock option (right to buy)	A - Award	D	28.92		62,400		62,400
2016-11-18	2016-11-18	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	S - Sale	I		22.7200	-9,598	-218		70,037
2016-11-18	2016-11-18	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	S - Sale	I		22.7200	-440,402	-10,006		3,213,532
2016-11-18	2016-11-16	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	S - Sale	I		27.3000	-9,765	-267		79,635
2016-11-18	2016-11-16	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	S - Sale	I		23.2500	-448,063	-10,417		3,653,934
2016-10-28	2016-10-26	4	Ali-Jackson Kamil	ACRS	Employee StockOption (right to buy)	M - Exercise	D	1.52		-3,912		6,522
2016-10-28	2016-10-26	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		21.8300	-3,912	-85		75,957
2016-10-28	2016-10-26	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		1.5200	3,912	6		79,869
2016-10-28	2016-10-26	4	FMR LLC / Fidelity Management & Research	ACRS	Common Stock	S - Sale	I		22.1500	-100	-2		2,571,354
2016-10-28	2016-10-26	4	FMR LLC / Fidelity Management & Research	ACRS	Common Stock	S - Sale	I		21.9300	-3,650	-80		2,571,454
2016-10-20	2016-10-19	4	FMR LLC / Fidelity Management & Research See Footnote 1	ACRS	Common Stock	J - Other	I			-84,223			2,575,104
2016-09-28	2016-09-28	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		24.6600	-1,841	-45		75,957
2016-09-28	2016-09-28	4	Ali-Jackson Kamil	ACRS	Common Stock	M - Exercise	D		0.7200	1,841	1		77,798
2016-09-28	2016-09-26	4	Ali-Jackson Kamil	ACRS	Employee StockOption (right to buy)	M - Exercise	D	0.72		-1,841		2,176
2016-09-19	2016-09-16	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	S - Sale	I		24.5429	-23,600	-579		2,102,169
2016-09-19	2016-09-16	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	S - Sale	I		24.5000	-150,000	-3,675		2,125,769
2016-09-19	2016-09-15	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	S - Sale	I		24.2000	-58,950	-1,427		2,275,769
2016-09-19	2016-09-15	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	S - Sale	I		24.0000	-273,000	-6,552		2,334,719
2016-09-19	2016-09-15	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	S - Sale	I		24.0350	-20,000	-481		2,607,719
2016-09-19	2016-09-15	4	Walker Neal	ACRS	Common Stock	J - Other	D			4,790			871,983
2016-09-19	2016-09-15	4	Walker Neal	ACRS	Common Stock	J - Other	D			81,686			867,193
2016-09-19	2016-09-15	4	Ali-Jackson Kamil	ACRS	Common Stock	J - Other	D			4,790			75,957
2016-09-19	2016-09-15	4	Ali-Jackson Kamil	ACRS	Common Stock	J - Other	D			50,878			71,167
2016-09-19	2016-09-15	4	Tullman Stephen A.	ACRS	Common Stock	J - Other	D			4,790			121,789
2016-09-19	2016-09-15	4	Tullman Stephen A. By NST, LLC	ACRS	Common Stock	J - Other	I			-50,002			94,151
2016-09-19	2016-09-15	4	Tullman Stephen A. By NST, LLC	ACRS	Common Stock	J - Other	I			144,153			144,153
2016-09-19	2016-09-15	4	Tullman Stephen A.	ACRS	Common Stock	J - Other	D			116,999			116,999
2016-09-19	2016-09-15	4	Tullman Stephen A. By NeXeption, LLC	ACRS	Common Stock	J - Other	I			-521,739			0
2016-09-19	2016-09-15	4	Ruffo Frank	ACRS	Common Stock	J - Other	D			4,790			142,702
2016-09-02	2016-09-01	4	Humphries William D.	ACRS	Stock Option (right to buy)	A - Award	D	20.68		10,000		10,000
2016-08-31	2016-08-30	4	FMR LLC / Fidelity Management & Research See Footnote 1	ACRS	Common Stock	J - Other	I			-130,571			2,659,327
2016-08-29	2016-08-26	4	Ali-Jackson Kamil	ACRS	Common Stock	S - Sale	D		20.3500	-3,738	-76		20,289
2016-07-01	2016-06-29	4	CHA ALBERT	ACRS	Stock Option (right to buy)	A - Award	D	18.32		6,632		6,632
2016-07-01	2016-06-29	4	Mehra Anand	ACRS	Stock Option (right to buy)	A - Award	D	18.32		6,632		6,632
2016-07-01	2016-06-29	4	Bierly Rick	ACRS	Stock Option (right to buy)	A - Award	D	18.32		6,632		6,632
2016-07-01	2016-06-29	4	Molineaux Christopher P.	ACRS	Stock Option (right to buy)	A - Award	D	18.32		6,632		6,632
2016-04-21	2016-04-19	4	FMR LLC / Fidelity Management & Research See Footnote 1	ACRS	Common Stock	J - Other	I			-1,014,381			2,789,898
2016-02-24	2016-02-23	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		17.6187	28,408	501		2,627,719
2016-02-24	2016-02-22	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		15.9885	11,318	181		2,599,311
2016-01-20	2016-01-20	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		19.8830	1,803	36		2,587,993
2016-01-20	2016-01-19	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		19.8763	4,200	83		2,586,190
2016-01-20	2016-01-15	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		19.8572	1,800	36		2,581,990
2016-01-13	2016-01-13	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		19.9665	5,543	111		2,580,190
2016-01-13	2016-01-12	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		19.1188	5,941	114		2,574,647
2016-01-13	2016-01-11	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		17.9337	4,153	74		2,568,706
2015-12-22	2015-12-18	4	Walker Neal	ACRS	Restricted stock units	A - Award	D			11,700		11,700
2015-12-22	2015-12-18	4	Walker Neal	ACRS	Stock option (right to buy)	A - Award	D	28.68		137,335		137,335
2015-12-22	2015-12-18	4	Molineaux Christopher P.	ACRS	Stock option (right to buy)	A - Award	D	28.68		2,759		2,759
2015-12-22	2015-12-18	4	Ruffo Frank	ACRS	Restricted stock units	A - Award	D			5,000		5,000
2015-12-22	2015-12-18	4	Ruffo Frank	ACRS	Stock option (right to buy)	A - Award	D	28.68		49,439		49,439
2015-12-22	2015-12-18	4	Tullman Stephen A.	ACRS	Stock option (right to buy)	A - Award	D	28.68		7,095		7,095
2015-12-22	2015-12-18	4	Ali-Jackson Kamil	ACRS	Restricted stock units	A - Award	D			4,300		4,300
2015-12-22	2015-12-18	4	Ali-Jackson Kamil	ACRS	Stock option (right to buy)	A - Award	D	28.68		45,939		45,939
2015-12-22	2015-12-18	4	Shanler Stuart	ACRS	Restricted stock units	A - Award	D			5,800		5,800
2015-12-22	2015-12-18	4	Shanler Stuart	ACRS	Stock option (right to buy)	A - Award	D	28.68		53,833		53,833
2015-12-22	2015-12-18	4	Powala Christopher	ACRS	Restricted stock units	A - Award	D			6,500		6,500
2015-12-22	2015-12-18	4	Powala Christopher	ACRS	Stock option (right to buy)	A - Award	D	28.68		58,516		58,516
2015-10-30	2015-10-29	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.0000	95,000	1,330		2,564,552
2015-10-30	2015-10-28	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.0000	149,200	2,089		2,469,552
2015-10-26	2015-10-22	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.0264	5,410	76		2,320,352
2015-10-21	2015-10-21	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.8311	3,100	46		2,314,942
2015-10-21	2015-10-20	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.9491	7,965	119		2,311,842
2015-10-21	2015-10-19	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.8763	23,934	356		2,303,877
2015-10-16	2015-10-14	4	RA CAPITAL MANAGEMENT, LLC	ACRS	Common Stock	P - Purchase	I		14.0563	42,813	602		2,279,943
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Series C Convertible Preferred Stock	C - Conversion	I			1,496,764		0
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Series B Convertible Preferred Stock	C - Conversion	I			1,818,182		0
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Series A Convertible Preferred Stock	C - Conversion	I			8,652,500		0
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Common Stock	P - Purchase	I		11.0000	335,455	3,690		3,804,279
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Common Stock	C - Conversion	I			433,844			3,468,824
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Common Stock	C - Conversion	I			527,009			3,034,980
2015-10-14	2015-10-13	4	FMR LLC / Fidelity Management & Research Beacon Bioventures Fund III Limited Partnership	ACRS	Common Stock	C - Conversion	I			2,507,971			2,507,971
2015-10-13		3	Kolchinsky Peter	ACRS	Common Stock, $0.00001 par value		I						4,474,260
2015-10-13		3	Kolchinsky Peter	ACRS	Common Stock, $0.00001 par value		I						4,474,260
2015-10-13		3	Kolchinsky Peter	ACRS	Common Stock, $0.00001 par value		I						4,474,260
2015-10-13	2015-10-13	4	Tullman Stephen A. By Trust	ACRS	Series C Preferred Stock	C - Conversion	I			-17,437		0
2015-10-13	2015-10-13	4	Tullman Stephen A. By Trust	ACRS	Series B Preferred Stock	C - Conversion	I			-31,913		0
2015-10-13	2015-10-13	4	Tullman Stephen A. By Trust	ACRS	Series A Preferred Stock	C - Conversion	I			-110,000		0
2015-10-13	2015-10-13	4	Tullman Stephen A. By Trust	ACRS	Common Stock	C - Conversion	I			46,188			394,014
2015-10-13	2015-10-13	4	CHA ALBERT By funds	ACRS	Series C Preferred Stock	C - Conversion	I			-1,375,405		0
2015-10-13	2015-10-13	4	CHA ALBERT By funds	ACRS	Series B Preferred Stock	C - Conversion	I			-1,818,182		0
2015-10-13	2015-10-13	4	CHA ALBERT By funds	ACRS	Series A Preferred Stock	C - Conversion	I			-8,652,500		0
2015-10-13	2015-10-13	4	CHA ALBERT By funds	ACRS	Common Stock	P - Purchase	I		11.0000	454,545	5,000		4,191,397
2015-10-13	2015-10-13	4	CHA ALBERT By funds	ACRS	Common Stock	C - Conversion	I			3,433,646			3,736,852
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Series C Preferred Stock	C - Conversion	I			-29,337		0
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Series C Preferred Stock	C - Conversion	I			-1,346,068		0
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Series B Preferred Stock	C - Conversion	I			-38,782		0
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Series B Preferred Stock	C - Conversion	I			-1,779,400		0
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Series A Preferred Stock	C - Conversion	I			-184,557		0
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Series A Preferred Stock	C - Conversion	I			-8,467,943		0
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	P - Purchase	I		11.0000	9,695	107		89,400
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	C - Conversion	I			73,238			79,705
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	P - Purchase	I		11.0000	444,850	4,893		4,101,997
2015-10-13	2015-10-13	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	C - Conversion	I			3,360,408			3,657,147
2015-10-13	2015-10-13	4	Mehra Anand By Funds	ACRS	Series C Preferred Stock	C - Conversion	I			-2,063,107		0
2015-10-13	2015-10-13	4	Mehra Anand By Funds	ACRS	Series B Preferred Stock	C - Conversion	I			-2,424,242		0
2015-10-13	2015-10-13	4	Mehra Anand By Funds	ACRS	Series A Preferred Stock	C - Conversion	I			-2,000,000		0
2015-10-13	2015-10-13	4	Mehra Anand By Funds	ACRS	Common Stock	P - Purchase	I		11.0000	409,090	4,500		2,289,480
2015-10-13	2015-10-13	4	Mehra Anand By Funds	ACRS	Common Stock	C - Conversion	I			1,880,390			1,880,390
2015-10-13	2015-10-13	4	Ali-Jackson Kamil	ACRS	Series B Preferred Stock	C - Conversion	D			-2,901		0
2015-10-13	2015-10-13	4	Ali-Jackson Kamil	ACRS	Series A Preferred Stock	C - Conversion	D			-10,000		0
2015-10-13	2015-10-13	4	Ali-Jackson Kamil	ACRS	Common Stock	C - Conversion	D			3,738			24,027
2015-10-13	2015-10-13	4	Ruffo Frank	ACRS	Series B Preferred Stock	C - Conversion	D			-5,802		0
2015-10-13	2015-10-13	4	Ruffo Frank	ACRS	Series A Preferred Stock	C - Conversion	D			-20,000		0
2015-10-13	2015-10-13	4	Ruffo Frank	ACRS	Common Stock	C - Conversion	D			7,478			137,912
2015-10-13	2015-10-13	4	Sofinnova Venture Partners VIII, L.P.	ACRS	Series C Preferred Stock	C - Conversion	D			-2,063,107		0
2015-10-13	2015-10-13	4	Sofinnova Venture Partners VIII, L.P.	ACRS	Series B Preferred Stock	C - Conversion	D			-2,424,242		0
2015-10-13	2015-10-13	4	Sofinnova Venture Partners VIII, L.P.	ACRS	Series A Preferred Stock	C - Conversion	D			-2,000,000		0
2015-10-13	2015-10-13	4	Sofinnova Venture Partners VIII, L.P.	ACRS	Common Stock	P - Purchase	D		11.0000	409,090	4,500		2,289,480
2015-10-13	2015-10-13	4	Sofinnova Venture Partners VIII, L.P.	ACRS	Common Stock	C - Conversion	D			1,880,390			1,880,390
2015-10-13	2015-10-08	4	RA CAPITAL MANAGEMENT, LLC See Footnote 1	ACRS	Common Stock	P - Purchase	I		10.9979	21,691	239		2,237,130
2015-10-13	2015-10-07	4	RA CAPITAL MANAGEMENT, LLC See Footnote 1	ACRS	Common Stock	P - Purchase	I		11.0000	27,398	301		2,215,439
2015-10-13	2015-10-07	4	RA CAPITAL MANAGEMENT, LLC See Footnote 1	ACRS	Common Stock	P - Purchase	I		11.0000	1,250,000	13,750		2,188,041
2015-10-13	2015-10-07	4	RA CAPITAL MANAGEMENT, LLC See Footnote 1	ACRS	Common Stock	P - Purchase	I		10.6605	938,041	10,000		938,041
2015-10-09	2015-10-07	4	VIVO VENTURES VII, LLC By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock	P - Purchase	I		11.0000	285	3		6,467
2015-10-09	2015-10-07	4	VIVO VENTURES VII, LLC By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock	P - Purchase	I		11.0000	13,067	144		296,739
2015-10-09	2015-10-07	4	CHA ALBERT By funds	ACRS	Common Stock	P - Purchase	I		11.0000	13,352	147		303,206
2015-10-06		3	Shanler Stuart	ACRS	Common Stock		D						521,738
2015-10-06		3	Shanler Stuart	ACRS	Common Stock		D						521,738
2015-10-06		3	Walker Neal	ACRS	Common Stock		D						1,571,014
2015-10-06		3	Walker Neal	ACRS	Common Stock		D						1,571,014
2015-10-06		3	Powala Christopher	ACRS	Common Stock		D						391,302
2015-10-06		3	Powala Christopher	ACRS	Common Stock		D						391,302
2015-10-06		3	Powala Christopher By Trust	ACRS	Common Stock		I						391,302
2015-10-06		3	Powala Christopher By Trust	ACRS	Common Stock		I						391,302
2015-10-06		3	Ruffo Frank	ACRS	Common Stock		D						260,868
2015-10-06		3	Ruffo Frank	ACRS	Common Stock		D						260,868
2015-10-06		3	Ali-Jackson Kamil	ACRS	Common Stock		D						40,578
2015-10-06		3	Ali-Jackson Kamil	ACRS	Common Stock		D						40,578
2015-10-06		3	Tullman Stephen A. By Trust	ACRS	Common Stock		I						1,217,391
2015-10-06		3	Tullman Stephen A. By Trust	ACRS	Common Stock		I						1,217,391
2015-10-06		3	Tullman Stephen A. By NeXeption, LLC	ACRS	Common Stock		I						1,391,304
2015-10-06		3	Tullman Stephen A. By NeXeption, LLC	ACRS	Common Stock		I						1,391,304
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock		I						296,036
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock		I						573,526
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock		I						573,526
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock		I						573,526
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock		I						296,036
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures Fund VII, L.P.	ACRS	Common Stock		I						573,526
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock		I						296,036
2015-10-06		3	Vivo Ventures VII Affiliates Fund, L.P. By Vivo Ventures VII Affiliates Fund, L.P.	ACRS	Common Stock		I						296,036
2015-10-06		3	CHA ALBERT By Funds	ACRS	Common Stock		I						579,708
2015-10-06		3	CHA ALBERT By Funds	ACRS	Common Stock		I						579,708
2015-10-06	2015-10-06	4	Bierly Rick	ACRS	Stock Option (right to buy)	A - Award	D	11.00		17,800		17,800

Pembelian sekuritas non-derivatif atau derivatif di pasar terbuka atau secara pribadi.

Penjualan terbuka atau penjualan pribadi atas sekuritas non-derivatif atau derivatif.

Hibah, penghargaan, atau perolehan sekuritas lainnya dari perusahaan (seperti opsi)

Konversi turunan

Penjualan atau pengalihan sekuritas kembali ke perusahaan.

Pembayaran harga pelaksanaan atau kewajiban pajak menggunakan sebagian sekuritas yang diterima dari perusahaan.

Pemberian sekuritas oleh atau kepada orang dalam.

Swap ekuitas dan transaksi lindung nilai serupa

Pelaksanaan atau konversi sekuritas derivatif yang diterima dari perusahaan (seperti opsi)

Transaksi yang dilaporkan secara sukarela pada Formulir 4.

Lainnya (disertai dengan catatan kaki yang menjelaskan transaksi tersebut)

ACRS / Aclaris Therapeutics, Inc. - Insider Trading and Ownership Report - SEC Form 3, 4, 5